메뉴 건너뛰기




Volumn 1, Issue 11, 2010, Pages 1124-1131

Regulation of G1 cell cycle progression: Distinguishing the restriction point from a nutrient-sensing cell growth checkpoint(s)

Author keywords

Cancer; Cell cycle; Cyclins; Mtor; Quiescence; Rb; Restriction point; Start; Tgf

Indexed keywords

GROWTH FACTOR; MAMMALIAN TARGET OF RAPAMYCIN;

EID: 79960048104     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601910392989     Document Type: Review
Times cited : (197)

References (83)
  • 1
    • 0034455671 scopus 로고    scopus 로고
    • Cell cycle control and cancer
    • Sherr CJ. Cell cycle control and cancer. Harvey Lect. 2000-2001;96:73-92.
    • (2000) Harvey Lect. , vol.96 , pp. 73-92
    • Sherr, C.J.1
  • 2
    • 77950882445 scopus 로고    scopus 로고
    • PRb and control of the cell cycle clock
    • New York: Garland Science
    • Weinberg RA. pRb and control of the cell cycle clock. In: The biology of cancer. New York: Garland Science; 2007. p. 255-307.
    • (2007) The Biology of Cancer , pp. 255-307
    • Weinberg, R.A.1
  • 3
    • 0036467506 scopus 로고    scopus 로고
    • Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes
    • Ho A, Dowdy SF. Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes. Curr Opin Genet Dev. 2002;12:47-52.
    • (2002) Curr Opin Genet Dev. , vol.12 , pp. 47-52
    • Ho, A.1    Dowdy, S.F.2
  • 5
    • 0034469509 scopus 로고    scopus 로고
    • Transforming growth factor-ß and breast cancer: Cell cycle arrest by transforming growth factor-ß and its disruption in cancer
    • Donovan J, Slingerland J. Transforming growth factor-ß and breast cancer: cell cycle arrest by transforming growth factor-ß and its disruption in cancer. Breast Cancer Res. 2000;2:116-24.
    • (2000) Breast Cancer Res. , vol.2 , pp. 116-124
    • Donovan, J.1    Slingerland, J.2
  • 6
    • 79960047535 scopus 로고    scopus 로고
    • Regulating the eukaryotic cell cycle
    • 6th ed. New York: WH Freeman
    • Lodish H, Berk A, Kaiser CA. Regulating the eukaryotic cell cycle. In: Molecular cell biology. 6th ed. New York: WH Freeman; 2007. p. 853-98.
    • (2007) Molecular Cell Biology , pp. 853-898
    • Lodish, H.1    Berk, A.2    Kaiser, C.A.3
  • 7
    • 0003418645 scopus 로고
    • A restriction point for control of normal animal cell proliferation
    • Pardee AB. A restriction point for control of normal animal cell proliferation. Proc Natl Acad Sci U S A. 1974;71:1286-90.
    • (1974) Proc Natl Acad Sci USA. , vol.71 , pp. 1286-1290
    • Pardee, A.B.1
  • 10
    • 0036118368 scopus 로고    scopus 로고
    • Enumeration of the simian virus 40 early region elements necessary for human cell transformation
    • Hahn WC, Dessain SK, Brooks MW, et al. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol. 2002;22:2111-23.
    • (2002) Mol Cell Biol. , vol.22 , pp. 2111-2123
    • Hahn, W.C.1    Dessain, S.K.2    Brooks, M.W.3
  • 12
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr CJ, McCormick F. The RB and p53 pathways in cancer. Cancer Cell. 2002;2:103-12.
    • (2002) Cancer Cell. , vol.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 13
    • 41549090369 scopus 로고    scopus 로고
    • Multiple pathways regulated by the tumor suppressor PP2A in transformation
    • Westermarck J, Hahn WC. Multiple pathways regulated by the tumor suppressor PP2A in transformation. Trends Mol Med. 2008;14:152-60.
    • (2008) Trends Mol Med. , vol.14 , pp. 152-160
    • Westermarck, J.1    Hahn, W.C.2
  • 14
    • 0034671578 scopus 로고    scopus 로고
    • TGF-ß inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest
    • Petritsch C, Beug H, Balmain A, Oft M. TGF-ß inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest. Genes Dev. 2000;14:3093-101.
