Protective mechanisms of anthocyanins from purple sweet potato against tert-butyl hydroperoxide-induced hepatotoxicity

Food and Chemical Toxicology

Volumn 49, Issue 9, 2011, Pages 2081-2089

  Hwang, Yong Pil ^a   Choi, Jae Ho ^a   Choi, Jun Min ^b   Chung, Young Chul ^b   Jeong, Hye Gwang ^a  

^a Chungnam National University   (South Korea)

^b Korea International University   (South Korea)

Author keywords

Anthocyanins; Hepatoprotection; Nrf2; Purple sweet potato; Tert butyl hydroperoxide

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTHOCYANIN; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CASPASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL DAMAGE; CELL LEVEL; CELL PROTECTION; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; HISTOPATHOLOGY; IN VITRO STUDY; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN TRANSPORT; RAT; SWEET POTATO; UPREGULATION;

ALANINE TRANSAMINASE; ANIMALS; ANTHOCYANINS; ASPARTATE AMINOTRANSFERASES; CELL LINE; GLUTATHIONE; HUMANS; IPOMOEA BATATAS; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TERT-BUTYLHYDROPEROXIDE;

IPOMOEA BATATAS; RATTUS;

EID: 79960846854     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.05.021     Document Type: Article

References (52)

1. Ahmed M., Akter M.S., Eun J.B. Impact of alpha-amylase and maltodextrin on physicochemical, functional and antioxidant capacity of spray-dried purple sweet potato flour. J. Sci. Food Agric. 2010, 90:494-502.
2. Alam J., Cook J.L. Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway. Curr. Pharm. Des. 2003, 9:2499-2511.
3. Bloom D.A., Jaiswal A.K. Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression. J. Biol. Chem. 2003, 278:44675-44682.
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
5. Breimer L.H. Molecular mechanism of oxygen radical carcinogenesis and mutagenesis: the role of DNA base damage. Mol. Carcinog. 1990, 3:188-197.
6. Chan K., Han X.D., Kan Y.W. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc. Natl. Acad. Sci. U S A 2001, 98:4611-4616.
7. Chen X.L., Kunsch C. Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases. Curr. Pharm. Des. 2004, 10:879-891.
8. Cho H.Y., Jedlicka A.E., Reddy S.P., Kensler T.W., Yamamoto M., Zhang L.Y., Kleeberger S.R. Role of NRF2 in protection against hyperoxic lung injury in mice. Am. J. Respir. Cell. Mol. Biol. 2002, 26:175-182.
9. Choi J.H., Choi C.Y., Lee K.J., Hwang Y.P., Chung Y.C., Jeong H.G. Hepatoprotective effects of an anthocyanins fraction from purple-fleshed sweet potato against acetaminophen-induced liver damage in mice. J. Med. Food 2009, 12:320-326.
10. Choi J.H., Hwang Y.P., Choi C.Y., Chung Y.C., Jeong H.G. Anti-fibrotic effects of the anthocyanins isolated from the purple-fleshed sweet potato on hepatic fibrosis induced by dimethylnitrosamine administration in rats. Food Chem. Toxicol. 2010, 48:3137-3143.
11. Choi J.H., Hwang Y.P., Park B.H., Choi C.Y., Chung Y.C., Jeong H.G. Anthocyanins isolated from the purple-fleshed sweet potato attenuate the proliferation of hepatic stellate cells by blocking the PDGF receptor. Environ. Toxicol. Pharmacol. 2011, 31:212-219.
12. Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997, 91:231-241.
13. Dhakshinamoorthy S., Jaiswal A.K. Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. Oncogene 2001, 20:3906-3917.
14. Foresti R., Hoque M., Bains S., Green C.J., Motterlini R. Haem and nitric oxide: synergism in the modulation of the endothelial haem oxygenase-1 pathway. Biochem. J. 2003, 372:381-390.
15. Goda Y., Shimizu T., Kato Y., Nakamura M., Maitani T., Yamada T., Terahara N., Yamaguchi M. Two acylated anthocyanins from purple sweet potato. Phytochemistry 1997, 18:183-186.
16. Gong P., Hu B., Cederbaum A.I. Diallyl sulfide induces heme oxygenase-1 through MAPK pathway. Arch. Biochem. Biophys. 2004, 432:252-260.
17. Halliwell B., Gutteridge J.M.C. Free Radicals in Biology and Medicine 1998, Oxford University Press, New York, pp. 27-30.
18. Hill-Kapturczak N., Truong L., Thamilselvan V., Visner G.A., Nick H.S., Agarwal A. Smad7-dependent regulation of heme oxygenase-1 by transforming growth factor-beta in human renal epithelial cells. J. Biol. Chem. 2000, 275:40904-40909.
19. Hwang Y.P., Choi J.H., Han E.H., Kim H.K., Kang S.K., Chung Y.C., Jeong H.G. Protective mechanisms of Aralia continentalis extract against tert-butyl hydroperoxide-induced hepatotoxicity: in vivo and in vitro studies. Food Chem. Toxicol. 2008, 46:3512-3521.
20. Hwang Y.P., Choi J.H., Yun H.J., Han E.H., Kim H.G., Kim J.Y., Park B.H., Khanal T., Choi J.M., Chung Y.C., Jeong H.G. Anthocyanins from purple sweet potato attenuate dimethylnitrosamine-induced liver injury in rats by inducing Nrf2-mediated antioxidant enzymes and reducing COX-2 and iNOS expression. Food Chem. Toxicol. 2011, 49:93-99.
21. Ikeda H., Nishi S., Sakai M. Transcription factor Nrf2/MafK regulates rat placental glutathione S-transferase gene during hepatocarcinogenesis. Biochem. J. 2004, 380:515-521.
