Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway

British Journal of Pharmacology

Volumn 163, Issue 8, 2011, Pages 1653-1665

  Kay, Hee Yeon ^a   Kim, Young Woo ^a   Ryu, Da Hye ^b   Sung, Sang Hyun ^a   Hwang, Se Jin ^b   Kim, Sang Geon ^a  

^a Seoul National University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

acetaminophen; GSK3 ; Nrf2; PKC ; sauchinone

Indexed keywords

2 AMINO N [4 [5 (2 PHENANTHRENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]PHENYL]ACETAMIDE; ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK PROTEIN 32; HEME OXYGENASE 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LACTATE DEHYDROGENASE; LIGNAN; PARACETAMOL; PROTEIN KINASE C DELTA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SAUCHINONE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; TRANSACTIVATION;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIOXIDANTS; BENZOPYRANS; DIOXOLES; GLUTATHIONE; GLYCOGEN SYNTHASE KINASE 3; HEP G2 CELLS; HUMANS; LIGNANS; LIVER; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; PHYTOTHERAPY; PLANT PREPARATIONS; PROTECTIVE AGENTS; PROTEIN KINASE C-DELTA; PROTEINS; SAURURACEAE; SIGNAL TRANSDUCTION;

EID: 79960900078     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01095.x     Document Type: Article

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