Expression of cox-2, nf-κb-p65, nf-κb-p50 and ikkα in malignant and adjacent normal human colorectal tissue

British Journal of Cancer

Volumn 101, Issue 1, 2009, Pages 106-115

  Charalambous, M P ^a   Lightfoot, T ^b   Speirs, V ^a   Horgan, K ^c   Gooderham, N J ^d  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

^c LEEDS GENERAL INFIRMARY   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Colorectal cancer; Cyclooxygenase 2; Fibroblasts; Macrophages; Nuclear factor B; Vascular endothelial cells

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P50; SYNAPTOTAGMIN I; I KAPPA B KINASE; TRANSCRIPTION FACTOR RELA;

ADULT; AGED; ARTICLE; CANCER CELL; CANCER STAGING; CELL TYPE; CLINICAL ARTICLE; COLON BIOPSY; COLON CANCER; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION COEFFICIENT; DISEASE SEVERITY; ENZYME INDUCTION; EPITHELIUM CELL; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM CANCER; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STROMA CELL; TUMOR GROWTH; BIOPSY; BIOSYNTHESIS; COLORECTAL TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2; FEMALE; HUMANS; I-KAPPA B KINASE; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NF-KAPPA B P50 SUBUNIT; TRANSCRIPTION FACTOR RELA;

EID: 67649846427     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605120     Document Type: Article

References (41)

