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Volumn 26, Issue 7, 2008, Pages 1663-1672

Concise review: Pax6 transcription factor contributes to both embryonic and adult neurogenesis as a multifunctional regulator

Author keywords

Adult neurogenesis; Differentiation; Embryonic neurogenesis; Neural stem cells; Pax6 transcription factor; Proliferation

Indexed keywords

CD15 ANTIGEN; CELL ADHESION MOLECULE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; FATTY ACID BINDING PROTEIN; FUCOSYLTRANSFERASE; FUCOSYLTRANSFERASE 9; ISOPROTEIN; NEUROGENIN 2; PROTEIN FABP7; PROTEIN WNT7B; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 55049119613     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0884     Document Type: Review
Times cited : (287)

References (141)
  • 1
    • 0026340588 scopus 로고
    • Pax-6, a murine paired box gene, is expressed in the developing CNS
    • Walther C, Gruss P. Pax-6, a murine paired box gene, is expressed in the developing CNS. Development 1991;113:1435-1449.
    • (1991) Development , vol.113 , pp. 1435-1449
    • Walther, C.1    Gruss, P.2
  • 2
    • 0026315044 scopus 로고
    • Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region
    • Ton CC, Hirvonen H, Miwa H et al. Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region. Cell 1991;67:1059-1074.
    • (1991) Cell , vol.67 , pp. 1059-1074
    • Ton, C.C.1    Hirvonen, H.2    Miwa, H.3
  • 3
    • 0026345992 scopus 로고
    • Mouse small eye results from mutations in a paired-like homeobox-containing gene
    • Hill RE, Favor J, Hogan BL et al. Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature 1991;354:522-525.
    • (1991) Nature , vol.354 , pp. 522-525
    • Hill, R.E.1    Favor, J.2    Hogan, B.L.3
  • 4
  • 5
    • 0033405043 scopus 로고    scopus 로고
    • Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development
    • Kioussi C, O'Connell S, St-Onge L et al. Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. Proc Natl Acad Sci U S A 1999;96:14378-14382.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 14378-14382
    • Kioussi, C.1    O'Connell, S.2    St-Onge, L.3
  • 6
    • 0034003392 scopus 로고    scopus 로고
    • Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas
    • Dohrmann C, Gruss P, Lemaire L. Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas. Mech Dev 2000;92:47-54.
    • (2000) Mech Dev , vol.92 , pp. 47-54
    • Dohrmann, C.1    Gruss, P.2    Lemaire, L.3
  • 7
    • 0035286958 scopus 로고    scopus 로고
    • The role of Pax6 in brain patterning
    • Osumi N. The role of Pax6 in brain patterning. Tohoku J Exp Med 2001;193:163-174.
    • (2001) Tohoku J Exp Med , vol.193 , pp. 163-174
    • Osumi, N.1
  • 8
    • 0036844682 scopus 로고    scopus 로고
    • Pax6; a pleiotropic player in development
    • Simpson TI, Price DJ. Pax6; a pleiotropic player in development. Bioessays 2002;24:1041-1051.
    • (2002) Bioessays , vol.24 , pp. 1041-1051
    • Simpson, T.I.1    Price, D.J.2
  • 9
    • 24344448563 scopus 로고    scopus 로고
    • Role of Pax6 in forebrain regionalization
    • Manuel M, Price DJ. Role of Pax6 in forebrain regionalization. Brain Res Bull 2005;66:387-393.
    • (2005) Brain Res Bull , vol.66 , pp. 387-393
    • Manuel, M.1    Price, D.J.2
  • 10
    • 0027506485 scopus 로고
    • A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells
    • Matsuo T, Osumi-Yamashita N, Noji S et al. A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells. Nat Genet 1993;3:299-304.
    • (1993) Nat Genet , vol.3 , pp. 299-304
    • Matsuo, T.1    Osumi-Yamashita, N.2    Noji, S.3
  • 11
    • 0030818548 scopus 로고    scopus 로고
    • Pax-6 is involved in the specification of hindbrain motor neuron subtype
    • Osumi N, Hirota A, Ohuchi H et al. Pax-6 is involved in the specification of hindbrain motor neuron subtype. Development 1997;124:2961-2972.
    • (1997) Development , vol.124 , pp. 2961-2972
    • Osumi, N.1    Hirota, A.2    Ohuchi, H.3
  • 12
    • 0028308664 scopus 로고
    • Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly
    • Hanson IM, Fletcher JM, Jordan T et al. Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly. Nat Genet 1994;6:168-173.
    • (1994) Nat Genet , vol.6 , pp. 168-173
    • Hanson, I.M.1    Fletcher, J.M.2    Jordan, T.3
  • 13
    • 0028562004 scopus 로고
    • Morphometric study of the optic nerve of adult normal mice and mice heterozygous for the Small eye mutation (Sey/+)
    • Dangata YY, Findlater GS, Dhillon B et al. Morphometric study of the optic nerve of adult normal mice and mice heterozygous for the Small eye mutation (Sey/+). J Anat 1994;185:627-635.
    • (1994) J Anat , vol.185 , pp. 627-635
    • Dangata, Y.Y.1    Findlater, G.S.2    Dhillon, B.3
  • 14
    • 0037076371 scopus 로고    scopus 로고
    • Iris hypoplasia in mice that lack the alternatively spliced Pax6(5a) isoform
    • Singh S, Mishra R, Arango NA et al. Iris hypoplasia in mice that lack the alternatively spliced Pax6(5a) isoform. Proc Natl Acad Sci U S A 2002;99:6812-6815.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 6812-6815
    • Singh, S.1    Mishra, R.2    Arango, N.A.3
  • 15
    • 33746158128 scopus 로고    scopus 로고
    • Abnormal migration and distribution of neural crest cells in Pax6 heterozygous mutant eye, a model for human eye diseases
    • Kanakubo S, Nomura T, Yamamura K et al. Abnormal migration and distribution of neural crest cells in Pax6 heterozygous mutant eye, a model for human eye diseases. Genes Cells 2006;11:919-933.
    • (2006) Genes Cells , vol.11 , pp. 919-933
    • Kanakubo, S.1    Nomura, T.2    Yamamura, K.3
  • 16
    • 0022558958 scopus 로고
    • Small eyes (Sey): A homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse
    • Hogan BL, Horsburgh G, Cohen J et al. Small eyes (Sey): A homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse. J Embryol Exp Morphol 1986;97:95-110.
    • (1986) J Embryol Exp Morphol , vol.97 , pp. 95-110
    • Hogan, B.L.1    Horsburgh, G.2    Cohen, J.3
  • 17
    • 0028175561 scopus 로고
    • Uchida rat (rSey): A new mutant rat with craniofacial abnormalities resembling those of the mouse Sey mutant
    • Fujiwara M, Uchida T, Osumi-Yamashita N et al. Uchida rat (rSey): A new mutant rat with craniofacial abnormalities resembling those of the mouse Sey mutant. Differentiation 1994;57:31-38.
