Cooperation between a coenzyme A-independent stand-alone initiation module and an iterative type I polyketide synthase during synthesis of mycobacterial phenolic glycolipids

Journal of the American Chemical Society

Volumn 131, Issue 46, 2009, Pages 16744-16750

  He, Weiguo ^a,c   Soll, Clifford E ^b   Chavadi, Sivagami Sundaram ^a   Zhang, Guangtao ^a   Warren, J David ^a   Quadri, Luis E N ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL CHAIN LENGTHS; BIOSYNTHETIC PATHWAY; CATALYTIC CYCLES; COENZYME A; GLYCOLIPIDS; HOST-PATHOGEN INTERACTIONS; IN-VITRO; MECHANISTIC PROPERTIES; MYCOBACTERIAL; MYCOBACTERIAL INFECTION; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS STRAINS; NATURAL PRODUCTS; POLYKETIDE SYNTHASES; RELAXED CONTROL; SMALL MOLECULES; STAND -ALONE; VIRULENCE FACTORS;

BIOCHEMISTRY; BIOSYNTHESIS; ENZYMES; FLUORINE CONTAINING POLYMERS; LIPIDS; PATHOGENS; PHENOLS;

PLANTS (BOTANY);

ALKANOIC ACID; ALKYL GROUP; COENZYME A; FADD22 PROTEIN; HYDROXYBENZOIC ACID DERIVATIVE; LONG CHAIN P HYDROXYPHENYLALKANOATE; PHENOLIC GLYCOLIPID; POLYKETIDE SYNTHASE; TYPE I POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; LIPOGENESIS; MYCOBACTERIUM MARINUM; NONHUMAN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

COENZYME A; FATTY ACIDS; GLYCOLIPIDS; MYCOBACTERIUM MARINUM; PHENOLS; POLYKETIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY;

EID: 70450183804     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja904792q     Document Type: Article

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