1. Adegboyega PA, Ololade O, Saada J, Mifflin R, Di Mari JF, Powell DW (2004) Subepithelial myofibroblasts express cyclooxygenase-2 in color- ectal tubular adenomas. Clin Cancer Res 10: 5870- 5879
2. Arnoletti JP, Upson J, Babb JS, Bellacosa A, Watson JC (2005) Differential stromal and epithelial localization of cyclooxygenase-2 (COX-2) during colorectal tumorigenesis. J Exp Clin Cancer Res 24: 279 - 287
3. Battu S, Chable-Rabinovitch H, Rigaud M, Beneytout JL (1998) Cycloox- ygenase-2 expression in human adenocarcinoma cell line HT29 cl.19A. Anticancer Res 18: 2397-2403
4. Bowie AG, O'Neill LA (2000) Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase. J Immunol 165: 7180-7188
5. Brown JR, DuBois RN (2005) COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol 23: 2840- 2855
6. Brueggemeier RW, Quinn AL, Parrett ML, Joarder FS, Harris RE, Robertson FM (1999) Correlation of aromatase and cyclooxygenase gene expression in human breast cancer specimens. Cancer Lett 140: 27-35
7. Charalambous MP, Maihoafner C, Bhambra U, Lightfoot T, Gooderham NJ, Colorectal Cancer Study Group (2003) Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells. Br J Cancer 88: 1598 - 1604
8. Cherukuri DP, Goulet AC, Inoue H, Nelson MA (2005) Selenomethionine regulates cyclooxygenase-2 (COX-2) expression through nuclear factor- kappa B (NF-kappaB) in colon cancer cells. Cancer Biol Ther 4: 175 - 180
9. Crofford LJ, Tan B, McCarthy CJ, Hla T (1997) Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes. Arthritis Rheum 40: 226-236
10. Duque J, Diaz-Munoz MD, Fresno M, Iniguez MA (2006) Up-regulation of cyclooxygenase-2 by interleukin-1beta in colon carcinoma cells. Cell Signal 18: 1262 - 1269
11. Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, DuBois RN (1994) Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 107: 1183 - 1188
12. Giardiello FM, Hamilton SR, Krush AJ, Piantadosi S, Hylind LM, Celano P, Booker SV, Robinson CR, Offerhaus GJ (1993) Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med 328: 1313-1316
13. Giovannucci E, Egan KM, Hunter DJ, Stampfer MJ, Colditz GA, Willett WC, Speizer FE (1995) Aspirin and the risk of colorectal cancer in women. N Engl J Med 333: 609 - 614
14. Goggi G, Dell'Orto P, Viale G (1986) Immunohistochemistry, Modern Methods and Applications pp 54-70. Butterworth-Heinemann: London
15. Half E, Tang XM, Gwyn K, Sahin A, Wathen K, Sinicrope FA (2002) Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. Cancer Res 62: 1676- 1681
16. Hida T, Yatabe Y, Achiwa H, Muramatsu H, Kozaki K, Nakamura S, Ogawa M, Mitsudomi T, Sugiura T, Takahashi T (1998) Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. Cancer Res 58: 3761 - 3764
17. Jones DA, Carlton DP, McIntyre TM, Zimmerman GA, Prescott SM (1993) Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J Biol Chem 268: 9049-9054
18. Karin M, Lin A (2002) NF-kappaB at the crossroads of life and death. Nat Immunol 3: 221 - 227
19. Konson A, Mahajna JA, Danon A, Rimon G, Agbaria R (2006) The involvement of nuclear factor-kappa B in cyclooxygenase-2 over- expression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene. Cancer Gene Ther 13: 1093 - 1104
20. Liu ES, Shin VY, Ye YN, Luo JC, Wu WK, Cho CH (2005) Cyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract. Eur J Pharmacol 518: 47 - 55
21. Marnett LJ (1992) Aspirin and the potential role of prostaglandins in colon cancer. Cancer Res 52: 5575 - 5589
22. Midgley R, Kerr D (1999) Colorectal cancer. Lancet 353: 391-399
23. Mitsiades CS, McMillin D, Kotoula V, Poulaki V, McMullan C, Negri J, Fanourakis G, Tseleni-Balafouta S, Ain KB, Mitsiades N (2006) Antitumour effects of the proteasome inhibitor Bortezomib in medullary and anaplastic thyroid carcinoma in vitro. J Clin Endocrinol Metab 91:4013 - 4021
24. Ohta T, Takahashi M, Ochiai A (2006) Increased protein expression of both inducible nitric oxide synthase and cyclooxygenase-2 in human colon cancers. Cancer Lett 239: 246 - 253
25. Pisano C, Ottaiano A, Tatangelo F, Di Bonito M, Falanga M, Iaffaioli VR, Botti G, Pignata S, Acquaviva AM (2005) Cyclooxygenase-2 expression is associated with increased size in human sporadic colorectal adenomas. Anticancer Res 25: 2065 - 2068
26. Plummer SM, Holloway KA, Manson MM, Munks RJ, Kaptein A, Farrow S, Howells L (1999) Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF- kappaB activation via the NIK/IKK signalling complex. Oncogene 18: 6013 - 6020
27. Ristimäki A, Honkanen N, Jänkälä H, Sipponen P, Härkönen M (1997) Expression of cyclooxygenase-2 in human gastric carcinoma. Cancer Res 57: 1276-1280
28. Sha WC (1998) Regulation of immune responses by NF-kappa B/Rel transcription factor. J Exp Med 187: 143 - 146
29. Sheehan KM, Sabah M, Cummins RJ, O'Grady A, Murray FE, Leader MB, Kay EW (2003) Cyclooxygenase-2 expression in stromal tumors of the gastrointestinal tract. Hum Pathol 34: 1242 - 1246
30. Sonoshita M, Takaku K, Oshima M, Sugihara K, Taketo MM (2002) Cyclooxygenase-2 expression in fibroblasts and endothelial cells of intestinal polyps. Cancer Res 62: 6846 - 6849
31. Tatsu K, Hayashi S, Shimada I, Matsui K (2005) Cyclooxygenase-2 in sporadic colorectal polyps: immunohistochemical study and its importance in the early stages of colorectal tumorigenesis. Pathol Res Pract 201: 427-433
32. Tazawa R, Xu XM, Wu KK, Wang LH (1994) Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene. Biochem Biophys Res Commun 203: 190- 199
33. Thun MJ, Namboodiri MM, Heath Jr CW (1991) Aspirin use and reduced risk of fatal colon cancer. N Engl J Med 325: 1593 - 1596
34. Tomozawa S, Tsuno NH, Sunami E, Hatano K, Kitayama J, Osada T, Saito S, Tsuruo T, Shibata Y, Nagawa H (2000) Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer. Br J Cancer 83: 324 - 328
35. Vandoros GP, Konstantinopoulos PA, Sotiropoulou-Bonikou G, Kominea A, Papachristou GI, Karamouzis MV, Gkermpesi M, Varakis I, Papavassiliou AG (2006) PPAR-gamma is expressed and NF-kB pathway is activated and correlates positively with COX-2 expression in stromal myofibroblasts surrounding colon adenocarcinomas. J Cancer Res Clin Oncol 132: 76- 84
36. Waddell WR, Loughry RW (1983) Sulindac for polyposis of the colon. J Surg Oncol 24: 83-87
37. Wendum D, Comperat E, Boelle PY, Parc R, Masliah J, Trugnan G, Flejou JF (2005) Cytoplasmic phospholipase A2 alpha overexpression in stromal cells is correlated with angiogenesis in human colorectal cancer. Mod Pathol 18: 212 - 220
38. Williams CS, Tsujii M, Reese J, Dey SK, DuBois RN (2000) Host cyclooxygenase-2 modulates carcinoma growth. J Clin Invest 105: 1589- 1594
39. Williams JL, Nath N, Chen J, Hundley TR, Gao J, Kopelovich L, Kashfi K, Rigas B (2003) Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor- kappaB, and NO synthase 2 inhibition: implications for chemopreven- tion. Cancer Res 63: 7613 - 7618
40. Yamashita K, Arimura Y, Shimizu H, Takahashi H, Endo T, Imai K, Yamano H (2003) Increased cyclooxygenase-2 expression in large flat colorectal tumors (laterally spreading tumors). J Gastroenterol 38: 69- 73
41. 53in flat and polypoid type colorectal tumours. Gut 35: 1258- 1261