Increased expression of pro-inflammatory cytokines and lack of up-regulation of anti-inflammatory cytokines in early distemper CNS lesions

Journal of Neuroimmunology

Volumn 125, Issue 1-2, 2002, Pages 30-41

  Markus, S ^a   Failing, K ^a   Baumgartner W ^a,b  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF APPLIED SCIENCES AND ARTS   (Germany)

Author keywords

Canine distemper virus; Cytokines; Demyelination; Leukoencephalomyelitis; Multiple sclerosis; Semi quantitative RT PCR

Indexed keywords

BETA ACTIN; CYTOKINE; ENZYME; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CANINE DISTEMPER MORBILLIVIRUS; CEREBELLUM; CONTROLLED STUDY; CYTOKINE RELEASE; DEMYELINATION; DOG DISEASE; ENCEPHALOMYELITIS; FEMALE; HOUSEKEEPING GENE; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CYTOKINES; DISEASE PROGRESSION; DISTEMPER; DISTEMPER VIRUS, CANINE; DOGS; GENE EXPRESSION; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-6; INTERLEUKIN-8; PROTEIN SUBUNITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, VIRAL; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0036229878     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(02)00027-9     Document Type: Article

References (54)

1. Up-regulation of major histocompatibility complex class II antigen expression in the central nervous system of dogs with spontaneous canine distemper virus encephalitis
2. Cytokines, ceramide and oligodendrocyte cytotoxicity
3. Penetration of interleukin-6 across the murine blood-brain barrier
4. Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression
5. Naturally occurring canine distemper virus encephalitis: Distribution and expression of viral polypeptides in nervous tissues
6. Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro
7. Transforming growth factor beta1 (TGFbeta1) mRNA level correlates with magnetic resonance imaging disease activity in multiple sclerosis patients
8. Tumor necrosis factor alpha mRNA expression in early multiple sclerosis lesions, correlation with demyelination activity and oligodendrocyte pathology
9. Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-β and interleukin-10
10. Cytokine localisation in multiple sclerosis lesions: Correlation with adhesion molecule expression and reactive nitrogen species
11. Morphological changes in oligodendrocytes in the intact mouse optic nerve following intravitreal injection of tumor necrosis factor
12. Cytokine gene expression in cells derived from CSF of multiple sclerosis patients
13. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6
14. Nitric oxide synthases: Targets for therapeutic strategies in neurological disease
15. Dominating interleukin-10 mRNA expression induction in cerebrospinal fluid cells of dogs with natural canine distemper virus induced demyelinating and non-demyelinating CNS lesions
16. Lack of correlation between virus nucleoprotein and mRNA expression and the inflammatory response in demyelinating distemper encephalitis indicates a biphasic disease process
17. Restricted infection with canine distemper virus leads to down-regulation of myelin gene transcription in cultured oligodendrocytes
18. RT-PCR amplification of various canine cytokines and so-called house-keeping genes in a species-specific macrophage cell line (DH82) and canine peripheral blood leukocytes
19. Cytokine mRNA expression in whole blood samples from dogs with natural canine distemper virus infection
20. Interleukin-1β, -6, -12 and tumor necrosis factor-α expression in brains of dogs with canine distemper virus infection
21. Isotype-specific regulation of MHC class II gene expression in human monocytes by exogenous and endogenous tumor necrosis factor
22. Cytokine-induced modulation of cellular adhesion to human cerebral endothelial cells is mediated by soluble vascular cell adhesion molecule-1
23. Measles: Immunosuppression, interleukin-12 and complement receptors
24. Animal model of human disease: Distemper-associated demyelinating encephalomyelitis
25. Canine distemper virus
26. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
27. The controversy surrounding the pathogenesis of the multiple sclerosis lesion
28. IL-6 detection in multiple sclerosis brain
29. Experimental canine distemper virus-induced demyelination
30. Human leukocyte antigens and cytokine expression in cerebral inflammatory demyelinative lesions of X-linked adrenoleukodystrophy and multiple sclerosis
31. Cytokines in inflammatory brain lesions: Helpful and harmful
32. Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGF beta
33. Host cell proteins required for measles virus reproduction
34. Review: Cytokines and the pathogenesis of multiple sclerosis
35. Restricted virus protein translation in canine distemper virus inclusion body polioencephalitis
36. IL-6 plays a crucial role in the induction phase of myelin oligodendrocyte glucoprotein 35-55 induced experimental autoimmune encephalomyelitis
37. Structural polypeptides of canine distemper virus
38. Effect of transforming growth factor-beta 1 on microglial MHC-class II expression
39. Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor α
40. Neuroimmune interactions, the role of cytokines
41. Acceleration of experimental autoimmune encephalomyelitis in interleukin-10-deficient mice: Roles of interleukin-10 in disease progression and recovery
42. On classification of post-mortem multiple sclerosis plaques for neuroscientists
43. Differential induction of cytokines by primary and persistent measles virus infections in human glial cells
44. Tumor necrosis factor-α, microglia and astrocytes in AIDS dementia complex
45. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
46. Early T cell response in the central nervous system in canine distemper virus infection
47. Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different disease stages in multiple sclerosis
48. Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system
49. Interferon-gamma-induced oligodendrocyte cell death: Implications for the pathogenesis of multiple sclerosis
50. Neural cells from dogs with spontaneous distemper encephalitis express class II major histocompatibility complex molecules
51. Cytokine production in the central nervous system
52. Identification of CD4+ and CD8+ T cell subsets and B cells in the brain of dogs with spontaneous acute-, subacute- and chronic-demyelinating distemper encephalitis
53. Oligodendroglial pathology in canine distemper