Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7- quinoxaline-2,3-diones: α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor agonists and antagonists

Journal of Medicinal Chemistry

Volumn 39, Issue 22, 1996, Pages 4430-4438

  Sun, Guoping ^a   Uretsky, Norman J ^b   Wallace, Lane J ^b   Shams, Gamal ^b   Weinstein, David M ^b   Miller, Duane D ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2' AMINO 2' CARBOXYETHYL) 1,4 DIHYDRO 6,7 QUINOXALINE 2,3 DIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR AGONIST; AMPA RECEPTOR ANTAGONIST; ISOXAZOLE DERIVATIVE; KAINIC ACID; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CENTRAL NERVOUS SYSTEM; CHIRALITY; DOPAMINERGIC TRANSMISSION; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENANTIOMER; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEUS ACCUMBENS; STEREOCHEMISTRY;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BRAIN; KAINIC ACID; NOREPINEPHRINE; QUINOXALINES; RATS; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID;

EID: 0029916027     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950632+     Document Type: Article

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