메뉴 건너뛰기




Volumn 41, Issue 8, 2011, Pages 711-721

Molecular characteristics of non-cancerous liver tissue in non-B non-C hepatocellular carcinoma

Author keywords

Hepatocarcinogenesis; Molecular mechanism; Non alcoholic fatty liver disease; Non alcoholic steatohepatitis; Occult hepatitis B virus infection

Indexed keywords

ACETALDEHYDE; ADIPONECTIN; BETA CATENIN; CORE PROTEIN; CYTOCHROME P450 26A1; INTERLEUKIN 6; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RESISTIN; SOMATOMEDIN C; STAT3 PROTEIN; TRANSCRIPTION FACTOR NRF1; TUMOR NECROSIS FACTOR ALPHA; VIRUS DNA; VIRUS PROTEIN; WNT PROTEIN;

EID: 79960709110     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2011.00818.x     Document Type: Review
Times cited : (28)

References (82)
  • 2
    • 58849143425 scopus 로고    scopus 로고
    • The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology
    • Caldwell S, Park SH. The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology. J Gastroenterol 2009; 44 (Suppl 19): 96-101.
    • (2009) J Gastroenterol , vol.44 , Issue.19 SUPPL. , pp. 96-101
    • Caldwell, S.1    Park, S.H.2
  • 4
    • 77954504346 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma: report of consensus meeting in the 45th Annual Meeting of the Japan Society of Hepatology (2009)
    • Arii S, Sata M, Sakamoto M etal. Management of hepatocellular carcinoma: report of consensus meeting in the 45th Annual Meeting of the Japan Society of Hepatology (2009). Hepatol Res 2010; 40: 667-85.
    • (2010) Hepatol Res , vol.40 , pp. 667-685
    • Arii, S.1    Sata, M.2    Sakamoto, M.3
  • 5
    • 60549106718 scopus 로고    scopus 로고
    • Major achievements in hepatocellular carcinoma
    • Bruix J, Llovet JM. Major achievements in hepatocellular carcinoma. Lancet 2009; 373: 614-6.
    • (2009) Lancet , vol.373 , pp. 614-616
    • Bruix, J.1    Llovet, J.M.2
  • 6
    • 34447335306 scopus 로고    scopus 로고
    • Report of the 17th nationwide follow-up survey of primary liver cancer in Japan
    • Ikai I, Arii S, Okazaki M etal. Report of the 17th nationwide follow-up survey of primary liver cancer in Japan. Hepatol Res 2007; 37: 676-91.
    • (2007) Hepatol Res , vol.37 , pp. 676-691
    • Ikai, I.1    Arii, S.2    Okazaki, M.3
  • 7
    • 77954382326 scopus 로고    scopus 로고
    • Management of hepatitis C; Report of the Consensus Meeting at the 45th Annual Meeting of the Japan Society of Hepatology (2009)
    • Namiki I, Nishiguchi S, Hino K etal. Management of hepatitis C; Report of the Consensus Meeting at the 45th Annual Meeting of the Japan Society of Hepatology (2009). Hepatol Res 2010; 40: 347-68.
    • (2010) Hepatol Res , vol.40 , pp. 347-368
    • Namiki, I.1    Nishiguchi, S.2    Hino, K.3
  • 8
    • 49049120459 scopus 로고    scopus 로고
    • Epidemiology of hepatocellular carcinoma in Japan
    • Umemura T, Kiyosawa K. Epidemiology of hepatocellular carcinoma in Japan. Hepatol Res 2007; 37 (Suppl 2): S95-100.
    • (2007) Hepatol Res , vol.37 , Issue.SUPPL. 2
    • Umemura, T.1    Kiyosawa, K.2
  • 9
    • 44649158914 scopus 로고    scopus 로고
    • Declining incidence of hepatocellular carcinoma in Osaka, Japan, from 1990 to 2003
    • Tanaka H, Imai Y, Hiramatsu N etal. Declining incidence of hepatocellular carcinoma in Osaka, Japan, from 1990 to 2003. Ann Intern Med 2008; 148: 820-6.
    • (2008) Ann Intern Med , vol.148 , pp. 820-826
    • Tanaka, H.1    Imai, Y.2    Hiramatsu, N.3
  • 10
    • 77949272200 scopus 로고    scopus 로고
    • Etiology of liver cirrhosis in Japan: a nationwide survey
    • Michitaka K, Nishiguchi S, Aoyagi Y etal. Etiology of liver cirrhosis in Japan: a nationwide survey. J Gastroenterol 2010; 45: 86-94.
