Protective mechanisms of Aralia continentalis extract against tert-butyl hydroperoxide-induced hepatotoxicity: In vivo and in vitro studies

Food and Chemical Toxicology

Volumn 46, Issue 11, 2008, Pages 3512-3521

  Hwang, Yong Pil ^a   Choi, Jae Ho ^a   Han, Eun Hee ^a   Kim, Hyung Kyun ^a   Kang, Shin Keon ^b   Chung, Young Chul ^b   Jeong, Hye Gwang ^a  

^a Chosun University   (South Korea)

^b International University of Korea   (South Korea)

Author keywords

Aralia continentalis; Hepatoprotection; Oxidative stress; Phase II; tert Butyl hydroperoxide

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ARALIA CONTINENTALIS EXTRACT; ASCORBIC ACID; CASPASE 3; FERRIC CHLORIDE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; PLANT EXTRACT; PROTOPORPHYRIN ZINC; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TERT BUTYL HYDROPEROXIDE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARALIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL VIABILITY; CONTROLLED STUDY; HEPA 1CC7 CELL; HISTOPATHOLOGY; IMMUNOCYTOCHEMISTRY; LIPID PEROXIDATION; LIVER CELL CULTURE; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ARALIA; CASPASE 3; CELL LINE; GLUTATHIONE; HEPATITIS, TOXIC; LIPID PEROXIDATION; LIVER; MALE; MICE; MICE, INBRED ICR; OXIDATION-REDUCTION; OXIDATIVE STRESS; PLANT EXTRACTS; RANDOM ALLOCATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TERT-BUTYLHYDROPEROXIDE;

ARALIA CONTINENTALIS;

EID: 54849415004     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.08.035     Document Type: Article

References (50)

