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Volumn 70, Issue 8, 2011, Pages 703-714

Prominent microglial activation in the early proinflammatory immune response in naturally occurring canine spinal cord injury

Author keywords

Cytokines; Dog; Inflammation; Microglia; Organotypic slice culture; Spinal cord injury; Translational research

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR;

EID: 79961031923     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3182270f8e     Document Type: Article
Times cited : (65)

References (95)
  • 1
    • 79953303613 scopus 로고    scopus 로고
    • A global map for traumatic spinal cord injury epidemiology: Towards a living data repository for injury prevention
    • Cripps RA, Lee BB, Wing P, et al. A global map for traumatic spinal cord injury epidemiology: Towards a living data repository for injury prevention. Spinal Cord 2011;49:493-501
    • (2011) Spinal Cord , vol.49 , pp. 493-501
    • Cripps, R.A.1    Lee, B.B.2    Wing, P.3
  • 2
    • 0141756286 scopus 로고    scopus 로고
    • Inflammation, degeneration and regeneration in the injured spinal cord: Insights from DNA microarrays
    • DOI 10.1016/j.tins.2003.08.004
    • Bareyre FM, Schwab ME. Inflammation, degeneration and regeneration in the injured spinal cord: Insights from DNA microarrays. Trends Neurosci 2003;26:555-63 (Pubitemid 37176911)
    • (2003) Trends in Neurosciences , vol.26 , Issue.10 , pp. 555-563
    • Bareyre, F.M.1    Schwab, M.E.2
  • 8
    • 0031013236 scopus 로고    scopus 로고
    • Cellular inflammatory response after spinal cord injury in Sprague- Dawley and Lewis rats
    • DOI 10.1002/(SICI)1096-9861(1997 0120)377:3<443::AID-CNE10>3.0. CO;2-S
    • Popovich PG, Wei P, Stokes BT. Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J Comp Neurol 1997;377:443-64 (Pubitemid 27016650)
    • (1997) Journal of Comparative Neurology , vol.377 , Issue.3 , pp. 443-464
    • Popovich, P.G.1    Wei, P.2    Stokes, B.T.3
  • 9
    • 0029739941 scopus 로고    scopus 로고
    • Concept of autoimmunity following spinal cord injury: Possible roles for T lymphocytes in the traumatized central nervous system
    • DOI 10.1002/(SICI)1097-4547(19960 815)45:4<349::AID-JNR4>3.0.CO;2-9
    • Popovich PG, Stokes BT, Whitacre CC. Concept of autoimmunity following spinal cord injury: Possible roles for T lymphocytes in the traumatized central nervous system. J Neurosci Res 1996;45:349-63 (Pubitemid 26299590)
    • (1996) Journal of Neuroscience Research , vol.45 , Issue.4 , pp. 349-363
    • Popovich, P.G.1    Stokes, B.T.2    Whitacre, C.C.3
  • 10
    • 0032821690 scopus 로고    scopus 로고
    • Acute inflammatory responses to mechanical lesions in the CNS: Differences between brain and spinal cord
    • DOI 10.1046/j.1460-9568.1999.00792.x
    • Schnell L, Fearn S, Klassen H, et al. Acute inflammatory responses to mechanical lesions in the CNS: Differences between brain and spinal cord. Eur J Neurosci 1999;11:3648-58 (Pubitemid 29484261)
    • (1999) European Journal of Neuroscience , vol.11 , Issue.10 , pp. 3648-3658
    • Schnell, L.1
  • 11
    • 0034966787 scopus 로고    scopus 로고
    • Protective autoimmunity: Regulation and prospects for vaccination after brain and spinal cord injuries
    • DOI 10.1016/S1471-4914(01)01993-1
    • Schwartz M, Kipnis J. Protective autoimmunity: Regulation and prospects for vaccination after brain and spinal cord injuries. Trends Mol Med 2001;7:252-58 (Pubitemid 32545521)
    • (2001) Trends in Molecular Medicine , vol.7 , Issue.6 , pp. 252-258
    • Schwartz, M.1    Kipnis, J.2
  • 12
    • 68049143269 scopus 로고    scopus 로고
    • Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice
    • Shechter R, London A, Varol C, et al. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med 2009;6:e1000113
    • (2009) PLoS Med , vol.6
    • Shechter, R.1    London, A.2    Varol, C.3
  • 13
    • 0032838089 scopus 로고    scopus 로고
    • Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury
    • DOI 10.1006/exnr.1999.7118
    • Popovich PG, Guan Z, Wei P, et al. Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp Neurol 1999;158:351-65 (Pubitemid 29382826)
    • (1999) Experimental Neurology , vol.158 , Issue.2 , pp. 351-365
    • Popovich, P.G.1    Guan, Z.2    Wei, P.3    Huitinga, I.4    Van Rooijen, N.5    Stokes, B.T.6
  • 14
    • 0030842973 scopus 로고    scopus 로고
    • Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse: An in situ hybridization study
    • DOI 10.1111/j.1460-9568.1997.tb01497.x
    • Bartholdi D, Schwab ME. Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse: An in situ hybridization study. Eur J Neurosci 1997;9:1422-38 (Pubitemid 27303243)
