Expression of leptin receptors in mononuclear cells from myelodysplastic syndromes and acute myeloid leukemias

Acta Haematologica

Volumn 114, Issue 2, 2005, Pages 71-77

  Tsiotra, Panayoula C ^a   Pappa, Vassiliki ^b   Koukourava, Athina ^a   Economopoulos, Theofanis ^b   Tsigos, Constantine ^a   Raptis, Sotirios A ^a,b  

^a Hellenic National Diabetes Center   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Acute myeloid leukemia; Leptin receptor; Myelodysplastic syndrome; Peripheral blood mononuclear cells; RT PCR; Southern blotting

Indexed keywords

ISOPROTEIN; LEPTIN RECEPTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; BLOOD LEVEL; CANCER PATIENT; CELL LINE; CELL STRAIN HL 60; CELL STRAIN K 562; CIRCULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MALE; MONONUCLEAR CELL; MYELODYSPLASTIC SYNDROME; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING;

ADULT; AGED; ALTERNATIVE SPLICING; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; HL-60 CELLS; HUMANS; K562 CELLS; LEPTIN; LEUKEMIA, MYELOCYTIC, ACUTE; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; PROTEIN ISOFORMS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 23844482137     PISSN: 00015792     EISSN: None     Source Type: Journal    
DOI: 10.1159/000086578     Document Type: Article

References (31)

1. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf AE, Monroe AC, Tepper RI: Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263-1271.
2. White DW, Kuropatwinski KK, Devos R, Baumann H, Tartaglia LA: Leptin receptor (OB-R) signaling: Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization. J Biol Chem 1997;272:4065-4071.
3. Cioffi AJ, Shafer WA, Zupancic JT, Smith-Gbur J, Mikhail A, Platika D, Snodgrass HR: Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction. Nat Med 1999;2:585-589.
4. Bennett DB, Solar PG, Yuan QJ, Mathias J, Thomas RG, Matthews W: A role for leptin and its cognate receptor in hemopoiesis. Curr Biol 1996;6:1170-1180.
5. Sierra-Honigmann MR, Nath KA, Murakami C, Garcia-Cardena G, Papapetropoulos A, Sessa CW, Madge AL, Schechner SJ, Schwabb BM, Polverini JP, Flores-Riveros RJ: Biological action of leptin as an angiogenic factor. Science 1998;281:1683-1686.
6. Hynes GR, Jones PJ: Leptin and its role in lipid metabolism. Curr Opin Lipidol 2001;12:321-327.
7. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998;394:897-901.
8. Tsiotra PC, Tsigos C, Raptis SA: TNF and leptin inhibit basal and glucose-stimulated insulin secretion and gene transcription in the HIT-T15 pancreatic cells. Int J Obes Relat Metab Disord 2001;25:1018-1026.
9. Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, Lai CF, Tartaglia LA: The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 1996;93:8374-8378.
10. Banks AS, Davis SM, Bates SH, Myers MG Jr: Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 2000;275:14563-14572.
11. Bjørbæk C, Uotani S, da Silva B, Flier JS: Divergent signaling capabilities of the long and short isoforms of the leptin receptor. J Biol Chem 1997;272:32686-32695.
12. Yamashita T, Murakami T, Otani S, Kuwajima M, Shima K: Leptin receptor signal transduction: OBRa and OBRb of fa type. Biochem Biophys Res Commun 1998;246:752-759.
13. Murakami T, Yamashita T, Iida M, Kuwajima M, Shima K: A short form of leptin receptor performs signal transduction. Biochem Biophys Res Commun 1997;231:26-29.
14. Chen SC, Kochan JP, Campfield LA, Burn P, Smeyne RJ: Splice variants of the OB receptor gene are differentially expressed in brain and peripheral tissues of mice. J Recept Signal Transduct Res 1999;19:245-266.
15. Burguera B, Couce ME, Long J, Lamsam J, Laakso K, Jensen MD, Parisi JE, Lloyd RV: The long form of the leptin receptor (OB-Rb) is widely expressed in the human brain. Neuroendocrinology 2000;71:187-195.
16. Gainsford T, Willson TA, Metcalf D, Handman E, McFarlane C, Ng A, Nicola NA, Alexander WS, Hilton DJ: Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 1996;93:14564-14568.
17. Laharrague P, Oppert JM, Brousset P, Charlet JP, Campfield A, Fontanilles AM, Guy-Grand B, Corberand JX, Penicaud L, Casteilla L: High concentration of leptin stimulates myeloid differentiation from human bone marrow CD34+ progenitors: Potential involvement in leukocytosis of obese subjects. Int J Obes Relat Metab Disord 2000;24:1212-1216.
18. Tsiotra PC, Pappa V, Raptis SA, Tsigos C: Expression of the long and short leptin receptor isoforms in peripheral blood mononuclear cells: Implications for leptin's actions. Metabolism 2000;49:1537-1541.
19. Santos-Alvarez J, Goberna R, Sanchez-Margalet V: Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol 1999;194:6-11.
20. Martin-Romero C, Santos-Alvarez J, Goberna R, Sanchez-Margalet V: Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 2000;199:15-24.
21. Nakao T, Hino M, Yamane T, Nishizawa Y, Mori H, Tatsumi N: Expression of the leptin receptor in human leukaemic blast cells. Br J Hematol 1998;102:740-745.
22. Konopleva M, Mikhail A, Estrov Z, Zhao S, Harris D, Sanchez-Williams G, Kornblau SM, Dong J, Kliche KO, Jiang S, Snodgrass HR, Estey EH, Andreeff M: Expression and function of leptin receptor isoforms in myeloid leukaemia and myelodysplastic syndromes: Proliferative and anti-apoptotic activities. Blood 1999;93:1668-1676.
23. Hino M, Nakao T, Yamane T, Ohta K, Takubo T, Tatsumi N: Leptin receptor and leukemia. Leuk Lymphoma 2000;36:457-461.
24. Iversen OP, Drevon AC, Reseland EJ: Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis. Blood 2002;100:4123-4128.
25. Tabe Y, Konopleva M, Munsell MF, Marini FC, Zompetta C, McQueen T, Tsao T, Zhao S, Pierce S, Igari J, Estey EH, Andreeff M: PML-RARα is associated with leptin-receptor induction: The role of mesenchymal stem cell-derived adipocytes in APL cell survival. Blood 2004;103:1815-1822.
26. Liu C, Liu XJ, Barry G, Ling N, Maki RA, De Souza EB: Expression and characterization of a putative high affinity human soluble leptin receptor. Endocrinology 1997;138:3548-3554.
27. Huang L, Wang Z, Li C: Modulation of circulating leptin levels by its soluble receptor. J Biol Chem 2001;276:6343-6349.
28. Church GM, Gilbert W: Genomic sequencing. Proc Natl Acad Sci USA 1984;81:1991-1995.
29. Kastin AJ, Pan W, Maness LM, Koletsky RJ, Ernsberger P: Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides 1997;20:1449-1453.
30. Wex H, Ponelis E, Wex T, Dressendorfer R, Mittler U, Vorwerk P: Plasma leptin and leptin receptor expression in childhood acute lymphoblastic leukemia. Int J Hematol 2002;76:446-452.
31. Maamra M, Bidlingmaier M, Postel-Vinay MC, Wu Z, Strasburger CJ, Ross RJ: Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology 2001;142:4389-4393.