Insulin resistance, serum leptin, and adiponectin levels and outcomes of viral hepatitis C cirrhosis

Journal of Hepatology

Volumn 53, Issue 5, 2010, Pages 827-833

  Nkontchou, Gisle ^a   Bastard, Jean Philippe ^b   Ziol, Marianne ^a   Aout, Mounir ^c   Cosson, Emmanuel ^a   Ganne Carrie, Nathalie ^a   Grando Lemaire, Véronique ^a   Roulot, Dominique ^a   Capeau, Jacqueline ^b   Trinchet, Jean Claude ^a   Vicaut, Eric ^a   Beaugrand, Michel ^a  

^a HÔPITAL JEAN VERDIER   (France)

^b HÔPITAL TENON   (France)

^c HÔPITAL LARIBOISIÈRE   (France)

Author keywords

Hepatocellular carcinoma; Liver related death; Overweight obesity; Prospective study

Indexed keywords

ADIPONECTIN; INTERFERON; LEPTIN;

ADULT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; FEMALE; HEPATITIS C; HISTOPATHOLOGY; HUMAN; INCIDENCE; INSULIN RESISTANCE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; VIRUS HEPATITIS;

ADIPONECTIN; ADULT; AGED; CARCINOMA, HEPATOCELLULAR; FEMALE; FOLLOW-UP STUDIES; HEPATITIS C; HUMANS; INSULIN RESISTANCE; LEPTIN; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; RISK FACTORS;

EID: 77957365464     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.04.035     Document Type: Article

References (42)

