Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion

Journal of Biological Chemistry

Volumn 280, Issue 38, 2005, Pages 32835-32842

  Yang, Jiang Yan ^a   Walicki, Joël ^a   Abdenrahmani, Amar ^a   Cornu, Marion ^a   Waeber, Gérard ^a,b   Thorens, Bernard ^a   Widmann, Christian ^a,c  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CATALYSIS; MOLECULAR BIOLOGY; MOLECULAR STRUCTURE; MUTAGENESIS;

ELECTROSTATIC CATALYSIS; HOMOLOGY; RANDOMIZATION; REACTION MECHANISM;

CELLS;

CASPASE; CASPASE 3; CYTOKINE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN RASGAP; RAS PROTEIN; REGULATOR PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TOXIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL IMMORTALIZATION; CELL PROTECTION; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME INDUCTION; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULINOMA; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL LINE; CISPLATIN; CROSS-LINKING REAGENTS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INSULIN; INSULIN-SECRETING CELLS; INSULINOMA; LENTIVIRUS; MICE; MICROSCOPY, FLUORESCENCE; NF-KAPPA B; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RAS GTPASE-ACTIVATING PROTEINS; RATS; RATS, WISTAR; TIME FACTORS;

EID: 25444486206     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M504058200     Document Type: Article

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