    • (2010) J Gastroenterol , vol.45 , pp. 86-94
    • Michitaka, K.1    Nishiguchi, S.2    Aoyagi, Y.3
  • 11
    • 58849166220 scopus 로고    scopus 로고
    • Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection
    • Koike K. Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection. J Gastroenterol 2009; 44: 82-8.
    • (2009) J Gastroenterol , vol.44 , pp. 82-88
    • Koike, K.1
  • 12
    • 0028241689 scopus 로고
    • Viruses and hepatocellular carcinoma
    • Sherlock S. Viruses and hepatocellular carcinoma. Gut 1994; 35: 828-32.
    • (1994) Gut , vol.35 , pp. 828-832
    • Sherlock, S.1
  • 13
    • 0033566684 scopus 로고    scopus 로고
    • Association between high serum alanine aminotransferase levels and more rapid development and higher rate of incidence of hepatocellular carcinoma in patients with hepatitis C virus-associated cirrhosis
    • Tarao K, Rino Y, Ohkawa S etal. Association between high serum alanine aminotransferase levels and more rapid development and higher rate of incidence of hepatocellular carcinoma in patients with hepatitis C virus-associated cirrhosis. Cancer 1999; 86: 589-95.
    • (1999) Cancer , vol.86 , pp. 589-595
    • Tarao, K.1    Rino, Y.2    Ohkawa, S.3
  • 14
    • 58849087179 scopus 로고    scopus 로고
    • Early HCC: diagnosis and molecular markers
    • Sakamoto M. Early HCC: diagnosis and molecular markers. J Gastroenterol 2009; 44: 108-11.
    • (2009) J Gastroenterol , vol.44 , pp. 108-111
    • Sakamoto, M.1
  • 15
    • 33745225917 scopus 로고    scopus 로고
    • Specific gene-expression profiles of noncancerous liver tissue predict the risk for multicentric occurrence of hepatocellular carcinoma in hepatitis C virus-positive patients
    • Utsunomiya T, Okamoto M, Wakiyama S etal. Specific gene-expression profiles of noncancerous liver tissue predict the risk for multicentric occurrence of hepatocellular carcinoma in hepatitis C virus-positive patients. Ann Surg Oncol 2006; 13: 947-54.
    • (2006) Ann Surg Oncol , vol.13 , pp. 947-954
    • Utsunomiya, T.1    Okamoto, M.2    Wakiyama, S.3
  • 16
    • 57349090407 scopus 로고    scopus 로고
    • Gene expression in fixed tissues and outcome in hepatocellular carcinoma
    • Hoshida Y, Villanueva A, Kobayashi M etal. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med 2008; 359: 1995-2004.
    • (2008) N Engl J Med , vol.359 , pp. 1995-2004
    • Hoshida, Y.1    Villanueva, A.2    Kobayashi, M.3
  • 17
    • 77950670673 scopus 로고    scopus 로고
    • Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma
    • Tsuchiya M, Parker JS, Kono H, Matsuda M, Fujii H, Rusyn I. Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma. Mol Cancer 2010; 9: 74.
    • (2010) Mol Cancer , vol.9 , pp. 74
    • Tsuchiya, M.1    Parker, J.S.2    Kono, H.3    Matsuda, M.4    Fujii, H.5    Rusyn, I.6
  • 18
    • 0037443891 scopus 로고    scopus 로고
    • Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection
    • Iizuka N, Oka M, Yamada Okabe H etal. Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection. Lancet 2003; 361: 923-9.
    • (2003) Lancet , vol.361 , pp. 923-929
    • Iizuka, N.1    Oka, M.2    Yamada Okabe, H.3
  • 19
    • 4444286417 scopus 로고    scopus 로고
    • Molecular-based prediction of early recurrence in hepatocellular carcinoma
    • Kurokawa Y, Matoba R, Takemasa I etal. Molecular-based prediction of early recurrence in hepatocellular carcinoma. J Hepatol 2004; 41: 284-91.
