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Volumn 1, Issue 1, 2009, Pages 23-38

N′1,n′3-dimethyl-n′1,n′3-bis(Phenylcarbonothioyl) propanedihydrazide (elesclomol) selectively kills cisplatin resistant lung cancer cells through reactive oxygen species (ros)

Author keywords

Cisplatin; Drug resistant; Elesclomol; Lung cancer; ROS

Indexed keywords


EID: 79955011809     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers1010023     Document Type: Article
Times cited : (53)

References (15)
  • 1
    • 23444435104 scopus 로고    scopus 로고
    • Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds
    • Witte, A.B.; Anestal, K.; Jerremalm, E.; Ehrsson, H.; Arner, E.S. Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds. Free Radic. Biol. Med. 2005, 39, 696–703.
    • (2005) Free Radic. Biol. Med , vol.39 , pp. 696-703
    • Witte, A.B.1    Anestal, K.2    Jerremalm, E.3    Ehrsson, H.4    Arner, E.S.5
  • 2
    • 0035890009 scopus 로고    scopus 로고
    • Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex
    • Arner, E.S.; Nakamura, H.; Sasada, T.; Yodoi, J.; Holmgren, A.; Spyrou, G. Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex. Free Radic. Biol. Med. 2001, 31, 1170–1178.
    • (2001) Free Radic. Biol. Med , vol.31 , pp. 1170-1178
    • Arner, E.S.1    Nakamura, H.2    Sasada, T.3    Yodoi, J.4    Holmgren, A.5    Spyrou, G.6
  • 3
    • 0034652113 scopus 로고    scopus 로고
    • Thioredoxin reductase
    • Pt 1
    • Mustacich, D.; Powis, G. Thioredoxin reductase. Biochem. J. 2000, 346 Pt 1, 1–8.
    • (2000) Biochem. J , vol.346 , pp. 1-8
    • Mustacich, D.1    Powis, G.2
  • 5
    • 54249105017 scopus 로고    scopus 로고
    • The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents
    • Sun, Y.; Rigas, B. The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. Cancer Res. 2008, 68, 8269–8277.
    • (2008) Cancer Res , vol.68 , pp. 8269-8277
    • Sun, Y.1    Rigas, B.2
  • 8
    • 0030889295 scopus 로고    scopus 로고
    • Overexpression of thioredoxin does not confer resistance to cisplatin in transfected human ovarian and colon cancer cell lines
    • Yamada, M.; Tomida, A.; Yoshikawa, H.; Taketani, Y.; Tsuruo, T. Overexpression of thioredoxin does not confer resistance to cisplatin in transfected human ovarian and colon cancer cell lines. Cancer Chemother. Pharmacol. 1997, 40, 31–37.
    • (1997) Cancer Chemother. Pharmacol , vol.40 , pp. 31-37
    • Yamada, M.1    Tomida, A.2    Yoshikawa, H.3    Taketani, Y.4    Tsuruo, T.5
  • 9
    • 48749099976 scopus 로고    scopus 로고
    • Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins
    • Wangpaichitr, M.; Wu, C.; You, M.; Kuo, M.T.; Feun, L.; Lampidis, T.; Savaraj, N. Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins. Eur. J. Pharmacol. 2008, 591, 124–127.
    • (2008) Eur. J. Pharmacol , vol.591 , pp. 124-127
    • Wangpaichitr, M.1    Wu, C.2    You, M.3    Kuo, M.T.4    Feun, L.5    Lampidis, T.6    Savaraj, N.7
  • 11
    • 1542435945 scopus 로고    scopus 로고
    • Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine
    • Savaraj, N.; Wu, C.; Wangpaichitr, M.; Kuo, M.T.; Lampidis, T.; Robles, C.; Furst, A.J.; Feun, L. Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine. Int. J. Oncol. 2003, 23, 173–179.
    • (2003) Int. J. Oncol , vol.23 , pp. 173-179
    • Savaraj, N.1    Wu, C.2    Wangpaichitr, M.3    Kuo, M.T.4    Lampidis, T.5    Robles, C.6    Furst, A.J.7    Feun, L.8
  • 12
    • 0029955068 scopus 로고    scopus 로고
    • Detection of 11q13 amplification as the origin of a homogeneously staining region in small cell lung cancer by chromosome microdissection
    • Xu, J.; Tyan, T.; Cedrone, E.; Savaraj, N., Wang, N. Detection of 11q13 amplification as the origin of a homogeneously staining region in small cell lung cancer by chromosome microdissection. Genes Chromosomes Cancer 1996, 17, 172–178.
    • (1996) Genes Chromosomes Cancer , vol.17 , pp. 172-178
    • Xu, J.1    Tyan, T.2    Cedrone, E.3    Savaraj, N.4    Wang, N.5
  • 13
    • 49849099471 scopus 로고    scopus 로고
    • Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia in lung cancer cell lines
    • Wangpaichitr, M.; Savaraj, N.; Maher, J.; Kurtoglu, M.; Lampidis, T.J. Intrinsically lower AKT, mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia in lung cancer cell lines. Mol. Cancer Ther. 2008, 7, 1506–1513.
    • (2008) Mol. Cancer Ther , vol.7 , pp. 1506-1513
    • Wangpaichitr, M.1    Savaraj, N.2    Maher, J.3    Kurtoglu, M.4    Lampidis, T.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.