    • (1997) European Journal of Neuroscience , vol.9 , Issue.7 , pp. 1422-1438
    • Bartholdi, D.1    Schwab, M.E.2
  • 15
    • 0036570042 scopus 로고    scopus 로고
    • Cytokine activity contributes to induction of inflammatory cytokine mRNAs in spinal cord following contusion
    • DOI 10.1002/jnr.10215
    • Pan JZ, Ni L, Sodhi A, et al. Cytokine activity contributes to induction of inflammatory cytokine mRNAs in spinal cord following contusion. J Neurosci Res 2002;68:315-22 (Pubitemid 34462536)
    • (2002) Journal of Neuroscience Research , vol.68 , Issue.3 , pp. 315-322
    • Pan, J.Z.1    Ni, L.2    Sodhi, A.3    Aguanno, A.4    Young, W.5    Hart, R.P.6
  • 16
    • 0030249926 scopus 로고    scopus 로고
    • Production of tumor necrosis factor in spinal cord following traumatic injury in rats
    • DOI 10.1016/S0165-5728(96)00080-X
    • Wang CX, Nuttin B, Heremans H, et al. Production of tumor necrosis factor in spinal cord following traumatic injury in rats. J Neuroimmunol 1996;69:151-56 (Pubitemid 26305640)
    • (1996) Journal of Neuroimmunology , vol.69 , Issue.1-2 , pp. 151-156
    • Wang, C.X.1    Nuttin, B.2    Heremans, H.3    Dom, R.4    Gybels, J.5
  • 17
    • 0030610578 scopus 로고    scopus 로고
    • Increase of interleukin-lβ mRNA and protein in the spinal cord following experimental traumatic injury in the rat
    • DOI 10.1016/S0006-8993(97)00254-0, PII S0006899397002540
    • Wang CX, Olschowka JA, Wrathall JR. Increase of interleukin-1beta mRNA and protein in the spinal cord following experimental traumatic injury in the rat. Brain Res 1997;759:190-96 (Pubitemid 27286694)
    • (1997) Brain Research , vol.759 , Issue.2 , pp. 190-196
    • Wang, C.X.1    Olschowka, J.A.2    Wrathall, J.R.3
  • 18
    • 0037102724 scopus 로고    scopus 로고
    • Treatment of spinal cord impact injury in the rat with transforming growth factor-β
    • DOI 10.1016/S0022-510X(02)00113-2, PII S0022510X02001132
    • Tyor WR, Avgeropoulos N, Ohlandt G, et al. Treatment of spinal cord impact injury in the rat with transforming growth factor-beta. J Neurol Sci 2002;200:33-41 (Pubitemid 34792739)
    • (2002) Journal of the Neurological Sciences , vol.200 , Issue.1-2 , pp. 33-41
    • Tyor, W.R.1    Avgeropoulos, N.2    Ohlandt, G.3    Hogan, E.L.4
  • 19
    • 33750197486 scopus 로고    scopus 로고
    • Clinical canine spinal cord injury provides an opportunity to examine the issues in translating laboratory techniques into practical therapy
    • DOI 10.1038/sj.sc.3101912, PII 3101912
    • Jeffery ND, Smith PM, Lakatos A, et al. Clinical canine spinal cord injury provides an opportunity to examine the issues in translating laboratory techniques into practical therapy. Spinal Cord 2006;44:584-93 (Pubitemid 44600320)
    • (2006) Spinal Cord , vol.44 , Issue.10 , pp. 584-593
    • Jeffery, N.D.1    Smith, P.M.2    Lakatos, A.3    Ibanez, C.4    Ito, D.5    Franklin, R.J.M.6
  • 21
    • 79954631977 scopus 로고    scopus 로고
    • All creatures great and small: Regulatory T cells in mice, humans, dogs and other domestic animal species
    • Garden OA, Pinheiro D, Cunningham F. All creatures great and small: Regulatory T cells in mice, humans, dogs and other domestic animal species. Int Immunopharmacol 2011;11:576-88
    • (2011) Int Immunopharmacol , vol.11 , pp. 576-588
    • Garden, O.A.1    Pinheiro, D.2    Cunningham, F.3
  • 22
    • 79955476564 scopus 로고    scopus 로고
    • Species-specific control of cellular proliferation and the impact of large animal models for the use of olfactory ensheathing cells and Schwann cells in spinal cord repair
    • Wewetzer K, Radtke C, Kocsis J, et al. Species-specific control of cellular proliferation and the impact of large animal models for the use of olfactory ensheathing cells and Schwann cells in spinal cord repair. J Exp Neurol 2011;229:80-87
    • (2011) J Exp Neurol , vol.229 , pp. 80-87
    • Wewetzer, K.1    Radtke, C.2    Kocsis, J.3
  • 24
    • 0033822466 scopus 로고    scopus 로고
    • Major histocompatibility complex class II expression by activated microglia caudal to lesions of descending tracts in the human spinal cord is not associated with a T cell response
    • Schmitt AB, Buss A, Breuer S, et al. Major histocompatibility complex class II expression by activated microglia caudal to lesions of descending tracts in the human spinal cord is not associated with a T cell response. Acta Neuropathol 2000;100:528-36
    • (2000) Acta Neuropathol , vol.100 , pp. 528-536
    • Schmitt, A.B.1    Buss, A.2    Breuer, S.3
  • 26
    • 28244487158 scopus 로고    scopus 로고
    • Autologous olfactory glial cell transplantation is reliable and safe in naturally occurring canine spinal cord injury
    • DOI 10.1089/neu.2005.22.1282