    • (2004) J Hepatol , vol.41 , pp. 284-291
    • Kurokawa, Y.1    Matoba, R.2    Takemasa, I.3
  • 20
    • 33750983646 scopus 로고    scopus 로고
    • A gene expression profile for vascular invasion can predict the recurrence after resection of hepatocellular carcinoma: a microarray approach
    • Ho MC, Lin JJ, Chen CN etal. A gene expression profile for vascular invasion can predict the recurrence after resection of hepatocellular carcinoma: a microarray approach. Ann Surg Oncol 2006; 13: 1474-84.
    • (2006) Ann Surg Oncol , vol.13 , pp. 1474-1484
    • Ho, M.C.1    Lin, J.J.2    Chen, C.N.3
  • 21
    • 35948981211 scopus 로고    scopus 로고
    • Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma
    • Wang SM, Ooi LL, Hui KM. Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma. Clin Cancer Res 2007; 13: 6275-83.
    • (2007) Clin Cancer Res , vol.13 , pp. 6275-6283
    • Wang, S.M.1    Ooi, L.L.2    Hui, K.M.3
  • 22
    • 42249087302 scopus 로고    scopus 로고
    • Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma
    • Woo HG, Park ES, Cheon JH etal. Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma. Clin Cancer Res 2008; 14: 2056-64.
    • (2008) Clin Cancer Res , vol.14 , pp. 2056-2064
    • Woo, H.G.1    Park, E.S.2    Cheon, J.H.3
  • 23
    • 38749094406 scopus 로고    scopus 로고
    • A three-gene predictor for early intrahepatic recurrence of hepatocellular carcinoma after curative hepatectomy
    • Somura H, Iizuka N, Tamesa T etal. A three-gene predictor for early intrahepatic recurrence of hepatocellular carcinoma after curative hepatectomy. Oncol Rep 2008; 19: 489-95.
    • (2008) Oncol Rep , vol.19 , pp. 489-495
    • Somura, H.1    Iizuka, N.2    Tamesa, T.3
  • 24
    • 61349127144 scopus 로고    scopus 로고
    • Molecular prediction of early recurrence after resection of hepatocellular carcinoma
    • Yoshioka S, Takemasa I, Nagano H etal. Molecular prediction of early recurrence after resection of hepatocellular carcinoma. Eur J Cancer 2009; 45: 881-9.
    • (2009) Eur J Cancer , vol.45 , pp. 881-889
    • Yoshioka, S.1    Takemasa, I.2    Nagano, H.3
  • 25
    • 46949109527 scopus 로고    scopus 로고
    • Recent advances in the pathogenesis and diagnosis of liver fibrosis
    • Torok NJ. Recent advances in the pathogenesis and diagnosis of liver fibrosis. J Gastroenterol 2008; 43: 315-21.
    • (2008) J Gastroenterol , vol.43 , pp. 315-321
    • Torok, N.J.1
  • 26
    • 4344576756 scopus 로고    scopus 로고
    • A gene-expression signature can quantify the degree of hepatic fibrosis in the rat
    • Utsunomiya T, Okamoto M, Hashimoto M etal. A gene-expression signature can quantify the degree of hepatic fibrosis in the rat. J Hepatol 2004; 41: 399-406.
    • (2004) J Hepatol , vol.41 , pp. 399-406
    • Utsunomiya, T.1    Okamoto, M.2    Hashimoto, M.3
  • 27
    • 33846588883 scopus 로고    scopus 로고
    • A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease
    • Utsunomiya T, Okamoto M, Wakiyama S etal. A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease. World J Gastroenterol 2007; 13: 383-90.
    • (2007) World J Gastroenterol , vol.13 , pp. 383-390
    • Utsunomiya, T.1    Okamoto, M.2    Wakiyama, S.3
  • 28
    • 77951622187 scopus 로고    scopus 로고
    • Viral hepatocarcinogenesis
    • Tsai WL, Chung RT. Viral hepatocarcinogenesis. Oncogene 2010; 29: 2309-24.
    • (2010) Oncogene , vol.29 , pp. 2309-2324
    • Tsai, W.L.1    Chung, R.T.2
  • 29
    • 79955482701 scopus 로고    scopus 로고
    • Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges
    • Bouchard MJ, Navas-Martin S. Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges. Cancer Lett 2010; 305: 123-43.
    • (2010) Cancer Lett , vol.305 , pp. 123-143
    • Bouchard, M.J.1    Navas-Martin, S.2
  • 30
    • 61649106928 scopus 로고    scopus 로고
    • Inflammation and liver cancer: new molecular links
    • Berasain C, Castillo J, Perugorria MJ etal. Inflammation and liver cancer: new molecular links. Ann N Y Acad Sci 2009; 1155: 206-21.
