Arecoline, a major alkaloid of the areca nut, causes neurotoxicity through enhancement of oxidative stress and suppression of the antioxidant protective system

Free Radical Biology and Medicine

Volumn 49, Issue 10, 2010, Pages 1471-1479

  Shih, Yu Tzu ^a   Chen, Po See ^b   Wu, Chi Han ^a   Tseng, Yu Ting ^a   Wu, Yang Chang ^a,c   Lo, Yi Ching ^a,c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Arecoline; Free radicals; Glutathione; NADPH oxidase; Neurotoxicity; Oxidative stress

Indexed keywords

ALKALOID DERIVATIVE; APOCYNIN; ARECOLINE; CASPASE 3; CASPASE 9; CATALASE; CYTOCHROME C; DIPHENYLIODONIUM SALT; GLUTATHIONE; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; ATTENUATION; BETEL NUT; BRAIN NERVE CELL; CELL DEATH; CYTOTOXICITY; EMBRYO; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; ARECA; ARECOLINE; CASPASES; CELL DEATH; CYTOCHROMES C; FEMALE; GLUTATHIONE; HUMANS; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; NEURONS; OXIDATIVE STRESS; PREGNANCY; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

ARECA CATECHU; RATTUS;

EID: 77957751263     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.07.017     Document Type: Article

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