Inactivation of tesA reduces cell wall lipid production and increases drug susceptibility in mycobacteria

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 24616-24625

  Chavadi, Sivagami Sundaram ^a   Edupuganti, Uthamaphani R ^a   Vergnolle, Olivia ^a   Fatima, Itrat ^a   Singh, Shaneen M ^a   Soll, Clifford E ^b   Quadri, Luis E N ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC THERAPY; CELL WALL LAYERS; CELL WALL LIPIDS; DELETION MUTANTS; DRUG SUSCEPTIBILITY; GLYCOLIPIDS; GROWTH YIELD; HUMAN PATHOGENS; MYCOBACTERIAL; MYCOBACTERIAL CELLS; MYCOBACTERIAL INFECTION; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; POLYKETIDES; ROBUST MODELS; THIOESTERASES; THREE-DIMENSIONAL STRUCTURE; TYPE II; WILD TYPES;

ANTIBIOTICS; BIOCHEMISTRY; BIOSYNTHESIS; DRUG THERAPY; KETONES; PATHOGENS; PHENOLS; THREE DIMENSIONAL;

LIPIDS;

ALANINE; AMPICILLIN; CEFUROXIME; CIPROFLOXACIN; DOXYCYCLINE; KANAMYCIN; LIPID; PHENOLIC GLYCOLIPID; PHTHIOCEROL DIMYCOCEROSATE; POLYKETIDE SYNTHASE; RIFAMPICIN; SERINE; STREPTOMYCIN; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM MUTANT; CONTROLLED STUDY; ENZYME INACTIVATION; ENZYME STRUCTURE; GENE DELETION; LIPOGENESIS; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM; MYCOBACTERIUM MARINUM; NONHUMAN; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; STRAIN DIFFERENCE; WILD TYPE;

ANTI-BACTERIAL AGENTS; CELL WALL; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; FATTY ACID SYNTHETASE COMPLEX; GENE DELETION; GLYCOLIPIDS; HUMANS; LIPIDS; MYCOBACTERIUM; MYCOBACTERIUM INFECTIONS; THIOLESTER HYDROLASES;

CORYNEBACTERINEAE; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM MARINUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 79960120382     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.247601     Document Type: Article

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