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Volumn 10, Issue 2, 2005, Pages 174-179

Pathogenesis of lupus nephritis: An update

Author keywords

Apoptosis; Autoantibody; Complement; Lupus nephritis; Nitric oxide; Nucleosome; Pathogenesis; Superoxide

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; AUTOANTIBODY; EPITOPE; MERCAPTAMINE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

EID: 20144375468     PISSN: 13205358     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1797.2005.00392.x     Document Type: Review
Times cited : (58)

References (52)
  • 1
    • 0001510054 scopus 로고
    • A serum factor in lupus erythematosus with affinity for tissue nuclei
    • Holborow EJ, Weir DM, Johnson GD. A serum factor in lupus erythematosus with affinity for tissue nuclei. Br. Med. J. 1957; 13: 732-4.
    • (1957) Br. Med. J. , vol.13 , pp. 732-734
    • Holborow, E.J.1    Weir, D.M.2    Johnson, G.D.3
  • 2
    • 0032493059 scopus 로고    scopus 로고
    • Antibodies to DNA
    • Hahn BH. Antibodies to DNA. N. Engl. J. Med. 1998; 338: 1359-68.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 1359-1368
    • Hahn, B.H.1
  • 3
    • 0017337322 scopus 로고
    • Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus. Association of high avidity antinative DNA antibody with glomerulonephritis
    • Winfield JB, Faiferman I, Koffler D. Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus. Association of high avidity antinative DNA antibody with glomerulonephritis. J. Clin. Invest. 1977; 59: 90-96.
    • (1977) J. Clin. Invest. , vol.59 , pp. 90-96
    • Winfield, J.B.1    Faiferman, I.2    Koffler, D.3
  • 4
    • 0029020939 scopus 로고
    • Prevention of relapses in systemic lupus erythematosus
    • Bootsma H, Spronk P, Derksen R et al. Prevention of relapses in systemic lupus erythematosus. Lancet 1995; 345: 1595-9.
    • (1995) Lancet , vol.345 , pp. 1595-1599
    • Bootsma, H.1    Spronk, P.2    Derksen, R.3
  • 6
    • 0023841089 scopus 로고
    • Circulating DNA and lupus nephritis
    • Fournie GJ. Circulating DNA and lupus nephritis. Kidney Int. 1988; 33: 487-97.
    • (1988) Kidney Int. , vol.33 , pp. 487-497
    • Fournie, G.J.1
  • 7
    • 1442274798 scopus 로고    scopus 로고
    • Anti-DNA antibody subpopulations and lupus nephritis
    • Rekvig OP, Kalaaji M, Nossent H. Anti-DNA antibody subpopulations and lupus nephritis. Autoimmun. Rev. 2004; 3: 1-6.
    • (2004) Autoimmun. Rev. , vol.3 , pp. 1-6
    • Rekvig, O.P.1    Kalaaji, M.2    Nossent, H.3
  • 8
    • 0029004164 scopus 로고
    • Endothelial cell binding by human polyclonal anti-DNA antibodies: Relationship to disease activity and endothelial functional alterations
    • Chan TM, Yu PM, Tsang KL, Cheng IK. Endothelial cell binding by human polyclonal anti-DNA antibodies: Relationship to disease activity and endothelial functional alterations. Clin. Exp. Immunol. 1995; 100: 506-13.
    • (1995) Clin. Exp. Immunol. , vol.100 , pp. 506-513
    • Chan, T.M.1    Yu, P.M.2    Tsang, K.L.3    Cheng, I.K.4
  • 9
    • 0030880077 scopus 로고    scopus 로고
    • Identification of endothelial cell membrane proteins that bind anti-DNA antibodies from patients with systemic lupus erythematosus by direct or indirect mechanisms
    • Chan TM, Cheng IK. Identification of endothelial cell membrane proteins that bind anti-DNA antibodies from patients with systemic lupus erythematosus by direct or indirect mechanisms. J. Autoimmun. 1997; 10: 433-9.