    • (2000) Genes Dev. , vol.14 , pp. 3093-3101
    • Petritsch, C.1    Beug, H.2    Balmain, A.3    Oft, M.4
  • 15
    • 22544450728 scopus 로고    scopus 로고
    • Transformation of human and murine fibroblasts without viral oncoproteins
    • Boehm JS, Hession MT, Bulmer SE, Hahn WC. Transformation of human and murine fibroblasts without viral oncoproteins. Mol Cell Biol. 2005;25:6464-74.
    • (2005) Mol Cell Biol. , vol.25 , pp. 6464-6474
    • Boehm, J.S.1    Hession, M.T.2    Bulmer, S.E.3    Hahn, W.C.4
  • 16
    • 0033618410 scopus 로고    scopus 로고
    • Multiple ras effector pathways contribute to G(1) cell cycle progression
    • Gille H, Downward J. Multiple ras effector pathways contribute to G(1) cell cycle progression. J Biol Chem. 1999;274:22033-40.
    • (1999) J Biol Chem. , vol.274 , pp. 22033-22040
    • Gille, H.1    Downward, J.2
  • 17
    • 0032541671 scopus 로고    scopus 로고
    • Cell cycle targets of Ras/Raf signalling
    • Kerkhoff E, Rapp UR. Cell cycle targets of Ras/Raf signalling. Oncogene. 1998;17:1457-62.
    • (1998) Oncogene , vol.17 , pp. 1457-1462
    • Kerkhoff, E.1    Rapp, U.R.2
  • 18
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: Variations on a theme
    • Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene. 2008;27:5497-510.
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 19
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007;129:1261-74.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 20
    • 44449161481 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex: A molecular switchboard controlling cell growth
    • Huang J, Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J. 2008;412:179-90.
    • (2008) Biochem J. , vol.412 , pp. 179-190
    • Huang, J.1    Manning, B.D.2
  • 21
    • 59749090661 scopus 로고    scopus 로고
    • Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor
    • Avruch J, Long X, Lin Y, et al. Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor. Biochem Soc Trans. 2009;37:223-6.
    • (2009) Biochem Soc Trans. , vol.37 , pp. 223-226
    • Avruch, J.1    Long, X.2    Lin, Y.3
  • 22
    • 46149098447 scopus 로고    scopus 로고
    • Phospholipase D1 is an effector of Rheb in the mTOR pathway
    • Sun Y, Fang Y, Yoon MS, et al. Phospholipase D1 is an effector of Rheb in the mTOR pathway. Proc Natl Acad Sci U S A. 2008;105:8286-91.
    • (2008) Proc Natl Acad Sci USA. , vol.105 , pp. 8286-8291
    • Sun, Y.1    Fang, Y.2    Yoon, M.S.3
  • 23
    • 62849111751 scopus 로고    scopus 로고
    • Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: Competition with rapamycin
    • Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin. Mol Cell Biol. 2009;29:1411-20.
    • (2009) Mol Cell Biol. , vol.29 , pp. 1411-1420
    • Toschi, A.1    Lee, E.2    Xu, L.3    Garcia, A.4    Gadir, N.5    Foster, D.A.6
  • 24
    • 68949103681 scopus 로고    scopus 로고
    • Phosphatidic acid signaling to mTOR: Signals for the survival of human cancer cells
    • Foster DA. Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells. Biochem Biophys Acta. 2009;791:949-55.
    • (2009) Biochem Biophys Acta. , vol.791 , pp. 949-955
    • Foster, D.A.1
  • 25
    • 36049043184 scopus 로고    scopus 로고
    • Rheb activates mTOR by antagonizing its endogenous inhibitor
    • Bai X, Ma D, Liu A, et al. Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science. 2007;318:977-80.
    • (2007) FKBP38. Science , vol.318 , pp. 977-980
    • Bai, X.1    Ma, D.2    Liu, A.3
  • 26
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell. 2007;12:9-22.
