메뉴 건너뛰기




Volumn 61, Issue 4, 2009, Pages 503-510

Synergism of simvastatin with losartan prevents angiotensin II-induced cardiomyocyte apoptosis in vitro

Author keywords

Angiotensin II; Bax; Bcl 2; Cardiomyocyte apoptosis; Losartan; Simvastatin

Indexed keywords

ANGIOTENSIN II; LOSARTAN; PROTEIN BAX; PROTEIN BCL 2; SIMVASTATIN;

EID: 66449122174     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp/61.04.0013     Document Type: Article
Times cited : (13)

References (35)
  • 1
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: A review of programmed cell death
    • Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol 2007; 35: 495-516.
    • (2007) Toxicol Pathol , vol.35 , pp. 495-516
    • Elmore, S.1
  • 2
    • 28244442462 scopus 로고    scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in human disease
    • Fadeel B, Orrenius S. Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. J Intern Med 2005; 258: 479-517.
    • (2005) J Intern Med , vol.258 , pp. 479-517
    • Fadeel, B.1    Orrenius, S.2
  • 3
    • 0031010638 scopus 로고    scopus 로고
    • Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat
    • Li Z et al. Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat. Am J Physiol 1997; 272: H2313-2319.
    • (1997) Am J Physiol , vol.272
    • Li, Z.1
  • 4
    • 85047694494 scopus 로고    scopus 로고
    • A mechanistic role for cardiac myocyte apoptosis in heart failure
    • Wencker D et al. A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest 2003; 111: 1497-1504.
    • (2003) J Clin Invest , vol.111 , pp. 1497-1504
    • Wencker, D.1
  • 5
    • 0036836660 scopus 로고    scopus 로고
    • Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling
    • Abbate A et al. Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling. J Am Coll Cardiol 2002; 193: 145-153.
    • (2002) J Am Coll Cardiol , vol.193 , pp. 145-153
    • Abbate, A.1
  • 6
    • 0033229866 scopus 로고    scopus 로고
    • p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by bcl-2
    • Li PF et al. p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by bcl-2. EMBO J 1999; 21: 6027-6036.
    • (1999) EMBO J , vol.21 , pp. 6027-6036
    • Li, P.F.1
  • 7
    • 0033564419 scopus 로고    scopus 로고
    • Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat
    • Condorelli G et al. Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat. Circulation 1999; 99: 3071-3078.
    • (1999) Circulation , vol.99 , pp. 3071-3078
    • Condorelli, G.1
  • 8
    • 34548415025 scopus 로고    scopus 로고
    • Role of cardiac overexpression of Ang II in the regulation of cardiac function and remodeling postmyocardial infarction
    • Xu J et al. Role of cardiac overexpression of Ang II in the regulation of cardiac function and remodeling postmyocardial infarction. Am J Physiol Heart Circ Physiol 2007; 293: H1900-1907.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Xu, J.1
  • 9
    • 34249283088 scopus 로고    scopus 로고
    • Overexpression of myofibrillogenesis regulator-1 aggravates cardiac hypertrophy induced by angiotensin II in mice
    • Li HL et al. Overexpression of myofibrillogenesis regulator-1 aggravates cardiac hypertrophy induced by angiotensin II in mice. Hypertension 2007; 49: 1399-1408.
    • (2007) Hypertension , vol.49 , pp. 1399-1408
    • Li, H.L.1
  • 10
    • 0036776926 scopus 로고    scopus 로고
    • Effects of angiotensin II type 1 and type 2 receptor on apoptosis
    • Ono H, Ishimitsu T Effects of angiotensin II type 1 and type 2 receptor on apoptosis. Nippon Rinsho 2002; 60: 1887-1892.
    • (2002) Nippon Rinsho , vol.60 , pp. 1887-1892
    • Ono, H.1    Ishimitsu, T.2
  • 11
    • 0030031398 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor mediates programmed cell death
    • Yamada T et al. Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad SciUSA 1996; 93: 156-160.
    • (1996) Proc Natl Acad SciUSA , vol.93 , pp. 156-160
    • Yamada, T.1
  • 12
    • 0031105576 scopus 로고    scopus 로고
    • Angiotensin II induces apoptosis of adult ventricular myocytes in vitro
    • Kajstura J et al.Angiotensin II induces apoptosis of adult ventricular myocytes in vitro. J Mol Cell Cardiol 1997; 29: 859-870.
    • (1997) J Mol Cell Cardiol , vol.29 , pp. 859-870
    • Kajstura, J.1
  • 13
    • 0347416958 scopus 로고    scopus 로고
