메뉴 건너뛰기




Volumn 14, Issue 4, 2011, Pages 308-317

Silymarin, a promising pharmacological agent for treatment of diseases

Author keywords

Antioxidant; Cancer; Liver; Medicinal plant; Silymarin

Indexed keywords

ALCOHOL; ALPHA AMANITIN; AMIODARONE; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CARBON TETRACHLORIDE; CASPASE 3; CELL NUCLEUS RECEPTOR; CISPLATIN; CYTOCHROME C; DAUNORUBICIN; DOXORUBICIN; ESTROGEN RECEPTOR; GALACTOSAMINE; GLYCOPROTEIN P; LIVERGOL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARACETAMOL; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SILIBININ; SILIBININ PHOSPHATIDYLCHOLINE COMPLEX; SILIDIANIN; SILYBUM MARIANUM EXTRACT; SILYMARIN; SUPEROXIDE DISMUTASE; THALLIUM; THIOACETAMIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VINBLASTINE;

EID: 79960182676     PISSN: 20083866     EISSN: 20083874     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (258)

References (60)
  • 1
    • 33744971866 scopus 로고    scopus 로고
    • Silybin and Silymarin - New effects and applications
    • Kren V, Walterova D. Silybin and Silymarin - New effects and applications. Biomed Papers 2005; 149:29-41.
    • (2005) Biomed Papers , vol.149 , pp. 29-41
    • Kren, V.1    Walterova, D.2
  • 3
    • 27444438669 scopus 로고    scopus 로고
    • Silymarin treatment of viral hepatitis: A systematic review
    • Mayer KE, Mayer RP, Lee SS. Silymarin treatment of viral hepatitis: a systematic review. J Viral Hepatitis 2005; 12:559-567.
    • (2005) J Viral Hepatitis , vol.12 , pp. 559-567
    • Mayer, K.E.1    Mayer, R.P.2    Lee, S.S.3
  • 6
    • 35348879054 scopus 로고    scopus 로고
    • Silymarin and epithelial cancer chemoprevention: How close we are to bedside?
    • Kaur M, Agarwal R. Silymarin and epithelial cancer chemoprevention: How close we are to bedside? Toxicol Appl Pharm 2007; 224:350-359.
    • (2007) Toxicol Appl Pharm , vol.224 , pp. 350-359
    • Kaur, M.1    Agarwal, R.2
  • 8
    • 62549116131 scopus 로고    scopus 로고
    • Differential effects of silymarin and its active component silybinin on plasma membrane stability and hepatocellular lysis
    • Basiglio CL, Sanchez Pozzi EJ, Mottino AD, Roma MG. Differential effects of silymarin and its active component silybinin on plasma membrane stability and hepatocellular lysis. Chem Biol Interact 2009; 179:297-303.
    • (2009) Chem Biol Interact , vol.179 , pp. 297-303
    • Basiglio, C.L.1    Sanchez, P.E.J.2    Mottino, A.D.3    Roma, M.G.4
  • 9
    • 33847265733 scopus 로고    scopus 로고
    • Silybin and silymarin - New and emerging applications in medicine
    • Gazak R, Walterova D, Kren V. Silybin and silymarin - New and emerging applications in medicine. Curr Med Chem 2007; 14:315-338.
    • (2007) Curr Med Chem , vol.14 , pp. 315-338
    • Gazak, R.1    Walterova, D.2    Kren, V.3
  • 10
    • 57949097025 scopus 로고    scopus 로고
    • Drug-drug interactions of silymarin on the perspective of pharmacokinetics
    • WenWu J, Lin L, Tsai T. Drug-drug interactions of silymarin on the perspective of pharmacokinetics. J Ethnopharmacol 2009; 121:185-193.
    • (2009) J Ethnopharmacol , vol.121 , pp. 185-193
    • Wenwu, J.1    Lin, L.2    Tsai, T.3
  • 12
    • 34548510607 scopus 로고    scopus 로고
    • Silymarin, the antioxidant component of silybum marianum, protects against burn-induced oxidative skin injury
    • Toklu HZ, Tunali-Akbay T, Erkanli G, Yuksel M, Ercan F, Sener G. Silymarin, the antioxidant component of silybum marianum, protects against burn-induced oxidative skin injury. Burns 2007; 33:908-916.