    • (1997) J. Autoimmun. , vol.10 , pp. 433-439
    • Chan, T.M.1    Cheng, I.K.2
  • 10
    • 0036232276 scopus 로고    scopus 로고
    • Mesangial cell-binding anti-DNA antibodies in patients with systemic lupus erythematosus
    • Chan TM, Leung JK, Ho SK, Yung S. Mesangial cell-binding anti-DNA antibodies in patients with systemic lupus erythematosus. J. Am. Soc. Nephrol. 2002; 13: 1219-29.
    • (2002) J. Am. Soc. Nephrol. , vol.13 , pp. 1219-1229
    • Chan, T.M.1    Leung, J.K.2    Ho, S.K.3    Yung, S.4
  • 11
    • 0032192564 scopus 로고    scopus 로고
    • Cellular penetration and nuclear localization of anti-DNA antibodies: Mechanisms, consequences, implications and applications
    • Madaio MP, Yanase K. Cellular penetration and nuclear localization of anti-DNA antibodies: Mechanisms, consequences, implications and applications. J. Autoimmun. 1998; 11: 535-8.
    • (1998) J. Autoimmun. , vol.11 , pp. 535-538
    • Madaio, M.P.1    Yanase, K.2
  • 13
    • 0029822118 scopus 로고    scopus 로고
    • Spontaneously produced anti-DNA/DNase I autoantibodies modulate nuclear apoptosis in living cells
    • Madaio MP, Fabbi M, Tiso M, Daga A, Puccetti A. Spontaneously produced anti-DNA/DNase I autoantibodies modulate nuclear apoptosis in living cells. Eur. J. Immunol. 1996; 26: 3035-41.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 3035-3041
    • Madaio, M.P.1    Fabbi, M.2    Tiso, M.3    Daga, A.4    Puccetti, A.5
  • 14
    • 0034861085 scopus 로고    scopus 로고
    • Monoclonal anti-double stranded DNA antibody is a leucocyte-binding protein to up-regulate interleukin-8 gene expression and elicit apoptosis of normal human polymorphonuclear neutrophils
    • Hsieh SC, Sun KH, Tsai CY et al. Monoclonal anti-double stranded DNA antibody is a leucocyte-binding protein to up-regulate interleukin-8 gene expression and elicit apoptosis of normal human polymorphonuclear neutrophils. Rheumatology (Oxford) 2001; 40: 851-8.
    • (2001) Rheumatology (Oxford) , vol.40 , pp. 851-858
    • Hsieh, S.C.1    Sun, K.H.2    Tsai, C.Y.3
  • 15
    • 0029936463 scopus 로고    scopus 로고
    • Enhancement of oxidative cleavage of DNA by the binding sites of two anti-double-stranded DNA antibodies
    • Kubota T, Watanabe N, Kanai Y, Stollar BD. Enhancement of oxidative cleavage of DNA by the binding sites of two anti-double-stranded DNA antibodies. J. Biol. Chem. 1996; 271: 6555-61.
    • (1996) J. Biol. Chem. , vol.271 , pp. 6555-6561
    • Kubota, T.1    Watanabe, N.2    Kanai, Y.3    Stollar, B.D.4
  • 16
    • 0030032222 scopus 로고    scopus 로고
    • Increased release of von Willebrand factor antigen from endothelial cells by anti-DNA autoantibodies
    • Lai KN, Leung JC, Lai KB, Lai FM, Wong KC. Increased release of von Willebrand factor antigen from endothelial cells by anti-DNA autoantibodies. Ann. Rheum. Dis. 1996; 55: 57-62.
    • (1996) Ann. Rheum. Dis. , vol.55 , pp. 57-62
    • Lai, K.N.1    Leung, J.C.2    Lai, K.B.3    Lai, F.M.4    Wong, K.C.5
  • 17
    • 0030561064 scopus 로고    scopus 로고
    • Upregulation of adhesion molecule expression on endothelial cells by anti-DNA autoantibodies in systemic lupus erythematosus
    • Lai KN, Leung JC, Lai KB, Wong KC, Lai CK. Upregulation of adhesion molecule expression on endothelial cells by anti-DNA autoantibodies in systemic lupus erythematosus. Clin. Immunol. Immunopathol. 1996; 81: 229-38.