    • (2007) Cancer Cell. , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 27
    • 7244226366 scopus 로고    scopus 로고
    • Oncogenic transformation of human cells: Shortcomings of rodent model systems
    • Akagi T. Oncogenic transformation of human cells: shortcomings of rodent model systems. Trends Mol Med. 2004;10:542-8.
    • (2004) Trends Mol Med. , vol.10 , pp. 542-548
    • Akagi, T.1
  • 28
    • 33646892169 scopus 로고    scopus 로고
    • Genetically engineered human cancer models utilizing mammalian transgene expression
    • Kendall SD, Adam SJ, Counter CM. Genetically engineered human cancer models utilizing mammalian transgene expression. Cell Cycle. 2006;5:1074-9.
    • (2006) Cell Cycle. , vol.5 , pp. 1074-1079
    • Kendall, S.D.1    Adam, S.J.2    Counter, C.M.3
  • 29
    • 0024473604 scopus 로고
    • G1 events and regulation of cell proliferation
    • Pardee AB. G1 events and regulation of cell proliferation. Science. 1989;246:603-8.
    • (1989) Science , vol.246 , pp. 603-608
    • Pardee, A.B.1
  • 30
    • 34547108336 scopus 로고    scopus 로고
    • What's taking so long? S-phase entry from quiescence versus proliferation
    • Coller HA. What's taking so long? S-phase entry from quiescence versus proliferation. Nat Rev Mol Cell Biol. 2007;8:667-70.
    • (2007) Nat Rev Mol Cell Biol. , vol.8 , pp. 667-670
    • Coller, H.A.1
  • 31
    • 0035052628 scopus 로고    scopus 로고
    • Accumulation of cyclin E is not a prerequisite for passage through the restriction point
    • Ekholm SV, Zickert P, Reed SI, Zetterberg A. Accumulation of cyclin E is not a prerequisite for passage through the restriction point. Mol Cell Biol. 2001;21:3256-65.
    • (2001) Mol Cell Biol. , vol.21 , pp. 3256-3265
    • Ekholm, S.V.1    Zickert, P.2    Reed, S.I.3    Zetterberg, A.4
  • 32
    • 16244362678 scopus 로고    scopus 로고
    • Single cell analysis of G1 check points-the relationship between the restriction point and phosphorylation of pRb
    • Martinsson HS, Starborg M, Erlandsson F, Zetterberg A. Single cell analysis of G1 check points-the relationship between the restriction point and phosphorylation of pRb. Exp Cell Res. 2005;305:383-91.
    • (2005) Exp Cell Res. , vol.305 , pp. 383-391
    • Martinsson, H.S.1    Starborg, M.2    Erlandsson, F.3    Zetterberg, A.4
  • 33
    • 0018089825 scopus 로고
    • Exponential 3T3 cells escape in mid-G1 from their high serum requirement
    • Yen A, Pardee AB. Exponential 3T3 cells escape in mid-G1 from their high serum requirement. Exp Cell Res. 1978;116:103-13.
    • (1978) Exp Cell Res. , vol.116 , pp. 103-113
    • Yen, A.1    Pardee, A.B.2
  • 34
    • 0018184091 scopus 로고
    • Arrested states produced by isoleucine deprivation and their relationship to the low serum produced arrested state in Swiss 3T3 cells
    • Yen A, Pardee AB. Arrested states produced by isoleucine deprivation and their relationship to the low serum produced arrested state in Swiss 3T3 cells. Exp Cell Res. 1978;114:389-95.
    • (1978) Exp Cell Res. , vol.114 , pp. 389-395
    • Yen, A.1    Pardee, A.B.2
  • 35
    • 5444256434 scopus 로고    scopus 로고
    • A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size
    • Jorgensen P, Rupes I, Sharom JR, Schneper L, Broach JR, Tyers M. A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev. 2004;18:2491-505.
    • (2004) Genes Dev. , vol.18 , pp. 2491-2505
    • Jorgensen, P.1    Rupes, I.2    Sharom, J.R.3    Schneper, L.4    Broach, J.R.5    Tyers, M.6
  • 36
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell. 2000;103:253-62.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 37
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar DC, Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene. 2004;23:3151-71.
