Cytokine activity contributes to induction of inflammatory cytokine mRNAs in spinal cord following contusion

Journal of Neuroscience Research

Volumn 68, Issue 3, 2002, Pages 315-322

  Pan, Jonathan Z ^a   Ni, Li ^a   Sodhi, Ajeet ^a   Aguanno, Ann ^b   Young, Wise ^c   Hart, Ronald P ^d  

^a DIVISION OF REPRODUCTIVE BIOLOGY   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c RESEARCH AND DEVELOPMENT   (Australia)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

Cytokine; Gene knockout; Inflammation; Methylprednisolone; Spinal cord injury

Indexed keywords

CYTOKINE; GLUCOCORTICOID; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; METHYLPREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CONTUSION; BRAIN SLICE; CONTROLLED STUDY; CYTOKINE PRODUCTION; INFLAMMATION; KNOCKOUT GENE; NERVE CELL CULTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPINAL CORD INJURY;

ANIMALS; CYTOKINES; FEMALE; INTERLEUKIN-1; INTERLEUKIN-6; MALE; MICE; MICE, KNOCKOUT; MYELITIS; RATS; RATS, LONG-EVANS; RECEPTORS, CYTOKINE; RECEPTORS, INTERLEUKIN-1; RECEPTORS, TUMOR NECROSIS FACTOR; RNA, MESSENGER; SPINAL CORD INJURIES; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0036570042     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10215     Document Type: Article

References (35)

1. Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse: An in situ hybridization study
2. Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats
3. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1
4. Effects of macrophage transplantation in the injured adult rat spinal cord: A combined immunocytochemical and biochemical study
5. Chemokine antagonist infusion attenuates cellular infiltration following spinal cord contusion injury in rat
6. Reduction of pathological and behavioral deficits following spinal cord contusion injury with the selective cyclooxygenase-2 inhibitor NS-398
7. Early induction ofcytokine mRNAs following spinal cord injury
8. Expression of neurotrophin and IL-1β mRNAs following spinal cord injury and the effects of methylprednisolone treatment
9. Sequential mRNA expression for immediate early genes, cytokines, and neurotrophins in spinal cord injury
10. Tumor necrosis factor-alpha induces cFOS and strongly potentiates glutamate-mediated cell death in the rat spinal cord
11. In vivo regulation of the IL-1β system (ligand, receptors I and II, receptor accessory protein, and receptor antagonist) and TNF-α mRNAs in specific brain regions
12. Expression of tumor necrosis factor-alpha in cultured human endothelial cells stimulated with lipopolysaccharide or interleukin-1 alpha
13. Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis protein 2 expression, and functional recovery after traumatic spinal cord injury
14. Effects of pro-inflammatory cytokines in experimental spinal cord injury
15. Peripheral nerve-stimulated macrophages simulate a peripheral nerve-like regenerative response in rat transected optic nerve
16. Cytokine chemokine expression in contused rat spinal cord
17. Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice
18. Species-specific activity of rat recombinant interleukin-1β
19. The synthesis of IL-1 receptor antagonist (IL-1ra) by synovial fibroblasts is markedly increased by the cytokines TNF-α and IL-1
20. Interleukin 1beta promotes repair of the CNS
21. Microglia: Intrinsic immunoeffector cell of the brain
22. Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury
23. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
24. MIP-1alpha, MCP-1, GM-CSF, and TNF-alpha control the immune cell response that mediates rapid phagocytosis of myelin from the adult mouse spinal cord
25. Effects of interleukin-10 (IL-10) on pain behavior and gene expression following excitotoxic spinal cord injury in the rat
26. Product differentiation by analysis of DNA melting curves during the polymerase chain reaction
27. Lymphocyte recruitment following spinal cord injury in mice is altered by prior viral exposure
28. Cytokine-induced acute inflammation in the brain and spinal cord
29. Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis
30. Analysis of cytokine receptor messenger RNA expression in human glioblastoma cells and normal astrocytes by reverse-transcription polymerase chain reaction
31. Production of tumor necrosis factor in spinal cord following traumatic injury in rats
32. Increase of interleukin-1β mRNA and protein in the spinal cord following experimental traumatic injury in the rat
33. Tumor necrosis factor alpha is an autocrine growth regulator during macrophage differentiation
34. Continuous fluorescence monitoring of rapid cycle DNA amplification
35. Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: Role in the induction of interleukin 6