Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity

Genes and Development

Volumn 25, Issue 13, 2011, Pages 1426-1438

  Wang, Yunyuan V ^a   Leblanc, Mathias ^a   Fox, Norma ^b   Mao, Jian Hua ^c,d   Tinkum, Kelsey L ^e,f   Krummel, Kurt ^a   Engle, Dannielle ^a   Piwnica Worms, David ^e,f   Piwnica Worms, Helen ^e,g   Balmain, Allan ^c   Kaushansky, Kenneth ^b   Wahl, Geoffrey M ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Apoptosis; C terminal modification; Cell cycle; HSC; P53; Radiosensitivity

Indexed keywords

PROTEIN P21; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; IRRADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; RADIOSENSITIVITY;

ANIMALS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; GAMMA RAYS; GENE DOSAGE; GENE EXPRESSION REGULATION; GENE KNOCK-IN TECHNIQUES; HEMATOPOIETIC STEM CELLS; HOMEOSTASIS; LONGEVITY; MALE; MICE; MICE, INBRED C57BL; MUTATION; PROTO-ONCOGENE PROTEINS C-MDM2; RADIATION TOLERANCE; TUMOR SUPPRESSOR PROTEIN P53;

MUS;

EID: 79960022026     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.2024411     Document Type: Article

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