    • Jeffery ND, Lakatos A, Franklin RJ. Autologous olfactory glial cell transplantation is reliable and safe in naturally occurring canine spinal cord injury. J Neurotrauma 2005;22:1282-93 (Pubitemid 41714073)
    • (2005) Journal of Neurotrauma , vol.22 , Issue.11 , pp. 1282-1293
    • Jeffery, N.D.1    Lakatos, A.2    Franklin, R.J.M.3
  • 27
    • 54549119027 scopus 로고    scopus 로고
    • Similar behaviour and primate-like properties of adult canine Schwann cells and olfactory ensheathing cells in long-term culture
    • Techangamsuwan S, Imbschweiler I, Kreutzer R, et al. Similar behaviour and primate-like properties of adult canine Schwann cells and olfactory ensheathing cells in long-term culture. Brain Res 2008;1240:31-38
    • (2008) Brain Res , vol.1240 , pp. 31-38
    • Techangamsuwan, S.1    Imbschweiler, I.2    Kreutzer, R.3
  • 28
    • 0025730112 scopus 로고
    • The effects of 4-aminopyridine on neurological deficits in chronic cases of traumatic spinal cord injury in dogs: A phase I clinical trial
    • Blight AR, Toombs JP, Bauer MS, et al. The effects of 4-aminopyridine on neurological deficits in chronic cases of traumatic spinal cord injury in dogs: A phase I clinical trial. J Neurotrauma 1991;8:103-9
    • (1991) J Neurotrauma , vol.8 , pp. 103-109
    • Blight, A.R.1    Toombs, J.P.2    Bauer, M.S.3
  • 32
    • 0033671255 scopus 로고    scopus 로고
    • Spontaneously occurring tumors of companion animals as models for human cancer
    • Vail DM, MacEwen EG. Spontaneously occurring tumors of companion animals as models for human cancer. Cancer Invest 2000;18:781-92
    • (2000) Cancer Invest , vol.18 , pp. 781-792
    • Vail, D.M.1    MacEwen, E.G.2
  • 33
    • 33749340148 scopus 로고    scopus 로고
    • Canine neurological diseases in a referral hospital population between 1989 and 2000 in Switzerland
    • DOI 10.1111/j.1748-5827.2006.00106.x
    • Fluehmann G, Doherr MG, Jaggy A. Canine neurological diseases in a referral hospital population between 1989 and 2000 in Switzerland. J Small Anim Pract 2006;47:582-87 (Pubitemid 44495500)
    • (2006) Journal of Small Animal Practice , vol.47 , Issue.10 , pp. 582-587
    • Fluehmann, G.1    Doherr, M.G.2    Jaggy, A.3
  • 34
    • 0036400846 scopus 로고    scopus 로고
    • Cryopreserved cells isolated from the adult canine olfactory bulb are capable of extensive remyelination following transplantation into the adult rat CNS
    • DOI 10.1006/exnr.2002.7936
    • Smith PM, Lakatos A, Barnett SC, et al. Cryopreserved cells isolated from the adult canine olfactory bulb are capable of extensive remyelination following transplantation into the adult rat CNS. Exp Neurol 2002;176:402-6 (Pubitemid 35193357)
    • (2002) Experimental Neurology , vol.176 , Issue.2 , pp. 402-406
    • Smith, P.M.1    Lakatos, A.2    Barnett, S.C.3    Jeffery, N.D.4    Franklin, R.J.M.5
  • 35
    • 33745030164 scopus 로고    scopus 로고
    • Histological and ultrastructural analysis of white matter damage after naturally-occurring spinal cord injury
    • DOI 10.1111/j.1750-3639.2006.00001.x
    • Smith PM, Jeffery ND. Histological and ultrastructural analysis of white matter damage after naturally-occurring spinal cord injury. Brain Pathol 2006;16:99-109 (Pubitemid 43876469)
    • (2006) Brain Pathology , vol.16 , Issue.2 , pp. 99-109
    • Smith, P.M.1    Jeffery, N.D.2
  • 36
    • 77955884085 scopus 로고    scopus 로고
    • The pathogenesis and treatment of acute spinal cord injuries in dogs
    • Olby N. The pathogenesis and treatment of acute spinal cord injuries in dogs. Vet Clin North Am Small Anim Pract 2010;40:791-807
    • (2010) Vet Clin North Am Small Anim Pract , vol.40 , pp. 791-807
    • Olby, N.1
  • 37
    • 0000344424 scopus 로고
    • Canine intervertebral disc disease-occurrence by age, breed, and sex among 8, 117 cases
    • Priester WA. Canine intervertebral disc disease-occurrence by age, breed, and sex among 8, 117 cases. Theriogenology 1976;6:293-303
    • (1976) Theriogenology , vol.6 , pp. 293-303
    • Priester, W.A.1
  • 38
    • 48049094733 scopus 로고    scopus 로고
    • Canine embryo-derived stem cells and models for human diseases
    • Schneider MR, Wolf E, Braun J, et al. Canine embryo-derived stem cells and models for human diseases. Hum Mol Genet 2008;17:R42-47
    • (2008) Hum Mol Genet , vol.17
    • Schneider, M.R.1    Wolf, E.2    Braun, J.3
  • 39
    • 57449096122 scopus 로고    scopus 로고
    • A prescription for human immunology
    • Davis MM. A prescription for human immunology. Immunity. 2008;29:835-38
    • (2008) Immunity , vol.29 , pp. 835-838
    • Davis, M.M.1
  • 40
    • 36849064283 scopus 로고    scopus 로고
    • Biotech for your companion?
