Marked MMP-2 transcriptional up-regulation in mononuclear leukocytes invading the subarachnoidal space in aseptic suppurative Steroid-Responsive Meningitis-Arteritis in dogs

Veterinary Immunology and Immunopathology

Volumn 133, Issue 2-4, 2010, Pages 198-206

  Schwartz, M ^a,b,c   Puff, C ^a   Stein, V M ^a   Baumgartner W ^a,b   Tipold, A ^a,b  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

^c QUEEN MOTHER HOSPITAL FOR ANIMALS   (United Kingdom)

Author keywords

Blood brain barrier; Canine; Leukocyte extravasation; Matrix metalloproteinases

Indexed keywords

ELONGATION FACTOR; GELATINASE A; GELATINASE B; GLUCOCORTICOID; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMMUNOGLOBULIN A; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ACUTE DISEASE; ANIMAL CELL; ARTICLE; ASEPTIC MENINGITIS; BLOOD CEREBROSPINAL FLUID BARRIER; CELL INVASION; CENTRAL NERVOUS SYSTEM TUMOR; CEREBROSPINAL FLUID CYTOLOGY; CONTROLLED STUDY; DOG; GENE EXPRESSION; LEUKOCYTE; MONONUCLEAR CELL; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PLEOCYTOSIS; POLYMORPHONUCLEAR CELL; STEROID RESPONSIVE MENINGITIS ARTERITIS; SUBARACHNOID SPACE; SYMPTOM; TRANSCRIPTION REGULATION; UPREGULATION;

ADRENAL CORTEX HORMONES; ANIMALS; BLOOD-BRAIN BARRIER; DOG DISEASES; DOGS; HUMANS; LEUKOCYTES, MONONUCLEAR; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MENINGITIS, ASEPTIC; NEUTROPHILS; RNA, MESSENGER; SUBARACHNOID SPACE; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2; UP-REGULATION;

ANIMALIA; CANIS FAMILIARIS;

EID: 72449143094     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2009.08.007     Document Type: Article

References (52)