    • (2007) Burns , vol.33 , pp. 908-916
    • Toklu, H.Z.1    Tunali-Akbay, T.2    Erkanli, G.3    Yuksel, M.4    Ercan, F.5    Sener, G.6
  • 13
    • 48449086178 scopus 로고    scopus 로고
    • Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals
    • Eminzade S, Uraz F, Izzettin FV. Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals. Nutr Metab 2008; 5.
    • (2008) Nutr Metab , pp. 5
    • Eminzade, S.1    Uraz, F.2    Izzettin, F.V.3
  • 14
    • 14844320063 scopus 로고    scopus 로고
    • Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation
    • Katiyar SK, Roy AM, Baliga MS. Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation. Mol Cancer Ther 2005; 4:207-216.
    • (2005) Mol Cancer Ther , vol.4 , pp. 207-216
    • Katiyar, S.K.1    Roy, A.M.2    Baliga, M.S.3
  • 15
    • 76749084248 scopus 로고    scopus 로고
    • Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage
    • Shaker E, Mahmoud H, Mnaa S. Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage. Food Chem Toxicol 2010; 48:803-6.
    • (2010) Food Chem Toxicol , vol.48 , pp. 803-806
    • Shaker, E.1    Mahmoud, H.2    Mnaa, S.3
  • 16
    • 75149191891 scopus 로고    scopus 로고
    • Silymarin inhibits in vitro tcell proliferation and cytokine production in hepatitis c virus infection
    • Morishima C, Shuhart MC, Wang CC, Paschal DM, Apodaca MC, Liu Y, et al. Silymarin inhibits in vitro tcell proliferation and cytokine production in hepatitis c virus infection. Gastroenterology 2010; 138:671-681.
    • (2010) Gastroenterology , vol.138 , pp. 671-681
    • Morishima, C.1    Shuhart, M.C.2    Wang, C.C.3    Paschal, D.M.4    Apodaca, M.C.5    Liu, Y.6
  • 17
    • 36649022057 scopus 로고    scopus 로고
    • Silymarin prevents palmitate-induced lipotoxicity in HepG2 cells: Involvement of maintenance of Akt kinase activation
    • Song Z, Song M, Lee DYW, Liu Y, Deaciuc IV, McClain CJ. Silymarin prevents palmitate-induced lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activation. Basic Clin Pharmacol Toxicol 2007; 101:262-8.
    • (2007) Basic Clin Pharmacol Toxicol , vol.101 , pp. 262-268
    • Song, Z.1    Song, M.2    Lee, D.Y.W.3    Liu, Y.4    Deaciuc, I.V.5    McClain, C.J.6
  • 18
    • 76749084248 scopus 로고    scopus 로고
    • Silymarin, the antioxidant component and silybum marianum extracts prevent liver damage
    • Shaker E, Mahmoud H, Mnaa S. Silymarin, the antioxidant component and silybum marianum extracts prevent liver damage. Food Chem Toxicol 2010; 48:803-806.
    • (2010) Food Chem Toxicol , vol.48 , pp. 803-806
    • Shaker, E.1    Mahmoud, H.2    Mnaa, S.3
  • 19
    • 77952878550 scopus 로고    scopus 로고
    • Involvement of multiple molecular events in pyrogallol-induced hepatotoxicity and silymarin-mediated protection: Evidence from gene expression profiles
    • Upadhyay G, Tiwari MN, Prakash O, Jyoti A, Shanker R, Singh MP. Involvement of multiple molecular events in pyrogallol-induced hepatotoxicity and silymarin-mediated protection: Evidence from gene expression profiles. Food Chem Toxicol 2010; 48:1660-1670.
    • (2010) Food Chem Toxicol , vol.48 , pp. 1660-1670
    • Upadhyay, G.1    Tiwari, M.N.2    Prakash, O.3    Jyoti, A.4    Shanker, R.5    Singh, M.P.6
  • 20
    • 34247583381 scopus 로고    scopus 로고
    • Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized silymarin
    • Polyak SJ, Morishima C, Shuhart MC. Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized silymarin. Gastroenterology 2007; 132:1925-1936.
    • (2007) Gastroenterology , vol.132 , pp. 1925-1936
    • Polyak, S.J.1    Morishima, C.2    Shuhart, M.C.3
  • 21
    • 77449092252 scopus 로고    scopus 로고
    • Silybinin and related compounds are direct inhibitors of hepatitis c virus rna-dependent rna polymerase
    • Ahmed-Belkacem A, Ahnou N, Barbotte L, Wychowski C, Pallier C, Brillet R, et al. Silybinin and related compounds are direct inhibitors of hepatitis c virus rna-dependent rna polymerase. Gastroenterology 2010; 138:1112-1122.