    • DOI 10.1038/nbt1207-1343, PII NBT12071343
    • Kling J. Biotech for your companion? Nat Biotechnol 2007;25:1343-45 (Pubitemid 350233112)
    • (2007) Nature Biotechnology , vol.25 , Issue.12 , pp. 1343-1345
    • Kling, J.1
  • 41
    • 0016441647 scopus 로고
    • Vasogenic edema following acute and chronic spinal cord compression in the dog
    • Griffiths IR. Vasogenic edema following acute and chronic spinal cord compression in the dog. J Neurosurg 1975;42:155-65
    • (1975) J Neurosurg , vol.42 , pp. 155-165
    • Griffiths, I.R.1
  • 42
    • 0017286696 scopus 로고
    • Spinal cord blood flow after acute experimental cord injury in dogs
    • Griffiths IR. Spinal cord blood flow after acute experimental cord injury in dogs. J Neurol Sci 1976;27:247-59
    • (1976) J Neurol Sci , vol.27 , pp. 247-259
    • Griffiths, I.R.1
  • 43
    • 0017864932 scopus 로고
    • Spinal cord injuries: A pathological study of naturally occurring lesions in the dog and cat
    • DOI 10.1016/0021-9975(78)90033-6
    • Griffiths IR. Spinal cord injuries: A pathological study of naturally occurring lesions in the dog and cat. J Comp Pathol 1978;88:303-15 (Pubitemid 8321122)
    • (1978) Journal of Comparative Pathology , vol.88 , Issue.2 , pp. 303-315
    • Griffiths, I.R.1
  • 44
    • 27744542561 scopus 로고    scopus 로고
    • FAS deficiency reduces apoptosis, spares axons and improves function after spinal cord injury
    • DOI 10.1016/j.expneurol.2005.08.020, PII S0014488605003134
    • Casha S, Yu WR, Fehlings MG. FAS deficiency reduces apoptosis, spares axons and improves function after spinal cord injury. Exp Neurol 2005;196:390-400 (Pubitemid 41607828)
    • (2005) Experimental Neurology , vol.196 , Issue.2 , pp. 390-400
    • Casha, S.1    Yu, W.R.2    Fehlings, M.G.3
  • 45
    • 0036807352 scopus 로고    scopus 로고
    • An in vitro model of neurotrauma in organotypic spinal cord cultures from adult mice
    • DOI 10.1016/S1385-299X(02)00180-0, PII S1385299X02001800
    • Krassioukov AV, Ackery A, Schwartz G, et al. An in vitro model of neurotrauma in organotypic spinal cord cultures from adult mice. Brain Res Brain Res Protoc 2002;10:60-68 (Pubitemid 35335971)
    • (2002) Brain Research Protocols , vol.10 , Issue.2 , pp. 60-68
    • Krassioukov, A.V.1    Ackery, A.2    Schwartz, G.3    Adamchik, Y.4    Liu, Y.5    Fehlings, M.G.6
  • 46
    • 21544469717 scopus 로고    scopus 로고
    • Characterisation of transverse slice culture preparations of postnatal rat spinal cord: Preservation of defined neuronal populations
    • DOI 10.1007/s00418-004-0743-4
    • Stavridis SI, Dehghani F, Korf HW, et al. Characterisation of transverse slice culture preparations of postnatal rat spinal cord: Preservation of defined neuronal populations. Histochem Cell Biol 2005;123:377-92 (Pubitemid 40922221)
    • (2005) Histochemistry and Cell Biology , vol.123 , Issue.4-5 , pp. 377-392
    • Stavridis, S.I.1    Dehghani, F.2    Korf, H.-W.3    Hailer, N.P.4
  • 47
    • 28044473409 scopus 로고    scopus 로고
    • A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices
    • Huuskonen J, Suuronen T, Miettinen R, et al. A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices. J Neuroinflammation 2005;2:25
    • (2005) J Neuroinflammation , vol.2 , pp. 25
    • Huuskonen, J.1    Suuronen, T.2    Miettinen, R.3
  • 48
    • 0025805120 scopus 로고
    • A simple method for organotypic cultures of nervous tissue
    • Stoppini L, Buchs P-A, Muller D. A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 1991;37:173-82
    • (1991) J Neurosci Methods , vol.37 , pp. 173-182
    • Stoppini, L.1    Buchs, P.-A.2    Muller, D.3
  • 49
    • 0036229878 scopus 로고    scopus 로고
    • Increased expression of pro-inflammatory cytokines and lack of up-regulation of anti-inflammatory cytokines in early distemper CNS lesions
    • DOI 10.1016/S0165-5728(02)00027-9, PII S0165572802000279
    • Markus S, Failing K, Baumgärtner W. Increased expression of proinflammatory cytokines and lack of up-regulation of anti-inflammatory cytokines in early distemper CNS lesions. J Neuroimmunol 2002;125:30-41 (Pubitemid 34327451)
    • (2002) Journal of Neuroimmunology , vol.125 , Issue.1-2 , pp. 30-41
    • Markus, S.1    Failing, K.2    Baumgartner, W.3
  • 50
    • 0029761977 scopus 로고    scopus 로고
