Signal transduction by serine proteinases in astrocytes: Regulation of proliferation, morphologic changes, and survival via proteinase-activated receptors

Drug Development Research

Volumn 60, Issue 1, 2003, Pages 43-50

  Wang, Hong ^a,b   Reiser, Georg ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CNS; Neuroprotection; Proliferation; Serine proteinase; Thrombin

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; FORSKOLIN; ISOPRENALINE; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN;

ASTROCYTE; BRAIN; CELL FUNCTION; CELL MATURATION; CELL MEMBRANE; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; DRUG RECEPTOR BINDING; DRUG SCREENING; NERVE CELL PLASTICITY; NONHUMAN; PATHOPHYSIOLOGY; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION;

EID: 0042819756     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10319     Document Type: Review

References (57)

1. Araque A, Carmignoto G, Haydon PG. 2001. Dynamic signaling between astrocytes and neurons. Annu Rev Physiol 63:795-813.
2. Beaman Hall CM, Leahy JC, Benmansour S, Vallano ML. 1998. Glia modulate NMDA-mediated signaling in primary cultures of cerebellar granule cells. J Neurochem 71:1993-2005.
3. Beecher KL, Andersen TT, Fenton JW, Festoff BW. 1994. Thrombin receptor peptides induce shape change in neonatal murine astrocytes in culture. J Neurosci Res 37:108-115.
4. Cavanaugh KP, Gurwitz D, Cunningham DD, Bradshaw RA. 1990. Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1. J Neurochem 54:1735-1743.
5. Choi BH, Suzuki M, Kim T, Wagner SL, Cunningham DD. 1990. Protease nexin-1. Localization in the human brain suggests a protective role against extravasated serine proteases. Am J Pathol 137:741-747.
6. Debeir T, Gueugnon J, Vige X, Benavides J. 1996. Transduction mechanisms involved in thrombin receptor-induced nerve growth factor secretion and cell division in primary cultures of astrocytes. J Neurochem 66:2320-2328.
7. Deschepper CF, Bigornia V, Berens ME, Lapointe MC. 1991. Production of thrombin and antithrombin III by brain and astroglial cell cultures. Brain Res Mol Brain Res 11:355-358.
8. Dihanich M, Kaser M, Reinhard E, Cunningham D, Monard D. 1991. Prothrombin mRNA is expressed by cells of the nervous system. Neuron 6:575-581.
9. Donovan FM, Pike CJ, Cotman CW, Cunningham DD. 1997. Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci 17:5316-5326.
10. Donovan FM, Cunningham DD. 1998. Signaling pathways involved in thrombin-induced cell protection. J Biol Chem 273:12746-12752.
11. Ehrenreich H, Costa T, Clouse KA, Pluta RM, Ogino Y, Coligan JE, Burd PR. 1993. Thrombin is a regulator of astrocytic endothelin-1. Brain Res 600:201-207.
12. Fields RD, Stevens-Graham B. 2002. New insights into neuron-glia communication. Science 298:556-562.
13. Gingrieh MB, Traynelis SF. 2000. Serine proteases and brain damage - is there a link? Trends Neurosci 23:399-407.
14. Grabham P, Cunningham DD. 1995. Thrombin receptor activation stimulates astrocyte proliferation and reversal of stellation by distinct pathways: involvement of tyrosine phosphorylation. J Neurochem 64:583-591.
15. Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, Araoz C. 1989. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A 86:7611-7615.
16. Hernandez M, Bayon Y, Sanchez Crespo M, Nieto ML. 1997. Thrombin produces phosphorylation of cytosolic phospholipase A2 by a mitogen-activated protein kinase kinase-independent mechanism in the human astrocytoma cell Iine 1321N1. Biochem J 328:263-269.
17. 2 and the distinct transcriptional programs of astrocytoma cells. Trends Neurosci 23:259-264.
18. Hollenberg MD, Compton SJ. 2002. International Union of Pharmacology. XXVIII. Proteinase-activated receptors. Pharmacol Rev 54:203-217.
19. Jiang Y, Wu J, Hua Y, Keep RF, Xiang J, Hoff JT, Xi G. 2002. Thrombin-receptor activation and thrombin-induced brain tolerance. J Cereb Blood Flow Metab 22:404-410.
20. i mobilization in human astrocytoma cells. J Cancer Res Clin Oncol 126:91-94.
21. Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R. 2001. Proteinase-activated receptors. Pharmacol Rev 53:245-282.
22. Mahajan VB, Pai KS, Lau A, Cunningham DD. 2000. Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton. Proc Natl Acad Sci USA 97:12062-12067.
23. 12-induced cytoskeletal responses. J Biol Chem 274:26815-26821.
24. Martin DL. 1992. Synthesis and release of neuroactive substances by glial cells. Glia 5:81-94.
25. Meli R, Raso GM, Cicala C, Esposito E, Fiorino F, Cirino G. 2001. Thrombin and PAR-1 activating peptide increase iNOS expression in cytolkine-stimulated C6 glioma cells. J Neurochem 79:556-563.