    • (2010) Gastroenterology , vol.138 , pp. 1112-1122
    • Ahmed-Belkacem, A.1    Ahnou, N.2    Barbotte, L.3    Wychowski, C.4    Pallier, C.5    Brillet, R.6
  • 22
    • 54349084283 scopus 로고    scopus 로고
    • Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: Role of multidrug resistance-associated protein 2 (Abcc2)
    • Miranda SR, Jin KL, Brouwer KLR, Wen Z, Smith PC, Hawke RL. Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: Role of multidrug resistance-associated protein 2 (Abcc2). Drug Metab Dispos 2008; 36:2219-2226.
    • (2008) Drug Metab Dispos , vol.36 , pp. 2219-2226
    • Miranda, S.R.1    Jin, K.L.2    Brouwer, K.L.R.3    Wen, Z.4    Smith, P.C.5    Hawke, R.L.6
  • 23
    • 36248991330 scopus 로고    scopus 로고
    • Silymarin: An effective hepatoprotective agent against diethylnitrosamine- induced hepatotoxicity in rats
    • Pradeep K, Mohan CVR, Gobianand K, Karthikeyan S. Silymarin: An effective hepatoprotective agent against diethylnitrosamine- induced hepatotoxicity in rats. Pharm Biol 2007; 45:707-714.
    • (2007) Pharm Biol , vol.45 , pp. 707-714
    • Pradeep, K.1    Mohan, C.V.R.2    Gobianand, K.3    Karthikeyan, S.4
  • 24
    • 33947282103 scopus 로고    scopus 로고
    • Herbal medicine in the treatment of liver diseases
    • Stickel F, Schuppan D. Herbal medicine in the treatment of liver diseases. Digest Liver Dis 2007; 39:293-304.
    • (2007) Digest Liver Dis , vol.39 , pp. 293-304
    • Stickel, F.1    Schuppan, D.2
  • 25
    • 34247583381 scopus 로고    scopus 로고
    • Inhibition of T-cell inflammatory cytokines, hepatocyte NF-B signaling, and HCV infection by standardized silymarin
    • Polyak SJ, Morishima C, Shuhart MC, Wang CC, Liu Y, Lee DYW. Inhibition of T-cell inflammatory cytokines, hepatocyte NF-B signaling, and HCV infection by standardized silymarin. Gastroenterol 2007; 132:1925-1936.
    • (2007) Gastroenterol , vol.132 , pp. 1925-1936
    • Polyak, S.J.1    Morishima, C.2    Shuhart, M.C.3    Wang, C.C.4    Liu, Y.5    Lee, D.Y.W.6
  • 26
    • 0035211762 scopus 로고    scopus 로고
    • The use of silymarin in the treatment of liver diseases
    • Saller R, Meier R, Brignoli R. The use of silymarin in the treatment of liver diseases. Drugs 2001; 61:2035-2063.
    • (2001) Drugs , vol.61 , pp. 2035-2063
    • Saller, R.1    Meier, R.2    Brignoli, R.3
  • 27
    • 3242786628 scopus 로고    scopus 로고
    • Synergistic anti- cancer effects of silybinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinomaMCF-7 and MDAMB468 cells
    • Tyagi AK, Agarwal C, Chan DC, Agarwal R. Synergistic anti- cancer effects of silybinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinomaMCF-7 and MDAMB468 cells. Oncol Rep 2004a; 11:493-499.
    • (2004) Oncol Rep , vol.11 , pp. 493-499
    • Tyagi, A.K.1    Agarwal, C.2    Chan, D.C.3    Agarwal, R.4
  • 28
    • 4544287556 scopus 로고    scopus 로고
    • Silybinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages
    • Tyagi A, Agarwal C, Harrison G, Glode L M, Agarwal R. Silybinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages. Carcinogenesis 2004b; 25:1711-1720.
    • (2004) Carcinogenesis , vol.25 , pp. 1711-1720
    • Tyagi, A.1    Agarwal, C.2    Harrison, G.3    Glode, L.M.4    Agarwal, R.5
  • 29
    • 3142765979 scopus 로고    scopus 로고
    • Silybinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2
    • Chu SC, Chiou HL, Chen PN, Yang SF, Hsieh YS. Silybinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Mol Carcinog 2004; 40:143-149.