    • (1996) Clin. Immunol. Immunopathol. , vol.81 , pp. 229-238
    • Lai, K.N.1    Leung, J.C.2    Lai, K.B.3    Wong, K.C.4    Lai, C.K.5
  • 18
    • 0031452106 scopus 로고    scopus 로고
    • Effect of anti-DNA autoantibodies on the gene expression of interleukin 8, transforming growth factor-beta, and nitric oxide synthase in cultured endothelial cells
    • Lai KN, Leung JC, Lai KB, Lai CK. Effect of anti-DNA autoantibodies on the gene expression of interleukin 8, transforming growth factor-beta, and nitric oxide synthase in cultured endothelial cells. Scand. J. Rheumatol. 1997; 26: 461-7.
    • (1997) Scand. J. Rheumatol. , vol.26 , pp. 461-467
    • Lai, K.N.1    Leung, J.C.2    Lai, K.B.3    Lai, C.K.4
  • 19
    • 0029912208 scopus 로고    scopus 로고
    • Anti-DNA autoantibodies stimulate the release of interleukin-1 and interleukin-6 from endothelial cells
    • Lai KN, Leung JC, Lai KB, Li PK, Lai CK. Anti-DNA autoantibodies stimulate the release of interleukin-1 and interleukin-6 from endothelial cells. J. Pathol. 1996; 178: 451-7.
    • (1996) J. Pathol. , vol.178 , pp. 451-457
    • Lai, K.N.1    Leung, J.C.2    Lai, K.B.3    Li, P.K.4    Lai, C.K.5
  • 20
    • 0034094660 scopus 로고    scopus 로고
    • Monoclonal anti-double-stranded DNA autoantibody stimulates the expression and release of IL-1beta, 1L-6, IL-8, 1L-10 and TNF-alpha from normal human mononuclear cells involving in the lupus pathogenesis
    • Sun KH, Yu CL, Tang SJ, Sun GH. Monoclonal anti-double-stranded DNA autoantibody stimulates the expression and release of IL-1beta, 1L-6, IL-8, 1L-10 and TNF-alpha from normal human mononuclear cells involving in the lupus pathogenesis. Immunology 2000; 99: 352-60.
    • (2000) Immunology , vol.99 , pp. 352-360
    • Sun, K.H.1    Yu, C.L.2    Tang, S.J.3    Sun, G.H.4
  • 21
    • 0035138056 scopus 로고    scopus 로고
    • Anti-dsDNA antibody up-regulates interleuldn 6, but not cyclo-oxygenase, gene expression in glomerular rnesangial cells: A marker of immune-mediated renal damage?
    • Yu CL, Sun KH, Tsai CY, Hsieh SC, Yu HS. Anti-dsDNA antibody up-regulates interleuldn 6, but not cyclo-oxygenase, gene expression in glomerular rnesangial cells: A marker of immune-mediated renal damage? Inflamm. Res. 2001; 50: 12-18.
    • (2001) Inflamm. Res. , vol.50 , pp. 12-18
    • Yu, C.L.1    Sun, K.H.2    Tsai, C.Y.3    Hsieh, S.C.4    Yu, H.S.5
  • 23
    • 0030850910 scopus 로고    scopus 로고
    • Lupus nephritis
    • Berden JH. Lupus nephritis. Kidney Int. 1997; 52: 538-58.
    • (1997) Kidney Int. , vol.52 , pp. 538-558
    • Berden, J.H.1
  • 24
    • 0032813046 scopus 로고    scopus 로고
    • Role of nucleosomes for induction and glomerular binding of autoantibodies in lupus nephritis
    • Berden JH, Licht R, van Bruggen MC, Tax WJ. Role of nucleosomes for induction and glomerular binding of autoantibodies in lupus nephritis. Curr. Opin. Nephrol. Hypertens. 1999; 8: 299-306.