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 38
    • 0345732640 scopus 로고    scopus 로고
    • mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
    • Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, Blenis J. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol. 2004:24:200-16.
    • (2004) Mol Cell Biol. , vol.24 , pp. 200-216
    • Fingar, D.C.1    Richardson, C.J.2    Tee, A.R.3    Cheatham, L.4    Tsou, C.5    Blenis, J.6
  • 39
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/ eIF4E
    • Fingar DC, Salama S, Tsou C, Harlow E, Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/ eIF4E. Genes Dev. 2002;16:1472-87.
    • (2002) Genes Dev. , vol.16 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3    Harlow, E.4    Blenis, J.5
  • 40
    • 0036491845 scopus 로고    scopus 로고
    • The restriction point of the cell cycle
    • Blagosklonny MV, Pardee AB. The restriction point of the cell cycle. Cell Cycle. 2002;1: 103-10.
    • (2002) Cell Cycle. , vol.1 , pp. 103-110
    • Blagosklonny, M.V.1    Pardee, A.B.2
  • 41
    • 33748047128 scopus 로고    scopus 로고
    • RB and cell cycle progression
    • Giacinti C, Giordano A. RB and cell cycle progression. Oncogene. 2006;25:5220-7.
    • (2006) Oncogene , vol.25 , pp. 5220-5227
    • Giacinti, C.1    Giordano, A.2
  • 42
    • 0034948814 scopus 로고    scopus 로고
    • Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo
    • Ezhevsky SA, Ho A, Becker-Hapak M, Davis PK, Dowdy SF. Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo. Mol Cell Biol. 2001;21:4773-84.
    • (2001) Mol Cell Biol. , vol.21 , pp. 4773-4784
    • Ezhevsky, S.A.1    Ho, A.2    Becker-Hapak, M.3    Davis, P.K.4    Dowdy, S.F.5
  • 43
    • 0033578816 scopus 로고    scopus 로고
    • Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
    • Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell. 1999;98:859-69.
    • (1999) Cell , vol.98 , pp. 859-869
    • Harbour, J.W.1    Luo, R.X.2    Dei Santi, A.3    Postigo, A.A.4    Dean, D.C.5
  • 44
    • 18344381018 scopus 로고    scopus 로고
    • Cyclin E in normal and neoplastic cell cycles
    • Hwang HC, Clurman BE. Cyclin E in normal and neoplastic cell cycles. Oncogene. 2005;24:2776-86.
    • (2005) Oncogene , vol.24 , pp. 2776-2286
    • Hwang, H.C.1    Clurman, B.E.2
  • 45
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
    • Lundberg AS, Weinberg RA. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol. 1998;18:753-61.
    • (1998) Mol Cell Biol. , vol.18 , pp. 753-761
    • Lundberg, A.S.1    Weinberg, R.A.2
  • 46
    • 0030883584 scopus 로고    scopus 로고
    • Sustained activation of extracellular-signalregulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase
    • Weber JD, Raben DM, Phillips PJ, Baldassare JJ. Sustained activation of extracellular-signalregulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem J. 1997;326:61-8.
    • (1997) Biochem J. , vol.326 , pp. 61-68
    • Weber, J.D.1    Raben, D.M.2    Phillips, P.J.3    Baldassare, J.J.4
  • 47
    • 0031921230 scopus 로고    scopus 로고
    • Epidermal growth factor induces cyclin D1 in a human prostate cancer cell line
    • Perry JE, Grossmann ME, Tindall DJ. Epidermal growth factor induces cyclin D1 in a human prostate cancer cell line. Prostate. 1998;35:117-24.
    • (1998) Prostate. , vol.35 , pp. 117-124
    • Perry, J.E.1    Grossmann, M.E.2    Tindall, D.J.3
  • 48
    • 0030996978 scopus 로고    scopus 로고
    • K-Ras modulates the cell cycle via both positive and negative regulatory pathways
    • Fan J, Bertino JR. K-Ras modulates the cell cycle via both positive and negative regulatory pathways. Oncogene. 1997;14:2595-607.