    • (1994) Differentiation , vol.57 , pp. 31-38
    • Fujiwara, M.1    Uchida, T.2    Osumi-Yamashita, N.3
  • 18
    • 0036850610 scopus 로고    scopus 로고
    • Pax6 is required for the normal development of the forebrain axonal connections
    • Jones L, Lopez-Bendito G, Gruss P et al. Pax6 is required for the normal development of the forebrain axonal connections. Development 2002;129:5041-5052.
    • (2002) Development , vol.129 , pp. 5041-5052
    • Jones, L.1    Lopez-Bendito, G.2    Gruss, P.3
  • 20
    • 0034642871 scopus 로고    scopus 로고
    • Fate mapping of the mouse prosencephalic neural plate
    • Inoue T, Nakamura S, Osumi N. Fate mapping of the mouse prosencephalic neural plate. Dev Biol 2000;219:373-383.
    • (2000) Dev Biol , vol.219 , pp. 373-383
    • Inoue, T.1    Nakamura, S.2    Osumi, N.3
  • 21
    • 18144415035 scopus 로고    scopus 로고
    • The cells of Cajal-Retzius: Still a mystery one century after
    • Soriano E, Del Rio JA. The cells of Cajal-Retzius: Still a mystery one century after. Neuron 2005;46:389-394.
    • (2005) Neuron , vol.46 , pp. 389-394
    • Soriano, E.1    Del Rio, J.A.2
  • 22
    • 0035511906 scopus 로고    scopus 로고
    • A long, remarkable journey: Tangential migration in the telencephalon
    • Marín O, Rubenstein JL. A long, remarkable journey: Tangential migration in the telencephalon. Nat Rev Neurosci 2001;2:780-790.
    • (2001) Nat Rev Neurosci , vol.2 , pp. 780-790
    • Marín, O.1    Rubenstein, J.L.2
  • 23
    • 18144365483 scopus 로고    scopus 로고
    • Developmental mechanisms underlying the generation of cortical interneuron diversity
    • Flames N, Marin O. Developmental mechanisms underlying the generation of cortical interneuron diversity. Neuron 2005;46:377-381.
    • (2005) Neuron , vol.46 , pp. 377-381
    • Flames, N.1    Marin, O.2
  • 24
    • 0037198598 scopus 로고    scopus 로고
    • Mosaic development of the olfactory cortex with Pax6-dependent and -independent components
    • Hirata T, Nomura T, Takagi Y et al. Mosaic development of the olfactory cortex with Pax6-dependent and -independent components. Brain Res Dev Brain Res 2002;136:17-26.
    • (2002) Brain Res Dev Brain Res , vol.136 , pp. 17-26
    • Hirata, T.1    Nomura, T.2    Takagi, Y.3
  • 25
    • 0036568734 scopus 로고    scopus 로고
    • Radial glia: Multi-purpose cells for vertebrate brain development
    • Campbell K, Götz M. Radial glia: Multi-purpose cells for vertebrate brain development. Trends Neurosci 2002;25:235-238.
    • (2002) Trends Neurosci , vol.25 , pp. 235-238
    • Campbell, K.1    Götz, M.2
  • 26
    • 0038304475 scopus 로고    scopus 로고
    • Radial glia diversity: A matter of cell fate
    • Kriegstein AR, Götz M. Radial glia diversity: A matter of cell fate. Glia 2003;43:37-43.
    • (2003) Glia , vol.43 , pp. 37-43
    • Kriegstein, A.R.1    Götz, M.2
  • 27
    • 0029030809 scopus 로고
    • Evidence for multiple precursor cell types in the embryonic rat cerebral cortex
    • Williams BP, Price J. Evidence for multiple precursor cell types in the embryonic rat cerebral cortex. Neuron 1995;14:1181-1188.
    • (1995) Neuron , vol.14 , pp. 1181-1188
    • Williams, B.P.1    Price, J.2
  • 28
    • 0034518641 scopus 로고    scopus 로고
    • Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
    • Malatesta P, Hartfuss E, Götz M. Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage. Development 2000;127:5253-5263.
    • (2000) Development , vol.127 , pp. 5253-5263
    • Malatesta, P.1    Hartfuss, E.2    Götz, M.3
  • 30
    • 27544465968 scopus 로고    scopus 로고
    • Symmetric versus asymmetric cell division during neurogenesis in the developing vertebrate central nervous system
    • Huttner WB, Kosodo Y. Symmetric versus asymmetric cell division during neurogenesis in the developing vertebrate central nervous system. Curr Opin Cell Biol 2005;17:648-657.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 648-657
    • Huttner, W.B.1    Kosodo, Y.2
  • 31
    • 1642458489 scopus 로고    scopus 로고
    • Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
    • Noctor SC, Martinez-Cerdeno V, Ivic L et al. Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases. Nat Neurosci 2004;7:136-144.
    • (2004) Nat Neurosci , vol.7 , pp. 136-144
    • Noctor, S.C.1    Martinez-Cerdeno, V.2    Ivic, L.3
  • 32
    • 1542297728 scopus 로고    scopus 로고
    • Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: A major site of neurogenesis
    • Haubensak W, Attardo A, Denk W et al. Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: A major site of neurogenesis. Proc Natl Acad Sci U S A 2004;101:3196-3201.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 3196-3201
    • Haubensak, W.1    Attardo, A.2    Denk, W.3
  • 33
    • 4043142765 scopus 로고    scopus 로고
    • Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells
    • Miyata T, Kawaguchi A, Saito K et al. Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells. Development 2004;131:3133-3145.
    • (2004) Development , vol.131 , pp. 3133-3145
    • Miyata, T.1    Kawaguchi, A.2    Saito, K.3
  • 34
    • 33646796006 scopus 로고    scopus 로고
    • Transcription factors in glutamatergic neurogenesis: Conserved programs in neocortex, cerebellum, and adult hippocampus
    • Hevner RF, Hodge RD, Daza RA et al. Transcription factors in glutamatergic neurogenesis: Conserved programs in neocortex, cerebellum, and adult hippocampus. Neurosci Res 2006;55:223-233.
    • (2006) Neurosci Res , vol.55 , pp. 223-233
    • Hevner, R.F.1    Hodge, R.D.2    Daza, R.A.3
  • 35
    • 12144266963 scopus 로고    scopus 로고
    • Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex
    • Englund C, Fink A, Lau C et al. Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex. J Neurosci 2005;25:247-251.
    • (2005) J Neurosci , vol.25 , pp. 247-251
    • Englund, C.1    Fink, A.2    Lau, C.3
  • 36
    • 0031050372 scopus 로고    scopus 로고
    • Patterns of gene expression in the neural plate and neural tube subdivide the embryonic forebrain into transverse and longitudinal domains
    • Shimamura K, Martinez S, Puelles L et al. Patterns of gene expression in the neural plate and neural tube subdivide the embryonic forebrain into transverse and longitudinal domains. Dev Neurosci 1997;19:88-96.
    • (1997) Dev Neurosci , vol.19 , pp. 88-96
    • Shimamura, K.1    Martinez, S.2    Puelles, L.3
  • 37
    • 0034520025 scopus 로고    scopus 로고
    • Induction and dorsoventral patterning of the telencephalon
    • Wilson SW, Rubenstein JL. Induction and dorsoventral patterning of the telencephalon. Neuron 2000;28:641-651.
