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Volumn 12, Issue 10, 2007, Pages 1857-1871

Mitochondrial anchoring of PKCα by PICK1 confers resistance to etoposide-induced apoptosis

Author keywords

Anchoring protein; Apoptosis; PICK1; PKC ; Signal transduction

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; ETOPOSIDE; PEPTIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN INTERACTING WITH PROTEIN KINASE C; PROTEIN KINASE C ALPHA; ANTINEOPLASTIC AGENT; CARBAZOLE DERIVATIVE; CARRIER PROTEIN; ENZYME INHIBITOR; INDOLE DERIVATIVE; NUCLEAR PROTEIN; PRKCABP PROTEIN, MOUSE; SERINE; UNCLASSIFIED DRUG;

EID: 34848834834     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-007-0098-0     Document Type: Article
Times cited : (20)

References (52)
  • 1
    • 0036855463 scopus 로고    scopus 로고
    • Alpha (PKC alpha): Regulation and biological function
    • Nakashima S, Protein kinase C (2002) alpha (PKC alpha): regulation and biological function. J Biochem (Tokyo) 132:669-675
    • (2002) J Biochem (Tokyo) , vol.132 , pp. 669-675
    • Nakashima, S.1    Protein Kinase, C.2
  • 2
    • 0033605542 scopus 로고    scopus 로고
    • Imaging protein kinase Calpha activation in cells
    • Ng T, Squire A, Hansra G et al (1999) Imaging protein kinase Calpha activation in cells. Science 283:2085-2089
    • (1999) Science , vol.283 , pp. 2085-2089
    • Ng, T.1    Squire, A.2    Hansra, G.3
  • 3
    • 0040951308 scopus 로고    scopus 로고
    • Membrane targeting and cytoplasmic sequestration in the spatiotemporal localization of human protein kinase C alpha
    • Vallentin A, Prevostel C, Fauquier T, Bonnefont X, Joubert D (2000) Membrane targeting and cytoplasmic sequestration in the spatiotemporal localization of human protein kinase C alpha. J Biol Chem 275:6014-6021
    • (2000) J Biol Chem , vol.275 , pp. 6014-6021
    • Vallentin, A.1    Prevostel, C.2    Fauquier, T.3    Bonnefont, X.4    Joubert, D.5
  • 4
    • 0036006680 scopus 로고    scopus 로고
    • Protein kinase Calpha is required for endothelin-1-induced proliferation of human myometrial cells
    • Eude I, Dallot E, Ferre F, Breuiller-Fouche M (2002) Protein kinase Calpha is required for endothelin-1-induced proliferation of human myometrial cells. Biol Reprod 66:44-49
    • (2002) Biol Reprod , vol.66 , pp. 44-49
    • Eude, I.1    Dallot, E.2    Ferre, F.3    Breuiller-Fouche, M.4
  • 5
    • 0031964645 scopus 로고    scopus 로고
    • Anchoring proteins for protein kinase C: A means for isozyme selectivity
    • Mochly-Rosen D, Gordon AS (1998) Anchoring proteins for protein kinase C: a means for isozyme selectivity. FASEB J 12:35-42
    • (1998) FASEB J , vol.12 , pp. 35-42
    • Mochly-Rosen, D.1    Gordon, A.S.2
  • 6
    • 0034057863 scopus 로고    scopus 로고
    • Protein kinase C binding partners
    • Jaken S, Parker PJ (2000) Protein kinase C binding partners. Bioessays 22:245-254
    • (2000) Bioessays , vol.22 , pp. 245-254
    • Jaken, S.1    Parker, P.J.2
  • 7
    • 1542503811 scopus 로고    scopus 로고
    • PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation
    • Jiffar T, Kurinna S, Suck G et al (2004) PKC alpha mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation. Leukemia 18:505-512
    • (2004) Leukemia , vol.18 , pp. 505-512
    • Jiffar, T.1    Kurinna, S.2    Suck, G.3
  • 8
    • 0032787540 scopus 로고    scopus 로고
    • The involvement of protein kinase C isoenzymes alpha, epsilon and zeta in the sensitivity to antitumor treatment and apoptosis induction
    • Spitaler M, Wiesenhofer B, Biedermann V et al (1999) The involvement of protein kinase C isoenzymes alpha, epsilon and zeta in the sensitivity to antitumor treatment and apoptosis induction. Anticancer Res 19:3969-3976