    • (1997) Oncogene , vol.14 , pp. 2595-2607
    • Fan, J.1    Bertino, J.R.2
  • 49
    • 0035963435 scopus 로고    scopus 로고
    • Specific protection against breast cancers by cyclin D1 ablation
    • Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature. 2001;411:1017-21.
    • (2001) Nature , vol.411 , pp. 1017-1121
    • Yu, Q.1    Geng, Y.2    Sicinski, P.3
  • 50
    • 0029863840 scopus 로고    scopus 로고
    • Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts
    • Herrera RE, Sah VP, Williams BO, Mäkelä TP, Weinberg RA, Jacks T. Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol Cell Biol. 1996;16:2402-7.
    • (1996) Mol Cell Biol. , vol.16 , pp. 2402-2407
    • Herrera, R.E.1    Sah, V.P.2    Williams, B.O.3    Mäkelä, T.P.4    Weinberg, R.A.5    Jacks, T.6
  • 51
    • 9244239811 scopus 로고    scopus 로고
    • G1 cell-cycle control and cancer
    • Massague J. G1 cell-cycle control and cancer. Nature. 2004;432:298-306.
    • (2004) Nature , vol.432 , pp. 298-306
    • Massague, J.1
  • 52
    • 32044441426 scopus 로고    scopus 로고
    • How to decrease p27Kip1 levels during tumor development
    • Koff A. How to decrease p27Kip1 levels during tumor development. Cancer Cell. 2006;9:75-6.
    • (2006) Cancer Cell , vol.9 , pp. 75-76
    • Koff, A.1
  • 53
    • 0035970035 scopus 로고    scopus 로고
    • Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor-ß growth arrest program
    • Chen CR, Kang Y, Massagué J. Defective repression of c-myc in breast cancer cells: a loss at the core of the transforming growth factor-ß growth arrest program. Proc Natl Acad Sci USA. 2001;98:992-9.
    • (2001) Proc Natl Acad Sci USA. , vol.98 , pp. 992-999
    • Chen, C.R.1    Kang, Y.2    Massagué, J.3
  • 54
    • 30444434212 scopus 로고    scopus 로고
    • Novel roles of Akt and mTOR in suppressing TGF-ß/ ALK5-mediated Smad3 activation
    • Song K, Wang H, Krebs TL, Danielpour D. Novel roles of Akt and mTOR in suppressing TGF-ß/ ALK5-mediated Smad3 activation. EMBO J. 2006;25:58-69.
    • (2006) EMBO J. , vol.25 , pp. 58-69
    • Song, K.1    Wang, H.2    Krebs, T.L.3    Danielpour, D.4
  • 55
    • 39149089610 scopus 로고    scopus 로고
    • Defective TGF-ß signaling sensitizes human cancer cells to rapamycin
    • Gadir N, Jackson D, Lee E, Foster DA. Defective TGF-ß signaling sensitizes human cancer cells to rapamycin. Oncogene. 2008;27:1055-62.
    • (2008) Oncogene , vol.27 , pp. 1055-1062
    • Gadir, N.1    Jackson, D.2    Lee, E.3    Foster, D.A.4
  • 57
    • 0022368305 scopus 로고
    • Specific growth response of ras-transformed embryo fibroblasts to tumour promoters
    • Dotto GP, Parada LF, Weinberg RA. Specific growth response of ras-transformed embryo fibroblasts to tumour promoters. Nature. 1985;318:472-5.
    • (1985) Nature , vol.318 , pp. 472-475
    • Dotto, G.P.1    Parada, L.F.2    Weinberg, R.A.3
  • 58
    • 0030987327 scopus 로고    scopus 로고
    • Tumor-promotion by depleting cells of protein kinase Cd
    • Lu Z, Hornia A, Jiang YW, et al. Tumor-promotion by depleting cells of protein kinase Cd. Mol Cell Biol. 1997;17:3418-28.
    • (1997) Mol Cell Biol. , vol.17 , pp. 3418-3428
    • Lu, Z.1    Hornia, A.2    Jiang, Y.W.3
  • 59
    • 0031907117 scopus 로고    scopus 로고
    • Activation of protein kinase C triggers its ubiquitination and degradation
    • Lu Z, Liu D, Hornia A, Devonish W, Pagano M, Foster DA. Activation of protein kinase C triggers its ubiquitination and degradation. Mol Cell Biol. 1998;18:839-45.
