Molecular features crucial to the activity of pyrimidine benzamide-based thrombopoietin receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 9, 2008, Pages 3000-3006

  Reiter, Lawrence A ^a   Jones, Christopher S ^a   Brissette, William H ^a   McCurdy, Sandra P ^a   Abramov, Yuriy A ^a   Bordner, Jon ^a   DiCapua, Frank M ^a   Munchhof, Michael J ^a   Rescek, Diane M ^a   Samardjiev, Ivan J ^a   Withka, Jane M ^a  

^a PFIZER INC   (United States)

Author keywords

Nuclear Overhauser effects; Thrombopoietin agonist; X ray crystal structure

Indexed keywords

BENZAMIDE DERIVATIVE; CYTOKINE RECEPTOR AGONIST; PYRIMIDINE BENZAMIDE; THROMBOPOIETIN RECEPTOR AGONIST;

ARTICLE; CONFORMATION; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BENZAMIDES; CELL LINE; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN CONFORMATION; PYRIMIDINES; RECEPTORS, THROMBOPOIETIN; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOPOIETIN;

EID: 43049181695     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.052     Document Type: Article

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