Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells

Cancer Chemotherapy and Pharmacology

Volumn 64, Issue 6, 2009, Pages 1115-1122

  Suzuki, Maiko ^a   Endo, Manabu ^a   Shinohara, Fumiaki ^a   Echigo, Seishi ^a   Rikiishi, Hidemi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cisplatin; Endoplasmic reticulum stress; Oral squamous cell carcinoma; Suberoylanilide hydroxamic acid

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BETA ACTIN; CASPASE; CASPASE 12; CASPASE 4; CISPLATIN; ETOPOSIDE; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; INITIATION FACTOR 2ALPHA; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN KINASE B; THAPSIGARGIN; VALPROIC ACID; VORINOSTAT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOUTH CARCINOMA; NICK END LABELING; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SQUAMOUS CELL CARCINOMA; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CASPASE 12; CASPASES, INITIATOR; CELL LINE, TUMOR; CINNAMATES; CISPLATIN; DRUG SYNERGISM; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; EUKARYOTIC INITIATION FACTOR-2; FEMALE; HEAT-SHOCK PROTEINS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; IN SITU NICK-END LABELING; MEMBRANE GLYCOPROTEINS; MOUTH NEOPLASMS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 1; PROTO-ONCOGENE PROTEINS C-AKT; THAPSIGARGIN; THIOUREA; TUNICAMYCIN; VALPROIC ACID;

EID: 69049084488     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-0969-x     Document Type: Article

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