    • (2000) Neuron , vol.28 , pp. 641-651
    • Wilson, S.W.1    Rubenstein, J.L.2
  • 38
    • 0036471390 scopus 로고    scopus 로고
    • Patterning centers, regulatory genes and extrinsic mechanisms controlling arealization of the neocortex
    • O'Leary DD, Nakagawa Y. Patterning centers, regulatory genes and extrinsic mechanisms controlling arealization of the neocortex. Curr Opin Neurobiol 2002;12:14-25.
    • (2002) Curr Opin Neurobiol , vol.12 , pp. 14-25
    • O'Leary, D.D.1    Nakagawa, Y.2
  • 39
    • 0036631456 scopus 로고    scopus 로고
    • Proneural genes and the specification of neural cell types
    • Bertrand N, Castro DS, Guillemot F. Proneural genes and the specification of neural cell types. Nat Rev Neurosci 2002;3:517-530.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 517-530
    • Bertrand, N.1    Castro, D.S.2    Guillemot, F.3
  • 40
    • 0038765091 scopus 로고    scopus 로고
    • Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6
    • Scardigli R, Baumer N, Gruss P et al. Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6. Development 2003;130:3269-3281.
    • (2003) Development , vol.130 , pp. 3269-3281
    • Scardigli, R.1    Baumer, N.2    Gruss, P.3
  • 41
    • 0033165994 scopus 로고    scopus 로고
    • NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus
    • Miyata T, Maeda T, Lee JE. NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev 1999;13:1647-1652.
    • (1999) Genes Dev , vol.13 , pp. 1647-1652
    • Miyata, T.1    Maeda, T.2    Lee, J.E.3
  • 42
    • 0034681192 scopus 로고    scopus 로고
    • Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy
    • Liu M, Pleasure SJ, Collins AE et al. Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy. Proc Natl Acad Sci U S A 2000;97:865-870.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 865-870
    • Liu, M.1    Pleasure, S.J.2    Collins, A.E.3
  • 43
    • 0027279692 scopus 로고
    • Defects of neuronal migration and the pathogenesis of cortical malformations are associated with Small eye (Sey) in the mouse, a point mutation at the Pax-6-locus
    • Schmahl W, Knoedlseder M, Favor J et al. Defects of neuronal migration and the pathogenesis of cortical malformations are associated with Small eye (Sey) in the mouse, a point mutation at the Pax-6-locus. Acta Neuropathol (Berl) 1993;86:126-135.
    • (1993) Acta Neuropathol (Berl) , vol.86 , pp. 126-135
    • Schmahl, W.1    Knoedlseder, M.2    Favor, J.3
  • 44
    • 0029855582 scopus 로고    scopus 로고
    • Forebrain patterning defects in Small eye mutant mice
    • Stoykova A, Fritsch R, Walther C et al. Forebrain patterning defects in Small eye mutant mice. Development 1996;122:3453-3465.
    • (1996) Development , vol.122 , pp. 3453-3465
    • Stoykova, A.1    Fritsch, R.2    Walther, C.3
  • 45
    • 0031453499 scopus 로고    scopus 로고
    • Determination of the migratory capacity of embryonic cortical cells lacking the transcription factor Pax-6
    • Carić D, Gooday D, Hill RE et al. Determination of the migratory capacity of embryonic cortical cells lacking the transcription factor Pax-6. Development 1997;124:5087-5096.
    • (1997) Development , vol.124 , pp. 5087-5096
    • Carić, D.1    Gooday, D.2    Hill, R.E.3
  • 46
    • 0032880081 scopus 로고    scopus 로고
    • The transcription factor, Pax6, is required for cell proliferation and differentiation in the developing cerebral cortex
    • Warren N, Caric D, Pratt T et al. The transcription factor, Pax6, is required for cell proliferation and differentiation in the developing cerebral cortex. Cereb Cortex 1999;9:627-635.
    • (1999) Cereb Cortex , vol.9 , pp. 627-635
    • Warren, N.1    Caric, D.2    Pratt, T.3
  • 47
    • 0034653924 scopus 로고    scopus 로고
    • Histogenesis of the cerebral cortex in rat fetuses with a mutation in the Pax-6 gene
    • Fukuda T, Kawano H, Osumi N et al. Histogenesis of the cerebral cortex in rat fetuses with a mutation in the Pax-6 gene. Brain Res Dev Brain Res 2000;120:65-75.
    • (2000) Brain Res Dev Brain Res , vol.120 , pp. 65-75
    • Fukuda, T.1    Kawano, H.2    Osumi, N.3
  • 48
    • 0036337981 scopus 로고    scopus 로고
    • Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors
    • Estivill-Torrus G, Pearson H, van Heyningen V et al. Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors. Development 2002;129:455-466.
    • (2002) Development , vol.129 , pp. 455-466
    • Estivill-Torrus, G.1    Pearson, H.2    van Heyningen, V.3
  • 49
    • 0032215091 scopus 로고    scopus 로고
    • Pax6 controls radial glia differentiation in the cerebral cortex
    • Götz M, Stoykova A, Gruss P. Pax6 controls radial glia differentiation in the cerebral cortex. Neuron 1998;21:1031-1044.
    • (1998) Neuron , vol.21 , pp. 1031-1044
    • Götz, M.1    Stoykova, A.2    Gruss, P.3
  • 50
    • 0036205830 scopus 로고    scopus 로고
    • Glial cells generate neurons: The role of the transcription factor Pax6
    • Heins N, Malatesta P, Cecconi F et al. Glial cells generate neurons: The role of the transcription factor Pax6. Nat Neurosci 2002;5:308-315.
    • (2002) Nat Neurosci , vol.5 , pp. 308-315
    • Heins, N.1    Malatesta, P.2    Cecconi, F.3
  • 51
    • 33846313612 scopus 로고    scopus 로고
    • Pax6 controls cerebral cortical cell number by regulating exit from the cell cycle and specifies cortical cell identity by a cell autonomous mechanism
    • Quinn JC, Molinek M, Martynoga BS et al. Pax6 controls cerebral cortical cell number by regulating exit from the cell cycle and specifies cortical cell identity by a cell autonomous mechanism. Dev Biol 2007;302:50-65.
    • (2007) Dev Biol , vol.302 , pp. 50-65
    • Quinn, J.C.1    Molinek, M.2    Martynoga, B.S.3
  • 52
    • 14544284571 scopus 로고    scopus 로고
    • Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type
    • Philips GT, Stair CN, Young Lee H et al. Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type. Dev Biol 2005;279:308-321.
    • (2005) Dev Biol , vol.279 , pp. 308-321
    • Philips, G.T.1    Stair, C.N.2    Young Lee, H.3
  • 53
    • 34047160933 scopus 로고    scopus 로고
    • The proliferation and expansion of retinal stem cells require functional Pax6
    • Xu S, Sunderland ME, Coles BL et al. The proliferation and expansion of retinal stem cells require functional Pax6. Dev Biol 2007;304:713-721.