    • (1999) Anticancer Res , vol.19 , pp. 3969-3976
    • Spitaler, M.1    Wiesenhofer, B.2    Biedermann, V.3
  • 9
    • 0027525536 scopus 로고
    • Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence
    • Nguyen M, Millar DG, Yong VW, Korsmeyer SJ, Shore GC (1993) Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence. J Biol Chem 268:25265-25268
    • (1993) J Biol Chem , vol.268 , pp. 25265-25268
    • Nguyen, M.1    Millar, D.G.2    Yong, V.W.3    Korsmeyer, S.J.4    Shore, G.C.5
  • 10
    • 0032566717 scopus 로고    scopus 로고
    • A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis
    • Ruvolo PP, Deng X, Carr BK, May WS (1998) A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. J Biol Chem 273:25436-25442
    • (1998) J Biol Chem , vol.273 , pp. 25436-25442
    • Ruvolo, P.P.1    Deng, X.2    Carr, B.K.3    May, W.S.4
  • 11
    • 0037213368 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Sensors and checkpoints for life-or-death decisions
    • Borner C (2003) The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol Immunol 39:615-647
    • (2003) Mol Immunol , vol.39 , pp. 615-647
    • Borner, C.1
  • 14
    • 0035425710 scopus 로고    scopus 로고
    • PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2
    • Perez JL, Khatri L, Chang C, Srivastava S, Osten P, Ziff EB (2001) PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2. J Neurosci 21:5417-5428
    • (2001) J Neurosci , vol.21 , pp. 5417-5428
    • Perez, J.L.1    Khatri, L.2    Chang, C.3    Srivastava, S.4    Osten, P.5    Ziff, E.B.6
  • 15
    • 0141844501 scopus 로고    scopus 로고
    • PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells
    • Wang WL, Yeh SF, Chang YI et al (2003) PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells. J Biol Chem 278:37705-37712
    • (2003) J Biol Chem , vol.278 , pp. 37705-37712
    • Wang, W.L.1    Yeh, S.F.2    Chang, Y.I.3
  • 16
    • 0028898641 scopus 로고
    • PICK1: A perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system
    • Staudinger J, Zhou J, Burgess R, Elledge SJ, Olson EN (1995) PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J Cell Biol 128:263-271
    • (1995) J Cell Biol , vol.128 , pp. 263-271
    • Staudinger, J.1    Zhou, J.2    Burgess, R.3    Elledge, S.J.4    Olson, E.N.5
  • 17
    • 0031465589 scopus 로고    scopus 로고
    • Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha
    • Staudinger J, Lu J, Olson EN (1997) Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha. J Biol Chem 272:32019-32024
    • (1997) J Biol Chem , vol.272 , pp. 32019-32024
    • Staudinger, J.1    Lu, J.2    Olson, E.N.3
  • 18
    • 10444276589 scopus 로고    scopus 로고
    • Making protein interactions druggable: Targeting PDZ domains
    • Dev KK (2004) Making protein interactions druggable: targeting PDZ domains. Nat Rev Drug Discov 3:1047-1056
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 1047-1056
    • Dev, K.K.1
  • 19
    • 0035868332 scopus 로고    scopus 로고
    • Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha- binding protein rPICK1
    • Lin WJ, Chang YF, Wang WL, Huang CY (2001) Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1. Biochem J 354:635-643
    • (2001) Biochem J , vol.354 , pp. 635-643
    • Lin, W.J.1    Chang, Y.F.2    Wang, W.L.3    Huang, C.Y.4
  • 20
    • 0034614350 scopus 로고    scopus 로고
    • Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors
    • Takeya R, Takeshige K, Sumimoto H (2000) Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors. Biochem Biophys Res Commun 267:149-155
