3-Hydroxypyridazine 1-oxides as carboxylate bioisosteres: A new series of subtype-selective AMPA receptor agonists

Neuropharmacology

Volumn 51, Issue 1, 2006, Pages 52-59

  Greenwood, Jeremy R ^a,b   Mewett, Ken N ^b   Allan, Robin D ^b   Martín, Belén Ortiz ^a   Pickering, Darryl S ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b University of Sydney   (Australia)

Author keywords

Bioisostere; Electrophysiology; Glutamate receptor; Molecular modelling; Radioligand binding; Willardiine

Indexed keywords

5 FLUOROWILLARDIINE; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; AZAWILLARDIINE; CARBOXYLIC ACID DERIVATIVE; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR 3; GLUTAMATE RECEPTOR 4; GLUTAMIC ACID DERIVATIVE; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG; WILLARDIINE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; ISOMER; MALE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; XENOPUS LAEVIS;

ALANINE; ANIMALS; CARBOXYLIC ACIDS; CEREBRAL CORTEX; CLONING, MOLECULAR; CYCLIC N-OXIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; MODELS, MOLECULAR; MOLECULAR MIMICRY; OOCYTES; PYRIDAZINES; PYRIMIDINONES; RADIOLIGAND ASSAY; RATS; RECEPTORS, AMPA; RECEPTORS, GLUTAMATE; RECOMBINANT PROTEINS; RNA, COMPLEMENTARY; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL; XENOPUS LAEVIS;

EID: 33745209653     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.02.013     Document Type: Article

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