    • (2007) Dev Biol , vol.304 , pp. 713-721
    • Xu, S.1    Sunderland, M.E.2    Coles, B.L.3
  • 54
    • 33846053993 scopus 로고    scopus 로고
    • Pax6 controls the proliferation rate of neuroepithelial progenitors from the mouse optic vesicle
    • Duparc RH, Abdouh M, David J et al. Pax6 controls the proliferation rate of neuroepithelial progenitors from the mouse optic vesicle. Dev Biol 2007;301:374-387.
    • (2007) Dev Biol , vol.301 , pp. 374-387
    • Duparc, R.H.1    Abdouh, M.2    David, J.3
  • 55
    • 0028239775 scopus 로고
    • Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes
    • Epstein J, Cai J, Glaser T et al. Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes. J Biol Chem 1994;269:8355-8361.
    • (1994) J Biol Chem , vol.269 , pp. 8355-8361
    • Epstein, J.1    Cai, J.2    Glaser, T.3
  • 56
    • 0028918392 scopus 로고
    • DNA-binding and transactivation properties of Pax-6: Three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5)
    • Czerny T, Busslinger M. DNA-binding and transactivation properties of Pax-6: Three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5). Mol Cell Biol 1995;15:2858-2871.
    • (1995) Mol Cell Biol , vol.15 , pp. 2858-2871
    • Czerny, T.1    Busslinger, M.2
  • 57
    • 0029837282 scopus 로고    scopus 로고
    • Cooperative interactions between paired domain and homeodomain
    • Jun S, Desplan C. Cooperative interactions between paired domain and homeodomain. Development 1996;122:2639-2650.
    • (1996) Development , vol.122 , pp. 2639-2650
    • Jun, S.1    Desplan, C.2
  • 58
    • 0000744672 scopus 로고    scopus 로고
    • Dissection of the transactivation function of the transcription factor encoded by the eye developmental gene PAX6
    • Tang HK, Singh S, Saunders GF. Dissection of the transactivation function of the transcription factor encoded by the eye developmental gene PAX6. J Biol Chem 1998;273:7210-7221.
    • (1998) J Biol Chem , vol.273 , pp. 7210-7221
    • Tang, H.K.1    Singh, S.2    Saunders, G.F.3
  • 59
    • 0028096639 scopus 로고
    • Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing
    • Epstein JA, Glaser T, Cai J et al. Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing. Genes Dev 1994;8:2022-2034.
    • (1994) Genes Dev , vol.8 , pp. 2022-2034
    • Epstein, J.A.1    Glaser, T.2    Cai, J.3
  • 60
    • 23944484521 scopus 로고    scopus 로고
    • Regulation of the Pax6: Pax6(5a) mRNA ratio in the developing mammalian brain
    • Pinson J, Mason JO, Simpson TI et al. Regulation of the Pax6: Pax6(5a) mRNA ratio in the developing mammalian brain. BMC Dev Biol 2005;5:13.
    • (2005) BMC Dev Biol , vol.5 , pp. 13
    • Pinson, J.1    Mason, J.O.2    Simpson, T.I.3
  • 61
    • 0032895297 scopus 로고    scopus 로고
    • Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity
    • Kammandel B, Chowdhury K, Stoykova A et al. Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Dev Biol 1999;205:79-97.
    • (1999) Dev Biol , vol.205 , pp. 79-97
    • Kammandel, B.1    Chowdhury, K.2    Stoykova, A.3
  • 62
    • 33645949095 scopus 로고    scopus 로고
    • Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb
    • Kim J, Lauderdale JD. Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb. Dev Biol 2006;292:486-505.
    • (2006) Dev Biol , vol.292 , pp. 486-505
    • Kim, J.1    Lauderdale, J.D.2
  • 63
    • 0036011258 scopus 로고    scopus 로고
    • Differential Pax6 promoter activity and transcript expression during forebrain development
    • Anderson TR, Hedlund E, Carpenter EM. Differential Pax6 promoter activity and transcript expression during forebrain development. Mech Dev 2002;114:171-175.
    • (2002) Mech Dev , vol.114 , pp. 171-175
    • Anderson, T.R.1    Hedlund, E.2    Carpenter, E.M.3
  • 64
    • 37549029789 scopus 로고    scopus 로고
    • Overexpression of pairedless Pax6 in the retina disrupts corneal development and affects lens cell survival
    • Kim J, Lauderdale JD. Overexpression of pairedless Pax6 in the retina disrupts corneal development and affects lens cell survival. Dev Biol 2008;313:434-454.
    • (2008) Dev Biol , vol.313 , pp. 434-454
    • Kim, J.1    Lauderdale, J.D.2
  • 65
    • 12344299825 scopus 로고    scopus 로고
    • Molecular dissection of Pax6 function: The specific roles of the paired domain and homeodomain in brain development
    • Haubst N, Berger J, Radjendirane V et al. Molecular dissection of Pax6 function: The specific roles of the paired domain and homeodomain in brain development. Development 2004;131:6131-6140.
    • (2004) Development , vol.131 , pp. 6131-6140
    • Haubst, N.1    Berger, J.2    Radjendirane, V.3
  • 66
    • 2942720409 scopus 로고    scopus 로고
    • Conservation of sequence and function in the Pax6 regulatory elements
    • Morgan R. Conservation of sequence and function in the Pax6 regulatory elements. Trends Genet 2004;20:283-287.
    • (2004) Trends Genet , vol.20 , pp. 283-287
    • Morgan, R.1
  • 67
    • 0037403778 scopus 로고    scopus 로고
    • Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene
    • Aota S, Nakajima N, Sakamoto R et al. Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene. Dev Biol 2003;257:1-13.
    • (2003) Dev Biol , vol.257 , pp. 1-13
    • Aota, S.1    Nakajima, N.2    Sakamoto, R.3
  • 68
    • 33847395395 scopus 로고    scopus 로고
    • Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization
    • Manuel M, Georgala PA, Carr CB et al. Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization. Development 2007;134:545-555.
    • (2007) Development , vol.134 , pp. 545-555
    • Manuel, M.1    Georgala, P.A.2    Carr, C.B.3
  • 69
    • 34248185512 scopus 로고    scopus 로고
    • Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosis
    • Berger J, Berger S, Tuoc TC et al. Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosis. Development 2007;134:1311-1322.
    • (2007) Development , vol.134 , pp. 1311-1322
    • Berger, J.1    Berger, S.2    Tuoc, T.C.3
  • 70
    • 7444233421 scopus 로고    scopus 로고
    • Regulation of gene expression by Pax6 in ocular cells: A case of tissue-preferred expression of crystallins in lens
    • Cvekl A, Yang Y, Chauhan BK et al. Regulation of gene expression by Pax6 in ocular cells: A case of tissue-preferred expression of crystallins in lens. Int J Dev Biol 2004;48:829-844.
    • (2004) Int J Dev Biol , vol.48 , pp. 829-844
    • Cvekl, A.1    Yang, Y.2    Chauhan, B.K.3
  • 71
    • 11144263623 scopus 로고    scopus 로고
    • Interplay of Pax6 and SOX2 in lens development as a paradigm of genetic switch mechanisms for cell differentiation
    • Kondoh H, Uchikawa M, Kamachi Y. Interplay of Pax6 and SOX2 in lens development as a paradigm of genetic switch mechanisms for cell differentiation. Int J Dev Biol 2004;48:819-827.