    • (1999) Curr. Opin. Nephrol. Hypertens. , vol.8 , pp. 299-306
    • Berden, J.H.1    Licht, R.2    Van Bruggen, M.C.3    Tax, W.J.4
  • 25
    • 0030928223 scopus 로고    scopus 로고
    • Autoantibodies to nucleosomes and histone-DNA complexes
    • Monestier M. Autoantibodies to nucleosomes and histone-DNA complexes. Methods 1997; 11: 36-43.
    • (1997) Methods , vol.11 , pp. 36-43
    • Monestier, M.1
  • 26
    • 0029150696 scopus 로고
    • Apoptosis, nucleosomes, and nephritis in systemic lupus erythematosus
    • Tax WJ, Kramers C, van Bruggen MC, Berden JH. Apoptosis, nucleosomes, and nephritis in systemic lupus erythematosus. Kidney Int. 1995; 48: 666-73.
    • (1995) Kidney Int. , vol.48 , pp. 666-673
    • Tax, W.J.1    Kramers, C.2    Van Bruggen, M.C.3    Berden, J.H.4
  • 27
    • 0028015572 scopus 로고
    • Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo
    • Kramers C, Hylkema MN, van Bruggen MCLR et al. Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo. J. Clin. Invest. 1994; 94: 568-77.
    • (1994) J. Clin. Invest. , vol.94 , pp. 568-577
    • Kramers, C.1    Hylkema, M.N.2    Van Bruggen, M.C.L.R.3
  • 28
    • 0031046862 scopus 로고    scopus 로고
    • Ultraviolet light-induced keratinocyte apoptosis: A potential mechanism for the induction of skin lesions and autoantibody production in LE
    • Casciola-Rosen L, Rosen A. Ultraviolet light-induced keratinocyte apoptosis: a potential mechanism for the induction of skin lesions and autoantibody production in LE. Lupus 1997; 6: 175-80.
    • (1997) Lupus , vol.6 , pp. 175-180
    • Casciola-Rosen, L.1    Rosen, A.2
  • 29
    • 0031891153 scopus 로고    scopus 로고
    • Isolation and characterization of apoptotic nucleosomes, free and complexed with lupus autoantibody generated during hybridoma B-cell apoptosis
    • Cabrespines A, Laderach D, Lebosse C, Bach JF, Koutouzov S. Isolation and characterization of apoptotic nucleosomes, free and complexed with lupus autoantibody generated during hybridoma B-cell apoptosis. J. Autoimmun. 1998; 11: 19-27.
    • (1998) J. Autoimmun. , vol.11 , pp. 19-27
    • Cabrespines, A.1    Laderach, D.2    Lebosse, C.3    Bach, J.F.4    Koutouzov, S.5
  • 30
    • 0031825552 scopus 로고    scopus 로고
    • Systemic exposure to irradiated apoptotic cells indices autoantibody production
    • Mevorach D, Zhou JL, Song X, Elkon KB. Systemic exposure to irradiated apoptotic cells indices autoantibody production. J. Exp. Med. 1998; 188: 387-92.
    • (1998) J. Exp. Med. , vol.188 , pp. 387-392
    • Mevorach, D.1    Zhou, J.L.2    Song, X.3    Elkon, K.B.4
  • 31
    • 0030971352 scopus 로고    scopus 로고
    • Antigen specificity of anti-nuclear antibodies complexed to nucleosomes determines glomerular basement membrane binding in vivo
    • van Bruggen MC, Walgreen B, Rijke TP et al. Antigen specificity of anti-nuclear antibodies complexed to nucleosomes determines glomerular basement membrane binding in vivo. Eur. J. Immunol. 1997; 27: 1564-9.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1564-1569
    • Van Bruggen, M.C.1    Walgreen, B.2    Rijke, T.P.3
  • 32
    • 8044257728 scopus 로고    scopus 로고
    • Nucleosomes and histones are present in glomeiular deposits in human lupus nephritis
    • van Bruggen MC, Kramers C, Walgreen B et al. Nucleosomes and histones are present in glomeiular deposits in human lupus nephritis. Nephrol. Dial. Transplant. 1997; 12: 57-66.
