Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1 H,3 H)-dione: Synthesis, molecular modeling, and pharmacological and biostructural characterization

Journal of Medicinal Chemistry

Volumn 54, Issue 13, 2011, Pages 4793-4805

  Venskutonytè, Raminta ^a   Butini, Stefania ^a,b   Sanna Coccone, Salvatore ^a,b   Gemma, Sandra ^a,b   Brindisi, Margherita ^a,b   Kumar, Vinod ^a,b   Guarino, Egeria ^a,b   Maramai, Samuele ^a,b   Valenti, Salvatore ^a,b   Amir, Ahmad ^a   Valadés, Elena Antón ^a   Frydenvang, Karla ^a   Kastrup, Jette S ^a   Novellino, Ettore ^a,b   Campiani, Giuseppe ^a,b   Pickering, Darryl S ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2' AMINO 2' CARBOXYETHYL) 1,2,3,4,5,6,7,8 OCTAHYDROBENZO[4,5]THIENO[2,3 D]PYRIMIDIN 2,4 DIONE; 1 (2' AMINO 2' CARBOXYETHYL) 3 [(2 CARBOXYTHIEN 3 YL)METHYL]THIENO[3,2 D]PYRIMIDIN 2,4 DIONE; 1 (2' AMINO 2' CARBOXYETHYL) 3 [(2 CARBOXYTHIEN 3 YL)METHYL]THIENO[3,4 D]PYRIMIDIN 2,4 DIONE; 1 (2' AMINO 2' CARBOXYETHYL)THIENO[2,3 D]PYRIMIDIN 2,4 DIONE; 1 (2' AMINO 2' CARBOXYETHYL)THIENO[3,4 D]PYRIMIDIN 2,4 DIONE; 1 [2' AMINO 2' CARBOXYETHYL] 3 [(2 PHOSPHONOTHIEN 3 YL)METHYL]THIENO[3,2 D]PYRIMIDIN 2,4 DIONE; 1 [2' AMINO 2' CARBOXYETHYL] 3 [(2 PHOSPHONOTHIEN 3 YL)METHYL]THIENO[3,4 D]PYRIMIDIN 2,4 DIONE; KAINIC ACID RECEPTOR; KAINIC ACID RECEPTOR AGONIST; KAINIC ACID RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG SYNTHESIS; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; RAT; X RAY CRYSTALLOGRAPHY;

ANIMALS; CELL LINE; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; FEMALE; LIGANDS; MODELS, MOLECULAR; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; PYRIMIDINES; RATS; RECEPTORS, KAINIC ACID; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; XENOPUS LAEVIS;

EID: 79960174808     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2004078     Document Type: Article

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