    • (2009) Ann N Y Acad Sci , vol.1155 , pp. 206-221
    • Berasain, C.1    Castillo, J.2    Perugorria, M.J.3
  • 31
    • 66149135640 scopus 로고    scopus 로고
    • Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer
    • McGivern DR, Lemon SM. Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer. Annu Rev Pathol 2009; 4: 399-415.
    • (2009) Annu Rev Pathol , vol.4 , pp. 399-415
    • McGivern, D.R.1    Lemon, S.M.2
  • 32
    • 44849129329 scopus 로고    scopus 로고
    • Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C
    • Fujita N, Sugimoto R, Ma N etal. Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C. J Viral Hepat 2008; 15: 498-507.
    • (2008) J Viral Hepat , vol.15 , pp. 498-507
    • Fujita, N.1    Sugimoto, R.2    Ma, N.3
  • 33
    • 0036165333 scopus 로고    scopus 로고
    • Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein
    • Okuda M, Li K, Beard MR etal. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 2002; 122: 366-75.
    • (2002) Gastroenterology , vol.122 , pp. 366-375
    • Okuda, M.1    Li, K.2    Beard, M.R.3
  • 34
    • 77956135578 scopus 로고    scopus 로고
    • Hepatic steatosis in chronic hepatitis C is a significant risk factor for developing hepatocellular carcinoma independent of age, sex, obesity, fibrosis stage and response to interferon therapy
    • Kurosaki M, Hosokawa T, Matsunaga K etal. Hepatic steatosis in chronic hepatitis C is a significant risk factor for developing hepatocellular carcinoma independent of age, sex, obesity, fibrosis stage and response to interferon therapy. Hepatol Res 2010; 40: 870-7.
    • (2010) Hepatol Res , vol.40 , pp. 870-877
    • Kurosaki, M.1    Hosokawa, T.2    Matsunaga, K.3
  • 35
    • 77954350897 scopus 로고    scopus 로고
    • Animal models for hepatitis C and related liver disease
    • Koike K, Moriya K, Matsuura Y. Animal models for hepatitis C and related liver disease. Hepatol Res 2010; 40: 69-82.
    • (2010) Hepatol Res , vol.40 , pp. 69-82
    • Koike, K.1    Moriya, K.2    Matsuura, Y.3
  • 36
    • 0842300373 scopus 로고    scopus 로고
    • Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease
    • Lonardo A, Adinolfi LE, Loria P, Carulli N, Ruggiero G, Day CP. Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology 2004; 126: 586-97.
    • (2004) Gastroenterology , vol.126 , pp. 586-597
    • Lonardo, A.1    Adinolfi, L.E.2    Loria, P.3    Carulli, N.4    Ruggiero, G.5    Day, C.P.6
  • 37
    • 0035360859 scopus 로고    scopus 로고
    • Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis
    • Moriya K, Nakagawa K, Santa T etal. Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res 2001; 61: 4365-70.
    • (2001) Cancer Res , vol.61 , pp. 4365-4370
    • Moriya, K.1    Nakagawa, K.2    Santa, T.3
  • 38
    • 33744512454 scopus 로고    scopus 로고
    • Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein
    • Furutani T, Hino K, Okuda M etal. Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein. Gastroenterology 2006; 130: 2087-98.
    • (2006) Gastroenterology , vol.130 , pp. 2087-2098
    • Furutani, T.1    Hino, K.2    Okuda, M.3
  • 39
    • 77957365464 scopus 로고    scopus 로고
    • Insulin resistance, serum leptin, and adiponectin levels and outcomes of viral hepatitis C cirrhosis
    • Nkontchou G, Bastard JP, Ziol M etal. Insulin resistance, serum leptin, and adiponectin levels and outcomes of viral hepatitis C cirrhosis. J Hepatol 2010; 53: 827-33.
    • (2010) J Hepatol , vol.53 , pp. 827-833
    • Nkontchou, G.1    Bastard, J.P.2    Ziol, M.3
  • 40
    • 50949118651 scopus 로고    scopus 로고
    • Statements from the Taormina expert meeting on occult hepatitis B virus infection
    • Raimondo G, Allain JP, Brunetto MR etal. Statements from the Taormina expert meeting on occult hepatitis B virus infection. J Hepatol 2008; 49: 652-7.