    • (1998) Mol Cell Biol. , vol.18 , pp. 839-845
    • Lu, Z.1    Liu, D.2    Hornia, A.3    Devonish, W.4    Pagano, M.5    Foster, D.A.6
  • 60
    • 0017581306 scopus 로고
    • Coordination of growth with cell division in the yeast Saccharomyces cerevisiae
    • Johnston GC, Pringle JR, Hartwell LH. Coordination of growth with cell division in the yeast Saccharomyces cerevisiae. Exp Cell Res. 1977;105:79-98.
    • (1977) Exp Cell Res. , vol.105 , pp. 79-98
    • Johnston, G.C.1    Pringle, J.R.2    Hartwell, L.H.3
  • 61
    • 0025734356 scopus 로고
    • Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family
    • Koff A, Cross F, Fisher A, et al. Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell. 1991;66:1217-28.
    • (1991) Cell , vol.66 , pp. 1217-1228
    • Koff, A.1    Cross, F.2    Fisher, A.3
  • 62
    • 0025850767 scopus 로고
    • Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast
    • Lew DJ, Dulic V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell. 1991;66:1197-206.
    • (1991) Cell , vol.66 , pp. 1197-1206
    • Lew, D.J.1    Dulic, V.2    Reed, S.I.3
  • 64
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer. 2008;8:915-28.
    • (2008) Nat Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 66
    • 33750058023 scopus 로고    scopus 로고
    • Upstream of the mammalian target of rapamycin: Do all roads pass through mTOR?
    • Corradetti MN, Guan KL. Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene. 2006;25:6347-60.
    • (2006) Oncogene , vol.25 , pp. 6347-6360
    • Corradetti, M.N.1    Guan, K.L.2
  • 67
    • 42949139481 scopus 로고    scopus 로고
    • AMPK phosphorylation of raptor mediates a metabolic checkpoint
    • Gwinn DM, Shackelford DB, Egan DF, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell. 2008;30:214-26.
    • (2008) Mol Cell. , vol.30 , pp. 214-226
    • Gwinn, D.M.1    Shackelford, D.B.2    Egan, D.F.3
  • 68
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
    • Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer. 2009;9:563-75.
    • (2009) Nat Rev Cancer. , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 69
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 2006;7:606-19.
    • (2006) Nat Rev Genet. , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 70
    • 37549054034 scopus 로고    scopus 로고
    • Ras and phosphoinositide 3-kinase: Partners in development and tumorigenesis
    • Ramjaun AR, Downward J. Ras and phosphoinositide 3-kinase: partners in development and tumorigenesis. Cell Cycle. 2007;6:2902-5.
    • (2007) Cell Cycle , vol.6 , pp. 2902-2905
    • Ramjaun, A.R.1    Downward, J.2
  • 71
    • 0141542631 scopus 로고    scopus 로고
    • Phospholipase D in cell proliferation and cancer
    • Foster DA, Xu L. Phospholipase D in cell proliferation and cancer. Mol Cancer Res. 2003;1:789-800.
    • (2003) Mol Cancer Res. , vol.1 , pp. 789-800
    • Foster, D.A.1    Xu, L.2
  • 72
    • 20444410041 scopus 로고    scopus 로고
    • Activation of RalA is critical for Ras-induced tumorigenesis of human cells
    • Lim KH, Baines AT, Fiordalisi JJ, et al. Activation of RalA is critical for Ras-induced tumorigenesis of human cells. Cancer Cell. 2005;7:533-45.
    • (2005) Cancer Cell , vol.7 , pp. 533-545
    • Lim, K.H.1    Baines, A.T.2    Fiordalisi, J.J.3
  • 73
    • 36048979906 scopus 로고    scopus 로고
    • Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-Ras
    • Shi M, Zheng Y, Garcia A, Xu L, Foster DA. Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-Ras. Cancer Lett. 2007;258:268-75.