    • (2000) Biochem Biophys Res Commun , vol.267 , pp. 149-155
    • Takeya, R.1    Takeshige, K.2    Sumimoto, H.3
  • 21
    • 0018085515 scopus 로고
    • Solid-phase peptide synthesis using mild base cleavage of N alpha-fluorenylmethyloxycarbonylamino acids, exemplified by a synthesis of dihydrosomatostatin
    • Chang CD, Meienhofer J (1978) Solid-phase peptide synthesis using mild base cleavage of N alpha-fluorenylmethyloxycarbonylamino acids, exemplified by a synthesis of dihydrosomatostatin. Int J Pept Protein Res 11:246-249
    • (1978) Int J Pept Protein Res , vol.11 , pp. 246-249
    • Chang, C.D.1    Meienhofer, J.2
  • 22
    • 0036189914 scopus 로고    scopus 로고
    • Markers of apoptosis: Methods for elucidating the mechanism of apoptotic cell death from the nervous system
    • Smyth PG, Berman SA (2002) Markers of apoptosis: methods for elucidating the mechanism of apoptotic cell death from the nervous system. Biotechniques 32:648-650, 652, 654
    • (2002) Biotechniques , vol.32 , pp. 648-650
    • Smyth, P.G.1    Berman, S.A.2
  • 23
    • 20144374482 scopus 로고    scopus 로고
    • Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
    • Madsen KL, Beuming T, Niv MY et al (2005) Molecular determinants for the complex binding specificity of the PDZ domain in PICK1. J Biol Chem 280:20539-20548
    • (2005) J Biol Chem , vol.280 , pp. 20539-20548
    • Madsen, K.L.1    Beuming, T.2    Niv, M.Y.3
  • 24
    • 0028054797 scopus 로고
    • Tat-mediated delivery of heterologous proteins into cells
    • Fawell S, Seery J, Daikh Y et al (1994) Tat-mediated delivery of heterologous proteins into cells. Proc Natl Acad Sci USA 91:664-668
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 664-668
    • Fawell, S.1    Seery, J.2    Daikh, Y.3
  • 25
    • 0027157640 scopus 로고
    • Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976
    • Martiny-Baron G, Kazanietz MG, Mischak H et al (1993) Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem 268:9194-9197
    • (1993) J Biol Chem , vol.268 , pp. 9194-9197
    • Martiny-Baron, G.1    Kazanietz, M.G.2    Mischak, H.3
  • 27
    • 14044252160 scopus 로고    scopus 로고
    • Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis
    • Sohn D, Schulze-Osthoff K, Janicke RU (2005) Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis. J Biol Chem 280:5267-5273
    • (2005) J Biol Chem , vol.280 , pp. 5267-5273
    • Sohn, D.1    Schulze-Osthoff, K.2    Janicke, R.U.3
  • 28
    • 1842739136 scopus 로고    scopus 로고
    • Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance
    • Deng X, Kornblau SM, Ruvolo PP, May WS Jr (2001) Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance. J Natl Cancer Inst Monogr 28:30-37
    • (2001) J Natl Cancer Inst Monogr , vol.28 , pp. 30-37
    • Deng, X.1    Kornblau, S.M.2    Ruvolo, P.P.3    May Jr., W.S.4
  • 29
    • 0030959304 scopus 로고    scopus 로고
    • Bcl-2 phosphorylation required for anti-apoptosis function
    • Ito T, Deng X, Carr B, May WS (1997) Bcl-2 phosphorylation required for anti-apoptosis function. J Biol Chem 272:11671-11673
    • (1997) J Biol Chem , vol.272 , pp. 11671-11673
    • Ito, T.1    Deng, X.2    Carr, B.3    May, W.S.4
  • 30
    • 9644252848 scopus 로고    scopus 로고
    • Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells
    • Romano MF, Avellino R, Petrella A, Bisogni R, Romano S, Venuta S (2004) Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells. Eur J Cancer 40:2829-2836
    • (2004) Eur J Cancer , vol.40 , pp. 2829-2836
    • Romano, M.F.1    Avellino, R.2    Petrella, A.3    Bisogni, R.4    Romano, S.5    Venuta, S.6
  • 31
