Toll-like receptor 2 contributes to antibacterial defence against pneumolysin-deficient pneumococci

Cellular Microbiology

Volumn 10, Issue 1, 2008, Pages 237-246

  Dessing, Mark C ^a   Florquin, Sandrine ^a   Paton, James C ^b   Van Der Poll, Tom ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PNEUMOLYSIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; CONTROLLED STUDY; HOST RESISTANCE; IMMUNE RESPONSE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN INTERACTION; RESPIRATORY TRACT INFECTION; SEROTYPE; SIGNAL TRANSDUCTION; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; WILD TYPE;

ANIMALS; BACTERIAL PROTEINS; COLONY COUNT, MICROBIAL; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PNEUMONIA, PNEUMOCOCCAL; STREPTOCOCCUS PNEUMONIAE; STREPTOLYSINS; SURVIVAL ANALYSIS; TOLL-LIKE RECEPTOR 2;

MUS; POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

EID: 36949011204     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2007.01035.x     Document Type: Article

References (39)

1. Albiger, B., Sandgren, A., Katsuragi, H., Meyer-Hoffert, U., Beiter, K., Wartha, F., et al. (2005) Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice. Cell Microbiol 7: 1603-1615.
2. Alouf, J.E. (2000) Cholesterol-binding cytolytic protein toxins. Int J Med Microbiol 290: 351-356.
3. Benton, K.A., Everson, M.P., and Briles, D.E. (1995) A pneumolysin-negative mutant of Streptococcus pneumoniae causes chronic bacteremia rather than acute sepsis in mice. Infect Immun 63: 448-455.
4. Bernstein, J.M. (1999) Treatment of community-acquired pneumonia - IDSA guidelines. Infectious Diseases Society of America. Chest 115: 9S-13S.
5. Berry, A.M., and Paton, J.C. (2000) Additive attenuation of virulence of Streptococcus pneumoniae by mutation of the genes encoding pneumolysin and other putative pneumococcal virulence proteins. Infect Immun 68: 133-140.
6. Berry, A.M., Yother, J., Briles, D.E., Hansman, D., and Paton, J.C. (1989) Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infect Immun 57: 2037-2042.
7. Branger, J., Knapp, S., Weijer, S., Leemans, J.C., Pater, J.M., Speelman, P., et al. (2004) Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice. Infect Immun 72: 788-794.
8. Campbell, G.D. Jr (1999) Commentary on the 1993 American Thoracic Society guidelines for the treatment of community-acquired pneumonia. Chest 115: 14S-18S.
9. Canvin, J.R., Marvin, A.P., Sivakumaran, M., Paton, J.C., Boulnois, G.J., Andrew, P.W., and Mitchell, T.J. (1995) The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus. J Infect Dis 172: 119-123.
10. Cockeran, R., Durandt, C., Feldman, C., Mitchell, T.J., and Anderson, R. (2002) Pneumolysin activates the synthesis and release of interleukin-8 by human neutrophils in vitro. J Infect Dis 186: 562-565.
11. Dessing, M.C., Knapp, S., Florquin, S., de Vos, A.F., and van der Poll, T. (2007) CD14 facilitates invasive respiratory tract infection by Streptococcus pneumoniae. Am J Respir Crit Care Med 175: 604-611.
12. Echchannaoui, H., Frei, K., Schnell, C., Leib, S.L., Zimmerli, W., and Landmann, R. (2002) Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation. J Infect Dis 186: 798-806.
13. Gilbert, R.J. (2002) Pore-forming toxins. Cell Mol Life Sci 59: 832-844.
14. Han, S.H., Kim, J.H., Martin, M., Michalek, S.M., and Nahm, M.H. (2003) Pneumococcal lipoteichoic acid (LTA) is not as potent as staphylococcal LTA in stimulating Toll-like receptor 2. Infect Immun 71: 5541-5548.
15. Hirst, R.A., Kadioglu, A., O'Callaghan, C., and Andrew, P.W. (2004) The role of pneumolysin in pneumococcal pneumonia and meningitis. Clin Exp Immunol 138: 195-201.
16. Houldsworth, S., Andrew, P.W., and Mitchell, T.J. (1994) Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes. Infect Immun 62: 1501-1503.
17. Jedrzejas, M.J. (2001) Pneumococcal virulence factors: Structure and function. Microbiol Mol Biol Rev 65: 187-207.