    • (2008) J Hepatol , vol.49 , pp. 652-657
    • Raimondo, G.1    Allain, J.P.2    Brunetto, M.R.3
  • 41
    • 34447628869 scopus 로고    scopus 로고
    • Prevalence of low-level hepatitis B viremia in patients with HBV surface antigen-negative hepatocellular carcinoma with and without hepatitis C virus infection in Japan: analysis by COBAS TaqMan real-time PCR
    • Toyoda H, Kumada T, Kiriyama S etal. Prevalence of low-level hepatitis B viremia in patients with HBV surface antigen-negative hepatocellular carcinoma with and without hepatitis C virus infection in Japan: analysis by COBAS TaqMan real-time PCR. Intervirology 2007; 50 (4): 241-4.
    • (2007) Intervirology , vol.50 , Issue.4 , pp. 241-244
    • Toyoda, H.1    Kumada, T.2    Kiriyama, S.3
  • 42
    • 0036902332 scopus 로고    scopus 로고
    • Occult hepatitis B virus infection and its clinical implications
    • Hu KQ. Occult hepatitis B virus infection and its clinical implications. J Viral Hepat 2002; 9: 243-57.
    • (2002) J Viral Hepat , vol.9 , pp. 243-257
    • Hu, K.Q.1
  • 43
    • 48249091184 scopus 로고    scopus 로고
    • Diagnosis and clinical impact of occult hepatitis B infection in patients with biopsy proven chronic hepatitis C: a multicenter study
    • Sagnelli E, Imparato M, Coppola N. Diagnosis and clinical impact of occult hepatitis B infection in patients with biopsy proven chronic hepatitis C: a multicenter study. J Med Virol 2008; 80: 1547-53.
    • (2008) J Med Virol , vol.80 , pp. 1547-1553
    • Sagnelli, E.1    Imparato, M.2    Coppola, N.3
  • 44
    • 9144224875 scopus 로고    scopus 로고
    • Hepatitis B virus maintains its pro-oncogenic properties in the case of occult HBV infection
    • Pollicino T, Squadrito G, Cerenzia G etal. Hepatitis B virus maintains its pro-oncogenic properties in the case of occult HBV infection. Gastroenterology 2004; 126: 102-10.
    • (2004) Gastroenterology , vol.126 , pp. 102-110
    • Pollicino, T.1    Squadrito, G.2    Cerenzia, G.3
  • 45
    • 33847694379 scopus 로고    scopus 로고
    • Molecular and functional analysis of occult hepatitis B virus isolates from patients with hepatocellular carcinoma
    • Pollicino T, Raffa G, Costantino L etal. Molecular and functional analysis of occult hepatitis B virus isolates from patients with hepatocellular carcinoma. Hepatology 2007; 45: 277-85.
    • (2007) Hepatology , vol.45 , pp. 277-285
    • Pollicino, T.1    Raffa, G.2    Costantino, L.3
  • 47
    • 34247630220 scopus 로고    scopus 로고
    • A weak association between occult HBV infection and non-B non-C hepatocellular carcinoma in Japan
    • Kusakabe A, Tanaka Y, Orito E etal. A weak association between occult HBV infection and non-B non-C hepatocellular carcinoma in Japan. J Gastroenterol 2007; 42: 298-305.
    • (2007) J Gastroenterol , vol.42 , pp. 298-305
    • Kusakabe, A.1    Tanaka, Y.2    Orito, E.3
  • 48
    • 65449174853 scopus 로고    scopus 로고
    • Occult hepatitis B virus infection increases hepatocellular carcinogenesis by eight times in patients with non-B, non-C liver cirrhosis: a cohort study
    • Ikeda K, Kobayashi M, Someya T etal. Occult hepatitis B virus infection increases hepatocellular carcinogenesis by eight times in patients with non-B, non-C liver cirrhosis: a cohort study. J Viral Hepat 2009; 16: 437-43.
    • (2009) J Viral Hepat , vol.16 , pp. 437-443
    • Ikeda, K.1    Kobayashi, M.2    Someya, T.3
  • 49
    • 67650093712 scopus 로고    scopus 로고
    • A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular carcinoma patients in Taiwan
    • Chen CH, Changchien CS, Lee CM etal. A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular carcinoma patients in Taiwan. Int J Cancer 2009; 125: 621-9.