1. Aljada A., Ghanim H., Mohanty P., Hofmeyer D., Tripathy D., and Dandona P. Hydrocortisone suppresses intranuclear activator-protein-1 (AP-1) binding activity in mononuclear cells and plasma matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9). J. Clin. Endocrinol. Metab. 86 (2001) 5988-5991
2. Allt G., and Lawrenson J.G. Is the pial microvessel a good model for blood-brain barrier studies?. Brain Res. Brain Res. Rev. 24 (1997) 67-76
3. Amir J., Harel L., Frydman M., Handsher R., and Varsano I. Shift of cerebrospinal polymorphonuclear cell percentage in the early stage of aseptic meningitis. J. Pediatr. 119 (1991) 938-941
4. Azeh I., Mader M., Smirnov A., Beuche W., Nau R., and Weber F. Experimental pneumococcal meningitis in rabbits: the increase of matrix metalloproteinase-9 in cerebrospinal fluid correlates with leucocyte invasion. Neurosci. Lett. 256 (1998) 127-130
5. Bas A., Forsberg G., Hammarstrom S., and Hammarstrom M.L. Utility of the housekeeping genes 18S rRNA, beta-actin and glyceraldehyde-3-phosphate-dehydrogenase for normalization in real-time quantitative reverse transcriptase-polymerase chain reaction analysis of gene expression in human T lymphocytes. Scand. J. Immunol. 59 (2004) 566-573
6. Behr S., and Cauzinille L. Aseptic suppurative meningitis in juvenile boxer dogs: retrospective study of 12 cases. J. Am. Anim. Hosp. Assoc. 42 (2006) 277-282
7. Bergman R.L., Inzana K.D., and Inzana T.J. Characterization of matrix metalloproteinase-2 and -9 in cerebrospinal fluid of clinically normal dogs. Am. J. Vet. Res. 63 (2002) 1359-1362
8. Brew K., Dinakarpandian D., and Nagase H. Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim. Biophys. Acta 1477 (2000) 267-283
9. Brooks P.N. Necrotizing vasculitis in a group of Beagles. Lab. Anim. 18 (1984) 285-290
10. Candelario-Jalil E., Yang Y., and Rosenberg G.A. Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Neuroscience 158 (2009) 983-994
11. Cizinauskas S., Jaggy A., and Tipold A. Long-term treatment of dogs with steroid-responsive meningitis-arteritis: clinical, laboratory and therapeutic results. J. Small Anim. Pract. 41 (2000) 295-301
12. Cundall M., Sun Y., Miranda C., Trudeau J.B., Barnes S., and Wenzel S.E. Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids. J. Allergy Clin. Immunol. 112 (2003) 1064-1071
13. Dickinson P.J., Sturges B.K., Kass P.H., and LeCouteur R.A. Characteristics of cisternal cerebrospinal fluid associated with intracranial meningiomas in dogs: 56 cases (1985-2004). J. Am. Vet. Med. Assoc. 228 (2006) 564-567
14. Gavin P.J., Crawford S.E., Shulman S.T., Garcia F.L., and Rowley A.H. Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 576-581
15. Harcourt R.A. Polyarteritis in a colony of beagles. Vet. Rec. 102 (1978) 519-522
16. Hayes T.J., Roberts G.K., and Halliwell W.H. An idiopathic febrile necrotizing arteritis syndrome in the dog: beagle pain syndrome. Toxicol. Pathol. 17 (1989) 129-137
17. Irving G., and Chrisman C. Long-term outcome of five cases of corticosteroid-responsive meningomyelitis. J. Am. Anim. Hosp. Assoc. 26 (1990) 324-328
18. Jamison E.M., and Lumsden J.H. Cerebrospinal fluid analysis in the dog: methodology and interpretation. Semin. Vet. Med. Surg. (Small Anim.) 3 (1988) 122-132
19. Kieseier B.C., Paul R., Koedel U., Seifert T., Clements J.M., Gearing A.J., Pfister H.W., and Hartung H.P. Differential expression of matrix metalloproteinases in bacterial meningitis. Brain 122 Pt 8 (1999) 1579-1587
20. Kolb S.A., Lahrtz F., Paul R., Leppert D., Nadal D., Pfister H.W., and Fontana A. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in viral meningitis: upregulation of MMP-9 and TIMP-1 in cerebrospinal fluid. J. Neuroimmunol. 84 (1998) 143-150
21. Leib S.L., Clements J.M., Lindberg R.L., Heimgartner C., Loeffler J.M., Pfister L.A., Tauber M.G., and Leppert D. Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis. Brain 124 (2001) 1734-1742
22. Leib S.L., Leppert D., Clements J., and Tauber M.G. Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis. Infect. Immun. 68 (2000) 615-620
23. Leppert D., Leib S.L., Grygar C., Miller K.M., Schaad U.B., and Hollander G.A. Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae. Clin. Infect. Dis. 31 (2000) 80-84
24. Leppert D., Waubant E., Galardy R., Bunnett N.W., and Hauser S.L. T cell gelatinases mediate basement membrane transmigration in vitro. J. Immunol. 154 (1995) 4379-4389
25. Levine J.M., Ruaux C.G., Bergman R.L., Coates J.R., Steiner J.M., and Williams D.A. Matrix metalloproteinase-9 activity in the cerebrospinal fluid and serum of dogs with acute spinal cord trauma from intervertebral disk disease. Am. J. Vet. Res. 67 (2006) 283-287
