BRCA1 185delAG mutant protein, BRAt, up-regulates maspin in ovarian epithelial cells

Gynecologic Oncology

Volumn 116, Issue 2, 2010, Pages 262-268

  O'Donnell, Joshua D ^a   Linger, Rebecca J ^a   Kruk, Patricia A ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

BRCA1; BRCA1 185delAG; Chemosensitivity; Cisplatin; Maspin; Ovarian cancer; Ovarian epithelial cells

Indexed keywords

ANTINEOPLASTIC AGENT; BRAT MUTANT PROTEIN; BRCA1 PROTEIN; CISPLATIN; LUCIFERASE; MASPIN; MUTANT PROTEIN; PROTEIN C JUN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CHEMOSENSITIVITY; CHEMOTHERAPY; CYTOTOXICITY; DOWNSTREAM PROCESSING; EPITHELIUM CELL; FRAMESHIFT MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEAR LOCALIZATION SIGNAL; OVARY CELL CULTURE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIDE EFFECT; UPREGULATION; WESTERN BLOTTING;

BINDING SITES; BRCA1 PROTEIN; EPITHELIAL CELLS; FEMALE; FRAMESHIFT MUTATION; GENES, BRCA1; HUMANS; OVARIAN NEOPLASMS; PROMOTER REGIONS, GENETIC; SERPINS; TRANSCRIPTION FACTOR AP-1; TRANSFECTION; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 74249106460     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2009.10.052     Document Type: Article

References (25)

1. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Murray T., et al. American Cancer Society cancer statistics 2008. CA Cancer J. Clin. 58 (2008) 71-96
2. Roa B.B., Boyd A.A., Volcik K., and Richards C.S. Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2. Nature Genetics 14 2 (1996) 185-187
3. Satagopan J.M., Boyd J., Kauff N.D., Robson M., Scheuer L., Narod S., et al. Ovarian cancer risk in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations. Clin. Cancer Res. 8 12 (2002) 3776-3781
4. Fan S., Yuan R., Ma Y.X., Meng Q., Goldberg I.D., and Rosen E.M. Mutant BRCA1 genes antagonize phenotype of wild-type BRCA1. Oncogene 20 57 (2001) 8215-8235
5. Sylvain V., Lafarge S., and Bignon Y.J. Dominant-negative activity of a Brca1 truncation mutant: effects on proliferation, tumorigenicity in vivo, and chemosensitivity in a mouse ovarian cancer cell line. Int. J. Oncol. 20 4 (2002) 845-853
6. Aida H., Takakuwa K., Nagata H., Tsuneki I., Takano M., Tsuji S., et al. Clinical features of ovarian cancer in Japanese women with germ-line mutations of BRCA1. Clin. Cancer Res. 4 (1998) 235-240
7. O' Donnell J.D., Johnson N.C., Turbeville T.D., Alfonso M.Y., and Kruk P.A. BRCA1 185delAG truncation protein, BRAt, amplifies caspase-mediated apoptosis in ovarian cells. In. Vitro. Cell. Dev. Biol. Anim. 44 8-9 (2008) 357-367
8. Zou Z., Anisowicz A., Hendrix M.J., Thor A., Neveu M., Sheng S., et al. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science 263 5146 (1994) 526-529
9. Jiang N., Meng Y., Zhang S., Mensah-Osman E., and Sheng S. Maspin sensitizes breast carcinoma cells to induced apoptosis. Oncogene 21 26 (2002) 4089-4098
10. Streuli C.H. Maspin is a tumour suppressor that inhibits breast cancer tumour metastasis in vivo. Breast Cancer Res. 4 4 (2002) 137-140
11. Abraham S., Zhang W., Greenberg N., and Zhang M. Maspin functions as tumor suppressor by increasing cell adhesion to extracellular matrix in prostate tumor cells. J. Urol. 169 3 (2003) 1157-1161
12. Maass N., Hojo T., Ueding M., Luttges J., Kloppel G., Jonat W., et al. Expression of the tumor suppressor gene maspin in human pancreatic cancers. Clin. Cancer Res. 7 4 (2001) 812-817
13. Hirai K., Koizumi K., Haraguchi S., Hirata T., Mikami I., Fukushima M., et al. Prognostic significance of the tumor suppressor gene maspin in non-small cell lung Cancer. Ann. Thorac. Surg. 79 1 (2005) 248-253
14. Zhang M., Magit D., and Sager R. Expression of maspin in prostate cells is regulated by a positive ets element and a negative hormonal responsive element site recognized by androgen receptor. Proc. Natl. Acad. Sci. U. S. A. 94 11 (1997) 5673-5678
15. Zou Z., Gao C., Nagaich A.K., Connell T., Saito S., Moul J.W., et al. p53 regulates the expression of the tumor suppressor gene maspin. J. Biol. Chem. 275 9 (2000) 6051-6054
16. Rose S.L., Fitzgerald M.P., White N.O., Hitchler M.J., Futscher B.W., De Geest K., et al. Epigenetic regulation of maspin expression in human ovarian carcinoma cells. Gynecol. Oncol. 102 2 (2006) 319-324
17. Sood A.K., Fletcher M.S., Gruman L.M., Coffin J.E., Jabbari S., Khalkhali-Ellis Z., et al. The paradoxical expression of maspin in ovarian carcinoma. Clin. Cancer Res. 8 9 (2002) 2924-2932
18. Solomon L.A., Munkarah A.R., Schimp V.L., Arabi M.H., Morris R.T., Nassar H., et al. Maspin expression and localization impact on angiogenesis and prognosis in ovarian Cancer. Gynecol. Oncol. 101 3 (2006) 385-389
19. Secord A.A., Lee P.S., Darcy K.M., Havrilesky L.J., Grace L.A., Marks J.R., et al. Maspin expression in epithelial ovarian cancer and associations with poor prognosis: a Gynecologic Oncology Group study. Gynecol. Oncol. 101 3 (2006) 390-397
20. Surowiak P., Materna V., Drag-Zalesinska M., Wojnar A., Kaplenko I., Spaczyński M., et al. Maspin expression is characteristic for cisplatin-sensitive ovarian cancer cells and for ovarian cancer cases of longer survival rates. Int. J. Gynecol. Pathol. 25 2 (2006) 131-139
21. Kruk P.A., Maines-Bandiera S.L., and Auersperg N. A simplified method to culture human ovarian surface epithelium. Lab. Invest. 63 (1990) 132-136
22. Yamaguchi H., Ding Y., Lee J.F., Zhang M., Pal A., Bornmann W., et al. Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin. Mol. Carcinog. 47 10 (2008) 739-743
23. Dobbelstein M., and Roth J. The large T antigen of simian virus 40 binds and inactivates p53 but not p73. J. Gen. Virol. 79 Pt 12 (1998) 3079-3083
24. Khalkhali-Ellis Z. Maspin: the new frontier. Clin. Cancer Res. 12 24 (2006) 7279-7283
25. Shi H., Zhang W., Liang R., Kittrell F., Templeton N., Medina D., et al. Modeling human breast cancer metastasis in mice: Maspin as a paradigm. Histol. Histopathol. 18 1 (2003) 201-206