Phosphatidylinositol 3-kinase-mediated regulation of IL-10 and IL-12 production in macrophages stimulated with CpG oligodeoxynucleotide

Molecular Immunology

Volumn 44, Issue 6, 2007, Pages 1323-1330

  Saegusa, Kazuharu ^a   Yotsumoto, Satoshi ^a   Kato, Sayaka ^a   Aramaki, Yukihiko ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

CpG ODN; IL 10; IL 12 p70; Macrophages; PI3K

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; CPG OLIGODEOXYNUCLEOTIDE; INTERLEUKIN 10; INTERLEUKIN 12; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN P70; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; MACROPHAGE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELLS, CULTURED; CPG ISLANDS; ENZYME ACTIVATION; INTERLEUKIN-10; INTERLEUKIN-12; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHATIDYLINOSITOL 3-KINASES;

EID: 33748798732     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.05.008     Document Type: Article

References (40)

1. Akdis C.A., and Blaser K. Mechanisms of interleukin-10-mediated immune suppression. Immunology 103 (2001) 131-136
2. Aksoy E., Vanden Berghe W., Detienne S., Amraoui Z., Fitzgerald K.A., Haegeman G., Goldman M., and Willems F. Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4. Eur. J. Immunol. 35 (2005) 2200-2209
3. Alexopoulou L., Holt A.C., Medzhitov R., and Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413 (2001) 732-738
4. Aste-Amezaga M., Ma X., Sartori A., and Trinchieri G. Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10. J. Immunol. 160 (1998) 5936-5944
5. Ballas Z.K., Rasmussen W.L., and Krieg A.M. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157 (1996) 1840-1845
6. Brazolot Millan C.L., Weeratna R., Krieg A.M., Siegrist C.A., and Davis H.L. CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 15553-15558
7. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 296 (2002) 1655-1657
8. Cowdery J.S., Chace J.H., Yi A.K., and Krieg A.M. Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides. J. Immunol. 156 (1996) 4570-4575
9. Dercamp C., Chemin K., Caux C., Trinchieri G., and Vicari A.P. Distinct and overlapping roles of interleukin-10 and CD25+ regulatory T cells in the inhibition of antitumor CD8 T-cell responses. Cancer. Res. 65 (2005) 8479-8486
10. Diaz-Guerra M.J., Castrillo A., Martin-Sanz P., and Bosca L. Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages. J. Immunol. 162 (1999) 6184-6190
11. Dragoi A.M., Fu X., Ivanov S., Zhang P., Sheng L., Wu D., Li G.C., and Chu W.M. DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA. EMBO J. 24 (2005) 779-789
12. Franke T.F., Kaplan D.R., Cantley L.C., and Toker A. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275 (1997) 665-668
13. Fratti R.A., Backer J.M., Gruenberg J., Corvera S., and Deretic V. Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest. J. Cell Biol. 154 (2001) 631-644
14. Fukao T., Tanabe M., Terauchi Y., Ota T., Matsuda S., Asano T., Kadowaki T., Takeuchi T., and Koyasu S. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat. Immunol. 3 (2002) 875-881
15. Gillooly D.J., Simonsen A., and Stenmark H. Phosphoinositides and phagocytosis. J. Cell Biol. 155 (2001) 15-17
16. Gubler U., Chua A.O., Schoenhaut D.S., Dwyer C.M., McComas W., Motyka R., Nabav N., Wolitzky A.G., Quinn P.M., and Familletti P.C. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 4143-4147
17. He H., and Kogut M.H. CpG-ODN-induced nitric oxide production is mediated through clathrin-dependent endocytosis, endosomal maturation, and activation of PKC, MEK1/2 and p38 MAPK, and NF-kappaB pathways in avian macrophage cells (HD11). Cell. Signal. 15 (2003) 911-917
18. Ishii K.J., Takeshita F., Gursel I., Gursel M., Conover J., Nussenzweig A., and Klinman D.M. Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. J. Exp. Med. 196 (2002) 269-274
