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Volumn 77, Issue 6, 2010, Pages 1005-1015

PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ADENYLATE CYCLASE; G PROTEIN ALPHA 12; G PROTEIN ALPHA 13; G PROTEIN ALPHA 14; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INOSITOL PHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PERTUSSIS TOXIN; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SERINE PROTEINASE; UNCLASSIFIED DRUG;

EID: 77952391929     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.062018     Document Type: Article
Times cited : (59)

References (47)
  • 2
    • 34247511554 scopus 로고    scopus 로고
    • i1 protein complex measured by bioluminescence resonance energy transfer in living cells
    • DOI 10.1124/mol.106.030304
    • Ayoub MA, Maurel D, Binet V, Fink M, Prézeau L, Ansanay H, and Pin JP (2007) Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells. Mol Pharmacol 71:1329-1340. (Pubitemid 46658686)
    • (2007) Molecular Pharmacology , vol.71 , Issue.5 , pp. 1329-1340
    • Ayoub, M.A.1    Maurel, D.2    Binet, V.3    Fink, M.4    Prezeau, L.5    Ansanay, H.6    Pin, J.-P.7
  • 3
    • 0033668989 scopus 로고    scopus 로고
    • Extracellular mutations of protease-activated receptor-1 result in differential activation by thrombin and thrombin receptor agonist peptide
    • Blackhart BD, Ruslim-Litrus L, Lu CC, Alves VL, Teng W, Scarborough RM, Reynolds EE, and Oksenberg D (2000) Extracellular mutations of protease-activated receptor-1 result in differential activation by thrombin and thrombin receptor agonist peptide. Mol Pharmacol 58:1178-1187.
    • (2000) Mol Pharmacol , vol.58 , pp. 1178-1187
    • Blackhart, B.D.1    Ruslim-Litrus, L.2    Lu, C.C.3    Alves, V.L.4    Teng, W.5    Scarborough, R.M.6    Reynolds, E.E.7    Oksenberg, D.8
  • 4
    • 0347364629 scopus 로고    scopus 로고
    • Gi protein activation in intact cells involves subunit rearrangement rather than dissociation
    • Bünemann M, Frank M, and Lohse MJ (2003) Gi protein activation in intact cells involves subunit rearrangement rather than dissociation. Proc Natl Acad Sci USA 100:16077-16082.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 16077-16082
    • Bünemann, M.1    Frank, M.2    Lohse, M.J.3
  • 6
    • 28344436780 scopus 로고    scopus 로고
    • Protease-activated receptors in hemostasis, thrombosis and vascular biology
    • DOI 10.1111/j.1538-7836.2005.01377.x
    • Coughlin SR (2005) Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 3:1800-1814. (Pubitemid 41716567)
    • (2005) Journal of Thrombosis and Haemostasis , vol.3 , Issue.8 , pp. 1800-1814
    • Coughlin, S.R.1
  • 7
    • 0023189259 scopus 로고
    • Further characterization of the slow muscarinic responses in Xenopus oocytes
    • Dascal N and Cohen S (1987) Further characterization of the slow muscarinic responses in Xenopus oocytes. Pflugers Arch 409:512-520. (Pubitemid 17112352)
    • (1987) Pflugers Archiv European Journal of Physiology , vol.409 , Issue.4-5 , pp. 512-520
    • Dascal, N.1    Cohen, S.2
  • 8
    • 0034689003 scopus 로고    scopus 로고
    • Beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2
    • DeFea KA, Zalevsky J, Thoma MS, Déry O, Mullins RD, and Bunnett NW (2000) Beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol 148:1267-1281.
    • (2000) J Cell Biol , vol.148 , pp. 1267-1281
    • DeFea, K.A.1    Zalevsky, J.2    Thoma, M.S.3    Déry, O.4    Mullins, R.D.5    Bunnett, N.W.6
  • 9
    • 0031744875 scopus 로고    scopus 로고
    • Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases
    • Déry O, Corvera CU, Steinhoff M, and Bunnett NW (1998) Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am J Physiol 274:C1429-C1452.
    • (1998) Am J Physiol , vol.274
    • Déry, O.1    Corvera, C.U.2    Steinhoff, M.3    Bunnett, N.W.4
  • 11
    • 0033017879 scopus 로고    scopus 로고
    • Stimulation of the extracellular signal-regulated kinase 1/2 pathway by human beta-3 adrenergic receptor: New pharmacological profile and mechanism of activation
    • Gerhardt CC, Gros J, Strosberg AD, and Issad T (1999) Stimulation of the extracellular signal-regulated kinase 1/2 pathway by human beta-3 adrenergic receptor: new pharmacological profile and mechanism of activation. Mol Pharmacol 55:255-262.