    • 0036076885 scopus 로고    scopus 로고
    • Bcl-2 phosphorylation and proteasome-dependent degradation induced by paclitaxel treatment: Consequences on sensitivity of isolated mitochondria to Bid
    • Brichese L, Barboule N, Heliez C, Valette A (2002) Bcl-2 phosphorylation and proteasome-dependent degradation induced by paclitaxel treatment: consequences on sensitivity of isolated mitochondria to Bid. Exp Cell Res 278:101-111
    • (2002) Exp Cell Res , vol.278 , pp. 101-111
    • Brichese, L.1    Barboule, N.2    Heliez, C.3    Valette, A.4
  • 32
    • 0034650523 scopus 로고    scopus 로고
    • Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria
    • 2
    • Antonsson B, Montessuit S, Lauper S, Eskes R, Martinou JC (2000) Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochem J 345(2):271-278
    • (2000) Biochem J , vol.345 , pp. 271-278
    • Antonsson, B.1    Montessuit, S.2    Lauper, S.3    Eskes, R.4    Martinou, J.C.5
  • 33
    • 0035853811 scopus 로고    scopus 로고
    • Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells
    • Antonsson B, Montessuit S, Sanchez B, Martinou JC (2001) Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. J Biol Chem 276:11615-11623
    • (2001) J Biol Chem , vol.276 , pp. 11615-11623
    • Antonsson, B.1    Montessuit, S.2    Sanchez, B.3    Martinou, J.C.4
  • 34
    • 24344487343 scopus 로고    scopus 로고
    • A-kinase-anchoring proteins
    • Langeberg LK, Scott JD (2005) A-kinase-anchoring proteins. J Cell Sci 118:3217-3220
    • (2005) J Cell Sci , vol.118 , pp. 3217-3220
    • Langeberg, L.K.1    Scott, J.D.2
  • 35
    • 0037073758 scopus 로고    scopus 로고
    • Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360
    • Dell'Acqua ML, Dodge KL, Tavalin SJ, Scott JD (2002) Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360. J Biol Chem 277:48796-48802
    • (2002) J Biol Chem , vol.277 , pp. 48796-48802
    • Dell'Acqua, M.L.1    Dodge, K.L.2    Tavalin, S.J.3    Scott, J.D.4
  • 37
    • 0031865351 scopus 로고    scopus 로고
    • Bcl-2 and Bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer
    • Mahajan NP, Linder K, Berry G, Gordon GW, Heim R, Herman B (1998) Bcl-2 and Bax interactions in mitochondria probed with green fluorescent protein and fluorescence resonance energy transfer. Nat Biotechnol 16:547-552
    • (1998) Nat Biotechnol , vol.16 , pp. 547-552
    • Mahajan, N.P.1    Linder, K.2    Berry, G.3    Gordon, G.W.4    Heim, R.5    Herman, B.6
  • 38
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 40
    • 0041384326 scopus 로고    scopus 로고
    • Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity
    • Wilson-Annan J, O'Reilly LA, Crawford SA et al (2003) Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity. J Cell Biol 162:877-887
    • (2003) J Cell Biol , vol.162 , pp. 877-887
    • Wilson-Annan, J.1    O'Reilly, L.A.2    Crawford, S.A.3
  • 41
    • 0142117313 scopus 로고    scopus 로고
    • The Bcl-2 family: Roles in cell survival and oncogenesis
    • Cory S, Huang DC, Adams JM (2003) The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22:8590-8607
    • (2003) Oncogene , vol.22 , pp. 8590-8607
    • Cory, S.1    Huang, D.C.2    Adams, J.M.3
  • 42
    • 0033499801 scopus 로고    scopus 로고
    • BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
    • Yamamoto K, Ichijo H, Korsmeyer SJ (1999) BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol 19:8469-8478
    • (1999) Mol Cell Biol , vol.19 , pp. 8469-8478
    • Yamamoto, K.1    Ichijo, H.2    Korsmeyer, S.J.3
  • 43
    • 0031036307 scopus 로고    scopus 로고
    • Raf-1/bcl-2 phosphorylation: A step from microtubule damage to cell death
