Relative roles of the different Pax6 domains for pancreatic alpha cell development

BMC Developmental Biology

Volumn 10, Issue , 2010, Pages

  Dames, Petra ^a   Puff, Ramona ^a   Weise, Michaela ^a   Parhofer, Klaus G ^a   Göke, Burkhard ^a   Götz, Magdalena ^b,c   Graw, Jochen ^b   Favor, Jack ^b   Lechner, Andreas ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MUS;

EYE PROTEIN; HOMEODOMAIN PROTEIN; PAIRED BOX TRANSCRIPTION FACTOR; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR PAX6;

ANIMAL; ARTICLE; CHEMISTRY; CYTOLOGY; METABOLISM; MOUSE; MOUSE MUTANT; PANCREAS; PANCREAS ISLET ALPHA CELL; PRENATAL DEVELOPMENT; PROTEIN TERTIARY STRUCTURE;

ANIMALS; EYE PROTEINS; GLUCAGON-SECRETING CELLS; HOMEODOMAIN PROTEINS; MICE; MICE, KNOCKOUT; PAIRED BOX TRANSCRIPTION FACTORS; PANCREAS; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS;

EID: 77950631621     PISSN: None     EISSN: 1471213X     Source Type: Journal    
DOI: 10.1186/1471-213X-10-39     Document Type: Article

References (28)

1. Transcription factors in pancreatic development. Animal models. M Martin V Hauer M Messmer C Orvain G Gradwohl, Endocr Dev 2007 12 24 32 17923766
2. Transcription factor expression in the developing human fetal endocrine pancreas. BM Lyttle J Li M Krishnamurthy F Fellows MB Wheeler CG Goodyer R Wang, Diabetologia 2008 51 1169 80 10.1007/s00125-008-1006-z 18491072
3. Genes controlling pancreas ontogeny. C Bonal PL Herrera, Int J Dev Biol 2008 52 823 35 10.1387/ijdb.072444cb 18956314
4. Pancreatic organogenesis - developmental mechanisms and implications for therapy. H Edlund, Nat Rev Genet 2002 3 524 32 10.1038/nrg841 12094230
5. Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes. R Ashery-Padan X Zhou T Marquardt P Herrera L Toube A Berry P Gruss, Dev Biol 2004 269 479 88 10.1016/j.ydbio.2004.01.040 15110714
6. Genetic determinants of pancreatic epsilon-cell development. RS Heller M Jenny P Collombat A Mansouri C Tomasetto OD Madsen G Mellitzer G Gradwohl P Serup, Dev Biol 2005 286 217 24 10.1016/j.ydbio.2005.06.041 16122727
7. Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development. N Haubst J Berger V Radjendirane J Graw J Favor GF Saunders A Stoykova M Gotz, Development 2004 131 6131 40 10.1242/dev.01524 15548580
8. Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. L St-Onge B Sosa-Pineda K Chowdhury A Mansouri P Gruss, Nature 1997 387 406 9 10.1038/387406a0 9163426
9. The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. RS Heller DA Stoffers A Liu A Schedl EB Crenshaw III OD Madsen P Serup, Dev Biol 2004 268 123 34 10.1016/j.ydbio.2003.12.008 15031110
10. Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. M Sander A Neubuser J Kalamaras HC Ee GR Martin MS German, Genes Dev 1997 11 1662 73 10.1101/gad.11.13.1662 9224716
11. Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas. C Dohrmann P Gruss L Lemaire, Mech Dev 2000 92 47 54 10.1016/S0925-4773(99)00324-X 10704887
12. Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus. J Favor CJ Gloeckner A-Klaus Neuhauser W Pretsch R Sandulache S Saule I Zaus, Genetics 2008 179 1345 55 10.1534/genetics.108.088591 18562673
13. Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters. J Graw J Loster O Puk D Munster N Haubst D Soewarto H Fuchs B Meyer P Nurnberg W Pretsch, et al. Invest Ophthalmol Vis Sci 2005 46 4671 83 10.1167/iovs.04-1407 16303964
14. Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2. LS Katz Y Gosmain E Marthinet J Philippe, Mol Cell Biol 2009 29 2322 34 10.1128/MCB.01543-08 19223471
15. Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells. D Malide NG Seidah M Chretien M Bendayan, J Histochem Cytochem 1995 43 11 9 7822759
16. Opposing actions of Arx and Pax4 in endocrine pancreas development. P Collombat A Mansouri J Hecksher-Sorensen P Serup J Krull G Gradwohl P Gruss, Genes Dev 2003 17 2591 603 10.1101/gad.269003 14561778
17. The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. A Petri J Ahnfelt-Ronne KS Frederiksen DG Edwards D Madsen P Serup J Fleckner RS Heller, J Mol Endocrinol 2006 37 301 16 10.1677/jme.1.02096 17032746
18. Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus. NG Smart AA Apelqvist X Gu EB Harmon JN Topper RJ MacDonald SK Kim, PLoS Biol 2006 4 39 10.1371/journal.pbio.0040039 16435884
19. Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. A Merglen S Theander B Rubi G Chaffard CB Wollheim P Maechler, Endocrinology 2004 145 667 78 10.1210/en.2003-1099 14592952
20. Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus. J Favor H Peters T Hermann W Schmahl B Chatterjee A Neuhauser-Klaus R Sandulache, Genetics 2001 159 1689 700 11779807
21. Interaction of Maf transcription factors with Pax-6 results in synergistic activation of the glucagon promoter. N Planque L Leconte FM Coquelle S Benkhelifa P Martin MP Felder-Schmittbuhl S Saule, J Biol Chem 2001 276 35751 60 10.1074/jbc.M104523200 11457839
22. Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression. Y Gosmain I Avril A Mamin J Philippe, J Biol Chem 2007 282 35024 34 10.1074/jbc.M702795200 17901057
23. Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. CL Prado AE-Bernard Pugh L Elghazi B-Pineda Sosa L Sussel, Proc Natl Acad Sci USA 2004 101 2924 9 10.1073/pnas.0308604100 14970313
24. Nuclear localization signals, DNA binding, and transactivation properties of quail Pax-6 (Pax-QNR) isoforms. C Carriere S Plaza J Caboche C Dozier M Bailly P Martin S Saule, Cell Growth Differ 1995 6 1531 40 9019158
25. DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5). T Czerny M Busslinger, Mol Cell Biol 1995 15 2858 71 7739566
26. Cooperative interactions between paired domain and homeodomain. S Jun C Desplan, Development 1996 122 2639 50 8787739
27. The homeodomain of PAX6 is essential for PAX6-dependent activation of the rat glucagon gene promoter: evidence for a PH0-like binding that induces an active conformation. M Grapp S Teichler J Kitz P Dibaj C Dickel W Knepel R Kratzner, Biochim Biophys Acta 2009 1789 403 12 19217949
28. Mouse small eye results from mutations in a paired-like homeobox-containing gene. RE Hill J Favor BL Hogan CC Ton GF Saunders IM Hanson J Prosser T Jordan ND Hastie V van Heyningen, Nature 1991 354 522 5 10.1038/354522a0 1684639