    • (1999) Mol Pharmacol , vol.55 , pp. 255-262
    • Gerhardt, C.C.1    Gros, J.2    Strosberg, A.D.3    Issad, T.4
  • 12
    • 4344635685 scopus 로고    scopus 로고
    • Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling
    • Hains MD, Siderovski DP, and Harden TK (2004) Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling. Methods Enzymol 389:71-88.
    • (2004) Methods Enzymol , vol.389 , pp. 71-88
    • Hains, M.D.1    Siderovski, D.P.2    Harden, T.K.3
  • 13
    • 33745143631 scopus 로고    scopus 로고
    • Galpha12/13- and rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors
    • Hains MD, Wing MR, Maddileti S, Siderovski DP, and Harden TK (2006) Galpha12/13- and rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors. Mol Pharmacol 69:2068-2075.
    • (2006) Mol Pharmacol , vol.69 , pp. 2068-2075
    • Hains, M.D.1    Wing, M.R.2    Maddileti, S.3    Siderovski, D.P.4    Harden, T.K.5
  • 14
    • 64249152749 scopus 로고    scopus 로고
    • Protease-activated receptor 1-dependent neuronal damage involves NMDA receptor function
    • Hamill CE, Mannaioni G, Lyuboslavsky P, Sastre AA, and Traynelis SF (2009) Protease-activated receptor 1-dependent neuronal damage involves NMDA receptor function. Exp Neurol 217:136-146.
    • (2009) Exp Neurol , vol.217 , pp. 136-146
    • Hamill, C.E.1    Mannaioni, G.2    Lyuboslavsky, P.3    Sastre, A.A.4    Traynelis, S.F.5
  • 16
    • 0026782001 scopus 로고
    • The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase
    • Hung DT, Wong YH, Vu TK, and Coughlin SR (1992) The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase. J Biol Chem 267:20831-20834.
    • (1992) J Biol Chem , vol.267 , pp. 20831-20834
    • Hung, D.T.1    Wong, Y.H.2    Vu, T.K.3    Coughlin, S.R.4
  • 18
    • 1542344841 scopus 로고    scopus 로고
    • Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins
    • Kelley GG, Reks SE, and Smrcka AV (2004) Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins. Biochem J 378:129-139.
    • (2004) Biochem J , vol.378 , pp. 129-139
    • Kelley, G.G.1    Reks, S.E.2    Smrcka, A.V.3
  • 19
    • 0033593667 scopus 로고    scopus 로고
    • 13 results in shape change and Rho/Rho-kinase- Mediated myosin light chain phosphorylation in mouse platelets
    • DOI 10.1083/jcb.144.4.745
    • Klages B, Brandt U, Simon MI, Schultz G, and Offermanns S (1999) Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 144:745-754. (Pubitemid 29234552)
    • (1999) Journal of Cell Biology , vol.144 , Issue.4 , pp. 745-754
    • Klages, B.1    Brandt, U.2    Simon, M.I.3    Schultz, G.4    Offermanns, S.5
  • 20
    • 0029036494 scopus 로고
    • Differential activation of cytosolic phospholipase A2 (cPLA2) by thrombin and thrombin receptor agonist peptide in human platelets. Evidence for activation of cPLA2 independent of the mitogen-activated protein kinases ERK1/2
    • Kramer RM, Roberts EF, Hyslop PA, Utterback BG, Hui KY, and Jakubowski JA (1995) Differential activation of cytosolic phospholipase A2 (cPLA2) by thrombin and thrombin receptor agonist peptide in human platelets. Evidence for activation of cPLA2 independent of the mitogen-activated protein kinases ERK1/2. J Biol Chem 270:14816-14823.
    • (1995) J Biol Chem , vol.270 , pp. 14816-14823
    • Kramer, R.M.1    Roberts, E.F.2    Hyslop, P.A.3    Utterback, B.G.4    Hui, K.Y.5    Jakubowski, J.A.6
  • 21
    • 15744364175 scopus 로고    scopus 로고
    • The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA
    • Lutz S, Freichel-Blomquist A, Yang Y, Rümenapp U, Jakobs KH, Schmidt M, and Wieland T (2005) The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA. J Biol Chem 280:11134-11139.
