Anti-neuroinflammatory activity of kamebakaurin from Isodon japonicus via inhibition of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells

Journal of Pharmacological Sciences

Volumn 116, Issue 3, 2011, Pages 296-308

  Kim, Byung Wook ^a   Koppula, Sushruta ^a   Kim, In Su ^a   Lim, Hyung Woo ^a   Hong, Sun Min ^a   Han, Sang Don ^b   Hwang, Bang Yeon ^c   Choi, Dong Kug ^a  

^a Konkuk University   (South Korea)

^b Konkuk University School of Medicine   (South Korea)

^c Chungbuk National University   (South Korea)

Author keywords

Inducible nitric oxide synthase; Kamebakaurin; Microglia; Neuroinflammation; Nitrite

Indexed keywords

CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; KAMEBAKAURIN; KAURANE DERIVATIVE; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYCLOOXYGENASE 2 GENE; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; GENE; GENE EXPRESSION REGULATION; INDUCIBLE NITRIC OXIDE SYNTHASE GENE; ISODON; ISODON JAPONICUS; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RAT;

EID: 79960422094     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.10324FP     Document Type: Article

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