    • (2004) Int J Dev Biol , vol.48 , pp. 819-827
    • Kondoh, H.1    Uchikawa, M.2    Kamachi, Y.3
  • 72
    • 0035873448 scopus 로고    scopus 로고
    • Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development
    • Kamachi Y, Uchikawa M, Tanouchi A et al. Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development. Genes Dev 2001;15:1272-1286.
    • (2001) Genes Dev , vol.15 , pp. 1272-1286
    • Kamachi, Y.1    Uchikawa, M.2    Tanouchi, A.3
  • 73
    • 0033548148 scopus 로고    scopus 로고
    • Pax-6 and Cdx-2/3 interact to activate glucagon gene expression on the G1 control element
    • Ritz-Laser B, Estreicher A, Klages N et al. Pax-6 and Cdx-2/3 interact to activate glucagon gene expression on the G1 control element. J Biol Chem 1999;274:4124-4132.
    • (1999) J Biol Chem , vol.274 , pp. 4124-4132
    • Ritz-Laser, B.1    Estreicher, A.2    Klages, N.3
  • 74
    • 0035929640 scopus 로고    scopus 로고
    • Interaction of Maf transcription factors with Pax-6 results in synergistic activation of the glucagon promoter
    • Planque N, Leconte L, Coquelle FM et al. Interaction of Maf transcription factors with Pax-6 results in synergistic activation of the glucagon promoter. J Biol Chem 2001;276:35751-35760.
    • (2001) J Biol Chem , vol.276 , pp. 35751-35760
    • Planque, N.1    Leconte, L.2    Coquelle, F.M.3
  • 75
    • 0032779254 scopus 로고    scopus 로고
    • Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages
    • Wood HB, Episkopou V. Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages. Mech Dev 1999;86:197-201.
    • (1999) Mech Dev , vol.86 , pp. 197-201
    • Wood, H.B.1    Episkopou, V.2
  • 76
    • 0028808183 scopus 로고
    • Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3
    • Yuan H, Corbi N, Basilico C et al. Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev 1995;9:2635-2645.
    • (1995) Genes Dev , vol.9 , pp. 2635-2645
    • Yuan, H.1    Corbi, N.2    Basilico, C.3
  • 77
    • 0031667843 scopus 로고    scopus 로고
    • POU transcription factors control expression of CNS stem cell-specific genes
    • Josephson R, Muller T, Pickel J et al. POU transcription factors control expression of CNS stem cell-specific genes. Development 1998;125:3087-3100.
    • (1998) Development , vol.125 , pp. 3087-3100
    • Josephson, R.1    Muller, T.2    Pickel, J.3
  • 78
    • 0034725588 scopus 로고    scopus 로고
    • Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer
    • Ambrosetti DC, Scholer HR, Dailey L et al. Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer. J Biol Chem 2000;275:23387-23397.
    • (2000) J Biol Chem , vol.275 , pp. 23387-23397
    • Ambrosetti, D.C.1    Scholer, H.R.2    Dailey, L.3
  • 79
    • 4744359068 scopus 로고    scopus 로고
    • Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells
    • Tanaka S, Kamachi Y, Tanouchi A et al. Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells. Mol Cell Biol 2004;24:8834-8846.
    • (2004) Mol Cell Biol , vol.24 , pp. 8834-8846
    • Tanaka, S.1    Kamachi, Y.2    Tanouchi, A.3
  • 80
    • 0028935673 scopus 로고
    • The mouse homolog of the orphan nuclear receptor tailless is expressed in the developing forebrain
    • Monaghan AP, Grau E, Bock D et al. The mouse homolog of the orphan nuclear receptor tailless is expressed in the developing forebrain. Development 1995;121:839-853.
    • (1995) Development , vol.121 , pp. 839-853
    • Monaghan, A.P.1    Grau, E.2    Bock, D.3
  • 81
    • 0037352942 scopus 로고    scopus 로고
    • Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon
    • Stenman J, Yu RT, Evans RM et al. Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. Development 2003;130:1113-1122.
    • (2003) Development , vol.130 , pp. 1113-1122
    • Stenman, J.1    Yu, R.T.2    Evans, R.M.3
  • 82
    • 3542996324 scopus 로고    scopus 로고
    • Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways
    • Schuurmans C, Armant O, Nieto M et al. Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. EMBO J 2004;23:2892-2902.
    • (2004) EMBO J , vol.23 , pp. 2892-2902
    • Schuurmans, C.1    Armant, O.2    Nieto, M.3
  • 83
    • 33847377569 scopus 로고    scopus 로고
    • The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter
    • Grocott T, Frost V, Maillard M et al. The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter. Nucleic Acids Res 2007;35:890-901.
    • (2007) Nucleic Acids Res , vol.35 , pp. 890-901
    • Grocott, T.1    Frost, V.2    Maillard, M.3
  • 84
    • 38549148570 scopus 로고    scopus 로고
    • A peroxisome proliferator-activated receptor gamma-retinoid X receptor heterodimer physically interacts with the transcriptional activator PAX6 to inhibit glucagon gene transcription
    • Krätzner R, Fröhlich F, Lepler K et al. A peroxisome proliferator-activated receptor gamma-retinoid X receptor heterodimer physically interacts with the transcriptional activator PAX6 to inhibit glucagon gene transcription. Mol Pharmacol 2008;73:509-517.
    • (2008) Mol Pharmacol , vol.73 , pp. 509-517
    • Krätzner, R.1    Fröhlich, F.2    Lepler, K.3
  • 85
    • 34247853278 scopus 로고    scopus 로고
    • The beta-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6
    • Gauthier BR, Gosmain Y, Mamin A et al. The beta-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6. Biochem J 2007;403:593-601.
    • (2007) Biochem J , vol.403 , pp. 593-601
    • Gauthier, B.R.1    Gosmain, Y.2    Mamin, A.3
  • 86
    • 34247507260 scopus 로고    scopus 로고
    • Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord
    • Sugimori M, Nagao M, Bertrand N et al. Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord. Development 2007;134:1617-1629.
    • (2007) Development , vol.134 , pp. 1617-1629
    • Sugimori, M.1    Nagao, M.2    Bertrand, N.3
  • 87
    • 27144511487 scopus 로고    scopus 로고
    • Role of Fabp7, a downstream gene of Pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex
    • Arai Y, Funatsu N, Numayama-Tsuruta K et al. Role of Fabp7, a downstream gene of Pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex. J Neurosci 2005;25:9752-9761.
    • (2005) J Neurosci , vol.25 , pp. 9752-9761
    • Arai, Y.1    Funatsu, N.2    Numayama-Tsuruta, K.3
  • 88
    • 0029059525 scopus 로고
    • Differentiating neurons activate transcription of the brain lipid-binding protein gene in radial glia through a novel regulatory element
    • Feng L, Heintz N. Differentiating neurons activate transcription of the brain lipid-binding protein gene in radial glia through a novel regulatory element. Development 1995;121:1719-1730.