    • (2009) Int J Cancer , vol.125 , pp. 621-629
    • Chen, C.H.1    Changchien, C.S.2    Lee, C.M.3
  • 50
    • 0032978313 scopus 로고    scopus 로고
    • Occult lifelong persistence of infectious hepadnavirus and residual liver inflammation in woodchucks convalescent from acute viral hepatitis
    • Michalak TI, Pardoe IU, Coffin CS etal. Occult lifelong persistence of infectious hepadnavirus and residual liver inflammation in woodchucks convalescent from acute viral hepatitis. Hepatology 1999; 29: 928-38.
    • (1999) Hepatology , vol.29 , pp. 928-938
    • Michalak, T.I.1    Pardoe, I.U.2    Coffin, C.S.3
  • 51
    • 77956228696 scopus 로고    scopus 로고
    • Occult hepatitis B virus infection with low viremia induces DNA damage, apoptosis and oxidative stress in peripheral blood lymphocytes
    • Bhargava A, Khan S, Panwar H. Occult hepatitis B virus infection with low viremia induces DNA damage, apoptosis and oxidative stress in peripheral blood lymphocytes. Virus Res 2010; 153: 143-50.
    • (2010) Virus Res , vol.153 , pp. 143-150
    • Bhargava, A.1    Khan, S.2    Panwar, H.3
  • 52
    • 77955712659 scopus 로고    scopus 로고
    • Hepatitis B virus-related hepatocarcinogenesis: molecular oncogenic potential of clear or occult infections
    • De Mitri MS, Cassini R, Bernardi M. Hepatitis B virus-related hepatocarcinogenesis: molecular oncogenic potential of clear or occult infections. Eur J Cancer 2010; 46: 2178-86.
    • (2010) Eur J Cancer , vol.46 , pp. 2178-2186
    • De Mitri, M.S.1    Cassini, R.2    Bernardi, M.3
  • 54
    • 77951456114 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection
    • Starley BQ, Calcagno CJ, Harrison SA. Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology 2010; 51: 1820-32.
    • (2010) Hepatology , vol.51 , pp. 1820-1832
    • Starley, B.Q.1    Calcagno, C.J.2    Harrison, S.A.3
  • 55
    • 34249699540 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and cancer
    • Bugianesi E. Non-alcoholic steatohepatitis and cancer. Clin Liver Dis 2007; 11: 191-207.
    • (2007) Clin Liver Dis , vol.11 , pp. 191-207
    • Bugianesi, E.1
  • 56
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
    • Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004; 4: 579-91.
    • (2004) Nat Rev Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 57
    • 15244359632 scopus 로고    scopus 로고
    • Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia
    • Xu Z, Chen L, Leung L etal. Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc Natl Acad Sci U S A 2005; 102: 4120-5.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4120-4125
    • Xu, Z.1    Chen, L.2    Leung, L.3
  • 58
    • 77954358490 scopus 로고    scopus 로고
    • Genetic analysis of expression profile involved in retinoid metabolism in non-alcoholic fatty liver disease
    • Ashla AA, Hoshikawa Y, Tsuchiya H etal. Genetic analysis of expression profile involved in retinoid metabolism in non-alcoholic fatty liver disease. Hepatol Res 2010; 40: 594-604.
    • (2010) Hepatol Res , vol.40 , pp. 594-604
    • Ashla, A.A.1    Hoshikawa, Y.2    Tsuchiya, H.3
  • 59
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • Hirosumi J, Tuncman G, Change L etal. A central role for JNK in obesity and insulin resistance. Nature 2002; 420: 333-6.
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Change, L.3
  • 60
    • 57449109370 scopus 로고    scopus 로고
    • Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation
    • Hui L, Zatloukal H, Scheuch H, Stepniak E, Wagner EF. Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation. J Clin Invest 2008; 118: 3943-53.
    • (2008) J Clin Invest , vol.118 , pp. 3943-3953
    • Hui, L.1    Zatloukal, H.2    Scheuch, H.3    Stepniak, E.4    Wagner, E.F.5
  • 61
    • 70349183424 scopus 로고    scopus 로고
    • JNK1, a potential therapeutic target for hepatocellular carcinoma
    • Chen F, Beezhold K, Castranova V. JNK1, a potential therapeutic target for hepatocellular carcinoma. Biochim Biophys Acta 2009; 1796: 242-51.
