Trk receptor inhibition induces apoptosis of proliferating but not quiescent human osteoblasts

Cancer Research

Volumn 62, Issue 4, 2002, Pages 986-989

  Pinski, Jacek ^a   Weeraratna, Ashani ^a   Uzgare, Aarti R ^a   Arnold, Julia T ^a   Denmeade, Samuel R ^a   Isaacs, John T ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; CEP 701; CEP 751; NEUROTROPHIN; NEUROTROPHIN 3; TYROSINE KINASE RECEPTOR; VIRUS LARGE T ANTIGEN;

APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; BONE METASTASIS; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; OSTEOBLAST; PARACRINE SIGNALING; PRIORITY JOURNAL; PROSTATE CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARBAZOLES; CELL DIVISION; CELL SURVIVAL; ENZYME INHIBITORS; HUMANS; MALE; OSTEOBLASTS; PROSTATIC NEOPLASMS; RECEPTOR, TRKA;

EID: 0036174319     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Cancer Statistics 2001
2. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma
3. Pathophysiologic interactions in skeletal metastasis
4. 1 checkpoint control induced by co-culture of prostate cancer cells with osteoblasts
5. Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo
6. Heparin binding affinity of rat prostate growth factor in normal and cancerous prostate: Partial purification and characterization of rat prostate growth factor in Dunning tumor
7. Effects of basic fibroblast growth factor on bone formation in vitro
8. Characterization and autoregulation of latent TGF-β complexes in osteoblast-like cell lines: Production of a latent complex lacking the latent TGF-β-binding protein (LTBP)
9. Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: Inactivation of PTH-rP stimulated cAMP accumulation in mouse osteoblasts
10. The effects of the endothelin family peptides on cultured osteoblastic cells from rat calvariae
11. Rational basis for trk inhibition therapy for prostate cancer
12. Expression of nerve growth factor family neuritrophins in mouse osteoblastic cell line
13. Expression of trkC in a mouse osteoblastic cell line and its response to neurotrophin-3
14. Anti-apoptotic action of nerve growth factor in mouse osteoblastic cell line
15. Development and characterization of a conditionally immortalized human fetal osteoblastic cell line
16. Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587)
17. CEP-751 inhibits trk receptor tyrosine kinase activity in vitro and exhibits anti-tumor activity
18. Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555)
19. Pan-trk inhibition decreases metastasis and enhances host survival in experimental models due to its selective induction of apoptosis of prostate cancer cells