    • (1995) Development , vol.121 , pp. 1719-1730
    • Feng, L.1    Heintz, N.2
  • 89
    • 0035173885 scopus 로고    scopus 로고
    • Characterization of CNS precursor subtypes and radial glia
    • Hartfuss E, Galli R, Heins N et al. Characterization of CNS precursor subtypes and radial glia. Dev Biol 2001;229:15-30.
    • (2001) Dev Biol , vol.229 , pp. 15-30
    • Hartfuss, E.1    Galli, R.2    Heins, N.3
  • 90
    • 18244386723 scopus 로고    scopus 로고
    • Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
    • Anthony TE, Mason HA, Gridley T et al. Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev 2005;19:1028-1033.
    • (2005) Genes Dev , vol.19 , pp. 1028-1033
    • Anthony, T.E.1    Mason, H.A.2    Gridley, T.3
  • 91
    • 0035815295 scopus 로고    scopus 로고
    • Pax6 is required for the multipotent state of retinal progenitor cells
    • Marquardt T, Ashery-Padan R, Andrejewski N et al. Pax6 is required for the multipotent state of retinal progenitor cells. Cell 2001;105:43-55.
    • (2001) Cell , vol.105 , pp. 43-55
    • Marquardt, T.1    Ashery-Padan, R.2    Andrejewski, N.3
  • 92
    • 0035797449 scopus 로고    scopus 로고
    • Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord
    • Scardigli R, Schuurmans C, Gradwohl G et al. Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord. Neuron 2001;31:203-217.
    • (2001) Neuron , vol.31 , pp. 203-217
    • Scardigli, R.1    Schuurmans, C.2    Gradwohl, G.3
  • 93
    • 34247618823 scopus 로고    scopus 로고
    • The on/off of Pax6 controls the tempo of neuronal differentiation in the developing spinal cord
    • Bel-Vialar S, Medevielle F, Pituello F. The on/off of Pax6 controls the tempo of neuronal differentiation in the developing spinal cord. Dev Biol 2007;305:659-673.
    • (2007) Dev Biol , vol.305 , pp. 659-673
    • Bel-Vialar, S.1    Medevielle, F.2    Pituello, F.3
  • 94
    • 0029095199 scopus 로고
    • FORSE-1, an antibody that labels regionally restricted subpopulations of progenitor cells in the embryonic central nervous system, recognizes the Le(x) carbohydrate on a proteoglycan and two glycolipid antigens
    • Allendoerfer KL, Magnani JL, Patterson PH. FORSE-1, an antibody that labels regionally restricted subpopulations of progenitor cells in the embryonic central nervous system, recognizes the Le(x) carbohydrate on a proteoglycan and two glycolipid antigens. Mol Cell Neurosci 1995;6:381-395.
    • (1995) Mol Cell Neurosci , vol.6 , pp. 381-395
    • Allendoerfer, K.L.1    Magnani, J.L.2    Patterson, P.H.3
  • 95
    • 0037127321 scopus 로고    scopus 로고
    • Pax6 controls the expression of Lewis x epitope in the embryonic forebrain by regulating α 1,3-fucosyltransferase IX expression
    • Shimoda Y, Tajima Y, Osanai T et al. Pax6 controls the expression of Lewis x epitope in the embryonic forebrain by regulating α 1,3-fucosyltransferase IX expression. J Biol Chem 2002;277:2033-2039.
    • (2002) J Biol Chem , vol.277 , pp. 2033-2039
    • Shimoda, Y.1    Tajima, Y.2    Osanai, T.3
  • 96
    • 0037194887 scopus 로고    scopus 로고
    • LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal
    • Capela A, Temple S. LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal. Neuron 2002;35:865-875.
    • (2002) Neuron , vol.35 , pp. 865-875
    • Capela, A.1    Temple, S.2
  • 97
    • 33644980252 scopus 로고    scopus 로고
    • LeX is expressed by principle progenitor cells in the embryonic nervous system, is secreted into their environment and binds Wnt-1
    • Capela A, Temple S. LeX is expressed by principle progenitor cells in the embryonic nervous system, is secreted into their environment and binds Wnt-1. Dev Biol 2006;291:300-313.
    • (2006) Dev Biol , vol.291 , pp. 300-313
    • Capela, A.1    Temple, S.2
  • 98
    • 0037135177 scopus 로고    scopus 로고
    • Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
    • Chenn A, Walsh CA. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 2002;297:365-369.
    • (2002) Science , vol.297 , pp. 365-369
    • Chenn, A.1    Walsh, C.A.2
  • 99
    • 0036333208 scopus 로고    scopus 로고
    • A mitogen gradient of dorsal midline Wnts organizes growth in the CNS
    • Megason SG, McMahon AP. A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 2002;129:2087-2098.
    • (2002) Development , vol.129 , pp. 2087-2098
    • Megason, S.G.1    McMahon, A.P.2
  • 100
    • 0038383629 scopus 로고    scopus 로고
    • Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2
    • Viti J, Gulacsi A, Lillien L. Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J Neurosci 2003;23:5919-5927.
    • (2003) J Neurosci , vol.23 , pp. 5919-5927
    • Viti, J.1    Gulacsi, A.2    Lillien, L.3
  • 101
    • 0037452932 scopus 로고    scopus 로고
    • Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors
    • Maretto S, Cordenonsi M, Dupont S et al. Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A 2003;100:3299-3304.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 3299-3304
    • Maretto, S.1    Cordenonsi, M.2    Dupont, S.3
  • 102
    • 3242889925 scopus 로고    scopus 로고
    • The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells
    • Hirabayashi Y, Itoh Y, Tabata H et al. The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells. Development 2004;131:2791-2801.
    • (2004) Development , vol.131 , pp. 2791-2801
    • Hirabayashi, Y.1    Itoh, Y.2    Tabata, H.3
  • 103
    • 0037904829 scopus 로고    scopus 로고
    • Pax6 regulates cell adhesion during cortical development
    • Tyas DA, Pearson H, Rashbass P et al. Pax6 regulates cell adhesion during cortical development. Cereb Cortex 2003;13:612-619.
    • (2003) Cereb Cortex , vol.13 , pp. 612-619
    • Tyas, D.A.1    Pearson, H.2    Rashbass, P.3
  • 104
    • 0033514944 scopus 로고    scopus 로고
    • A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins
    • Meech R, Kallunki P, Edelman GM et al. A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins. Proc Natl Acad Sci U S A 1999;96:2420-2425.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 2420-2425
    • Meech, R.1    Kallunki, P.2    Edelman, G.M.3
  • 105
    • 27444436336 scopus 로고    scopus 로고
    • The Optimedin gene is a downstream target of Pax6
    • Grinchuk O, Kozmik Z, Wu X et al. The Optimedin gene is a downstream target of Pax6. J Biol Chem 2005;280:35228-35237.