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 242-251
    • Chen, F.1    Beezhold, K.2    Castranova, V.3
  • 62
    • 65249190240 scopus 로고    scopus 로고
    • Statins are associated with a reduced risk of hepatocellular carcinoma in a large cohort of patients with diabetes
    • El-Serag HB, Johnson ML, Hachem C, Morgana RO. Statins are associated with a reduced risk of hepatocellular carcinoma in a large cohort of patients with diabetes. Gastroenterology 2009; 136: 1601-8.
    • (2009) Gastroenterology , vol.136 , pp. 1601-1608
    • El-Serag, H.B.1    Johnson, M.L.2    Hachem, C.3    Morgana, R.O.4
  • 63
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park EJ, Lee JH, Yu GY etal. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010; 140: 197-208.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3
  • 64
    • 85047694402 scopus 로고    scopus 로고
    • Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
    • Horie Y, Suzuki A, Kataoka E etal. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 2004; 113 (12): 1774-83.
    • (2004) J Clin Invest , vol.113 , Issue.12 , pp. 1774-1783
    • Horie, Y.1    Suzuki, A.2    Kataoka, E.3
  • 65
    • 34249791226 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice
    • Watanabe S, Horie Y, Kataoka E etal. Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice. J Gastroenterol Hepatol 2007; 22 (Suppl 1): S96-S100.
    • (2007) J Gastroenterol Hepatol , vol.22 , Issue.SUPPL. 1
    • Watanabe, S.1    Horie, Y.2    Kataoka, E.3
  • 66
    • 59349092761 scopus 로고    scopus 로고
    • Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice
    • Ishii H, Horie Y, Ohshima S etal. Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. J Hepatol 2009; 50: 562-71.
    • (2009) J Hepatol , vol.50 , pp. 562-571
    • Ishii, H.1    Horie, Y.2    Ohshima, S.3
  • 67
    • 78049497993 scopus 로고    scopus 로고
    • Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis
    • Martínez-López N, Varela-Rey M, Fernández-Ramos D etal. Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis. Hepatology 2010; 52: 1621-31.
    • (2010) Hepatology , vol.52 , pp. 1621-1631
    • Martínez-López, N.1    Varela-Rey, M.2    Fernández-Ramos, D.3
  • 68
    • 39549099942 scopus 로고    scopus 로고
    • Etiology-dependent molecular mechanisms in human hepatocarcinogenesis
    • Schlaeger C, Longerich T, Schiller C etal. Etiology-dependent molecular mechanisms in human hepatocarcinogenesis. Hepatology 2008; 47: 511-20.
    • (2008) Hepatology , vol.47 , pp. 511-520
    • Schlaeger, C.1    Longerich, T.2    Schiller, C.3
  • 69
    • 55449094777 scopus 로고    scopus 로고
    • Gene expression profiling of non-alcoholic steatohepatitis using gene set enrichment analysis
    • Yoneda M, Endo H, Mawatari H etal. Gene expression profiling of non-alcoholic steatohepatitis using gene set enrichment analysis. Hepatol Res 2008; 38: 1204-12.
    • (2008) Hepatol Res , vol.38 , pp. 1204-1212
    • Yoneda, M.1    Endo, H.2    Mawatari, H.3
  • 70
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S, Kozlitina J, Xing C etal. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008; 40: 1461-5.
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 72
    • 34547118090 scopus 로고    scopus 로고
    • Molecular mechanisms of alcohol-mediated carcinogenesis
    • Seitz HK, Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Nat Rev Cancer 2007; 7: 599-612.
    • (2007) Nat Rev Cancer , vol.7 , pp. 599-612
    • Seitz, H.K.1    Stickel, F.2
  • 73
    • 79954815090 scopus 로고    scopus 로고
    • Hepatitis C virus and alcohol: same mitotic targets but different signaling pathways
    • Alisi A, Ghidinelli M, Zerbini A, Missale G, Balsano C. Hepatitis C virus and alcohol: same mitotic targets but different signaling pathways. J Hepatol 2010; 54: 956-63.
    • (2010) J Hepatol , vol.54 , pp. 956-963
    • Alisi, A.1    Ghidinelli, M.2    Zerbini, A.3    Missale, G.4    Balsano, C.5
  • 74
    • 78650876710 scopus 로고    scopus 로고
    • Alcohol consumption appears to protect against non-alcoholic fatty liver disease
    • Moriya A, Iwasaki Y, Ohguchi S etal. Alcohol consumption appears to protect against non-alcoholic fatty liver disease. Aliment Pharmacol Ther 2011; 33: 378-88.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 378-388
    • Moriya, A.1    Iwasaki, Y.2    Ohguchi, S.3
  • 75
    • 46249090385 scopus 로고    scopus 로고
    • Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver disease
    • Dunn W, Xu R, Schwimmer JB. Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver disease. Hepatology 2008; 47: 1947-54.