1. Alam J., and Cook J.L. Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway. Curr. Pharm. Des. 9 (2003) 2499-2511
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
3. Chen X.L., and Kunsch C. Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases. Curr. Pharm. Des. 10 (2004) 879-891
4. Chung C.K., and Jung M.E. Ethanol fraction of Aralia elata Seemann enhances antioxidant activity and lowers serum lipids in rats when administered with benzo(a)pyrene. Biol. Pharm. Bull. 26 (2003) 1502-1504
5. Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., and Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91 (1997) 231-241
6. Dinkova-Kostova A.T., Liby K.T., Stephenson K.K., Holtzclaw W.D., Gao X., Suh N., Williams C., Risingsong R., Honda T., Gribble G.W., Sporn M.B., and Talalay P. Extremely potent triterpenoid inducers of the phase II response: correlations of protection against oxidant and inflammatory stress. Proc. Natl. Acad. Sci. USA 102 (2005) 4584-4589
7. Dinkova-Kostova A.T., Jenkins S.N., Wehage S.L., Huso D.L., Benedict A.L., Stephenson K.K., Fahey J.W., Liu H., Liby K.T., Honda T., Gribble G.W., Sporn M.B., and Talalay P. A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice. Biochem. Biophys. Res. Commun. 367 (2008) 859-865
8. Droge W. Free radicals in the physiological control of cell function. Physiol. Rev. 82 (2002) 47-95
9. Fairhurst S., Barber D.J., Clark B., and Horton A.A. Studies on paracetamol-induced lipid peroxidation. Toxicology 23 (1982) 249-259
10. Forman H.J., and Ruden D. Introduction to serial reviews on EpRE and its signaling pathway. Free Radic. Biol. Med. 15 (2004) 1197-1198
11. Gong P., Hu B., and Cederbaum A.I. Dialyl sulfide induces heme oxygenase-1 through MAPK pathway. Arch. Biochem. Biophys. 432 (2004) 252-260
12. Grunberger D., Banerjee R., Eisinger K., Oltz E.M., Efros L., Caldwell M., Estevez V., and Nakanishi K. Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Experientia 44 (1988) 230-232
13. Hill-Kapturczak N., Truong L., Thamilselvan V., Visner G.A., Nick H.S., and Agarwal A. Smad7-dependent regulation of heme oxygenase-1 by transforming growth factor-beta in human renal epithelial cells. J. Biol. Chem. 275 (2000) 40904-40909
14. Hwang J.M., Tseng T.H., Hsieh Y.S., Chou F.P., Wang C.J., and Chu C.Y. Inhibitory effect of atracrylon on tert-butyl hydroperoxide induced DNA damage and hepatic toxicity in rat hepatocytes. Arch. Toxicol. 70 (1996) 640-644
15. Itoh K., Tong K.I., and Yamamoto M. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic. Biol. Med. 36 (2004) 1208-1213
16. Jeong W.S., Keum Y.S., Chen C., Jain M.R., Shen G., Kim J.H., Li W., and Kong A.N. Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells. J. Biochem. Mol. Biol. 38 (2005) 167-176
17. Jun H.S., Kim S.E., and Sung M.K. Protective effect of soybean saponins and major antioxidants against aflatoxin B1-induced mutagenicity and DNA-adduct formation. J. Med. Food 5 (2002) 235-240
18. Kapitulnik J. Bilirubin: an endogenous product of heme degradation with both cytotoxic and cytoprotective properties. Mol. Pharmacol. 66 (2004) 773-779
19. Kensler T.W. Chemoprevention by inducers of carcinogen detoxication enzymes. Environ. Health Perspect. 4 (1997) 965-970
20. Kong A.N., Owuor E., Yu R., Hebbar V., Chen C., Hu R., and Mandlekar S. Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metab. Rev. 33 (2001) 255-271
21. Kwak M.K., Wakabayashi N., and Kensler T.W. Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers. Mutat. Res. 555 (2004) 133-148
22. Lee K.J., Choi C.Y., Chung Y.C., Kim Y.S., Ryu S.Y., Roh S.H., and Jeong H.G. Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity. Toxicol. Lett. 147 (2004) 271-282
23. Lee K.J., and Jeong H.G. Protective effect of Platycodi radix on carbon tetrachloride-induced hepatotoxicity. Food Chem. Toxicol. 40 (2002) 517-525
24. Loguercio C., and Federico A. Oxidative stress in viral and alcoholic hepatitis. Free Radic. Biol. Med. 34 (2003) 1-10
25. Luper S. A review of plants used in the treatment of liver disease: part 1. Altern. Med. Rev. 3 (1998) 410-421
26. Martin C., Martinez R., Navarro R., Ruiz-Sanz J.I., Lacort M., and Ruiz-Larrea M.B. tert-Butyl hydroperoxide-induced lipid signaling in hepatocytes: involvement of glutathione and free radicals. Biochem. Pharmacol. 62 (2001) 705-712
