Blocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer model

Cancer Research

Volumn 61, Issue 18, 2001, Pages 6945-6951

  Shi, Heidi Y ^a   Zhang, Weiguo ^a   Liang, Rong ^a   Abraham, Shaji ^a   Kittrell, Francis S ^a   Medina, Daniel ^a   Zhang, Ming ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MASPIN; RNA; SERINE PROTEINASE INHIBITOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER INHIBITION; CANCER INVASION; CONTROLLED STUDY; FEMALE; IMMUNOHISTOCHEMISTRY; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELL DIVISION; DISEASE MODELS, ANIMAL; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; PROTEIN BIOSYNTHESIS; PROTEINS; SERPINS; TRANSFECTION;

EID: 0035884506     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Tumor cell interactions with the extracellular matrix during invasion and metastasis
2. Cyclooxygenase regulates angiogenesis induced by colon cancer cells
3. The mammary gland: A unique organ for the study of development and tumorigenesis
4. Experimental models of development, function, and neoplasia
5. Development of mammary preneoplasias in vivo from mouse mammary epithelial cell lines in vitro
6. The preneoplastic phenotype in murine mammary tumorigenesis
7. Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis
8. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells
9. Production, purification, and characterization of recombinant maspin proteins
10. RNA genetics of breast cancer: Maspin as paradigm
11. Expression of maspin in prostate cells is regulated by a positive ets element and a negative hormonal responsive element site recognized by androgen receptor
12. Maspin suppresses the invasive phenotype of human breast carcinoma
13. De-mystifying the mechanism(s) of maspin
14. The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin
15. Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells
16. mMaspin: The mouse homolog of a human tumor suppressor gene inhibits mammary tumor invasion and motility
17. The human myoepithelial cell is a natural tumor suppressor
18. Maspin is an intracellular serpin that partitions into secretory vesicles and is present at the cell surface
19. Maspin: A tumor suppressing serpin
20. Maspin is an angiogenesis inhibitor
21. Transactivation through Ets and Apl transcription sites determines the expression of the tumor-suppressing gene maspin
22. p53 regulates the expression of the tumor suppressor gene maspin
23. Epigenetic silencing of maspin gene expression in human breast cancer
24. Reduced mammary tumor progression in WAP-TAg/WAP-maspin bitransgenic mice
25. Stable expression and heterologous coupling of the κ opioid receptor in cell lines of neural and nonneural origin
26. A new family of murine retroviral vectors with extended multiple cloning sites for gene insertion
27. High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma
28. Expression of the maspin gene, a recently discovered antiangiogenesis tumor suppressor, protects high-risk breast cancer patients from relapse
29. Terminal differentiation of human breast cancer through PPAR γ
30. γ linolenic acid regulates expression of maspin and the motility of cancer cells
31. Expression of a viral oncoprotein during mammary gland development alters cell fate and function: Induction of p53-independent apoptosis is followed by impaired milk protein production in surviving cells
32. Tumor encapsulation in hepatocellular carcinoma. A pathologic study of 189 cases
33. Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast
34. The mammary fat pad as a privileged transplantation site
35. Transplantation of isologous male mammary gland tissue into the mammary fat-pads of female mice