    • Blagosklonny MV, Giannakakou P, el-Deiry WS et al (1997) Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death. Cancer Res 57:130-135
    • (1997) Cancer Res , vol.57 , pp. 130-135
    • Blagosklonny, M.V.1    Giannakakou, P.2    El-Deiry, W.S.3
  • 44
    • 0036478989 scopus 로고    scopus 로고
    • The permeability transition pore complex: Another view
    • Halestrap AP, McStay GP, Clarke SJ (2002) The permeability transition pore complex: another view. Biochimie 84:153-166
    • (2002) Biochimie , vol.84 , pp. 153-166
    • Halestrap, A.P.1    McStay, G.P.2    Clarke, S.J.3
  • 45
    • 0035839423 scopus 로고    scopus 로고
    • Molecular determinants for PICK1 synaptic aggregation and mGluR7a receptor coclustering: Role of the PDZ, coiled-coil, and acidic domains
    • Boudin H, Craig AM (2001) Molecular determinants for PICK1 synaptic aggregation and mGluR7a receptor coclustering: role of the PDZ, coiled-coil, and acidic domains. J Biol Chem 276:30270-30276
    • (2001) J Biol Chem , vol.276 , pp. 30270-30276
    • Boudin, H.1    Craig, A.M.2
  • 46
  • 47
    • 0030604722 scopus 로고    scopus 로고
    • Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ
    • Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R (1996) Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell 85:1067-1076
    • (1996) Cell , vol.85 , pp. 1067-1076
    • Doyle, D.A.1    Lee, A.2    Lewis, J.3    Kim, E.4    Sheng, M.5    MacKinnon, R.6
  • 48
    • 10244267435 scopus 로고    scopus 로고
    • Expression levels of protein kinase C-alpha in non-small-cell lung cancer
    • Lahn M, Su C, Li S et al (2004) Expression levels of protein kinase C-alpha in non-small-cell lung cancer. Clin Lung Cancer 6:184-189
    • (2004) Clin Lung Cancer , vol.6 , pp. 184-189
    • Lahn, M.1    Su, C.2    Li, S.3
  • 49
    • 0028106219 scopus 로고
    • Evidence that protein kinase C-alpha activation is a critical event in phorbol ester-induced multiple drug resistance in human colon cancer cells
    • Gravitt KR, Ward NE, Fan D, Skibber JM, Levin B, O'Brian CA (1994) Evidence that protein kinase C-alpha activation is a critical event in phorbol ester-induced multiple drug resistance in human colon cancer cells. Biochem Pharmacol 48:375-381
    • (1994) Biochem Pharmacol , vol.48 , pp. 375-381
    • Gravitt, K.R.1    Ward, N.E.2    Fan, D.3    Skibber, J.M.4    Levin, B.5    O'Brian, C.A.6
  • 50
    • 0035354188 scopus 로고    scopus 로고
    • Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells
    • Mandil R, Ashkenazi E, Blass M et al (2001) Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells. Cancer Res 61:4612-4619
    • (2001) Cancer Res , vol.61 , pp. 4612-4619
    • Mandil, R.1    Ashkenazi, E.2    Blass, M.3
  • 51
    • 0032990503 scopus 로고    scopus 로고
    • Ribozyme inhibition of the protein kinase C alpha triggers apoptosis in glioma cells
    • Leirdal M, Sioud M (1999) Ribozyme inhibition of the protein kinase C alpha triggers apoptosis in glioma cells. Br J Cancer 80:1558-1564
    • (1999) Br J Cancer , vol.80 , pp. 1558-1564
    • Leirdal, M.1    Sioud, M.2
  • 52
    • 2442543262 scopus 로고    scopus 로고
    • The role of protein kinase C-alpha (PKC-alpha) in cancer and its modulation by the novel PKC-alpha-specific inhibitor aprinocarsen
    • Hanauske AR, Sundell K, Lahn M (2004) The role of protein kinase C-alpha (PKC-alpha) in cancer and its modulation by the novel PKC-alpha-specific inhibitor aprinocarsen. Curr Pharm Des 10:1923-1936
    • (2004) Curr Pharm des , vol.10 , pp. 1923-1936
    • Hanauske, A.R.1    Sundell, K.2    Lahn, M.3


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