Intracellular delivery of the p38 mitogen-activated protein kinase inhibitor SB202190 [4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H- imidazole] in renal tubular cells: A novel strategy to treat renal fibrosis

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 1, 2006, Pages 8-19

  Prakash, Jai ^a   Sandovici, Maria ^a   Saluja, Vinay ^a   Lacombe, Marie ^b   Schaapveld, Roel Q J ^b   De Borst, Martin H ^a   Van Goor, Harry ^a   Henning, Robert H ^a   Proost, Johannes H ^a   Moolenaar, Frits ^a   Këri, György ^c   Meijer, Dirk K F ^a   Poelstra, Klaas ^a   Kok, Robbert J ^a,d  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b Kreatech Biotechnology BV   (Netherlands)

^c Vichem Chemie Ltd   (Hungary)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALBUMIN; ALPHA SMOOTH MUSCLE ACTIN; CARBAMIC ACID; LYSOZYME; MONOCYTE CHEMOTACTIC PROTEIN 1; PLATINUM DERIVATIVE; PROCOLLAGEN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG RELEASE; DRUG STABILITY; GENE EXPRESSION; HUMAN; HUMAN CELL; INCUBATION TIME; KIDNEY FIBROSIS; KIDNEY HOMOGENATE; KIDNEY ISCHEMIA; KIDNEY TUBULE CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION;

ANIMALS; BIOLOGICAL TRANSPORT; CISPLATIN; FIBROSIS; IMIDAZOLES; KIDNEY; KIDNEY TUBULES, PROXIMAL; MALE; MURAMIDASE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PYRIDINES; RATS; RATS, WISTAR; REPERFUSION INJURY;

EID: 33749007708     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.106054     Document Type: Article

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