    • (1997) Nephrol. Dial. Transplant. , vol.12 , pp. 57-66
    • Van Bruggen, M.C.1    Kramers, C.2    Walgreen, B.3
  • 34
    • 0028927607 scopus 로고
    • The Fas death factor
    • Nagata S, Golstein P. The Fas death factor. Science 1995; 267: 1449-56.
    • (1995) Science , vol.267 , pp. 1449-1456
    • Nagata, S.1    Golstein, P.2
  • 35
    • 0033954463 scopus 로고    scopus 로고
    • Apoptosis in rheumatic diseases
    • Grodzicky T, Elkon KB. Apoptosis in rheumatic diseases. Am. J. Med. 2000; 108: 73-82.
    • (2000) Am. J. Med. , vol.108 , pp. 73-82
    • Grodzicky, T.1    Elkon, K.B.2
  • 36
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770-76.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 37
    • 0025786164 scopus 로고
    • bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
    • Strasser A, Harris AW, Cory S. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 1991; 67: 889-99.
    • (1991) Cell , vol.67 , pp. 889-899
    • Strasser, A.1    Harris, A.W.2    Cory, S.3
  • 38
    • 0033120556 scopus 로고    scopus 로고
    • Contribution of renal secreted complement C3 to the circulating pool in humans
    • Tang S, Zhou W, Sheerin NS, Vaughan RW, Sacks SH. Contribution of renal secreted complement C3 to the circulating pool in humans. J. Immunol. 1999; 162: 4336-41.
    • (1999) J. Immunol. , vol.162 , pp. 4336-4341
    • Tang, S.1    Zhou, W.2    Sheerin, N.S.3    Vaughan, R.W.4    Sacks, S.H.5
  • 39
    • 0029764359 scopus 로고    scopus 로고
    • Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5
    • Wang Y, Hu Q, Madri JA, Rollins SA, Chodera A, Matis LA. Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5. Proc. Natl. Acad. Sci. U S A 1996; 93: 8563-8.
    • (1996) Proc. Natl. Acad. Sci. U S A , vol.93 , pp. 8563-8568
    • Wang, Y.1    Hu, Q.2    Madri, J.A.3    Rollins, S.A.4    Chodera, A.5    Matis, L.A.6
  • 40
    • 0035849176 scopus 로고    scopus 로고
    • Complement. Second of two parts
    • Walport MJ. Complement. Second of two parts. N. Engl. J. Med. 2001; 344: 1140-44.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1140-1144
    • Walport, M.J.1
  • 42
    • 0035338308 scopus 로고    scopus 로고
    • Accelerated nephrotoxic nephritis is exacerbated in C1q-deficient mice
    • Robson MG, Cook HT, Botto M et al. Accelerated nephrotoxic nephritis is exacerbated in C1q-deficient mice. J. Immunol. 2001; 166: 6820-28.
    • (2001) J. Immunol. , vol.166 , pp. 6820-6828
    • Robson, M.G.1    Cook, H.T.2    Botto, M.3
  • 43
    • 0036467412 scopus 로고    scopus 로고
    • Complement C4 is protective for lupus disease independent of C3
    • Einav S, Pozdnyakova OO, Ma M, Carroll MC. Complement C4 is protective for lupus disease independent of C3. J. Immunol. 2002; 168: 1036-41.
    • (2002) J. Immunol. , vol.168 , pp. 1036-1041
    • Einav, S.1    Pozdnyakova, O.O.2    Ma, M.3    Carroll, M.C.4
  • 44
    • 0035873190 scopus 로고    scopus 로고
    • Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice
    • Sekine H, Reilly CM, Molano ID et al. Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice. J. Immunol. 2001; 166: 6444-51.
    • (2001) J. Immunol. , vol.166 , pp. 6444-6451
    • Sekine, H.1    Reilly, C.M.2    Molano, I.D.3
  • 45
    • 0036499075 scopus 로고    scopus 로고
    • C1q deficiency and autoimmunity: The effects of genetic background on disease expression
    • Mitchell DA, Pickering MC, Warren J et al. C1q deficiency and autoimmunity: The effects of genetic background on disease expression. J. Immunol. 2002; 168: 2538-43.