    • (2004) Mol Carcinog , vol.40 , pp. 143-149
    • Chu, S.C.1    Chiou, H.L.2    Chen, P.N.3    Yang, S.F.4    Hsieh, Y.S.5
  • 30
    • 0033082440 scopus 로고    scopus 로고
    • A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in the SENCAR mouse skin tumorigenesis model
    • Lahiri-Chatterjee M, Katiyar SK, Mohan RR, Agarwal R. A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in the SENCAR mouse skin tumorigenesis model. Cancer Res 1999; 59:622-632.
    • (1999) Cancer Res , vol.59 , pp. 622-632
    • Lahiri-Chatterjee, M.1    Katiyar, S.K.2    Mohan, R.R.3    Agarwal, R.4
  • 31
    • 33244472101 scopus 로고    scopus 로고
    • Silymarin and silybinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: A comparison of flavanone silybinin with flavanolignan mixture silymarin
    • Deep G, Singh RP, Agarwal C, Kroll DJ, Agarwal R. Silymarin and silybinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silybinin with flavanolignan mixture silymarin. Oncogene 2006; 25:1053-1069.
    • (2006) Oncogene , vol.25 , pp. 1053-1069
    • Deep, G.1    Singh, R.P.2    Agarwal, C.3    Kroll, D.J.4    Agarwal, R.5
  • 32
    • 2642583226 scopus 로고    scopus 로고
    • Silybinin down-regulates prostate epithelium-derived Ets transcription factor in LNCaP prostate cancer cells
    • Thelen P, Jarry H, Ringert RH, Wuttke W. Silybinin down-regulates prostate epithelium-derived Ets transcription factor in LNCaP prostate cancer cells. Planta Med 2004; 70:397-400.
    • (2004) Planta Med , vol.70 , pp. 397-400
    • Thelen, P.1    Jarry, H.2    Ringert, R.H.3    Wuttke, W.4
  • 33
    • 33745002041 scopus 로고    scopus 로고
    • Prostate cancer chemoprevention by silybinin: Bench to bedside
    • Rana P, Agarwal S, Agarwal R. Prostate cancer chemoprevention by silybinin: bench to bedside. Mol Carcinog 2006; 45:436-442
    • (2006) Mol Carcinog , vol.45 , pp. 436-442
    • Rana, P.1    Agarwal, S.2    Agarwal, R.3
  • 35
    • 0344827261 scopus 로고    scopus 로고
    • Silybinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells
    • Agarwal C, Singh RP, Dhanalakshmi S, Tyagi AK, Tecklenburg M, Sclafani RA, et al. Silybinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene 2003; 22: 8271-8282.
    • (2003) Oncogene , vol.22 , pp. 8271-8282
    • Agarwal, C.1    Singh, R.P.2    Dhanalakshmi, S.3    Tyagi, A.K.4    Tecklenburg, M.5    Sclafani, R.A.6
  • 36
    • 35348956057 scopus 로고    scopus 로고
    • Silymarin enhanced cytotoxic effect of anti-Fas agonistic antibody CH11 on A375-S2 cells
    • Li LH, Wu LJ, Jiang YY, Tashiro S, Onodera S, Uchiumi F, et al. Silymarin enhanced cytotoxic effect of anti-Fas agonistic antibody CH11 on A375-S2 cells. J Asian Nat Prod Res 2007; 9:593-602.
    • (2007) J Asian Nat Prod Res , vol.9 , pp. 593-602
    • Li, L.H.1    Wu, L.J.2    Jiang, Y.Y.3    Tashiro, S.4    Onodera, S.5    Uchiumi, F.6
  • 37
    • 51349164386 scopus 로고    scopus 로고
    • Multitargeted therapy of cancer by silymarin
    • Ramasamy K, Agarwal R. Multitargeted therapy of cancer by silymarin. Cancer Lett 2008; 352-362
    • (2008) Cancer Lett , pp. 352-362
    • Ramasamy, K.1    Agarwal, R.2
  • 38
    • 34248169275 scopus 로고    scopus 로고
    • Effect of silymarin on Nnitrosodiethylamine induced hepatocarcinogenesis in rats
    • Ramakrishnan G, Augustine TA, Jagan S, Vinodhkumar R, Devaki T. Effect of silymarin on Nnitrosodiethylamine induced hepatocarcinogenesis in rats. Exp Oncol 2007; 29:39-44.