    • (2005) J Biol Chem , vol.280 , pp. 11134-11139
    • Lutz, S.1    Freichel-Blomquist, A.2    Yang, Y.3    Rümenapp, U.4    Jakobs, K.H.5    Schmidt, M.6    Wieland, T.7
  • 24
    • 21644449969 scopus 로고    scopus 로고
    • Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1
    • McLaughlin JN, Shen L, Holinstat M, Brooks JD, Dibenedetto E, and Hamm HE (2005) Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. J Biol Chem 280:25048-25059.
    • (2005) J Biol Chem , vol.280 , pp. 25048-25059
    • McLaughlin, J.N.1    Shen, L.2    Holinstat, M.3    Brooks, J.D.4    Dibenedetto, E.5    Hamm, H.E.6
  • 25
    • 45449115620 scopus 로고    scopus 로고
    • S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses
    • Means CK, Miyamoto S, Chun J, and Brown JH (2008) S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. J Biol Chem 283:11954-11963.
    • (2008) J Biol Chem , vol.283 , pp. 11954-11963
    • Means, C.K.1    Miyamoto, S.2    Chun, J.3    Brown, J.H.4
  • 28
    • 58149103867 scopus 로고    scopus 로고
    • Antagonistic regulation of neurite morphology through Gq/G11 and G12/G13
    • Nürnberg A, Braüer AU, Wettschureck N, and Offermanns S (2008) Antagonistic regulation of neurite morphology through Gq/G11 and G12/G13. J Biol Chem 283:35526-35531.
    • (2008) J Biol Chem , vol.283 , pp. 35526-35531
    • Nürnberg, A.1    Braüer, A.U.2    Wettschureck, N.3    Offermanns, S.4
  • 30
    • 0028179510 scopus 로고
    • G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets
    • Offermanns S, Laugwitz KL, Spicher K, and Schultz G (1994) G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. Proc Natl Acad Sci USA 91:504-508.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 504-508
    • Offermanns, S.1    Laugwitz, K.L.2    Spicher, K.3    Schultz, G.4
  • 31
    • 0030605209 scopus 로고    scopus 로고
    • Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells
    • Ogino Y, Tanaka K, and Shimizu N (1996) Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells. Eur J Pharmacol 316:105-109.
    • (1996) Eur J Pharmacol , vol.316 , pp. 105-109
    • Ogino, Y.1    Tanaka, K.2    Shimizu, N.3
  • 32
    • 34247877612 scopus 로고    scopus 로고
    • Proteinase-activated receptors 1 and 2 in rat olfactory system: Layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons
    • Olianas MC, Dedoni S, and Onali P (2007) Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons. Neuroscience 146:1289-1301.
    • (2007) Neuroscience , vol.146 , pp. 1289-1301
    • Olianas, M.C.1    Dedoni, S.2    Onali, P.3
  • 33
    • 0021931758 scopus 로고
    • Inositol 1,4,5-trisphosphate mimics muscarinic response in Xenopus oocytes
    • Oron Y, Dascal N, Nadler E, and Lupu M (1985) Inositol 1,4,5-trisphosphate mimics muscarinic response in Xenopus oocytes. Nature 313:141-143.
    • (1985) Nature , vol.313 , pp. 141-143
    • Oron, Y.1    Dascal, N.2    Nadler, E.3    Lupu, M.4
  • 34
    • 1642279517 scopus 로고    scopus 로고
    • Protease-activated receptors: Contribution to physiology and disease
    • Ossovskaya VS and BunnettNW(2004) Protease-activated receptors: contribution to physiology and disease. Physiol Rev 84:579-621.
    • (2004) Physiol Rev , vol.84 , pp. 579-621
    • Ossovskaya, V.S.1    Bunnett, N.W.2
  • 35
    • 0034175489 scopus 로고    scopus 로고
    • Thrombomodulin as a new marker of lesion-induced astrogliosis: Involvement of thrombin through the G-protein-coupled protease-activated receptor-1
    • Pindon A, Berry M, and Hantaï D (2000) Thrombomodulin as a new marker of lesion-induced astrogliosis: involvement of thrombin through the G-protein-coupled protease-activated receptor-1. J Neurosci 20:2543-2550.
    • (2000) J Neurosci , vol.20 , pp. 2543-2550
    • Pindon, A.1    Berry, M.2    Hantaï, D.3
  • 36
    • 0029990852 scopus 로고    scopus 로고
    • Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells
    • Post GR, Collins LR, Kennedy ED, Moskowitz SA, Aragay AM, Goldstein D, and Brown JH (1996) Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells. Mol Biol Cell 7:1679-1690.