22. Jaiswal A.K. Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic. Biol. Med. 2004, 36:1199-1207.
23. Karlsen A., Retterstøl L., Laake P., Paur I., Kjølsrud-Bøhn S., Sandvik L., Blomhoff R. Anthocyanins inhibit nuclear factor-kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults. J. Nutr. 2007, 137:1951-1954.
24. Kong A.N., Owuor E., Yu R., Hebbar V., Chen C., Hu R., Mandlekar S. Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metab. Rev. 2001, 33:255-271.
25. Lee J.M., Shih A.Y., Murphy T.H., Johnson J.A. NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. J. Biol. Chem. 2003, 278:37948-37956.
26. Lee L.S., Chang E.J., Rhim J.W., Ko B.S., Choi S.W. Isolation and identification of anthocyanins from purple sweet potatoes. J. Food Sci. Nutr. 1997, 2:83-88.
27. Lee L.S., Kim S.J., Rhim J.W. Analysis of anthocyanin pigments from purplefleshed sweet potato (Jami). J. Korean Soc. Food Sci. Nutr. 2000, 29:555-560.
28. Leung L., Kwong M., Hou S., Lee C., Chan J.Y. Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress. J. Biol. Chem. 2003, 278:48021-48029.
29. Lila M.A. Anthocyanins and human health: an in vitro investigative approach. J. Biomed. Biotechnol. 2004, 5:306-313.
30. Martin C., Martinez R., Navarro R., Ruiz-Sanz J.I., Lacort M., Ruiz-Larrea M.B. Tert-Butyl hydroperoxide-induced lipid signaling in hepatocytes: involvement of glutathione and free radicals. Biochem. Pharmacol. 2001, 62:705-712.
31. Masaki N., Kyle M.E., Serroni A., Farber J.L. Mitochondrial damage as a mechanism of cell injury in the killing of cultured hepatocytes by tert-butyl hydroperoxide. Arch Biochem. Biophys. 1989, 270:672-680.
32. Minotti G., Borrello S., Palombini G., Galeotti T. Cytochrome P-450 deficiency and resistance to t-butyl hydroperoxide of hepatoma microsomal lipid peroxidation. Biochim. Biophys. Acta 1986, 876:220-225.
33. Nakaso K., Yano H., Fukuhara Y., Takeshima T., Wada-Isoe K., Nakashima K. PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells. FEBS Lett. 2003, 546:181-184.
34. Numazawa S., Ishikawa M., Yoshida A., Tanaka S., Yoshida T. A typical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress. Am. J. Physiol. Cell Physiol. 2003, 285:334-342.
35. Oakley F.D., Abbott D., Li Q., Engelhardt J.F. Signaling components of redox active endosomes: the redoxosomes. Antioxid. Redox Signal. 2009, 11:1313-1333.
36. Odake K., Terahara N., Saito N., Toki K., Honda T. Chemical structures of two anthocyanins from purple sweet potatoes Ipomoea batatas. Phytochemistry 1992, 31:2127-2130.
37. Otterbein L.E., Soares M.P., Yamashita K., Bach F.H. Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol. 2003, 24:449-455.
38. Park S.J., Shin W.H., Seo J.W., Kim E.J. Anthocyanins inhibit airway inflammation and hyperresponsiveness in a murine asthma model. Food Chem. Toxicol. 2007, 45:1459-1467.
39. Qiu F., Luo J., Yao S., Ma L., Kong L. Preparative isolation and purification of anthocyanins from purple sweet potato by high-speed counter-current chromatography. J. Sep. Sci. 2009, 32:2146-2151.
40. Recknagel R.O., Glende E.A., Dolak J.A., Waller R.L. Mechanisms of carbon tetrachloride toxicity. Pharmacol. Ther. 1989, 43:139-154.
41. Rush G.F., Gorski J.R., Ripple M.G., Sowinski J., Bugelski F., Hewitt W.R. Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes. Toxicol. Appl. Pharmacol. 1985, 78:473-483.
42. Rushmore T.H., Kong A.N. Pharmacogenomics, regulation and signaling pathways of phase I and phase II drug metabolizing enzymes. Curr. Drug Metab. 2002, 3:481-490.
43. Sedlak J., Lindsay R.H. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 1968, 25:192-205.
44. Shih P.H., Yeh C.T., Yen G.C. Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells. Food Chem. Toxicol. 2005, 43:1557-1566.
45. Shih P.H., Yeh C.T., Yen G.C. Anthocyanins induce the activation of phase II enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis. J. Agric. Food Chem. 2007, 55:9427-9435.
46. Surh Y.J. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 2003, 3:768-780.
47. Tian Q., Konczak I., Schwartz S.J. Probing anthocyanins profiles in purple sweet potato cell line (Ipomoea batatas L. Cv. Ayamurasaki) by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. J. Agric. Food Chem. 2005, 53:6503-6509.
48. Tsuda T., Horio F., Uchida K., Aoki H., Osawa T. Dietary cyanidin 3-O-beta-d-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J. Nutr. 2003, 133:2125-2130.
49. Williams G.M., Jeffrey A.M. Oxidative DNA damage: endogenous and chemically induced. Regul. Toxicol. Pharmacol. 2000, 32:283-292.
50. Zhang Y., Gordon G.B. A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway. Mol. Cancer Ther. 2004, 3:885-893.
51. Zhao C.R., Gao Z.H., Qu X.J. Nrf2-ARE signaling pathway and natural products for cancer chemoprevention. Cancer Epidemiol. 2010, 34:523-533.
52. Zipper L.M., Mulcahy R.T. Inhibition of ERK and p38 MAP kinases inhibits binding of Nrf2 and induction of GCS genes. Biochem. Biophys. Res. Commun. 2000, 278:484-492.