Small-interfering RNA-mediated silencing of the MAPK p42 gene induces dual effects in HeLa cells

Oncology Letters

Volumn 1, Issue 4, 2010, Pages 649-655

  Yuan, Jing Yi ^a,b   Liu, Li Ying ^a   Wang, Pei ^a   Li, Zong Fang ^b   Ni, Lei ^a   Wang, Aiying ^a   Xiao, Sheng Xiang ^a,b   Song, Tu Sheng ^a   Huang, Chen ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Interferon like response; MAPK p42; RNA interference; Targeting response

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2',5' OLIGOADENYLATE SYNTHETASE; LIPOFECTAMINE; MITOGEN ACTIVATED PROTEIN KINASE 1; NUCLEOPORIN; NUCLEOPORIN 188; PROMYELOCYTIC LEUKEMIA PROTEIN; SMALL INTERFERING RNA; STAT1 PROTEIN; STAT2 PROTEIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA SYNTHESIS; UPREGULATION;

EID: 77954990732     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol_00000114     Document Type: Article

References (36)

1. Lohmann JU, Endl I and Bosch TC: Silencing of developmental genes in Hydra. Dev Biol 214: 211-214, 1999.
2. Yang D, Lu H and Erickson JW: Evidence that processed small dsRNAs may mediate sequence-specifc mRNA degradation during RNAi in Drosophila embryos. Curr Biol 10: 1191-1200, 2001.
3. Zhao Z, Cao Y, Li M, et al: A double-stranded RAN injection produces nonspecifc defects in zebrafsh. Dev Biol 229: 215-223, 2001.
4. Wianny F and Zernicka-Goetz M: Specifc interference with gene function by double-stranded RNA in early mouse development. Nat Cell Biol 2: 70-75, 2000.
5. Fire A, xu S, Montgomery MK, et al: Potent and specifc genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811, 1998.
6. Quon K and Kassner PD: RNA interference screening for the discovery of oncology targets. Expert Opin Ther Targets 13: 1027-1035, 2009.
7. Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, Rubin MA and Chinnaiyan AM: The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419: 624-629, 2002.
8. Rodríguez-Lebrón E, Gouvion CM, Moore SA, Davidson BL and Paulson HL: Allele-specifc RNAi mitigates phenotypic progression in a transgenic model of Alzheimer's disease. Mol Ther 17: 1563-1573, 2009.
9. Courties G, Presumey J, Duroux-Richard I, Jorgensen C and Apparailly F: RNA interference-based gene therapy for successful treatment of rheumatoid arthritis. Expert Opin Biol Ther 9: 535-538, 2009.
10. Pfster EL, Kennington L, Straubhaar J, Wagh S, Liu W, DiFiglia M, Landwehrmeyer B, Vonsattel JP, Zamore PD and Aronin N: Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients. Curr Biol 19: 774-778, 2009.
11. Paddison PJ, Caudy AA and Hannon GJ: Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci USA 99: 1443-1448, 2002.
12. Bridge AJ, Pebernard S, Ducraux A, Nicoulaz AL and Iggo R: Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet 34: 263-264, 2003.
13. Sledz CA, Holko M, de Veer MJ, Silverman RH and Williams BR: Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 5: 834-839, 2003.
14. Boulton TG, Nye SH, Robbins DJ, et al: ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65: 663-675, 1991.
15. Derijard B, Hibi M, Wu IH, et al: JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76: 1025-1037, 1994.
16. Han J, Lee JD, Bibbs L, et al: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811, 1994.
17. Kyriakis JM and Avruch J: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and infammation. Physiol Rev 81: 807-869, 2001.