    • Up-regulation of major histocompatibility complex class II antigen expression in the central nervous system of dogs with spontaneous canine distemper virus encephalitis
    • DOI 10.1007/s004010050518
    • Alldinger S, Wünschmann A, Baumgärtner W, et al. Up-regulation of major histocompatibility complex class II antigen expression in the central nervous system of dogs with spontaneous canine distemper virus encephalitis. Acta Neuropathol 1996;92:273-80 (Pubitemid 26278958)
    • (1996) Acta Neuropathologica , vol.92 , Issue.3 , pp. 273-280
    • Alldinger, S.1    Wunschmann, A.2    Baumgartner, W.3    Voss, C.4    Kremmer, E.5
  • 51
    • 27944511106 scopus 로고    scopus 로고
    • Up-regulation of mRNA for matrix metalloproteinases-9 and -14 in advanced lesions of demyelinating canine distemper leukoencephalitis
    • DOI 10.1007/s00401-005-1055-z
    • Gröters S, Alldinger S, Baumgärtner W. Up-regulation of mRNA for matrix metalloproteinases-9 and-14 in advanced lesions of demyelinating canine distemper leukoencephalitis. Acta Neuropathol 2005;110:369-82 (Pubitemid 41672182)
    • (2005) Acta Neuropathologica , vol.110 , Issue.4 , pp. 369-382
    • Groters, S.1    Alldinger, S.2    Baumgartner, W.3
  • 52
    • 77950824570 scopus 로고    scopus 로고
    • Axonal pathology and loss precede demyelination and accompany chronic lesions in a spontaneously occurring animal model of multiple sclerosis
    • Seehusen F, Baumgärtner W. Axonal pathology and loss precede demyelination and accompany chronic lesions in a spontaneously occurring animal model of multiple sclerosis. Brain Pathol 2010;20:551-59
    • (2010) Brain Pathol , vol.20 , pp. 551-559
    • Seehusen, F.1    Baumgärtner, W.2
  • 53
    • 67549111912 scopus 로고    scopus 로고
    • Generation and characterization of a polyclonal antibody for the detection of Theiler's murine encephalomyelitis virus by light and electron microscopy
    • Kummerfeld M, Meens J, Haas L, et al. Generation and characterization of a polyclonal antibody for the detection of Theiler's murine encephalomyelitis virus by light and electron microscopy. J Virol Methods 2009;160:185-88
    • (2009) J Virol Methods , vol.160 , pp. 185-188
    • Kummerfeld, M.1    Meens, J.2    Haas, L.3
  • 54
    • 67349202761 scopus 로고    scopus 로고
    • Systemic adenovirus infection in bearded dragons (Pogona vitticeps): Histological, ultrastructural and molecular findings
    • Moormann S, Seehusen F, Reckling D, et al. Systemic adenovirus infection in bearded dragons (Pogona vitticeps): Histological, ultrastructural and molecular findings. J Comp Pathol 2009;141:78-83
    • (2009) J Comp Pathol , vol.141 , pp. 78-83
    • Moormann, S.1    Seehusen, F.2    Reckling, D.3
  • 55
    • 67349163999 scopus 로고    scopus 로고
    • Influence of persistent canine distemper virus infection on expression of RECK, matrix-metalloproteinases and their inhibitors in a canine macrophage/monocytic tumour cell line (DH82)
    • Puff C, Krudewig C, Imbschweiler I, et al. Influence of persistent canine distemper virus infection on expression of RECK, matrix-metalloproteinases and their inhibitors in a canine macrophage/monocytic tumour cell line (DH82). Vet J 2009;182:100-7
    • (2009) Vet J , vol.182 , pp. 100-107
    • Puff, C.1    Krudewig, C.2    Imbschweiler, I.3
  • 56
    • 72449143094 scopus 로고    scopus 로고
    • Marked MMP-2 transcriptional up-regulation in mononuclear leukocytes invading the subarachnoidal space in aseptic suppurative steroid-responsive meningitis-arteritis in dogs
    • Schwartz M, Puff C, Stein VM, et al. Marked MMP-2 transcriptional up-regulation in mononuclear leukocytes invading the subarachnoidal space in aseptic suppurative steroid-responsive meningitis-arteritis in dogs. Vet Immunol Immunopathol 2010;133:198-206
    • (2010) Vet Immunol Immunopathol , vol.133 , pp. 198-206
    • Schwartz, M.1    Puff, C.2    Stein, V.M.3
  • 57
    • 26444511083 scopus 로고    scopus 로고
    • Impact of formalin-fixation and paraffin-embedding on the ratio between mRNA copy numbers of differently expressed genes
    • DOI 10.1007/s00418-005-0013-0
    • von Smolinski D, Leverkoehne I, von Samson-Himmelstjerna G, et al. Impact of formalin-fixation and paraffin-embedding on the ratio between mRNA copy numbers of differently expressed genes. Histochem Cell Biol 2005;124:177-88 (Pubitemid 41429773)
