Melatonin prevents endotoxin-induced circulatory failure in rats

Journal of Pineal Research

Volumn 30, Issue 3, 2001, Pages 147-156

  Wu, Chin Chen ^a   Chiao, Chin Wei ^a   Hsiao, George ^b   Chen, Ann ^a   Yen, Mao Hsiung ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Lipopolysaccharide; Melatonin; NO synthase II; Polymorphonuclear neutrophils; Superoxide anion; Tumor necrosis factor

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; MELATONIN; NITRIC OXIDE SYNTHASE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; ENDOTOXEMIA; HEMODYNAMICS; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; RAT; SEPTIC SHOCK; SURVIVAL RATE;

ANIMALS; ANTIOXIDANTS; AORTA, THORACIC; BLOTTING, WESTERN; CHEMOTAXIS, LEUKOCYTE; ENDOTOXEMIA; ESCHERICHIA COLI; FREE RADICAL SCAVENGERS; LIPOPOLYSACCHARIDES; LIVER; MALE; MELATONIN; NEUTROPHILS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; RATS; RATS, INBRED WKY; SHOCK, SEPTIC; SUPEROXIDES; SURVIVAL RATE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035087432     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-079X.2001.300303.x     Document Type: Article

References (48)

1. Pathophysiology of septic shock and implications for therapy
2. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
3. Ciliary neurotrophic factor (CNTF) inhibits brain and peripheral TNF production and, in association with its soluble receptor, protects mice against LPS toxicity
4. Melatonin reduces nitric oxide synthase activity in rat hypothalamus
5. The biology of cachectin/TNF-α: A primary mediator of the host response
6. Induction of nitric oxide synthase by cytokines
7. Glomerular localization of nephritogenic protein complexes on a nonimmunological basis
8. Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats
9. Multiple organ failure: Pathophysiology and potential future therapy
10. Inhibition of nitric oxide synthase in experimental gram-negative sepsis
11. The protective role of endogenously synthesized nitric oxide in staphylococcal enterotoxin B-induced shock in mice
12. Melatonin is a scavenger of peroxynitrite
13. Manifestations of sepsis
14. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
15. The immunoneuroendocrine role of melatonin
16. Melatonin as a therapeutic agent in experimental endotoxic shock
17. Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced ruthenium red in vivo
18. Effects of endotoxin on gluconeogenesis, glycogen synthesis and liver glycogen synthase in mice
19. Potent protective effect of melatonin on in vivo paraquat-induced oxidative damage in rats
20. Nitric oxide: Physiology, pathophysiology and pharmacology
21. Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis
22. Secretory products of macrophages
23. Nitric oxide as a secretory product of mammalian cells
24. Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion
25. Oxidative processes and antioxidative defense mechanisms in the aging brain
26. Oxidative damage in the central nervous system: Protection by melatonin
27. Mechanism of the inhibitory effect of melatonin on tumor necrosis factor production in vivo and in vitro
28. Alterations of lipid metabolism in mice injected with endotoxin
29. Lipid peroxide formation and membrane damage in endotoxin poisoned mice
30. Melatonin reduces both basal and bacterial lipid peroxidation in vitro
31. Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin
32. The role of lipid peroxidation in endotoxin-induced hepatic damage and the protective effect of antioxidants
33. Changes in the levels of endogenous antioxidants in the liver of mice with experimental endotoxemia and the protective effects of the antioxidants
34. Interleukin-1 contributes to the induction of nitric oxide synthase by endotoxin in vivo
35. Alterations in nitric oxide production in various forms of circulatory shock
36. Melatonin: A potent, endogenous hydroxyl radical scavenger
37. The role of the L-arginine: Nitric oxide pathway in circulatory shock
38. Role of tumor necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock
39. The multiple organ dysfunction syndrome caused by endotoxin in the rat: Attenuation of liver dysfunction by inhibitors of nitric oxide synthase
40. Tumor necrosis factor (cachectin) in the biology of septic shock syndrome
41. Tumor necrosis factor, other cytokines and disease
42. Tumor necrosis factor enhances the susceptibility of vascular endothelium to neutrophil mediated killing
43. Beneficial effects of dantrolene on lipopolysaccharide-induced hemodynamic alterations in rats and mortality in mice
44. Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock
45. Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat
46. Comparison of the effects of aminoguanidine and Nω-nitro-L-arginine methyl ester on the multiple organ dysfunction caused by endotoxemia in the rat
47. Evidence for inducible nitric oxide synthase in spontaneously hypertensive rats