    • (2007) Exp Oncol , vol.29 , pp. 39-44
    • Ramakrishnan, G.1    Augustine, T.A.2    Jagan, S.3    Vinodhkumar, R.4    Devaki, T.5
  • 39
    • 0035691617 scopus 로고    scopus 로고
    • The mechanism of alloxan and streptozocin action in B cells of the rat pancreas
    • Szkudelski T. The mechanism of alloxan and streptozocin action in B cells of the rat pancreas. Physiol Res 2001; 50:536-546.
    • (2001) Physiol Res , vol.50 , pp. 536-546
    • Szkudelski, T.1
  • 41
    • 4344675511 scopus 로고    scopus 로고
    • Silymarin induces recovery of pancreatic function after alloxan damage in rats
    • Soto C, Mena R, Luna J, Cerbón M, Larrieta E, Vital P, et al. Silymarin induces recovery of pancreatic function after alloxan damage in rats. Life Sci 2004; 75:2167-2180.
    • (2004) Life Sci , vol.75 , pp. 2167-2180
    • Soto, C.1    Mena, R.2    Luna, J.3    Cerbón, M.4    Larrieta, E.5    Vital, P.6
  • 42
    • 78149406055 scopus 로고    scopus 로고
    • Effect of silymarin on kidneys of rats suffering from alloxan-induced diabetes mellitus
    • Soto C, Pérez J, García V, Uría E, Vadillo M, Raya L. Effect of silymarin on kidneys of rats suffering from alloxan-induced diabetes mellitus. Phytomedicine 2010; 17:1090-1094.
    • (2010) Phytomedicine , vol.17 , pp. 1090-1094
    • Soto, C.1    Pérez, J.2    García, V.3    Uría, E.4    Vadillo, M.5    Raya, L.6
  • 44
    • 24344479620 scopus 로고    scopus 로고
    • Cisplatin nephrotoxicity and protection by milk thistle extract in rats
    • Karimi G, Ramezani M, Tahoonian Z. Cisplatin nephrotoxicity and protection by milk thistle extract in rats. Evid Based Complment Alternat 2005; 2:383-386.
    • (2005) Evid Based Complment Alternat , vol.2 , pp. 383-386
    • Karimi, G.1    Ramezani, M.2    Tahoonian, Z.3
  • 45
    • 20444450147 scopus 로고    scopus 로고
    • Protective effect of silybum marianum (l.) gaertn. seeds extract and silymarin against cisplatin-induced acute nephrotoxicity in rats
    • Karimi G, Fallah Huseini H, Ramezani M, Tahoonian Z. Protective effect of silybum marianum (l.) gaertn. seeds extract and silymarin against cisplatin-induced acute nephrotoxicity in rats. J Med Plants 2005; 4:42-45.
    • (2005) J Med Plants , vol.4 , pp. 42-45
    • Karimi, G.1    Fallah, H.H.2    Ramezani, M.3    Tahoonian, Z.4
  • 46
    • 77956058430 scopus 로고    scopus 로고
    • Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumor promotion response
    • Kaur G, Athar M, Alam MS. Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumor promotion response. Invest New Drugs 2010; 28:703-13.
    • (2010) Invest New Drugs , vol.28 , pp. 703-713
    • Kaur, G.1    Athar, M.2    Alam, M.S.3
  • 48
    • 69549089774 scopus 로고    scopus 로고
    • Effect of silymarin on biochemical parameters of oxidative stress in aged and young rat brain
    • Galhardi F, Mesquita K, Monserrat JM, Barros DM. Effect of silymarin on biochemical parameters of oxidative stress in aged and young rat brain. Food Chem Toxicol 2009; 47:2655-60.
    • (2009) Food Chem Toxicol , vol.47 , pp. 2655-2660
    • Galhardi, F.1    Mesquita, K.2    Monserrat, J.M.3    Barros, D.M.4
  • 49
    • 33846345425 scopus 로고    scopus 로고
    • Protective effect of silymarin on oxidative stress in rat brain
    • Nencini C, Giorgi G, Micheli L. Protective effect of silymarin on oxidative stress in rat brain. Phytomedicine 2007; 14:129-135.
    • (2007) Phytomedicine , vol.14 , pp. 129-135
    • Nencini, C.1    Giorgi, G.2    Micheli, L.3
  • 50
    • 0034456207 scopus 로고    scopus 로고
    • Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems
    • Davies K J. Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems. IUBMB Life 2000; 50:279-289.