    • (2002) J. Immunol. , vol.168 , pp. 2538-2543
    • Mitchell, D.A.1    Pickering, M.C.2    Warren, J.3
  • 46
    • 0036186965 scopus 로고    scopus 로고
    • Modulation of renal disease in MRL/lpr mice by pharmacologic inhibition of inducible nitric oxide synthase
    • Reilly CM, Farrelly LW, Viti D et al. Modulation of renal disease in MRL/lpr mice by pharmacologic inhibition of inducible nitric oxide synthase. Kidney Int. 2002; 61: 839-46.
    • (2002) Kidney Int. , vol.61 , pp. 839-846
    • Reilly, C.M.1    Farrelly, L.W.2    Viti, D.3
  • 47
    • 0034141531 scopus 로고    scopus 로고
    • Inhibition of mesangial cell nitric oxide in MRL/lpr mice by prostaglandin J2 and proliferator activation receptor-gamma agonists
    • Reilly CM, Oates JC, Cook JA, Morrow JD, Halushka PV, Gilkeson GS. Inhibition of mesangial cell nitric oxide in MRL/lpr mice by prostaglandin J2 and proliferator activation receptor-gamma agonists. J. Immunol. 2000; 164: 1498-504.
    • (2000) J. Immunol. , vol.164 , pp. 1498-1504
    • Reilly, C.M.1    Oates, J.C.2    Cook, J.A.3    Morrow, J.D.4    Halushka, P.V.5    Gilkeson, G.S.6
  • 48
    • 0034687429 scopus 로고    scopus 로고
    • Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis
    • Hong Kong-Guangzhou Nephrology Study Group
    • Chan TM, Li FK, Tang CS et al. Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. Hong Kong-Guangzhou Nephrology Study Group. N. Engl. J. Med. 2000; 343: 1156-62.
    • (2000) N. Engl. J. Med. , vol.343 , pp. 1156-1162
    • Chan, T.M.1    Li, F.K.2    Tang, C.S.3
  • 49
    • 0034956077 scopus 로고    scopus 로고
    • Mycophenolate mofetil reduces renal cortical inducible nitric oxide synthase mRNA expression and diminishes glomerulosclerosis in MRL/lpr mice
    • Yu CC, Yang CW, Wu MS et al. Mycophenolate mofetil reduces renal cortical inducible nitric oxide synthase mRNA expression and diminishes glomerulosclerosis in MRL/lpr mice. J. Lab. Clin. Med. 2001; 138: 69-77.
    • (2001) J. Lab. Clin. Med. , vol.138 , pp. 69-77
    • Yu, C.C.1    Yang, C.W.2    Wu, M.S.3
  • 50
    • 0036024147 scopus 로고    scopus 로고
    • Effect of mycophenolate mofetil on severity of nephritis and nitric oxide production in lupus-prone MRL/lpr mice
    • Lui SL, Tsang R, Wong D et al. Effect of mycophenolate mofetil on severity of nephritis and nitric oxide production in lupus-prone MRL/lpr mice. Lupus 2002; 11: 411-18.
    • (2002) Lupus , vol.11 , pp. 411-418
    • Lui, S.L.1    Tsang, R.2    Wong, D.3
  • 51
    • 0036199685 scopus 로고    scopus 로고
    • Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
    • Zou MH, Shi C, Cohen RA. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J. Clin. Invest. 2002; 109: 817-26.
    • (2002) J. Clin. Invest. , vol.109 , pp. 817-826
    • Zou, M.H.1    Shi, C.2    Cohen, R.A.3
  • 52
    • 0035059028 scopus 로고    scopus 로고
    • Antioxidants suppress mortality in the female NZB × NZW F1 mouse model of systemic lupus erythematosus (SLE)
    • Suwannaroj S, Lagoo A, Keisler D, McMurray RW. Antioxidants suppress mortality in the female NZB × NZW F1 mouse model of systemic lupus erythematosus (SLE). Lupus 2001; 10: 258-65.
    • (2001) Lupus , vol.10 , pp. 258-265
    • Suwannaroj, S.1    Lagoo, A.2    Keisler, D.3    McMurray, R.W.4


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