Rasgap-Derived fragment N increases the resistance of beta cells towards apoptosis in NOD mice and delays the progression from mild to overt diabetes

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Bulat, Natasa ^a   Jaccard, Evrim ^a   Peltzer, Nieves ^a   Khalil, Hadi ^a   Yang, Jiang Yan ^a   Dubuis, Gilles ^a   Widmann, Christian ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

FRAGMENT N PROTEIN; GLUCOSE; INSULIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PEPTIDE FRAGMENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GLUCOSE BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET BETA CELL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; TRANSGENE; ANIMAL; AUTOIMMUNITY; CHEMISTRY; DIABETES MELLITUS; DRUG EFFECT; GENE EXPRESSION REGULATION; IMMUNOLOGY; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TIME; TUMOR CELL LINE;

MUS; RATTUS;

ANIMALS; APOPTOSIS; AUTOIMMUNITY; CELL LINE, TUMOR; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION; INSULIN-SECRETING CELLS; MICE; MICE, INBRED NOD; PEPTIDE FRAGMENTS; RAS GTPASE-ACTIVATING PROTEINS; RATS; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 79960739322     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022609     Document Type: Article

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