    • (2000) IUBMB Life , vol.50 , pp. 279-289
    • Davies, K.J.1
  • 51
    • 0001573631 scopus 로고    scopus 로고
    • Reactive oxygen species and reactive nitrogen species: Relevance to cyto(neuro)toxicity events and neurological disorders
    • Metodiewa D, Koska C. Reactive oxygen species and reactive nitrogen species: relevance to cyto(neuro)toxicity events and neurological disorders. Neurotox Res 2000; 1:197-233.
    • (2000) Neurotox Res , vol.1 , pp. 197-233
    • Metodiewa, D.1    Koska, C.2
  • 52
    • 77954956439 scopus 로고    scopus 로고
    • Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: Involvement of estrogen receptors and oxidative stress
    • Baluchnejadmojarad T, Roghani M, Mafakheri M. Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: involvement of estrogen receptors and oxidative stress. Neurosci Lett 2010; 480:206-210.
    • (2010) Neurosci Lett , vol.480 , pp. 206-210
    • Baluchnejadmojarad, T.1    Roghani, M.2    Mafakheri, M.3
  • 53
    • 42249107665 scopus 로고    scopus 로고
    • Evaluation of antidepressant effect of ethanolic and aqueous extracts of Silybum marianum L. seed in mice
    • Karimi G, Saradeghi Keisari M. Evaluation of antidepressant effect of ethanolic and aqueous extracts of Silybum marianum L. seed in mice. J Med Plants 2007; 6:38-43.
    • (2007) J Med Plants , vol.6 , pp. 38-43
    • Karimi, G.1    Saradeghi, K.M.2
  • 54
    • 77950626596 scopus 로고    scopus 로고
    • Silymarin suppress CD4+ T cell activation and proliferation: Effects on NFκ-B activity and IL-2 production
    • Gharagozloo M, Velardi E, Bruscoli S, Agostini M, Di Sante M, Donato V, et al. Silymarin suppress CD4+ T cell activation and proliferation: Effects on NFκ-B activity and IL-2 production. Pharmacol Res 2010; 61:405-409.
    • (2010) Pharmacol Res , vol.61 , pp. 405-409
    • Gharagozloo, M.1    Velardi, E.2    Bruscoli, S.3    Agostini, M.4    di Sante, M.5    Donato, V.6
  • 55
    • 0036661901 scopus 로고    scopus 로고
    • Silymarin effect in the pancreas of alloxan-induced diabetes mellitus in the rat
    • Soto PC, Sánchez RM, Uría CE, Favari PL. Silymarin effect in the pancreas of alloxan-induced diabetes mellitus in the rat. Rev Mex Cien Farm 2002; 33:5-10.
    • (2002) Rev Mex Cien Farm , vol.33 , pp. 5-10
    • Soto, P.C.1    Sánchez, R.M.2    Uría, C.E.3    Favari, P.L.4
  • 57
    • 33845323358 scopus 로고    scopus 로고
    • Protective effects of Silymarin against free radical-induced erythrocyte lysis
    • Karimi GH, Hassanzadeh M, Mehri S. Protective effects of Silymarin against free radical-induced erythrocyte lysis. J Alternat Complement Med 2006; 3.
    • (2006) J Alternat Complement Med , pp. 3
    • Karimi, G.H.1    Hassanzadeh, M.2    Mehri, S.3
  • 58
    • 4043174109 scopus 로고    scopus 로고
    • Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. part III. apigenin, baicalelin, kaempherol, luteolin and quercetin
    • Psotová J, Chlopčíková S, Miketová P, Hrbáč J, Šimánek V. Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. part III. apigenin, baicalelin, kaempherol, luteolin and quercetin. Phytother Res 2004; 18:516-521.
    • (2004) Phytother Res , vol.18 , pp. 516-521
    • Psotová, J.1    Chlopčíková, S.2    Miketová, P.3    Hrbáč, J.4    Šimánek, V.5
  • 59
    • 73449128972 scopus 로고    scopus 로고
    • Evidences for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats
    • El-Shitany NA, Hegazy S, El-desoky K. Evidences for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats. Phytomedicine 2010; 17:116-125.
    • (2010) Phytomedicine , vol.17 , pp. 116-125
    • El-Shitany, N.A.1    Hegazy, S.2    El-Desoky, K.3
  • 60
    • 77955269962 scopus 로고    scopus 로고
    • Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes-an in vitro study
    • Kiruthiga PV, Pandian SK, Devi KP. Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes-an in vitro study. Toxicol Appl Pharmacol 2010; 247:116-128.
    • (2010) Toxicol Appl Pharmacol , vol.247 , pp. 116-128
    • Kiruthiga, P.V.1    Pandian, S.K.2    Devi, K.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.