    • (2008) Hepatology , vol.47 , pp. 1947-1954
    • Dunn, W.1    Xu, R.2    Schwimmer, J.B.3
  • 76
    • 75349084543 scopus 로고    scopus 로고
    • Risk of HCC: genetic heterogeneity and complex genetics
    • Dragani TA. Risk of HCC: genetic heterogeneity and complex genetics. J Hepatol 2010; 52: 252-7.
    • (2010) J Hepatol , vol.52 , pp. 252-257
    • Dragani, T.A.1
  • 77
    • 20944445756 scopus 로고    scopus 로고
    • N-Acetyltransferase-2, glutathione S-transferase M1 and T1 genetic polymorphisms, cigarette smoking and hepatocellular carcinoma: a case-control study
    • Gelatti U, Covolo L, Talamini R etal. N-Acetyltransferase-2, glutathione S-transferase M1 and T1 genetic polymorphisms, cigarette smoking and hepatocellular carcinoma: a case-control study. Int J Cancer 2005; 115: 301-6.
    • (2005) Int J Cancer , vol.115 , pp. 301-306
    • Gelatti, U.1    Covolo, L.2    Talamini, R.3
  • 78
    • 36949028554 scopus 로고    scopus 로고
    • Case-control study on cigarette smoking and the risk of hepatocellular carcinoma among Japanese
    • Hara M, Tanaka K, Sakamoto T etal. Case-control study on cigarette smoking and the risk of hepatocellular carcinoma among Japanese. Cancer Sci 2008; 99: 93-7.
    • (2008) Cancer Sci , vol.99 , pp. 93-97
    • Hara, M.1    Tanaka, K.2    Sakamoto, T.3
  • 79
    • 77950340458 scopus 로고    scopus 로고
    • Comprehensive gene expression analysis of 5'-end of mRNA identified novel intronic transcripts associated with hepatocellular carcinoma
    • Hodo Y, Hashimoto S, Honda M etal. Comprehensive gene expression analysis of 5'-end of mRNA identified novel intronic transcripts associated with hepatocellular carcinoma. Genomics 2010; 95: 217-23.
    • (2010) Genomics , vol.95 , pp. 217-223
    • Hodo, Y.1    Hashimoto, S.2    Honda, M.3
  • 80
    • 77949265477 scopus 로고    scopus 로고
    • Molecular signatures of noncancerous liver tissue can predict the risk for late recurrence of hepatocellular carcinoma
    • Utsunomiya T, Shimada M, Imura S, Morine Y, Ikemoto T, Mori M. Molecular signatures of noncancerous liver tissue can predict the risk for late recurrence of hepatocellular carcinoma. J Gastroenterol 2010; 45: 146-52.
    • (2010) J Gastroenterol , vol.45 , pp. 146-152
    • Utsunomiya, T.1    Shimada, M.2    Imura, S.3    Morine, Y.4    Ikemoto, T.5    Mori, M.6
  • 81
    • 41349085813 scopus 로고    scopus 로고
    • Translational microarray systems for outcome prediction of hepatocellular carcinoma
    • Iizuka N, Hamamoto Y, Tsunedomi R, Oka M. Translational microarray systems for outcome prediction of hepatocellular carcinoma. Cancer Sci 2008; 99: 659-65.
    • (2008) Cancer Sci , vol.99 , pp. 659-665
    • Iizuka, N.1    Hamamoto, Y.2    Tsunedomi, R.3    Oka, M.4
  • 82
    • 33846137878 scopus 로고    scopus 로고
    • Central genetic alterations common to all HCV-positive, HBV-positive and non-B, non-C hepatocellular carcinoma: a new approach to identify novel tumor markers
    • Kurokawa Y, Honma K, Takemasa I etal. Central genetic alterations common to all HCV-positive, HBV-positive and non-B, non-C hepatocellular carcinoma: a new approach to identify novel tumor markers. Int J Oncol 2006; 2: 383-91.
    • (2006) Int J Oncol , vol.2 , pp. 383-391
    • Kurokawa, Y.1    Honma, K.2    Takemasa, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.