Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole α1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia

Journal of Medicinal Chemistry

Volumn 44, Issue 12, 2001, Pages 1971-1985

  Meyer, M D ^a   Altenbach, R J ^a   Bai, H ^a   Basha, F Z ^a   Carroll, W A ^a   Kerwin Jr , J F ^a   Lebold, S A ^a   Lee, E ^a   Pratt, J K ^a   Sippy, K B ^a   Tietje, K ^a   Wendt, M D ^a   Brune, M E ^a   Buckner, S A ^a   Hancock, A A ^a   Drizin, I ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; CARBON; HEXAHYDROBENZ[E]ISOINDOLE DERIVATIVE; ISOINDOLE DERIVATIVE; RADIOLIGAND; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG DETERMINATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; LIGAND BINDING; PROSTATE HYPERTROPHY; STRUCTURE ACTIVITY RELATION;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CELL LINE; DOGS; DOXAZOSIN; DRUG DESIGN; HUMANS; INDICATORS AND REAGENTS; INDOLES; L CELLS (CELL LINE); MALE; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PRAZOSIN; PROSTATE; PROSTATIC HYPERPLASIA; QUINAZOLINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; RECOMBINANT PROTEINS; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS;

EID: 0035821588     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000541z     Document Type: Article

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