    • (1996) Mol Biol Cell , vol.7 , pp. 1679-1690
    • Post, G.R.1    Collins, L.R.2    Kennedy, E.D.3    Moskowitz, S.A.4    Aragay, A.M.5    Goldstein, D.6    Brown, J.H.7
  • 37
    • 70349324342 scopus 로고    scopus 로고
    • Agonist-biased signaling via proteinase activated receptor-2: Differential activation of calcium and mitogen-activated protein kinase pathways
    • Ramachandran R, Mihara K, Mathur M, Rochdi MD, Bouvier M, Defea K, and Hollenberg MD (2009) Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways. Mol Pharmacol 76:791-801.
    • (2009) Mol Pharmacol , vol.76 , pp. 791-801
    • Ramachandran, R.1    Mihara, K.2    Mathur, M.3    Rochdi, M.D.4    Bouvier, M.5    Defea, K.6    Hollenberg, M.D.7
  • 39
    • 33645223519 scopus 로고    scopus 로고
    • Role of the PAR1 receptor 8th helix in signaling: The 7-8-1 receptor activation mechanism
    • Swift S, Leger AJ, Talavera J, Zhang L, Bohm A, and Kuliopulos A (2006) Role of the PAR1 receptor 8th helix in signaling: the 7-8-1 receptor activation mechanism. J Biol Chem 281:4109-4116.
    • (2006) J Biol Chem , vol.281 , pp. 4109-4116
    • Swift, S.1    Leger, A.J.2    Talavera, J.3    Zhang, L.4    Bohm, A.5    Kuliopulos, A.6
  • 40
    • 34247141459 scopus 로고    scopus 로고
    • Protease-activated receptor signaling: New roles and regulatory mechanisms
    • Traynelis SF and Trejo J (2007) Protease-activated receptor signaling: new roles and regulatory mechanisms. Curr Opin Hematol 14:230-235.
    • (2007) Curr Opin Hematol , vol.14 , pp. 230-235
    • Traynelis, S.F.1    Trejo, J.2
  • 41
    • 53749092612 scopus 로고    scopus 로고
    • Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines
    • Vandell AG, Larson N, Laxmikanthan G, Panos M, Blaber SI, Blaber M, and Scarisbrick IA (2008) Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines. J Neurochem 107:855-870.
    • (2008) J Neurochem , vol.107 , pp. 855-870
    • Vandell, A.G.1    Larson, N.2    Laxmikanthan, G.3    Panos, M.4    Blaber, S.I.5    Blaber, M.6    Scarisbrick, I.A.7
  • 43
    • 0031002654 scopus 로고    scopus 로고
    • The thrombin receptor second cytoplasmic loop confers coupling to Gq-like G proteins in chimeric receptors. Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors
    • Verrall S, Ishii M, Chen M, Wang L, Tram T, and Coughlin SR (1997) The thrombin receptor second cytoplasmic loop confers coupling to Gq-like G proteins in chimeric receptors. Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors. J Biol Chem 272:6898-6902.
    • (1997) J Biol Chem , vol.272 , pp. 6898-6902
    • Verrall, S.1    Ishii, M.2    Chen, M.3    Wang, L.4    Tram, T.5    Coughlin, S.R.6
  • 44
    • 34247545661 scopus 로고    scopus 로고
    • PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis
    • Voss B, McLaughlin JN, Holinstat M, Zent R, and Hamm HE (2007) PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis. Mol Pharmacol 71:1399-1406.
    • (2007) Mol Pharmacol , vol.71 , pp. 1399-1406
    • Voss, B.1    McLaughlin, J.N.2    Holinstat, M.3    Zent, R.4    Hamm, H.E.5
  • 45
    • 0026035523 scopus 로고
    • Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    • Vu TK, Hung DT, Wheaton VI, and Coughlin SR (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64:1057-1068.
    • (1991) Cell , vol.64 , pp. 1057-1068
    • Vu, T.K.1    Hung, D.T.2    Wheaton, V.I.3    Coughlin, S.R.4
  • 46
    • 0036838021 scopus 로고    scopus 로고
    • Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways
    • Wang H, Ubl JJ, Stricker R, and Reiser G (2002) Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways. Am J Physiol Cell Physiol 283:C1351-C1364.
    • (2002) Am J Physiol Cell Physiol , vol.283
    • Wang, H.1    Ubl, J.J.2    Stricker, R.3    Reiser, G.4


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