    • (2005) Histochemistry and Cell Biology , vol.124 , Issue.2 , pp. 177-188
    • Von Smolinski, D.1    Leverkoehne, I.2    Von Samson-Himmelstjerna, G.3    Gruber, A.D.4
  • 58
    • 0029147782 scopus 로고
    • Induction of interleukin-6 synthesis in the myocardium. Potential role in postreperfusion inflammatory injury
    • Kukielka GL, Smith CW, Manning AM, et al. Induction of interleukin-6 synthesis in the myocardium. Potential role in postreperfusion inflammatory injury. Circulation 1995;92:1866-75
    • (1995) Circulation , vol.92 , pp. 1866-1875
    • Kukielka, G.L.1    Smith, C.W.2    Manning, A.M.3
  • 60
    • 0033990048 scopus 로고    scopus 로고
    • Primer3 on the www for general users and for biologist programmers
    • Rozen S, Skaletsky H. Primer3 on the www for general users and for biologist programmers. Methods Mol Biol 2000;132:365-86
    • (2000) Methods Mol Biol , vol.132 , pp. 365-386
    • Rozen, S.1    Skaletsky, H.2
  • 61
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of RTqPCR data by geometric averaging of multiple internal control genes
    • Vandesompele J, De Preter K, Pattyn F, et al. Accurate normalization of RTqPCR data by geometric averaging of multiple internal control genes. Genome Biol 2002;3:RESEARCH0034
    • (2002) Genome Biol , vol.3
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3
  • 62
    • 1542373666 scopus 로고    scopus 로고
    • Microglia, macrophages, perivascular macrophages, and pericytes: A review of function and identification
    • DOI 10.1189/jlb.0303114
    • Guillemin GJ, Brew BJ. Microglia, macrophages, perivascular macrophages, and pericytes: A review of function and identification. J Leukoc Biol 2004;75:388-97 (Pubitemid 38316367)
    • (2004) Journal of Leukocyte Biology , vol.75 , Issue.3 , pp. 388-397
    • Guillemin, G.J.1    Brew, B.J.2
  • 64
    • 48249146633 scopus 로고    scopus 로고
    • Dynamics of the inflammatory response after murine spinal cord injury revealed by flow cytometry
    • Stirling DP, Yong VW. Dynamics of the inflammatory response after murine spinal cord injury revealed by flow cytometry. J Neurosci Res 2008;86:1944-58
    • (2008) J Neurosci Res , vol.86 , pp. 1944-1958
    • Stirling, D.P.1    Yong, V.W.2
  • 65
    • 31044456582 scopus 로고    scopus 로고
    • Methylprednisolone causes minimal improvement after spinal cord injury in rats, contrasting with benefits of an anti-integrin treatment
    • DOI 10.1089/neu.2005.22.1375
    • Weaver LC, Gris D, Saville LR, et al. Methylprednisolone causes minimal improvement after spinal cord injury in rats, contrasting with benefits of an anti-integrin treatment. J Neurotrauma 2005;22:1375-87 (Pubitemid 43122353)
    • (2005) Journal of Neurotrauma , vol.22 , Issue.12 , pp. 1375-1387
    • Weaver, L.C.1    Gris, D.2    Saville, L.R.3    Oatway, M.A.4    Chen, Y.5    Marsh, D.R.6    Hamilton, E.F.7    Dekaban, G.A.8
  • 66
    • 57449109542 scopus 로고    scopus 로고
    • Axon regeneration inhibitors
    • Yang LJ, Schnaar RL. Axon regeneration inhibitors. Neurol Res 2008;30:1047-52
    • (2008) Neurol Res , vol.30 , pp. 1047-1052
    • Yang, L.J.1    Schnaar, R.L.2
  • 67
    • 77954659876 scopus 로고    scopus 로고
    • Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation
    • Mukaino M, Nakamura M, Yamada O, et al. Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation. Exp Neurol 2010;224:403-14
    • (2010) Exp Neurol , vol.224 , pp. 403-414
    • Mukaino, M.1    Nakamura, M.2    Yamada, O.3
  • 68
    • 0027491366 scopus 로고
    • Flow cytometry: Measurement of proteolytic and cytotoxic activity of microglia
    • Banati RB, Kreutzberg GW. Flow cytometry: Measurement of proteolytic and cytotoxic activity of microglia. Clin Neuropathol 1993;12:285-88 (Pubitemid 23287200)
    • (1993) Clinical Neuropathology , vol.12 , Issue.5 , pp. 285-288
    • Banati, R.B.1    Kreutzberg, G.W.2
  • 69
    • 77956649224 scopus 로고    scopus 로고
    • Regional topographical differences of canine microglial immunophenotype and function in the healthy spinal cord
    • Ensinger EM, Boekhoff TM, Carlson R, et al. Regional topographical differences of canine microglial immunophenotype and function in the healthy spinal cord. J Neuroimmunol 2010;227:144-52
    • (2010) J Neuroimmunol , vol.227 , pp. 144-152
    • Ensinger, E.M.1    Boekhoff, T.M.2    Carlson, R.3
  • 70