    • (2005) J Biol Chem , vol.280 , pp. 35228-35237
    • Grinchuk, O.1    Kozmik, Z.2    Wu, X.3
  • 106
    • 33845810953 scopus 로고    scopus 로고
    • Optimedin induces expression of N-cadherin and stimulates aggregation of NGF-stimulated PC12 cells
    • Lee HS, Tomarev SI. Optimedin induces expression of N-cadherin and stimulates aggregation of NGF-stimulated PC12 cells. Exp Cell Res 2007;313:98-108.
    • (2007) Exp Cell Res , vol.313 , pp. 98-108
    • Lee, H.S.1    Tomarev, S.I.2
  • 107
    • 1842410675 scopus 로고    scopus 로고
    • Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain
    • Stoykova A, Götz M, Gruss P et al. Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain. Development 1997;124:3765-3777.
    • (1997) Development , vol.124 , pp. 3765-3777
    • Stoykova, A.1    Götz, M.2    Gruss, P.3
  • 108
    • 0242440836 scopus 로고    scopus 로고
    • R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer axons
    • Andrews GL, Mastick GS. R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer axons. J Neurosci 2003;23:9873-9880.
    • (2003) J Neurosci , vol.23 , pp. 9873-9880
    • Andrews, G.L.1    Mastick, G.S.2
  • 109
    • 0036349738 scopus 로고    scopus 로고
    • Dendrite-like process formation and cytoskeletal remodeling regulated by δ-catenin expression
    • Kim K, Sirota A, Chen YH et al. Dendrite-like process formation and cytoskeletal remodeling regulated by δ-catenin expression. Exp Cell Res 2002;275:171-184.
    • (2002) Exp Cell Res , vol.275 , pp. 171-184
    • Kim, K.1    Sirota, A.2    Chen, Y.H.3
  • 110
    • 33845391367 scopus 로고    scopus 로고
    • Pax6 is required for delta-catenin/neurojugin expression during retinal, cerebellar and cortical development in mice
    • Duparc RH, Boutemmine D, Champagne MP et al. Pax6 is required for delta-catenin/neurojugin expression during retinal, cerebellar and cortical development in mice. Dev Biol 2006;300:647-655.
    • (2006) Dev Biol , vol.300 , pp. 647-655
    • Duparc, R.H.1    Boutemmine, D.2    Champagne, M.P.3
  • 111
    • 0034923069 scopus 로고    scopus 로고
    • Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and migration
    • Garcion E, Faissner A, ffrench-Constant C. Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and migration. Development 2001;128:2485-2496.
    • (2001) Development , vol.128 , pp. 2485-2496
    • Garcion, E.1    Faissner, A.2    ffrench-Constant, C.3
  • 112
    • 4243187213 scopus 로고    scopus 로고
    • Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C
    • Garcion E, Halilagic A, Faissner A et al. Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C. Development 2004;131:3423-3432.
    • (2004) Development , vol.131 , pp. 3423-3432
    • Garcion, E.1    Halilagic, A.2    Faissner, A.3
  • 113
    • 34247860969 scopus 로고    scopus 로고
    • Neural stem/progenitor cells express 20 tenascin C isoforms that are differentially regulated by Pax6
    • von Holst A, Egbers U, Prochiantz A et al. Neural stem/progenitor cells express 20 tenascin C isoforms that are differentially regulated by Pax6. J Biol Chem 2007;282:9172-9181.
    • (2007) J Biol Chem , vol.282 , pp. 9172-9181
    • von Holst, A.1    Egbers, U.2    Prochiantz, A.3
  • 114
    • 0033786113 scopus 로고    scopus 로고
    • Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of α5β1 integrin expression
    • Duncan MK, Kozmik Z, Cveklova K et al. Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of α5β1 integrin expression. J Cell Sci 2000;113:3173-3185.
    • (2000) J Cell Sci , vol.113 , pp. 3173-3185
    • Duncan, M.K.1    Kozmik, Z.2    Cveklova, K.3
  • 115
    • 33747833061 scopus 로고    scopus 로고
    • Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube
    • Lei Q, Jeong Y, Misra K et al. Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev Cell 2006;11:325-337.
    • (2006) Dev Cell , vol.11 , pp. 325-337
    • Lei, Q.1    Jeong, Y.2    Misra, K.3
  • 116
    • 0031458813 scopus 로고    scopus 로고
    • Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
    • Ericson J, Rashbass P, Schedl A et al. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 1997;90:169-180.
    • (1997) Cell , vol.90 , pp. 169-180
    • Ericson, J.1    Rashbass, P.2    Schedl, A.3
  • 117
    • 33750414811 scopus 로고    scopus 로고
    • Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antero-posterior axis
    • Nolte C, Rastegar M, Amores A et al. Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antero-posterior axis. Dev Biol 2006;299:582-593.
    • (2006) Dev Biol , vol.299 , pp. 582-593
    • Nolte, C.1    Rastegar, M.2    Amores, A.3
  • 118
    • 33845915509 scopus 로고    scopus 로고
    • Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon
    • Holm PC, Mader MT, Haubst N et al. Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon. Mol Cell Neurosci 2007;34:99-119.
    • (2007) Mol Cell Neurosci , vol.34 , pp. 99-119
    • Holm, P.C.1    Mader, M.T.2    Haubst, N.3
  • 119
    • 0028207924 scopus 로고
    • Roles of Pax-genes in developing and adult brain as suggested by expression patterns
    • Stoykova A, Gruss P. Roles of Pax-genes in developing and adult brain as suggested by expression patterns. J Neurosci 1994;14:1395-1412.
    • (1994) J Neurosci , vol.14 , pp. 1395-1412
    • Stoykova, A.1    Gruss, P.2
  • 120
    • 0032821713 scopus 로고    scopus 로고
    • Role of Pax6 in development of the cerebellar system
    • Engelkamp D, Rashbass P, Seawright A et al. Role of Pax6 in development of the cerebellar system. Development 1999;126:3585-3596.
    • (1999) Development , vol.126 , pp. 3585-3596
    • Engelkamp, D.1    Rashbass, P.2    Seawright, A.3
  • 121
    • 0033620601 scopus 로고    scopus 로고
    • Pax-6 is required for thalamocortical pathway formation in fetal rats
    • Kawano H, Fukuda T, Kubo K et al. Pax-6 is required for thalamocortical pathway formation in fetal rats. J Comp Neurol 1999;408:147-160.
    • (1999) J Comp Neurol , vol.408 , pp. 147-160
    • Kawano, H.1    Fukuda, T.2    Kubo, K.3
  • 122
    • 0034846113 scopus 로고    scopus 로고
    • Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum
    • Yamasaki T, Kawaji K, Ono K et al. Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum. Development 2001;128:3133-3144.
    • (2001) Development , vol.128 , pp. 3133-3144
    • Yamasaki, T.1    Kawaji, K.2    Ono, K.3
  • 123
    • 14944384231 scopus 로고    scopus 로고
    • Selective requirement of Pax6, but not Emx2, in the specification and development of several nuclei of the amygdaloid complex
    • Tole S, Remedios R, Saha B et al. Selective requirement of Pax6, but not Emx2, in the specification and development of several nuclei of the amygdaloid complex. J Neurosci 2005;25:2753-2760.
