Protective effect of Silybum marianum (L.) Gaertn. seeds extract and silymarin against cisplatin-induced acute nephrotoxicity in rats

Journal of Medicinal Plants

Volumn 4, Issue SUPPL. 1, 2005, Pages 42-45

  Karimi, G H ^a,c   Fallah Huseini, H ^b   Ramezani, M ^a   Tahoonian, Z ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Institute of Medicinal Plants Iran   (Iran)

^c Biotechnology Section   (Iran)

Author keywords

Cisplatin; Renal toxicity; Silybum marianum; Silymarin

Indexed keywords

CISPLATIN; CREATININE; METHANOL; NITROGEN; SILYBUM MARIANUM EXTRACT; SILYMARIN; UREA;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; KIDNEY TUBULE NECROSIS; NEPHROTOXICITY; NONHUMAN; PLANT SEED; RAT; RENAL PROTECTION; UREA NITROGEN BLOOD LEVEL;

ANIMALIA; RATTUS NORVEGICUS; SILYBUM MARIANUM;

EID: 20444450147     PISSN: 2717204X     EISSN: 27172058     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Rozeneweing M, Van Hoff D, Slavil M and Maggia FM. Cis- Diaminedichloroplatinum, a new anticancer agent. Ann. Int. Med. 1977; 86: 803-809.
2. Winston JA and Safirstein R. Reduced renal flow in early cisplatin-induced acute renal failure in the rat. Am. Physiol. 1985; 249: F490-F496.
3. Sugihara K, Nakano S, Koda M, Tanaka K, Fukuishi N and Gemba M. Stimulatory effect of cisplatin on production of lipid peroxidation in renal tissues. Jpn. J. Pharmacol. 1987; 43: 247-252.
4. Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem. Pharmacol. 1983; 32: 1141-1148.
5. Mora A, Paya M, Rios J and Alcaraz M. Structure activity relationships of polymetoxyflavones and other flavonoids as inhibitors of non-enzymatic lipid peroxidation. Biochem. Pharmacol. 1990; 40: 793-794.
6. DerMarderosian. A The Review of Natural Product. Fact and Comparison, St. Louis. 2001, pp: 405-409.
7. Fleming T. PDR for Herbal Medicines. Medical Economic Company. New Jersy. 2000, pp: 516-518.
8. McClatchey KD. Clinical laboratory medicine. Williams and Wilkins, London. 1994, pp: 376-378.
9. Hammersen F. Histology. Urban and Schwarzenberg, Munich. 1985, pp: 1-4.
10. Matsushima H, Yonemara K, Ohishi K and Hishida A. The role of oxygen free radicals in cisplatin induced acute renal failure in rats. J. Lab. Clin. Med. 1998; 131: 518-526.
11. Gaedeke J, Fels LM, Bokemeyer C, Mengs U, Stolte H, Lentzen H. Cisplatin nephrotoxicity and protection by silibinin. Nephrol. Dial. Transplant. 1996; 11: 55-62.
12. Heidman HT, Gerkens JF, Jackson EK, Branch RA. Attenuation of cisplatin induced nephrotoxicity in the rat by high salt diet, furosemide and acetazolamide. Arch. Pharmacol. 1985; 329: 201-205.
13. Rao M and Rao MM. Protective effects of selenomethionine against cisplatin-induced renal toxicity in mice and rats. J. Pharm. Pharmacol. 1992; 50: 687-691.
14. Jones TW, Chopra S, Kaufman JS, Flamenbaum W and Trump B. Cis-diammine-dichloroplatinium-induced acute renal failure in the rat. Lab. Invest. 1985; 52: 363-374.
15. Rubanyi GM and Vanhoutte PM. Superoxide anions and hypoxia inactivate endothelium derived relaxing factor. Am. J. Physiol. 1986; 250: H822-H827.