26. Miller S, Sehati N, Romano C, Cotman CW. 1996. Exposure of astrocytes to thrombin reduces levels of the metabotropic glutamate receptor mGluR5. J Neurochem 67:1435-1447.
27. Neveu I, Jehan F, Jandrot Perrus M, Wion D, Brachet P. 1993. Enhancement of the synthesis and secretion of nerve growth factor in primary cultures of glial cells by proteases: a possible involvement of thrombin. J Neurochem 60:858-867.
28. Pai KS, Mahajan VB, Lau A, Cunningham DD. 2001. Thrombin receptor signaling to cytoskeleton requires Hsp90. J Biol Chem 276:32642-32647.
29. Pierce KL, Luttrell LM, Lefkowitz RJ. 2001. New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene 20:1532-1539.
30. Pike CJ, Vaughan PJ, Cunningham DD, Cotman CW. 1996. Thrombin attenuates neuronal cell death and modulates astrocyte reactivity induced by b-amyloid in vitro. J Neurochem 66:1374-1382.
31. Reinhard E, Suidan HS, Pavlik A, Monard D. 1994. Glia-derived nexin/protease nexin-1 is expressed by a subset of neurons in the rat brain. J Neurosci Res 37:256-270.
32. Ridet JL, Malhotra SK, Privat A, Gage FH. 1997. Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci 20:570-577.
33. Russo C, Dolcini V, Salis S, Venezia M, Zambrano N, Russo T, Schettini G. 2002. Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain. J Biol Chem 277:35282-35288.
34. Sawada K, Nishibori M, Nakaya N, Wang Z, Saeki K. 2000. Purification and characterization of a trypsin-like serine proteinase from rat brain slices that degrades laminin and type IV collagen and stimulates protease-activated receptor-2. J Neurochem 74:1731-1738.
35. 2+ response in rat astrocytes by endogenous arachidonic acid liberation. J Neurochem 82:1252-1261.
36. 2+ response in rat astrocytes by endogenous arachidonic acid liberation. J Neurochem 82:1252-1261.
37. 2+ influx. Cell Calcium 33:283-292.
38. Shikamoto Y, Morita T. 1999. Expression of factor X in both the rat brain and cells of the central nervous system. FEBS Lett 463:387-389.
39. Striggow F, Riek M, Breder J, Henrich Noack P, Reymann KG, Reiser G. 2000. The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations. Proc Natl Acad Sci U S A 97:2264-2269.
40. Striggow F, Riek-Burchardt M, Kiesel A, Schmidt W, Henrich-Noack P, Breder J, Krug M, Reymann KG, Reiser G. 2001. Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia. Eur J Neurosci 14:595-608
41. Sugiyama K, Brunori A, Mayer ML. 1989. Glial uptake of excitatory amino acids influences neuronal survival in cultures of mouse hippocampus. Neuroscience 32:779-791.
42. Suidan HS, Bouvier J, Schaerer E, Stone SR, Monard D, Tschopp J. 1994. Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes. Proc Natl Acad Sci USA 91:8112-8116.
43. Suidan HS, Nobes CD, Hall A, Monard D. 1997. Astrocyte spreading in response to thrombin and lysophosphatidic acid is dependent on the Rho GTPase. Glia 21:244-252.
44. Tomimatsu Y, Idemoto S, Moriguchi S, Watanabe S, Nakanishi H. 2002. Proteases involved in long-term potentiation. Life Sci 72:355-361.
45. 2+ signalling evoked by proteinase-activated receptor-1 (PAR-1) in rat astrocytes. Adv Exp Med Biol 477:323-329.
46. 2+ signalling evoked by the tethered ligand. J Physiol (Lond.) 525:319-330.
47. Vaughan PJ, Su J, Cotman CW, Cunningham DD. 1994. Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease. Brain Res 668:160-170.
48. Vaughan PJ, Pike CJ, Cotman CW, Cunningham DD. 1995. Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults. J Neurosci 15:5389-5401.
49. Verkhratsky A, Orkand RK, Kettenmann H. 1998. Glial calcium: homeostasis and signaling function. Physiol Rev 78:99-141.
50. 2+-sensitive tyrosine kinase Pyk2 and Src in thrombin signaling in rat astrocytes. J Neurochem 84:1349-1357.
51. Wang H, Reiser G. 2003b. Thrombin signalling in the brain - role of protease-activated receptors. Biol Chem 384:193-202.
52. Wang H, Ubl JJ, Reiser G. 2002a. The four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling. Glia 37:53-63.
53. Wang H, Ubl JJ, Stricker R, Reiser G. 2002b. Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways. Am J Physiol Cell Physiol 283:C1351-1364.
54. Xi G, Hua Y, Keep RF, Duong HK, Hoff JT 2001. Activation of p44/42 mitogen activated protein kinases in thrombin-induced brain tolerance. Brain Res 895:153-159.
55. Xi G, Reiser G, Keep RF. 2003. The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective? J Neurochem 84:3-9.
56. Zieger M, Tausch S, Henklein P, Nowak G, Kaufmann R. 2001. A novel PAR-1-Type thrombin receptor signaling pathway: cyclic AMP-independent activation of PKA in SNB-19 glioblastoma cells. Biochem Biophys Res Commun 282:952-957.
57. Zonta M, Angulo MC, Gobbo S, Rosengarten B, Hossmann KA, Pozzan T, Carmignoto G. 2003. Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat Neurosci 6:43-50.