    • Role of angiotensin AT1 and AT2 receptors in cardiac hypertrophy and cardiac remodelling
    • Zhu YC et al. Role of angiotensin AT1 and AT2 receptors in cardiac hypertrophy and cardiac remodelling. Clin Exp Pharmacol Physiol 2003; 30: 911-918.
    • (2003) Clin Exp Pharmacol Physiol , vol.30 , pp. 911-918
    • Zhu, Y.C.1
  • 14
    • 0142257958 scopus 로고    scopus 로고
    • A novel activation process of protein kinase C in the remote, non-ischemic area of an infarcted heart is mediated by angiotensin-AT1 receptors
    • Simonis G et al. A novel activation process of protein kinase C in the remote, non-ischemic area of an infarcted heart is mediated by angiotensin-AT1 receptors. J Mol Cell Cardiol 2003; 35: 1349-1358.
    • (2003) J Mol Cell Cardiol , vol.35 , pp. 1349-1358
    • Simonis, G.1
  • 16
    • 0036720089 scopus 로고    scopus 로고
    • Long-term combined therapy with an angiotensin type I receptor blocker and an angiotensin converting enzyme inhibitor prolongs survival in dilated cardiomyopathy
    • Shimizu T et al. Long-term combined therapy with an angiotensin type I receptor blocker and an angiotensin converting enzyme inhibitor prolongs survival in dilated cardiomyopathy. Jpn Heart J 2002; 43: 531-543.
    • (2002) Jpn Heart J , vol.43 , pp. 531-543
    • Shimizu, T.1
  • 17
    • 0037277959 scopus 로고    scopus 로고
    • Effects of the AT1 receptor antagonist eprosartan on the progression of left ventricular dysfunction in dogs with heart failure
    • Suzuki G et al. Effects of the AT1 receptor antagonist eprosartan on the progression of left ventricular dysfunction in dogs with heart failure. Br J Pharmacol 2003; 138: 301-309.
    • (2003) Br J Pharmacol , vol.138 , pp. 301-309
    • Suzuki, G.1
  • 18
    • 0035964390 scopus 로고    scopus 로고
    • Improvement of left ventricular remodeling and function by hydroxymethylglutaryl coenzyme A reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction
    • Bauersachs J et al. Improvement of left ventricular remodeling and function by hydroxymethylglutaryl coenzyme A reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction. Circulation 2001; 104: 982-985.
    • (2001) Circulation , vol.104 , pp. 982-985
    • Bauersachs, J.1
  • 19
    • 1442324356 scopus 로고    scopus 로고
    • OPTIMAAL Investigators. Effect of combined statin and beta-blocker treatment on one-year morbidity and mortality after acute myocardial infarction associated with heart failure
    • Hognestad A et al., OPTIMAAL Investigators. Effect of combined statin and beta-blocker treatment on one-year morbidity and mortality after acute myocardial infarction associated with heart failure. Am J Cardiol 2004; 93: 603-606.
    • (2004) Am J Cardiol , vol.93 , pp. 603-606
    • Hognestad, A.1
  • 20
    • 20844431696 scopus 로고    scopus 로고
    • Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase
    • Landmesser U et al. Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase. Circulation 2004; 110: 1933-1939.
    • (2004) Circulation , vol.110 , pp. 1933-1939
    • Landmesser, U.1
  • 21
    • 0037036971 scopus 로고    scopus 로고
    • the OPTIMAAL Steering Committee of the OPTIMAAL Study Group. Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: The OPTIMAAL randomised trial: Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan
    • Dickstein K, Kjekshus J, the OPTIMAAL Steering Committee of the OPTIMAAL Study Group. Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial: Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan. Lancet 2002; 360: 752-760.
    • (2002) Lancet , vol.360 , pp. 752-760
    • Dickstein, K.1    Kjekshus, J.2
  • 22
    • 0036199909 scopus 로고    scopus 로고
    • Impact of HMG CoA reductase inhibition on small GTPases in the heart
    • Laufs U et al. Impact of HMG CoA reductase inhibition on small GTPases in the heart. Cardiovasc Res 2002; 53: 911-920.
    • (2002) Cardiovasc Res , vol.53 , pp. 911-920
    • Laufs, U.1
  • 23
    • 0141841614 scopus 로고    scopus 로고
    • Oxygen free-radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment
    • Maack C et al. Oxygen free-radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment. Circulation 2003; 108: 1567-1574.
    • (2003) Circulation , vol.108 , pp. 1567-1574
    • Maack, C.1
  • 24
    • 0344541709 scopus 로고    scopus 로고
    • Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men
    • Nickenig G et al. Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men. Circulation 1999; 100: 2131-2134.
    • (1999) Circulation , vol.100 , pp. 2131-2134
    • Nickenig, G.1
  • 25
    • 38149125631 scopus 로고    scopus 로고
    • Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy
    • Tang SC et al. Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy. Kidney Int 2008; 73: 288-299.
    • (2008) Kidney Int , vol.73 , pp. 288-299
    • Tang, S.C.1
  • 26
    • 0141505060 scopus 로고    scopus 로고
    • Adenosine protects against angiotensin II-induced apoptosis in rat cardiocyte cultures
    • Goldenberg I et al. Adenosine protects against angiotensin II-induced apoptosis in rat cardiocyte cultures. Mol Cell Biochem 2003; 252: 133-139.
    • (2003) Mol Cell Biochem , vol.252 , pp. 133-139
    • Goldenberg, I.1
  • 27
    • 12344299349 scopus 로고    scopus 로고
    • Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats
    • Xie HH et al. Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats. J Hypertens 2005; 23: 193-201.
    • (2005) J Hypertens , vol.23 , pp. 193-201
    • Xie, H.H.1
  • 28
    • 33746393309 scopus 로고    scopus 로고
    • Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats
    • Wang J et al. Effects of nine antihypertensive drugs on blood pressure variability in sinoaortic-denervated rats. Acta Pharmacol Sin 2006; 27: 1013-1017.
    • (2006) Acta Pharmacol Sin , vol.27 , pp. 1013-1017
    • Wang, J.1
  • 29
    • 1342346683 scopus 로고    scopus 로고
    • Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro
    • Pang JJ et al. Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro. Am J Physiol Heart Circ Physiol 2004; 286: H1063-1069.
    • (2004) Am J Physiol Heart Circ Physiol , vol.286
    • Pang, J.J.1
  • 30
    • 33748444706 scopus 로고    scopus 로고
    • Angiotensin-II activates apoptosis, proliferation and protein synthesis in the left heart ventricle of newborn albino rats
    • Mel'nikova NP et al. Angiotensin-II activates apoptosis, proliferation and protein synthesis in the left heart ventricle of newborn albino rats. Int J Cardiol 2006; 112: 219-222.
    • (2006) Int J Cardiol , vol.112 , pp. 219-222
    • Mel'nikova, N.P.1
  • 31
    • 0019178118 scopus 로고    scopus 로고
    • Jin ZJ. Addition in drug combination. Acta Pharmacol Sin 1980; 1: 70-76.
    • Jin ZJ. Addition in drug combination. Acta Pharmacol Sin 1980; 1: 70-76.
  • 32
    • 33751355498 scopus 로고    scopus 로고
    • Synergism of hydrochlorothiazide and nitrendipine on reduction of blood pressure and blood pressure variability in spontaneously hypertensive rats
    • Han P et al. Synergism of hydrochlorothiazide and nitrendipine on reduction of blood pressure and blood pressure variability in spontaneously hypertensive rats. Acta Pharmacol Sin 2006; 27: 1575-1579.
    • (2006) Acta Pharmacol Sin , vol.27 , pp. 1575-1579
    • Han, P.1
  • 33
    • 35649014355 scopus 로고    scopus 로고
    • Effects of combination therapy with atenolol and amlodipine on blood pressure control and stroke prevention in stroke-prone spontaneously hypertensive rats
    • Ling G et al. Effects of combination therapy with atenolol and amlodipine on blood pressure control and stroke prevention in stroke-prone spontaneously hypertensive rats. Acta Pharmacol Sin 2007; 28: 1755-1760.
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 1755-1760
    • Ling, G.1
  • 34
    • 0035122832 scopus 로고    scopus 로고
    • Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: Involvement of angiotensin AT1 receptor expression and Rac1 GTPase
    • Wassmann S et al. Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase. Mol Pharmacol 2001; 59: 646-654.
    • (2001) Mol Pharmacol , vol.59 , pp. 646-654
    • Wassmann, S.1
  • 35
    • 0032745205 scopus 로고    scopus 로고
    • Simvastatin inhibits cardiac hypertrophy and angiotensin-converting enzyme activity in rats with aortic stenosis
    • Luo JD et al. Simvastatin inhibits cardiac hypertrophy and angiotensin-converting enzyme activity in rats with aortic stenosis. Clin Exp Pharmacol Physiol 1999; 26: 903-908.
    • (1999) Clin Exp Pharmacol Physiol , vol.26 , pp. 903-908
    • Luo, J.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.