Blood-retinal barrier glycerol permeability in diabetic macular edema and healthy eyes: Estimations from macular volume changes after peroral glycerol

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 6, 2010, Pages 2827-2834

  Thornit, Dorte Nellemann ^a   Vinten, Carl Martin ^a   Sander, Birgit ^a   Lund Andersen, Henrik ^a   La Cour, Morten ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCEROL; CREATININE; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BLOOD RETINA BARRIER; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC MACULAR EDEMA; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MACULAR VOLUME; MALE; MATHEMATICAL MODEL; MONITORING; NON INSULIN DEPENDENT DIABETES MELLITUS; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; VISUAL ACUITY; VISUAL SYSTEM PARAMETERS; BLOOD; BLOOD PRESSURE; BODY WATER; CAPILLARY PERMEABILITY; CLINICAL TRIAL; COMPARATIVE STUDY; DIABETIC RETINOPATHY; METABOLISM; MIDDLE AGED; OSMOLARITY; PHYSIOLOGY; PROSPECTIVE STUDY; RETINA; RETINA MACULA EDEMA; THEORETICAL MODEL; TRANSPORT AT THE CELLULAR LEVEL;

AGED; BIOLOGICAL TRANSPORT; BLOOD PRESSURE; BLOOD-RETINAL BARRIER; BODY WATER; CAPILLARY PERMEABILITY; CREATININE; DIABETIC RETINOPATHY; FEMALE; GLYCEROL; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MACULAR EDEMA; MALE; MIDDLE AGED; MODELS, THEORETICAL; OSMOLAR CONCENTRATION; PROSPECTIVE STUDIES; RETINA; TOMOGRAPHY, OPTICAL COHERENCE; VISUAL ACUITY;

EID: 77953240236     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-4172     Document Type: Article

References (36)