27. Masaki N., Kyle M.E., Serroni A., and Farber J.L. Mitochondrial damage as a mechanism of cell injury in the killing of cultured hepatocytes by tert-butyl hydroperoxide. Arch. Biochem. Biophys. 270 (1989) 672-680
28. Minotti G., Borrello S., Palombini G., and Galeotti T. Cytochrome P-450 deficiency and resistance to tert-butyl hydroperoxide of hepatoma microsomal lipid peroxidation. Biochim. Biophys. Acta 876 (1986) 220-225
29. Nakaso K., Yano H., Fukuhara Y., Takeshima T., Wada-Isoe K., and Nakashima K. PI3K is a key molecule in the Nrf2-mediated regulation of antioxidative proteins by hemin in human neuroblastoma cells. FEBS Lett. 546 (2003) 181-184
30. Numazawa S., Ishikawa M., Yoshida A., Tanaka S., and Yoshida T. A typical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress. Am. J. Physiol. Cell Physiol. 285 (2003) 334-342
31. Okuyama E., Nishimura S., and Yamazaki M. Analgesic principle from Aralia cordata Thunb. Chem. Pharm. Bull. 39 (1991) 405-407
32. Owuor E.D., and Kong A.N. Antioxidants and oxidants regulated signal transduction pathways. Biochem. Pharmacol. 64 (2002) 765-770
33. Park H.J., Hong M.S., Lee J.S., Leem K.H., Kim C.J., Kim J.W., and Lim S. Effects of Aralia continentalis on hyperalgesia with peripheral inflammation. Phytother. Res. 19 (2005) 511-513
34. Recknagel R.O., Glende Jr. E.A., Dolak J.A., and Waller R.L. Mechanisms of carbon tetrachloride toxicity. Pharmacol. Ther. 43 (1989) 139-154
35. Rushmore T.H., and Kong A.N. Pharmacogenomics, regulation and signaling pathways of phase I and phase II drug metabolizing enzymes. Curr. Drug Metab. 3 (2002) 481-490
36. Sedlak J., and Lindsay R.H. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 25 (1968) 192-205
37. Sheweita S.A., and Tilmisany A.K. Cancer and phase II drug-metabolizing enzymes. Curr. Drug Metab. 4 (2003) 45-58
38. Song S.J., Nakamura N., Ma C.M., Hattori M., and Xu S.X. Four new saponins from the root bark of Aralia elata. Chem. Pharm. Bull. 48 (2000) 838-842
39. Song S.J., Nakamura N., Ma C.M., Hattori M., and Xu S.X. Five saponins from the root bark of Aralia elata. Phytochemistry 56 (2001) 491-497
40. Surh Y.J. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 3 (2003) 768-780
41. Takahashi T., Morita K., Akagi R., and Sassa S. Heme oxygenase-1: a novel therapeutic target in oxidative tissue injuries. Curr. Med. Chem. 11 (2004) 1545-1561
42. Ursini F., Maiorino M., Morazzoni P., Roveri A., and Pifferi G. A novel antioxidant flavonoid affecting molecular mechanisms of cellular activation. Free Radical Biol. Med. 16 (1994) 547-553
43. Williams G.M., and Jeffrey A.M. Oxidative DNA damage: endogenous and chemically induced. Regul. Toxicol. Pharmacol. 32 (2000) 283-292
44. Wu D., Zhai Q., and Shi X. Alcohol-induced oxidative stress and cell responses. J. Gastroenterol. Hepatol. 21 (2006) S26-S29
45. Yen G.C., Yeh C.T., and Chen Y.J. Protective effect of Mesona procumbens against tert-butyl hydroperoxide-induced acute hepatic damage in rats. J. Agric. Food Chem. 52 (2004) 4121-4127
46. Yoshikawa M., Matsuda H., Harada E., Murakami T., Wariishi N., Yamahara J., and Murakami N. Elatoside E, a new hypoglycemic principle from the root cortex of Aralia elata Seem.: structure-related hypoglycemic activity of oleanolic acid glycosides. Chem. Pharm. Bull. 42 (1994) 1354-1356
47. Yoshikawa M., Morikawa T., Kashima Y., Ninomiya K., and Matsuda H. Structures of new dammarane-type triterpene saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins. J. Nat. Prod. 66 (2003) 922-927
48. Yoshikawa M., Murakami T., Harada E., Murakami N., Yamahara J., and Matsuda H. Bioactive saponins and glycosides. VI. Elatosides A and B, potent inhibitors of ethanol absorption, from the bark of Aralia elata SEEM. (Araliaceae): the structure-requirement in oleanolic acid glucuronide-saponins for the inhibitory activity. Chem. Pharm. Bull. 44 (1996) 1915-1922
49. Zhang Y., and Gordon G.B. A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway. Mol. Cancer Ther. 3 (2004) 885-893
50. Zipper L.M., and Mulcahy R.T. Inhibition of ERK and p38 MAP kinases inhibits binding of Nrf2 and induction of GCS genes. Biochem. Biophys. Res. Commun. 278 (2000) 484-492