1. B.L. Bressler, M. Guindi, G. Tomlinson, and J. Heathcote High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C Hepatology 38 2003 639 644
2. J.E. Everhart, A.S. Lok, H.Y. Kim, T.R. Morgan, K.L. Lindsay, and R.T. Chung HALT-C trial group. Weight-related effects on disease progression in the hepatitis C antiviral long-term treatment against cirrhosis trial Gastroenterology 137 2009 549 557
3. G. N'Kontchou, J. Paries, M.T. Htar, N. Ganne-Carrie, L. Costentin, and V. Grando-Lemaire Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis Clin Gastroenterol Hepatol 4 2006 1062 1068
4. G. Sabio, M. Das, A. Mora, Z. Zhang, J.Y. Jun, and H.J. Ko A stress signaling pathway in adipose tissue regulates hepatic insulin resistance Science 5 2008 1539 1543
5. K.G. Park, K.S. Park, M.J. Kim, H.S. Kim, Y.S. Suh, and J.D. Ahn Relationship between serum adiponectin and leptin concentrations and body fat distribution Diabetes Res Clin Pract 63 2004 135 142
6. B. Antuna-Puente, B. Feve, S. Fellahi, and J.P. Bastard Adipokines: the missing link between insulin resistance and obesity Diabetes Metab 34 2008 2 11
7. D. LeRoith, R. Novosyadlyy, E.J. Gallagher, D. Lann, A. Vijayakumar, and S. Yakar Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence Exp Clin Endocrinol Diabetes 116 Suppl. 1 2008 S4 S6
8. R. Kaaks, and A. Lukanova Energy balance and cancer: the role of insulin and insulin-like growth factor-I Proc Nutr Soc 60 2001 91 106
9. Z. Laron Insulin-a growth hormone Arch Physiol Biochem 114 2008 11 16
10. D.L. White, V. Ratziu, and H.B. El-Serag Hepatitis C infection and risk of diabetes: a systematic review and meta-analysis J Hepatol 49 2008 831 844
11. J.M. Hui, A. Sud, G.C. Farrell, P. Bandara, K. Byth, and J.G. Kench Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression Gastroenterology 125 2003 1695 1704
12. D. Ribatti, A.S. Belloni, B. Nico, M. Di Comite, E. Crivellato, and A. Vacca Leptin receptor are involved in angiogenesis in human hepatocellular carcinoma Peptides 29 2008 1596 1602
13. N.K. Saxena, D. Sharma, X. Ding, S. Lin, F. Marra, and D. Merlin Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells Cancer Res 67 2007 2497 2507
14. J. Wang, I. Leclercq, J.M. Brymora, N. Xu, M. Ramezani-Moghadam, and R.M. London Kupffer cells mediate leptin-induced liver fibrosis Gastroenterology 137 2009 713 723
15. E. Tsochatzis, G.V. Papatheodoridis, and A.J. Archimandritis The evolving role of leptin and adiponectin in chronic liver diseases Am J Gastroenterol 101 2006 2629 2640
16. F. Marra, and C. Bertolani Adipokines in liver diseases Hepatology 50 2009 957 969
17. E. Brkenhielm, N. Veitonmäki, R. Cao, S. Kihara, Y. Matsuzawa, and B. Zhivotovsky Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis Proc Natl Acad Sci USA 101 2004 2476 2481
18. Y. Wang, J.B. Lam, K.S. Lam, J. Liu, M.C. Lam, and R.L. Hoo Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signalling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice Cancer Res 66 2006 11462 11470
19. H. Huang, P.H. Park, M.R. McMullen, and L.E. Nagy Mechanisms for the anti-inflammatory effects of adiponectin in macrophages J Gastroenterol Hepatol 23 Suppl. 1 2008 S50 S53
20. I. Wedemeyer, L.P. Bechmann, M. Odenthal, C. Jochum, G. Marquitan, and U. Drebber Adiponectin inhibits steatotic CD95/Fas up-regulation by hepatocytes: therapeutic implications for hepatitis C J Hepatol 50 2009 140 149
21. M. Adachi, and D.A. Brenner High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase Hepatology 47 2008 677 685
22. Y. Kamada, S. Tamura, S. Kiso, H. Matsumoto, Y. Saji, and Y. Yoshida Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin Gastroenterology 125 2003 1796 1807
23. D.R. Matthews, J.P. Hosker, and A.S. Rudenski Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419
24. J. Bruix, M. Sherman, J. Llovet, M. Beaugrand, R. Lencioni, and A. Burroughs Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference J Hepatol 35 2001 421 430
25. G. Fattovich, T. Stroffolini, I. Zagni, and F. Donato Hepatocellular carcinoma in cirrhosis: incidence and risk factors Gastroenterology 127 2004 S35 S50
26. C. Camm, S. Petta, V. Di Marco, F. Bronte, S. Ciminnisi, and G. Licata Insulin resistance is a risk factor for esophageal varices in hepatitis C virus cirrhosis Hepatology 49 2009 195 203
27. E. Vanni, M.L. Abate, E. Gentilcore, I. Hickman, R. Gambino, and M. Cassader Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C Hepatology 50 2009 697 706
28. J.M. Hui, A. Sud, G.C. Farrell, P. Bandara, K. Byth, and J.G. Kench Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression Gastroenterology 125 2003 1695 1704
29. K.A. McAuley, J.I. Mann, J.G. Chase, T.F. Lotz, and G.M. Shaw Point: HOMA - satisfactory for the time being: HOMA: the best bet for the simple determination of insulin sensitivity, until something better comes along Diabetes Care 30 2007 2411 2413
30. B.J. Veldt, J.J. Poterucha, K.D. Watt, R.H. Wiesner, J.E. Hay, and C.B. Rosen Insulin resistance, serum adipokines and risk of fibrosis progression in patients transplanted for hepatitis C Am J Transplant 9 2009 1406 1413
31. A. Brenzel, and A.M.C. Gressner Characterization of insulin-like growth factor (IGF)-I-receptor binding sites during in vitro transformation of rat hepatic stellate cells to myofibroblasts Eur J Clin Chem Clin Biochem 34 1996 401 409
32. I.A. Leclercq, A. Da Silva Morais, B. Schroyen, N. Van Hul, and A. Geerts Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences J Hepatol 47 2007 142 156
33. G. Boden, X. Chen, J. Ruiz, J.V. White, and L. Rossetti Mechanisms of fatty acid-induced inhibition of glucose uptake J Clin Invest 93 1994 2438 2446
34. W. Jiang, Z. Zhu, and H.J. Thompson Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver Cancer Res 68 2008 5492 5499
35. A. Villanueva, D.Y. Chiang, P. Newell, J. Peix, S. Thung, and C. Alsinet Pivotal role of mTOR signaling in hepatocellular carcinoma Gastroenterology 135 2008 1972 1983
36. L. Hui, K. Zatloukal, H. Scheuch, E. Stepniak, and E.F. Wagner Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation J Clin Invest 118 2008 3943 3953
37. I.H. Cua, J.M. Hui, P. Bandara, J.G. Kench, G.C. Farrell, and G.W. McCaughan Insulin resistance and liver injury in hepatitis C is not associated with virus-specific changes in adipocytokines Hepatology 46 2007 66 73
38. H. Shimizu, S. Kakizaki, T. Tsuchiya, T. Nagamine, H. Takagi, and H. Takayama An increase of circulating leptin in patients with liver cirrhosis Int J Obes Relat Metab Disord 22 1998 1234 1238
39. J.M. Petit, A. Minello, V. Jooste, J.B. Bour, F. Galland, and L. Duvillard Decreased plasma adiponectin concentrations are closely related to steatosis in hepatitis C virus-infected patients J. Clin Endocrinol Metab 90 2005 2240 2243
40. S. Kaser, A. Moschen, A. Kaser, O. Ludwiczek, C.F. Ebenbichler, and W. Vogel Circulating adiponectin reflects severity of liver disease but not insulin sensitivity in liver cirrhosis J Intern Med 258 2005 274 280
41. H.B. El-Serag, H. Hampel, and F. Javadi The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence Clin Gastroenterol Hepatol 4 2006 369 380
42. B.J. Veldt, W. Chen, E.J. Heathcote, H. Wedemeyer, J. Reichen, and W.P. Hofmann Increased risk of hepatocellular carcinoma among patients with hepatitis C cirrhosis and diabetes mellitus Hepatology 47 2008 1856 1862