Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 6, 2009, Pages 2476-2482

  Freitas, Renato F ^a   Prokopczyk, Igor M ^a   Zottis, Aderson ^a   Oliva, Glaucius ^a   Andricopulo, Adriano D ^a   Trevisan, Maria Teresa S ^b   Vilegas, Wagner ^c   Silva, Maria Goretti V ^a,b   Montanari, Carlos A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Chagas' disease; GAPDH inhibitors; LBVS; SBVS; Trypanosoma cruzi

Indexed keywords

ANACARDIC ACID; ENZYME INHIBITOR; FLAVONOID; GLUCOSYLXANTHONE DERIVATIVE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE INHIBITOR; GUAJAVERIN; MANGIFERIN; NATURAL PRODUCT; QUERCETIN; TILIROSIDE; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ARTICLE; CHAGAS DISEASE; DRUG CONFORMATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; NONHUMAN; STRUCTURE ANALYSIS; TRYPANOSOMA CRUZI;

ANIMALS; ENZYME INHIBITORS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; KINETICS; MODELS, MOLECULAR; SPECTROPHOTOMETRY, ULTRAVIOLET; THERMODYNAMICS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI; TRYPANOSOMATIDAE;

EID: 62149091122     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.01.079     Document Type: Article

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