    • (2007) Cancer Lett. , vol.258 , pp. 268-275
    • Shi, M.1    Zheng, Y.2    Garcia, A.3    Xu, L.4    Foster, D.A.5
  • 74
    • 48249084606 scopus 로고    scopus 로고
    • Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells
    • Garcia A, Zheng Y, Zhao C, et al. Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin Cancer Res. 2008;14:4267-74.
    • (2008) Clin Cancer Res. , vol.14 , pp. 4267-4274
    • Garcia, A.1    Zheng, Y.2    Zhao, C.3
  • 75
    • 0035150990 scopus 로고    scopus 로고
    • Growth-factor-dependent mitogenesis requires two distinct phases of signalling
    • Jones SM, Kazlauskas A. Growth-factor-dependent mitogenesis requires two distinct phases of signalling. Nat Cell Biol. 2001;3:165-72.
    • (2001) Nat Cell Biol. , vol.3 , pp. 165-172
    • Jones, S.M.1    Kazlauskas, A.2
  • 76
    • 0020520516 scopus 로고
    • Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
    • Land H, Parada LF, Weinberg RA. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature. 1983;304:596-602.
    • (1983) Nature , vol.304 , pp. 596-602
    • Land, H.1    Parada, L.F.2    Weinberg, R.A.3
  • 77
    • 0042528364 scopus 로고    scopus 로고
    • Cyclin E ablation in the mouse
    • Geng Y, Yu Q, Sicinska E, et al. Cyclin E ablation in the mouse. Cell. 2003;114:431-43.
    • (2003) Cell , vol.114 , pp. 431-443
    • Geng, Y.1    Yu, Q.2    Sicinska, E.3
  • 78
    • 0141737069 scopus 로고    scopus 로고
    • Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells
    • Parisi T, Beck AR, Rougier N, et al. Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J. 2003;22:4794-803.
    • (2003) EMBO J. , vol.22 , pp. 4794-4803
    • Parisi, T.1    Beck, A.R.2    Rougier, N.3
  • 79
    • 33847784791 scopus 로고    scopus 로고
    • Multiple levels of cyclin specificity in cell-cycle control
    • Bloom J, Cross FR. Multiple levels of cyclin specificity in cell-cycle control. Nat Rev Mol Cell Biol. 2007;8:149-60.
    • (2007) Nat Rev Mol Cell Biol. , vol.8 , pp. 149-160
    • Bloom, J.1    Cross, F.R.2
  • 80
    • 77956069978 scopus 로고    scopus 로고
    • Can defective TGF-ß signaling be an Achilles heel in cancer?
    • Foster DA, Gadir N. Can defective TGF-ß signaling be an Achilles heel in cancer? Chin J Cancer. 2008;27:882-4.
    • (2008) Chin J Cancer. , vol.27 , pp. 882-884
    • Foster, D.A.1    Gadir, N.2
  • 81
    • 41649109807 scopus 로고    scopus 로고
    • Translating insights from the cancer genome into clinical practice
    • Chin L, Gray JW. Translating insights from the cancer genome into clinical practice. Nature. 2008;452:553-63.
    • (2008) Nature , vol.452 , pp. 553-563
    • Chin, L.1    Gray, J.W.2
  • 82
    • 33845200848 scopus 로고    scopus 로고
    • Mutation analysis of 24 known cancer genes in the NCI-60 cell line set
    • Ikediobi ON, Davies H, Bignell G, et al. Mutation analysis of 24 known cancer genes in the NCI-60 cell line set. Mol Cancer Ther. 2006;5:2606-12.
    • (2006) Mol Cancer Ther. , vol.5 , pp. 2606-2612
    • Ikediobi, O.N.1    Davies, H.2    Bignell, G.3
  • 83
    • 0032514376 scopus 로고    scopus 로고
    • Translational induction of the c-myc oncogene via activation of the FRAP/TOR signaling pathway
    • West MJ, Stoneley M, Willis AE. Translational induction of the c-myc oncogene via activation of the FRAP/TOR signaling pathway. Oncogene. 1998;17:769-80.
    • (1998) Oncogene , vol.17 , pp. 769-780
    • West, M.J.1    Stoneley, M.2    Willis, A.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.