19. Jakob T., Walker P.S., Krieg A.M., von Stebut E., Udey M.C., and Vogel J.C. Bacterial DNA and CpG-containing oligodeoxynucleotides activate cutaneous dendritic cells and induce IL-12 production: implications for the augmentation of Th1 responses. Int. Arch. Allergy Immunol. 118 (1999) 457-461
20. Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20 (2002) 709-760
21. Krieg A.M., Love-Homan L., Yi A.K., and Harty J.T. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J. Immunol. 161 (1998) 2428-2434
22. Kuhn R., Lohler J., Rennick D., Rajewsky K., and Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75 (1993) 263-274
23. Latz E., Schoenemeyer A., Visintin A., Fitzgerald K.A., Monks B.G., Knetter C.F., Lien E., Nilsen N.J., Espevik T., and Golenbock D.T. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5 (2004) 190-198
24. Martin M., Schifferle R.E., Cuesta N., Vogel S.N., Katz J., and Michalek S.M. Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide. J. Immunol. 171 (2003) 717-725
25. Park Y., Lee S.W., and Sung Y.C. Cutting Edge: CpG DNA inhibits dendritic cell apoptosis by up-regulating cellular inhibitor of apoptosis proteins through the phosphatidylinositide-3′-OH kinase pathway. J. Immunol. 168 (2002) 5-8
26. Rennick D.M., Fort M.M., and Davidson N.J. Studies with IL-10-/- mice: an overview. J. Leukoc. Biol. 61 (1997) 389-396
27. Rodriguez-Viciana P., Warne P.H., Dhand R., Vanhaesebroeck B., Gout I., Fry M.J., Waterfield M.D., and Downward J. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370 (1994) 527-532
28. Rodriguez-Viciana P., Warne P.H., Vanhaesebroeck B., Waterfield M.D., and Downward J. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J. 15 (1996) 2442-2451
29. Snijders A., Hilkens C.M., van der Pouw Kraan T.C., Engel M., Aarden L.A., and Kapsenberg M.L. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J. Immunol. 156 (1996) 1207-1212
30. Stokoe D., Stephens L.R., Copeland T., Gaffney P.R., Reese C.B., Painter G.F., Holmes A.B., McCormick F., and Hawkins P.T. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 277 (1997) 567-570
31. Trinchieri G. Immunobiology of interleukin-12. Immunol. Res. 17 (1998) 269-278
32. Trinchieri G., and Scott P. The role of interleukin 12 in the immune response, disease and therapy. Immunol. Today 15 (1994) 460-463
33. Vicari A.P., Chiodoni C., Vaure C., Ait-Yahia S., Dercamp C., Matsos F., Reynard O., Taverne C., Merle P., Colombo M.P., O'Garra A., Trinchieri G., and Caux C. Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody. J. Exp. Med. 196 (2002) 541-549
34. Vieira O.V., Botelho R.J., Rameh L., Brachmann S.M., Matsuo T., Davidson H.W., Schreiber A., Backer J.M., Cantley L.C., and Grinstein S. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J. Cell Biol. 155 (2001) 19-25
35. Wagner H. Bacterial CpG DNA activates immune cells to signal infectious danger. Adv. Immunol. 73 (1999) 329-368
36. Wagner M., Poeck H., Jahrsdoerfer B., Rothenfusser S., Prell D., Bohle B., Tuma E., Giese T., Ellwart J.W., Endres S., and Hartmann G. IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA. J. Immunol. 172 (2004) 954-963
37. Yamamoto S., Yamamoto T., and Tokunaga T. The discovery of immunostimulatory DNA sequence. Springer Semin. Immunopathol. 22 (2000) 11-19
38. Yasuda K., Rutz M., Schlatter B., Metzger J., Luppa P.B., Schmitz F., Haas T., Heit A., Bauer S., and Wagner H. CpG motif-independent activation of TLR9 upon endosomal translocation of "natural" phosphodiester DNA. Eur. J. Immunol. 174 (2005) 431-436
39. Yasuda K., Yu P., Kirschning C.J., Schlatter B., Schmitz F., Heit A., Bauer S., Hochrein H., and Wagner H. Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways. J. Immunol. 77 (2005) 6129-6136
40. Yi A.K., Yoon J.G., Yeo S.J., Hong S.C., English B.K., and Krieg A.M. Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: central role of extracellular signal-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response. J. Immunol. 168 (2002) 4711-4720