18. Huang C, Liu LY, Song TS, et al: Small interfering RNA-mediated MAPK p42 silencing induces apoptosis of HeLa cells. Nan Fang Yi Ke Da xue xue Bao 26: 11-15, 2006.
19. Liu L, Huang C, Li Z, et al: Related genes for HeLa cell apoptosis induced by siRNA-mediated MAPK p42 silencing. Acta Med Univ Sci Technol Huazhong 37: 129-132, 2008.
20. Huang C, Liu L, Li Z, et al: Effects of small interfering RNAs targeting MAPK1 on gene expression profle in HeLa cells as revealed by microarray analysis. Cell Biol Int 32: 1081-1090, 2008.
21. Staber PB, Linkesch W, Zauner D, Beham-Schmid C, Guelly C, Schauer S, Sill H and Hoefer G: Common alterations in gene expression and increased proliferation in recurrent acute myeloid leukemia. Oncogene 23: 894-904, 2004.
22. Huang D, Ding Y, Luo WM, Bender S, Qian CN, Kort E, Zhang ZF, van den Beldt K, Duesbery NS, Resau JH and Teh BT: Inhibition of MAPK kinase signaling pathways suppressed renal cell carcinoma growth and angiogenesis in vivo. Cancer Res 68: 81-88, 2008.
23. Salh B, Marotta A, Matthewson C, Ahluwalia M, Flint J, Owen D and Pelech S: Investigation of the Mek-MAP kinase-Rsk pathway in human breast cancer. Anticancer Res 19: 731-740, 1999.
24. Steinmetz R, Wagoner HA, Zeng P, Hammond JR, Hannon TS, Meyers JL and Pescovitz OH: Mechanisms regulating the constitutive activation of the extracellular signal-regulated kinase (ERK) signaling pathway in ovarian cancer and the effect of ribonucleic acid interference for ERK1/2 on cancer cell proliferation. Mol Endocrinol 18: 2570-2582, 2004.
25. Tamemoto H, Kadowaki T, Tobe K, Ueki K, Izumi T, Chatani Y, Kohno M, Kasuga M, Yazaki Y and Akanuma Y: Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells. J Biol Chem 267: 20293-20297, 1992.
26. Bradham C and McClay DR: p38 MAPK in development and cancer. Cell Cycle 5: 824-828, 2006.
27. Parameswaran N, Nambi, P, Hall CS, Brooks DP and Spielman WS: Adrenomedullin decreases extracellular signal-regulated kinase activity through an increase in protein phosphatase-2A activity in mesangial cells. Eur J Pharmacol 388: 133-138, 2000.
28. Sen GC: Viruses and interferons. Annu Rev Microbiol 55: 255-281, 2001.
29. Saunders LR and Barber GN: The dsRNA binding protein family: critical roles, diverse cellular functions. FASEB J 17: 961-983, 2003.
30. Hovanessian AG and Justesen J: The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation. Biochimie 89: 779-788, 2007.
31. Boese A, Sommer P, Gaussin A, Reimann A and Nehrbass U: Ini1/hSNF5 is dispensable for retrovirus-induced cytoplasmic accumulation of PML and does not interfere with integration. FEBS Lett 578: 291-296, 2004.
32. Heidel JD, Hu S, Liu xF, Triche TJ and Davis ME: Lack of inter-feron response in animals to naked siRNAs. Nat Biotechnol 22: 1579-1582, 2004.
33. Sledz CA and Williams BR: RNA interference and double-stranded-RNA-activated pathways. Biochem Soc Trans 32: 952-956, 2004.
34. Lapi E, Di Agostino S, Donzelli S, Gal H, Domany E, Rechavi G, Pandolf PP, Givol D, Strano S, Lu X and Blandino G: PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop. Mol Cell 32: 803-814, 2008.
35. Youlyouz-Marfak I, Gachard N, Le Clorennec C, Najjar I, Baran-Marszak F, Reminieras L, May E, Bornkamm GW, Fagard R and Feuillard J: Identifcation of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents. Cell Death Differ 15: 376-385, 2008.
36. Negoro S, Kunisada K, Tone E, et al: Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction. Cardiovasc Res 47: 797-805, 2000.