    • 77954589146 scopus 로고    scopus 로고
    • Immune response by microglia in the spinal cord
    • Olson JK. Immune response by microglia in the spinal cord. Ann N Y Acad Sci 2010;1198:271-78
    • (2010) Ann N Y Acad Sci , vol.1198 , pp. 271-278
    • Olson, J.K.1
  • 72
    • 70350558453 scopus 로고    scopus 로고
    • Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    • Kigerl KA, Gensel JC, Ankeny DP, et al. Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci 2009;29:13435-44
    • (2009) J Neurosci , vol.29 , pp. 13435-13444
    • Kigerl, K.A.1    Gensel, J.C.2    Ankeny, D.P.3
  • 73
    • 0033824640 scopus 로고    scopus 로고
    • Phagocytosis of neuronal or glial debris by microglial cells: Upregulation of MHC class II expression and multinuclear giant cell formation in vitro
    • Beyer M, Gimsa U, Eyüpoglu IY, et al. Phagocytosis of neuronal or glial debris by microglial cells: Upregulation of MHC class II expression and multinuclear giant cell formation in vitro. Glia 2000;31:262-66
    • (2000) Glia , vol.31 , pp. 262-266
    • Beyer, M.1    Gimsa, U.2    Eyüpoglu, I.Y.3
  • 74
    • 0027466971 scopus 로고
    • Microglia present myelin antigens to T cells after phagocytosis of oligodendrocytes
    • DOI 10.1006/cimm.1993.1053
    • Cash E, Zhang Y, Rott O. Microglia present myelin antigens to T cells after phagocytosis of oligodendrocytes. Cell Immunol 1993;147:129-38 (Pubitemid 23100971)
    • (1993) Cellular Immunology , vol.147 , Issue.1 , pp. 129-138
    • Cash, E.1    Zhang, Y.2    Rott, O.3
  • 75
  • 77
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • DOI 10.1016/0166-2236(96)10049-7
    • Kreutzberg GW. Microglia: A sensor for pathological events in the CNS. Trends Neurosci 1996;19:312-18 (Pubitemid 26349059)
    • (1996) Trends in Neurosciences , vol.19 , Issue.8 , pp. 312-318
    • Kreutzberg, G.W.1
  • 79
    • 0028950550 scopus 로고
    • Class II MHC gene expression in microglia. Regulation by the cytokines IFN-gamma, TNF-alpha, and TGF-beta
    • Panek RB, Benveniste EN. Class II MHC gene expression in microglia. Regulation by the cytokines IFN-gamma, TNF-alpha, and TGF-beta. J Immunol 1995;154:2846-54
    • (1995) J Immunol , vol.154 , pp. 2846-2854
    • Panek, R.B.1    Benveniste, E.N.2
  • 80
    • 0028326548 scopus 로고
    • Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord
    • Dusart I, Schwab ME. Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord. Eur J Neurosci 1994;6:712-24 (Pubitemid 24143919)
    • (1994) European Journal of Neuroscience , vol.6 , Issue.5 , pp. 712-724
    • Dusart, I.1    Schwab, M.E.2
  • 81
    • 61349140638 scopus 로고    scopus 로고
    • Absence of endogenous interleukin-10 enhances secondary inflammatory process after spinal cord compression injury in mice
    • Genovese T, Esposito E, Mazzon E, et al. Absence of endogenous interleukin-10 enhances secondary inflammatory process after spinal cord compression injury in mice. J Neurochem 2009;108:1360-72
    • (2009) J Neurochem , vol.108 , pp. 1360-1372
    • Genovese, T.1    Esposito, E.2    Mazzon, E.3
  • 82
    • 0032865257 scopus 로고    scopus 로고
    • Neuroprotective effects of interleukin-10 following excitotoxic spinal cord injury
    • DOI 10.1006/exnr.1999.7173
    • Brewer KL, Bethea JR, Yezierski RP. Neuroprotective effects of interleukin-10 following excitotoxic spinal cord injury. Exp Neurol 1999;159:484-93 (Pubitemid 29485234)
    • (1999) Experimental Neurology , vol.159 , Issue.2 , pp. 484-493
    • Brewer, K.L.1    Bethea, J.R.2    Yezierski, R.P.3
  • 83
    • 70349730234 scopus 로고    scopus 로고
    • IL-10 promotes neuronal survival following spinal cord injury
    • Zhou Z, Peng X, Insolera R, et al. IL-10 promotes neuronal survival following spinal cord injury. Exp Neurol 2009;220:183-90
    • (2009) Exp Neurol , vol.220 , pp. 183-190
    • Zhou, Z.1    Peng, X.2    Insolera, R.3
  • 84
    • 0345379630 scopus 로고    scopus 로고
    • Dominating interleukin-10 mRNA expression induction in cerebrospinal fluid cells of dogs with natural canine distemper virus induced demyelinating and non-demyelinating CNS lesions
    • DOI 10.1016/S0165-5728(99)00055-7, PII S0165572899000557
    • Frisk AL, Baumgärtner W, Gröne A. Dominating interleukin-10 mRNA expression induction in cerebrospinal fluid cells of dogs with natural canine distemper virus induced demyelinating and non-demyelinating CNS lesions. J Neuroimmunol 1999;97:102-9 (Pubitemid 29301419)
