A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain

Combinatorial Chemistry and High Throughput Screening

Volumn 14, Issue 7, 2011, Pages 590-600

  Thorsen, Thor S ^a   Madsen, Kenneth L ^a   Dyhring, Tino ^b   Bach, Anders ^c   Peters, Dan ^b   Strømgaard, Kristian ^c   Rønn, Lars Christian B ^b   Gether, Ulrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NEUROSEARCH A S   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Fluorescence polarization; PDZ domains; Protein protein interactions; Small molecule inhibitors

Indexed keywords

AMPA RECEPTOR; CSC 03; CSC 04; CSC 178; CSC 43; FSC 231; FSC 240; GLUTAMATE RECEPTOR; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; LIGAND; NEW DRUG; PEPTIDE; PROTEIN INTERACTING WITH PROTEIN KINASE C; RECEPTOR SUBUNIT; SMALL MOLECULE INHIBITOR; UNCLASSIFIED DRUG;

ADDICTION; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; DRUG SCREENING; DRUG TARGETING; ESCHERICHIA COLI; FLUORESCENCE POLARIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; NEOPLASM; NEUROPATHIC PAIN; NONHUMAN; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; STROKE;

CARRIER PROTEINS; FLUORESCENCE POLARIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR WEIGHT; NUCLEAR PROTEINS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960681294     PISSN: 13862073     EISSN: 18755402     Source Type: Journal    
DOI: 10.2174/138620711796367201     Document Type: Article

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