26. Lindberg R.L., Sorsa T., Tervahartiala T., Hoffmann F., Mellanen L., Kappos L., Schaad U.B., Leib S.L., and Leppert D. Gelatinase B [matrix metalloproteinase (MMP)-9] and collagenases (MMP-8/-13) are upregulated in cerebrospinal fluid during aseptic and bacterial meningitis in children. Neuropathol. Appl. Neurobiol. 32 (2006) 304-317
27. Meric S.M. Canine meningitis. A changing emphasis. J. Vet. Intern. Med. 2 (1988) 26-35
28. Meric S.M., Child G., and Higgins R.J. Necrotizing vasculitis of the spinal pachyleptomeningeal arteries in three Bernese mountain dog littermates. J. Am. Anim. Hosp. Assoc. 21 (1986) 459-465
29. Meric S.M., Perman V., and Hardy R.M. Corticosteroid-responsive meningitis in ten dogs. J. Am. Anim. Hosp. Assoc. 21 (1985) 677-684
30. Mun-Bryce S., Lukes A., Wallace J., Lukes-Marx M., and Rosenberg G.A. Stromelysin-1 and gelatinase A are upregulated before TNF-alpha in LPS-stimulated neuroinflammation. Brain Res. 933 (2002) 42-49
31. Mun-Bryce S., and Rosenberg G.A. Gelatinase B modulates selective opening of the blood-brain barrier during inflammation. Am. J. Physiol. 274 (1998) R1203-1211
32. Negrini B., Kelleher K.J., and Wald E.R. Cerebrospinal fluid findings in aseptic versus bacterial meningitis. Pediatrics 105 (2000) 316-319
33. Opdenakker G., Van den Steen P.E., Dubois B., Nelissen I., Van Coillie E., Masure S., Proost P., and Van Damme J. Gelatinase B functions as regulator and effector in leukocyte biology. J. Leukoc. Biol. 69 (2001) 851-859
34. Paul R., Lorenzl S., Koedel U., Sporer B., Vogel U., Frosch M., and Pfister H.W. Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis. Ann. Neurol. 44 (1998) 592-600
35. Poncelet L., and Balligand M. Steroid responsive meningitis in three boxer dogs. Vet. Rec. 132 (1993) 361-362
36. Radaelli S.T., and Platt S.R. Bacterial meningoencephalomyelitis in dogs: a retrospective study of 23 cases (1990-1999). J. Vet. Intern. Med. 16 (2002) 159-163
37. Ransohoff R.M., Kivisakk P., and Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat. Rev. Immunol. 3 (2003) 569-581
38. Rosenberg G.A. Matrix metalloproteinases in neuroinflammation. Glia 39 (2002) 279-291
39. Rosenberg G.A., Kornfeld M., Estrada E., Kelley R.O., Liotta L.A., and Stetler-Stevenson W.G. TIMP-2 reduces proteolytic opening of blood-brain barrier by type IV collagenase. Brain Res. 576 (1992) 203-207
40. Rozen S., and Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 132 (2000) 365-386
41. Schwartz M., Carlson R., and Tipold A. Selective CD11a upregulation on neutrophils in the acute phase of steroid-responsive Meningitis-Arteritis in dogs. Vet. Immunol. Immunopathol. 126 (2008) 248-255
42. Schwartz M., Moore P.F., and Tipold A. Disproportionally strong increase of B cells in inflammatory cerebrospinal fluid of dogs with steroid-responsive meningitis-arteritis. Vet. Immunol. Immunopathol. 125 (2008) 274-283
43. Scott-Moncrieff J.C., Snyder P.W., Glickman L.T., Davis E.L., and Felsburg P.J. Systemic necrotizing vasculitis in nine young beagles. J. Am. Vet. Med. Assoc. 201 (1992) 1553-1558
44. Timpl R. Structure and biological activity of basement membrane proteins. Eur. J. Biochem. 180 (1989) 487-502
45. Tipold A. Diagnosis of inflammatory and infectious diseases of the central nervous system in dogs: a retrospective study. J. Vet. Intern. Med. 9 (1995) 304-314
46. Tipold A., and Jaggy A. Steroid responsive meningitis-arteritis in dogs: long-term study of 32 cases. J. Small Anim. Pract. 35 (1994) 311-316
47. Tipold A., Pfister H., Zurbriggen A., and Vandevelde M. Intrathecal synthesis of major immunoglobulin classes in inflammatory diseases of the canine CNS. Vet. Immunol. Immunopathol. 42 (1994) 149-159
48. Tipold A., Vandevelde M., and Zurbriggen A. Neuroimmunological studies in steroid-responsive meningitis-arteritis in dogs. Res. Vet. Sci. 58 (1995) 103-108
49. Turba M.E., Forni M., Gandini G., and Gentilini F. Recruited leukocytes and local synthesis account for increased matrix metalloproteinase-9 activity in cerebrospinal fluid of dogs with central nervous system neoplasm. J. Neurooncol. 81 (2007) 123-129
50. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., and Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3 (2002) RESEARCH0034
51. Wellman M.L., Krakowka S., Jacobs R.M., and Kociba G.J. A macrophage-monocyte cell line from a dog with malignant histiocytosis. In Vitro Cell Dev. Biol. 24 (1988) 223-229
52. Yong V.W., Power C., Forsyth P., and Edwards D.R. Metalloproteinases in biology and pathology of the nervous system. Nat. Rev. Neurosci. 2 (2001) 502-511