    • (1999) Journal of Neuroimmunology , vol.97 , Issue.1-2 , pp. 102-109
    • Frisk, A.L.1    Baumgartner, W.2    Grone, A.3
  • 85
    • 77956615515 scopus 로고    scopus 로고
    • Activation of TNF receptor 2 in microglia promotes induction of anti-inflammatory pathways
    • Veroni C, Gabriele L, Canini I, et al. Activation of TNF receptor 2 in microglia promotes induction of anti-inflammatory pathways. Mol Cell Neurosci 2010;45:234-44
    • (2010) Mol Cell Neurosci , vol.45 , pp. 234-244
    • Veroni, C.1    Gabriele, L.2    Canini, I.3
  • 86
    • 23944440904 scopus 로고    scopus 로고
    • Role of IL-6 in spinal cord injury in a mouse model
    • Nakamura M, Okada S, Toyama Y, et al. Role of IL-6 in spinal cord injury in a mouse model. Clin Rev Allergy Immunol 2005;28:197-204
    • (2005) Clin Rev Allergy Immunol , vol.28 , pp. 197-204
    • Nakamura, M.1    Okada, S.2    Toyama, Y.3
  • 87
    • 0030746939 scopus 로고    scopus 로고
    • Effects of pro-inflammatory cytokines in experimental spinal cord injury
    • DOI 10.1016/S0006-8993(97)00381-8, PII S0006899397003818
    • Klusman I, Schwab ME. Effects of pro-inflammatory cytokines in experimental spinal cord injury. Brain Res 1997;762:173-84 (Pubitemid 27315947)
    • (1997) Brain Research , vol.762 , Issue.1-2 , pp. 173-184
    • Klusman, I.1    Schwab, M.E.2
  • 88
    • 0033667998 scopus 로고    scopus 로고
    • Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice
    • Penkowa M, Giralt M, Carrasco J, et al. Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice. Glia 2000;32:271-85
    • (2000) Glia , vol.32 , pp. 271-285
    • Penkowa, M.1    Giralt, M.2    Carrasco, J.3
  • 89
    • 56849122702 scopus 로고    scopus 로고
    • Inflammatory mediators of cerebrospinal fluid from patients with spinal cord injury
    • Tsai MC, Wei CP, Lee DY, et al. Inflammatory mediators of cerebrospinal fluid from patients with spinal cord injury. Surg Neurol 2008;70(Suppl 1):19-24
    • (2008) Surg Neurol , vol.70 , Issue.1 SUPPL. , pp. 19-24
    • Tsai, M.C.1    Wei, C.P.2    Lee, D.Y.3
  • 90
    • 77951287743 scopus 로고    scopus 로고
    • Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury
    • Kwon BK, Stammers AM, Belanger LM, et al. Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury. J Neurotrauma 2010;27:669-82
    • (2010) J Neurotrauma , vol.27 , pp. 669-682
    • Kwon, B.K.1    Stammers, A.M.2    Belanger, L.M.3
  • 91
    • 65449167187 scopus 로고    scopus 로고
    • Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis
    • Kuhle J, Lindberg RL, Regeniter A, et al. Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis. Eur J Neurol 2009;16:771-74
    • (2009) Eur J Neurol , vol.16 , pp. 771-774
    • Kuhle, J.1    Lindberg, R.L.2    Regeniter, A.3
  • 93
    • 0033564198 scopus 로고    scopus 로고
    • Function of microglia in organotypic slice cultures
    • DOI 10.1002/(SICI)1097-4547(19990 615)56:6<644::AID-JNR10>3.0.CO;2- 9
    • Czapiga M, Colton CA. Function of microglia in organotypic slice cultures. J Neurosci Res 1999;56:644-51 (Pubitemid 29246846)
    • (1999) Journal of Neuroscience Research , vol.56 , Issue.6 , pp. 644-651
    • Czapiga, M.1    Colton, C.A.2
  • 94
    • 0033963283 scopus 로고    scopus 로고
    • Microglia in organotypic hippocampal slice culture and effects of hypoxia: Ultrastructure and lipocortin-1 immunoreactivity
    • DOI 10.1016/S0306-4522(99)00562-X, PII S030645229900562X
    • Skibo GG, Nikonenko IR, Savchenko VL, et al. Microglia in organotypic hippocampal slice culture and effects of hypoxia: Ultrastructure and lipocortin-1 immunoreactivity. Neuroscience 2000;96:427-38 (Pubitemid 30100424)
    • (2000) Neuroscience , vol.96 , Issue.2 , pp. 427-438
    • Skibo, G.G.1    Nikonenko, I.R.2    Savchenko, V.L.3    McKanna, J.A.4
  • 95
    • 77649320806 scopus 로고    scopus 로고
    • Importance of oligodendrocyte protection, BBB breakdown and inflammation for remyelination
    • Watzlawik J, Warrington AE, Rodriguez M. Importance of oligodendrocyte protection, BBB breakdown and inflammation for remyelination. Expert Rev Neurother 2010;10:441-57
    • (2010) Expert Rev Neurother , vol.10 , pp. 441-457
    • Watzlawik, J.1    Warrington, A.E.2    Rodriguez, M.3


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