PTP1B inhibitors: Synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 8, 2008, Pages 2719-2724

  Holmes, Christopher P ^a   Li, Xianfeng ^a   Pan, Yijun ^a   Xu, Caiding ^a   Bhandari, Ashok ^a   Moody, Claire M ^a   Miguel, Joy A ^a   Ferla, Steven W ^a   De Francisco, M Nuria ^a   Frederick, Brian T ^a   Zhou, Siqun ^a   Macher, Natalie ^a   Jang, Larry ^a   Irvine, Jennifer D ^a   Grove, J Russell ^a  

^a AFFYMAX RESEARCH INSTITUTE   (United States)

Author keywords

Bioisostere; Phosphatase; PTP1B; Sulfonamide

Indexed keywords

DIFLUOROMETHYLENEPHOSPHONATE; MOLECULAR SCAFFOLD; PHOSPHONIC ACID DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS;

ENZYME INHIBITORS; FLUORINE COMPOUNDS; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 41849149691     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.007     Document Type: Article

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