    • (2005) J Neurosci , vol.25 , pp. 2753-2760
    • Tole, S.1    Remedios, R.2    Saha, B.3
  • 124
    • 26044464225 scopus 로고    scopus 로고
    • Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis
    • Maekawa M, Takashima N, Arai Y et al. Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis. Genes Cells 2005;10:1001-1014.
    • (2005) Genes Cells , vol.10 , pp. 1001-1014
    • Maekawa, M.1    Takashima, N.2    Arai, Y.3
  • 125
    • 27444444760 scopus 로고    scopus 로고
    • Expression of the transcription factor Pax 6 in the adult rat dentate gyrus
    • Nacher J, Varea E, Blasco-Ibanez JM et al. Expression of the transcription factor Pax 6 in the adult rat dentate gyrus. J Neurosci Res 2005;81:753-761.
    • (2005) J Neurosci Res , vol.81 , pp. 753-761
    • Nacher, J.1    Varea, E.2    Blasco-Ibanez, J.M.3
  • 126
    • 23744461668 scopus 로고    scopus 로고
    • Neuronal fate determinants of adult olfactory bulb neurogenesis
    • Hack MA, Saghatelyan A, de Chevigny A et al. Neuronal fate determinants of adult olfactory bulb neurogenesis. Nat Neurosci 2005;8:865-872.
    • (2005) Nat Neurosci , vol.8 , pp. 865-872
    • Hack, M.A.1    Saghatelyan, A.2    de Chevigny, A.3
  • 127
    • 23044452071 scopus 로고    scopus 로고
    • Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb
    • Kohwi M, Osumi N, Rubenstein JL et al. Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb. J Neurosci 2005;25:6997-7003.
    • (2005) J Neurosci , vol.25 , pp. 6997-7003
    • Kohwi, M.1    Osumi, N.2    Rubenstein, J.L.3
  • 128
    • 0036096542 scopus 로고    scopus 로고
    • Identification of neural stem cells in the adult vertebrate brain
    • Alvarez-Buylla A, Seri B, Doetsch F. Identification of neural stem cells in the adult vertebrate brain. Brain Res Bull 2002;57:751-758.
    • (2002) Brain Res Bull , vol.57 , pp. 751-758
    • Alvarez-Buylla, A.1    Seri, B.2    Doetsch, F.3
  • 129
    • 0036469896 scopus 로고    scopus 로고
    • Neurogenesis in the adult brain
    • Gage FH. Neurogenesis in the adult brain. J Neurosci 2002;22:612-613.
    • (2002) J Neurosci , vol.22 , pp. 612-613
    • Gage, F.H.1
  • 130
    • 0037162691 scopus 로고    scopus 로고
    • Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    • Nakatomi H, Kuriu T, Okabe S et al. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 2002;110:429-441.
    • (2002) Cell , vol.110 , pp. 429-441
    • Nakatomi, H.1    Kuriu, T.2    Okabe, S.3
  • 132
    • 37249080159 scopus 로고    scopus 로고
    • Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype
    • Watanabe A, Toyota T, Owada Y et al. Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype. PLoS Biol 2007;5:e297.
    • (2007) PLoS Biol , vol.5
    • Watanabe, A.1    Toyota, T.2    Owada, Y.3
  • 133
    • 1542268981 scopus 로고    scopus 로고
    • For the long run: Maintaining germinal niches in the adult brain
    • Alvarez-Buylla A, Lim DA. For the long run: Maintaining germinal niches in the adult brain. Neuron 2004;41:683-686.
    • (2004) Neuron , vol.41 , pp. 683-686
    • Alvarez-Buylla, A.1    Lim, D.A.2
  • 134
    • 21744443627 scopus 로고    scopus 로고
    • Integrating new neurons into the adult olfactory bulb: Joining the network, life-death decisions, and the effects of sensory experience
    • Lledo PM, Saghatelyan A. Integrating new neurons into the adult olfactory bulb: Joining the network, life-death decisions, and the effects of sensory experience. Trends Neurosci 2005;28:248-254.
    • (2005) Trends Neurosci , vol.28 , pp. 248-254
    • Lledo, P.M.1    Saghatelyan, A.2
  • 135
    • 0032556665 scopus 로고    scopus 로고
    • Olfactory bulb development is altered in small-eye (Sey) mice
    • Dellovade TL, Pfaff DW, Schwanzel-Fukuda M. Olfactory bulb development is altered in small-eye (Sey) mice. J Comp Neurol 1998;402:402-418.
    • (1998) J Comp Neurol , vol.402 , pp. 402-418
    • Dellovade, T.L.1    Pfaff, D.W.2    Schwanzel-Fukuda, M.3
  • 136
    • 35748933472 scopus 로고    scopus 로고
    • Role of a transcription factor Pax6 in the developing vertebrate olfactory system
    • Nomura T, Haba H, Osumi N. Role of a transcription factor Pax6 in the developing vertebrate olfactory system. Dev Growth Differ 2007;49:683-690.
    • (2007) Dev Growth Differ , vol.49 , pp. 683-690
    • Nomura, T.1    Haba, H.2    Osumi, N.3
  • 137
    • 0004210529 scopus 로고    scopus 로고
    • 8th ed. Sunderland, MA: Sinauer Associates
    • Gilbert SF. Developmental Biology. 8th ed. Sunderland, MA: Sinauer Associates, 2006.
    • (2006) Developmental Biology
    • Gilbert, S.F.1
  • 138
    • 34548386210 scopus 로고    scopus 로고
    • Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells
    • Tamai H, Shinohara H, Miyata T et al. Pax6 transcription factor is required for the interkinetic nuclear movement of neuroepithelial cells. Genes Cells 2007;12:983-996.
    • (2007) Genes Cells , vol.12 , pp. 983-996
    • Tamai, H.1    Shinohara, H.2    Miyata, T.3
  • 139
    • 0001807820 scopus 로고
    • Kinetics of cellular proliferation
    • Fujita S. Kinetics of cellular proliferation. Exp Cell Res 1962;28:52-60.
    • (1962) Exp Cell Res , vol.28 , pp. 52-60
    • Fujita, S.1
  • 140
    • 0036008319 scopus 로고    scopus 로고
    • New 3′ elements control Pax6 expression in the developing pretectum, neural retina and olfactory region
    • Griffin C, Kleinjan DA, Doe B et al. New 3′ elements control Pax6 expression in the developing pretectum, neural retina and olfactory region. Mech Dev 2002;112:89-100.
    • (2002) Mech Dev , vol.112 , pp. 89-100
    • Griffin, C.1    Kleinjan, D.A.2    Doe, B.3
  • 141
    • 0035289571 scopus 로고    scopus 로고
    • Pax-6 regulates expression of SFRP-2 and Wnt-76 in the developing CNS
    • Kim AS, Anderson SA, Rubenstein JL et al. Pax-6 regulates expression of SFRP-2 and Wnt-76 in the developing CNS. J Neurosci 2001;21:RC132(1-5).
    • (2001) J Neurosci , vol.21 , Issue.1-5
    • Kim, A.S.1    Anderson, S.A.2    Rubenstein, J.L.3


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