1. Tornquist P. Capillary permeability in cat choroid, studied with the single injection technique (II). Acta Physiol Scand. 1979;106:425-430.
2. Tornquist P, Alm A, Bill A. Studies on ocular blood flow and retinal capillary permeability to sodium in pigs. Acta Physiol Scand. 1979;106:343-350.
3. Mathews MK, Merges C, McLeod DS, Lutty GA. Vascular endothelial growth factor and vascular permeability changes in human diabetic retinopathy. Invest Ophthalmol Vis Sci. 1997;38:2729-2741.
4. Aiello LP, Northrup JM, Keyt BA, Takagi H, Iwamoto MA. Hypoxic regulation of vascular endothelial growth factor in retinal cells. Arch Ophthalmol. 1995;113:1538-1544.
5. Do carmo A, Ramos P, Reis A, Proenca R, Cunha-Vaz JG. Breakdown of the inner and outer blood retinal barrier in streptozotocininduced diabetes. Exp Eye Res. 1998;67:569-575.
6. Murata T, Ishibashi T, Khalil A, Hata Y, Yoshikawa H, Inomata H. Vascular endothelial growth factor plays a role in hyperpermeability of diabetic retinal vessels. Ophthalmic Res. 1995;27:48-52.
7. Sander B, Larsen M, Moldow B, Lund-Andersen H. Diabetic macular edema: passive and active transport of fluorescein through the blood-retina barrier. Invest Ophthalmol Vis Sci. 2001;42:433-438.
8. Gao BB, Clermont A, Rook S, et al. Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. Nat Med. 2007;13:181-188.
9. la Cour M, Zeuthen T. Osmotic properties of the frog retinal pigment epithelium. Exp Eye Res. 1993;56:521-530.
10. Eriksson U, Alm A. Repeatability in and interchangeability between the macular and the fast macular thickness map protocols: a study on normal eyes with Stratus optical coherence tomography. Acta Ophthalmol. Published online October 7, 2008.
11. Thornit DN, Sander B, la Cour M, Lund-Andersen H. The effects of peroral glycerol on plasma osmolarity in diabetic patients and healthy subjects. Basic Clin Pharmacol Toxicol. 2009;105:289-293.
12. Negi A, Marmor MF. Effects of subretinal and systemic osmolality on the rate of subretinal fluid resorption. Invest Ophthalmol Vis Sci. 1984;25:616-620.
13. Luan H, Roberts R, Sniegowski M, Goebel DJ, Berkowitz BA. Retinal thickness and subnormal retinal oxygenation response in experimental diabetic retinopathy. Invest Ophthalmol Vis Sci. 2006;47:320-328.
14. Lund-Andersen H, Krogsaa B, Larsen J. Calculation of the permeability of the blood-retinal barrier to fluorescein. Graefes Arch Clin Exp Ophthalmol. 1985;222:173-176.
15. Krogsaa B, Lund-Andersen H, Mehlsen J, Sestoft L, Larsen J. The blood-retinal barrier permeability in diabetic patients. Acta Ophthalmol (Copenh). 1981;59:689-694.
16. Marmor MF. Mechanisms of fluid accumulation in retinal edema. Doc Ophthalmol. 1999;97:239-249.
17. Soliman W, Sander B, Jorgensen TM. Enhanced optical coherence patterns of diabetic macular oedema and their correlation with the pathophysiology. Acta Ophthalmol Scand. 2007;85:613-617.
18. Krzystolik MG, Strauber SF, Aiello LP, et al. Reproducibility of macular thickness and volume using Zeiss optical coherence tomography in patients with diabetic macular edema. Ophthalmology. 2007;114:1520-1525.
19. Krogsaa B, Lund-Andersen H, Mehlsen J, Sestoft L. The bloodretinal barrier permeability to fluorescein in normal subjects and in juvenile diabetics without retinopathy. Acta Ophthalmol (Copenh). 1986;64:173-179.
20. Engler CB, Sander B, Larsen M, Dalgaard P, Lund-Andersen H. Fluorescein transport across the human blood-retina barrier in the direction vitreous to blood: quantitative assessment in vivo. Acta Ophthalmol (Copenh). 1994;72:655-662.
21. Engler CB, Parving HH, Mathiesen ER, Larsen M, Lund-Andersen H. Blood-retina barrier permeability in diabetes during acute ACEinhibition. Acta Ophthalmol (Copenh). 1991;69:581-585.
22. Sander B, Larsen M, Engler C, et al. Diabetic macular oedema: a comparison of vitreous fluorometry, angiography, and retinopathy. Br J Ophthalmol. 2002;86:316-320.
23. Kato T, Hayashi Y, Inoue K, Yuasa H. Glycerol absorption by Na+-dependent carrier-mediated transport in the closed loop of the rat small intestine. Biol Pharm Bull. 2005;28:553-555.
24. Agre P, King LS, Yasui M, et al. Aquaporin water channels: from atomic structure to clinical medicine. J Physiol. 2002;542:3-16.
25. Verkman AS. Role of aquaporin water channels in eye function. Exp Eye Res. 2003;76:137-143.
26. Verkman AS, Ruiz-Ederra J, Levin MH. Functions of aquaporins in the eye. Prog Retin Eye Res. 2008;27:420-433.
27. Tilton RG, Chang KC, LeJeune WS, Stephan CC, Brock TA, Williamson JR. Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF. Invest Ophthalmol Vis Sci. 1999;40:689-696.
28. Xu Q, Qaum T, Adamis AP. Sensitive blood-retinal barrier breakdown quantitation using Evans blue. Invest Ophthalmol Vis Sci. 2001;42:789-794.
29. Trick GL, Liggett J, Levy J, et al. Dynamic contrast enhanced MRI in patients with diabetic macular edema: initial results. Exp Eye Res. 2005;81:97-102.
30. Hamann S, la Cour M. Water homeostasis in the ischaemic retina: is aquaporin-4 involved? Acta Ophthalmol Scand. 2005;83:523-525.
31. Bringmann A, Reichenbach A, Wiedemann P. Pathomechanisms of cystoid macular edema. Ophthalmic Res. 2004;36:241-249.
32. Frank RN, Schulz L, Abe K, Iezzi R. Temporal variation in diabetic macular edema measured by optical coherence tomography. Ophthalmology. 2004;111:211-217.
33. Larsen M, Wang M, Sander B. Overnight thickness variation in diabetic macular edema. Invest Ophthalmol Vis Sci. 2005;46: 2313-2316.
34. Paques M, Massin P, Sahel JA, et al. Circadian fluctuations of macular edema in patients with morning vision blurring: correlation with arterial pressure and effect of light deprivation. Invest Ophthalmol Vis Sci. 2005;46:4707-4711.
35. Polito A, Del Borrello M, Polini G, Furlan F, Isola M, Bandello F. Diurnal variation in clinically significant diabetic macular edema measured by the Stratus OCT. Retina. 2006;26:14-20.
36. Knudsen ST, Bek T, Poulsen PL, Hove MN, Rehling M, Mogensen CE. Macular edema reflects generalized vascular hyperpermeability in type 2 diabetic patients with retinopathy. Diabetes Care. 2002; 25:2328-2334.