18. Kadioglu, A., Taylor, S., Iannelli, F., Pozzi, G., Mitchell, T.J., and Andrew, P.W. (2002) Upper and lower respiratory tract infection by Streptococcus pneumoniae is affected by pneumolysin deficiency and differences in capsule type. Infect Immun 70: 2886-2890.
19. Kawai, T., and Akira, S. (2005) Pathogen recognition with Toll-like receptors. Curr Opin Immunol 17: 338-344.
20. Khan, A.Q., Chen, Q., Wu, Z.Q., Paton, J.C., and Snapper, C.M. (2005) Both innate immunity and type 1 humoral immunity to Streptococcus pneumoniae are mediated by MyD88 but differ in their relative levels of dependence on toll-like receptor 2. Infect Immun 73: 298-307.
21. Knapp, S., Wieland, C.W., van 't Veer, C., Takeuchi, O., Akira, S., et al. (2004) Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense. J Immunol 172: 3132-3138.
22. Knapp, S., Schultz, M.J., and Poll, T.V. (2005) Pneumonia models and innate immunity to respiratory bacterial pathogens. Shock 24 (Suppl. 1): 12-18.
23. Koedel, U., Angele, B., Rupprecht, T., Wagner, H., Roggenkamp, A., Pfister, H.W., and Kirschning, C.J. (2003) Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis. J Immunol 170: 438-444.
24. Malley, R., Henneke, P., Morse, S.C., Cieslewicz, M.J., Lipsitch, M., Thompson, C.M., et al. (2003) Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci USA 100: 1966-1971.
25. Mogensen, T.H., Paludan, S.R., Kilian, M., and Ostergaard, L. (2006) Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2,4, and 9 in species-specific patterns. J Leukoc Biol 80: 267-277.
26. Moore, T.A., and Standiford, T.J. (2001) Cytokine immunotherapy during bacterial pneumonia: From benchtop to bedside. Semin Respir Infect 16: 27-37.
27. Paterson, G.K., and Mitchell, T.J. (2006) Innate immunity and the pneumococcus. Microbiology 152: 285-293.
28. Paton, J.C. (1996) The contribution of pneumolysin to the pathogenicity of Streptococcus pneumoniae. Trends Microbiol 4: 103-106.
29. Paton, J.C., and Ferrante, A. (1983) Inhibition of human polymorphonuclear leukocyte respiratory burst, bactericidal activity, and migration by pneumolysin. Infect Immun 41: 1212-1216.
30. Pikis, A., Akram, S., Donkersloot, J.A., Campos, J.M., and Rodriguez, W.J. (1995) Penicillin-resistant pneumococci from pediatric patients in the Washington, DC, area. Arch Pediatr Adolesc Med 149: 30-35.
31. van der Poll, T., Keogh, C.V., Buurman, W.A., and Lowry, S.F. (1997) Passive immunization against tumor necrosis factor-alpha impairs host defense during pneumococcal pneumonia in mice. Am J Respir Crit Care Med 155: 603-608.
32. Rijneveld, A.W., Florquin, S., Branger, J., Speelman, P., Van Deventer, S.J., and van der Poll, T. (2001) TNF-alpha compensates for the impaired host defense of IL-1 type I receptor-deficient mice during pneumococcal pneumonia. J Immunol 167: 5240-5246.
33. van Rossum, A.M., Lysenko, E.S., and Weiser, J.N. (2005) Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73: 7718-7726.
34. Rubins, J.B., Charboneau, D., Paton, J.C., Mitchell, T.J., Andrew, P.W., and Janoff, E.N. (1995) Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia. J Clin Invest 95: 142-150.
35. Schreiber, J.R., and Jacobs, M.R. (1995) Antibiotic-resistant pneumococci. Pediatr Clin North Am 42: 519-537.
36. Schroder, N.W., Morath, S., Alexander, C., Hamann, L., Hartung, T., Zahringer, U., et al. (2003) Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J Biol Chem 278: 15587-15594.
37. Srivastava, A., Henneke, P., Visintin, A., Morse, S.C., Martin, V., Watkins, C., et al. (2005) The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease. Infect Immun 73: 6479-6487.
38. Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443-451.
39. Yoshimura, A., Lien, E., Ingalls, R.R., Tuomanen, E., Dziarski, R., and Golenbock, D. (1999) Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol 163: 1-5.