Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response

Diabetes

Volumn 51, Issue 4, 2002, Pages 958-965

  Banarer, Salomon ^a   McGregor, Veronica P ^a   Cryer, Philip E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; C PEPTIDE; GLUCAGON; GLUCOSE; INSULIN; NORADRENALIN; PANCREAS POLYPEPTIDE; TOLBUTAMIDE;

ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; CLINICAL TRIAL; DRUG INFUSION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HUMAN; HYPERINSULINEMIA; HYPOGLYCEMIA; IATROGENIC DISEASE; INSULIN INFUSION; INSULIN RELEASE; MALE; NORADRENALIN BLOOD LEVEL; NORMAL HUMAN; PANCREAS ISLET; PANCREAS ISLET ALPHA CELL; PARASYMPATHETIC NERVE; PATHOGENESIS; PRIORITY JOURNAL; SYMPATHETIC NERVE;

EID: 0036227054     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.4.958     Document Type: Article

References (57)

1. Hypoglycemia: The limiting factor in the management of IDDM
2. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
3. Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes
4. Lack of glucagon response to hypoglycemia in diabetes: Evidence for an intrinsic pancreatic alpha cell defect
5. Abnormal glucose counterregulation in insulin dependent diabetes mellitus: Interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion
6. Hypoglycemia-associated autonomic failure in insulin dependent diabetes mellitus
7. Identification of type 1 diabetic patients at increased risk for hypoglycemia during intensive therapy
8. A reliable and reproducible test for adequate glucose counterregulation in type 1 diabetes
9. Frequency of severe hypoglycemia in patients with type 1 diabetes with impaired awareness of hypoglycemia
10. Correlation between minimal secretory capacity of pancreatic β-cells and stability of diabetic control
11. Brief twice weekly episodes of hypoglycemia reduce detection of clinical hypoglycemia in type 1 diabetes mellitus
12. Impact of nocturnal hypoglycemia on hypoglycemic cognitive dysfunction in type 1 diabetes mellitus
13. Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM
14. Counterregulation during hypoglycemia is directed by widespread brain regions
15. Autonomic mediation of glucagon secretion during hypoglycemia
16. Effect of nicotinic and nicotinic-cholinergic blockade on the glucagon response to insulin-induced hypoglycemia in normal men
17. Activation of autonomic nerves and the adrenal medulla contributes to increased glucagon secretion during moderate insulin-induced hypoglycemia in women
18. Autonomic regulation of islet hormone secretion: Implications for health and disease
19. Mechanisms of awareness of hypoglycemia: Perception of neurogenic (predominantly cholinergic) rather than neuroglycopenic symptoms
20. Plasma glucagon and glucose recovery after hypoglycemia: The effects of total autonomic blockade
21. Glucagon, catecholamine and pancreatic polypeptide secretion in type 1 diabetic recipients of pancreas allografts
22. The glucose sensor protein glucokinase is expressed in glucagon-producing α-cells
23. Interplay of nutrients and hormones in the regulation of glucagon release
24. Glucagon-insulin interrelationships
25. Glucagon secretion from the perfused pancreas of streptozotocin-treated rats
26. Insulin within islets is a physiologic glucagon release inhibitor
27. The order of islet microvascular cellular perfusion is B → A → D in the perfused rat pancreas
28. Intra-islet cell-cell interactions and insulin secretion
29. In vivo inhibition of glucagon secretion by paracrine beta cell activity in man
30. Circulating insulin inhibits glucagon secretion induced by arginine in type 1 diabetes
31. Suppression of glucagon secretion during a tolbutamide infusion in normal and non-insulin-dependent diabetic subjects
32. Suppression of counterregulatory hormone response to hypoglycemia by insulin perse
33. A high concentration of circulating insulin suppresses the glucagon response to hypoglycemia in normal man
34. The effects of differing insulin levels on the counterregulatory response in normal man
35. Similar physiological and symptomatic responses to sulphonylurea and insulin induced hypoglycemia in normal subjects
36. The use of tolbutamide-induced hypoglycemia to examine the intraislet role of insulin in mediating glucagon release in normal humans
37. Counterregulatory response to hypoglycemia differs according to the insulin delivery route, but does not affect glucose production in normal humans
38. Oral glibenclamide suppresses glucagon secretion during insulin-induced hypoglycemia in patients with type 2 diabetes
39. Determination of free and total insulin and C-peptide in insulin-treated diabetics
40. Immunoassays for glucagon
41. Regional pancreatic concentration and in vitro secretion of canine pancreatic polypeptide, insulin, and glucagon
42. A sensitive double antibody radioimmunoassay for growth hormone in plasma
43. Plasma cortisol determination: Radioimmunoassay and competitive protein binding compared
44. External and internal standards in the single-isotope derivative (radioenzymatic) measurement of plasma norepinephrine and epinephrine
45. A new colorimetric method for the determination of free fatty acids with acyl-CoA synthetase and acyl-CoA oxidase
46. Enzymatic assay of glycerol, dihydroxyacetone and glyceraldehyde
47. Effect of ischemia on known substrates and co-factors of the glycolyptic pathway of the brain
48. Hormone-fuel interrelationships during fasting
49. Nonparametric input estimation in physiological systems: Problems, methods, case studies
50. WINSTODEC: A stochastic deconvolution interactive program for physiological and pharmacokinetic systems
51. Prehepatic insulin production in man: Kinetic analysis using peripheral connecting peptide behavior
52. Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance
53. ATP) conductance in rat pancreatic A-cells
54. Forearm norepinephrine spillover during prolonged standing, hyperinsulinemia and hypoglycemia
55. Arterial insulin sensitivity controls the alpha cell response to hypoglycemia in the dog
56. Exogenous insulin dose-dependently suppresses glucopenia-induced glucagon secretion from perfused rat pancreas