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Volumn 103, Issue 3, 2011, Pages 429-436

The elephant in the room: Do microRNA-based therapies have a realistic chance of succeeding for brain tumors such as glioblastoma?

Author keywords

Delivery; Glioblastoma; Glioma; MicroRNA

Indexed keywords

MICRORNA; MICRORNA 21; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TEMOZOLOMIDE; VIRUS VECTOR;

EID: 79959808781     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-010-0449-5     Document Type: Review
Times cited : (32)

References (76)
  • 1
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
    • DOI 10.1038/35888
    • Fire A, Xu S, Montgomery MK et al (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391:806-811 (Pubitemid 28099681)
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 2
    • 17844364875 scopus 로고    scopus 로고
    • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    • DOI 10.1016/S0092-8674(01)00431-7
    • Grishok A, Pasquinelli AE, Conte D et al (2001) Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106:23-34 (Pubitemid 32709955)
    • (2001) Cell , vol.106 , Issue.1 , pp. 23-34
    • Grishok, A.1    Pasquinelli, A.E.2    Conte, D.3    Li, N.4    Parrish, S.5    Ha, I.6    Baillie, D.L.7    Fire, A.8    Ruvkun, G.9    Mello, C.C.10
  • 3
    • 0033615491 scopus 로고    scopus 로고
    • A species of small antisense RNA in posttranscriptional gene silencing in plants
    • Hamilton AJ, Baulcombe DC (1999) A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 286:950-952
    • (1999) Science , vol.286 , pp. 950-952
    • Hamilton, A.J.1    Baulcombe, D.C.2
  • 4
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • DOI 10.1038/35005107
    • Hammond SM, Bernstein E, Beach D et al (2000) An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404:293-296 (Pubitemid 30163547)
    • (2000) Nature , vol.404 , Issue.6775 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 5
    • 0024963695 scopus 로고
    • A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans
    • Ambros V (1989) A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans. Cell 57:49-57
    • (1989) Cell , vol.57 , pp. 49-57
    • Ambros, V.1
  • 6
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • DOI 10.1126/science.1064921
    • Lagos-Quintana M, Rauhut R, Lendeckel W et al (2001) Identification of novel genes coding for small expressed RNAs. Science 294:853-858 (Pubitemid 33032103)
    • (2001) Science , vol.294 , Issue.5543 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 8
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • DOI 10.1016/0092-8674(93)90530-4
    • Wightman B, Ha I, Ruvkun G (1993) Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75:855-862 (Pubitemid 24014543)
    • (1993) Cell , vol.75 , Issue.5 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 10
    • 0035955366 scopus 로고    scopus 로고
    • An extensive class of small RNAs in Caenorhabditis elegans
    • DOI 10.1126/science.1065329
    • Lee RC, Ambros V (2001) An extensive class of small RNAs in Caenorhabditis elegans. Science 294:862-864 (Pubitemid 33032105)
    • (2001) Science , vol.294 , Issue.5543 , pp. 862-864
    • Lee, R.C.1    Ambros, V.2
  • 12
    • 0037144546 scopus 로고    scopus 로고
    • A microRNA in a multiple-turnover RNAi enzyme complex
    • Hutvagner G, Zamore PD (2002) A microRNA in a multiple-turnover RNAi enzyme complex. Science 297:2056-2060
    • (2002) Science , vol.297 , pp. 2056-2060
    • Hutvagner, G.1    Zamore, P.D.2
  • 13
  • 14
    • 0029801668 scopus 로고    scopus 로고
    • A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation
    • Ha I, Wightman B, Ruvkun G (1996) A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation. Genes Dev 10:3041-3050 (Pubitemid 26412530)
    • (1996) Genes and Development , vol.10 , Issue.23 , pp. 3041-3050
    • Ha, I.1    Wightman, B.2    Ruvkun, G.3
  • 15
    • 18244402404 scopus 로고    scopus 로고
    • Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-boxclass microRNAs
    • Lai EC, Tam B, Rubin GM (2005) Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-boxclass microRNAs. Genes Dev 19:1067-1080
    • (2005) Genes Dev , vol.19 , pp. 1067-1080
    • Lai, E.C.1    Tam, B.2    Rubin, G.M.3
  • 16
    • 22144478256 scopus 로고    scopus 로고
    • MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
    • DOI 10.1038/ncb1274
    • Liu J, Valencia-Sanchez MA, Hannon GJ et al (2005) MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol 7:719-723 (Pubitemid 40975754)
    • (2005) Nature Cell Biology , vol.7 , Issue.7 , pp. 719-723
    • Liu, J.1    Valencia-Sanchez, M.A.2    Hannon, G.J.3    Parker, R.4
  • 17
    • 20444427566 scopus 로고    scopus 로고
    • Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies
    • DOI 10.1038/ncb1265
    • Sen GL, Blau HM (2005) Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. Nat Cell Biol 7:633-636 (Pubitemid 40796987)
    • (2005) Nature Cell Biology , vol.7 , Issue.6 , pp. 633-636
    • Sen, G.L.1    Blau, H.M.2
  • 18
    • 49949116902 scopus 로고    scopus 로고
    • The impact of microRNAs on protein output
    • Baek B, Villen J, Shin C et al (2008) The impact of microRNAs on protein output. Nature 455:44-45
    • (2008) Nature , vol.455 , pp. 44-45
    • Baek, B.1    Villen, J.2    Shin, C.3
  • 19
    • 49949117302 scopus 로고    scopus 로고
    • Widespread changes in protein synthesis induced by microRNAs
    • Selbach M, Schwanhausser B, Thierfelder N et al (2008) Widespread changes in protein synthesis induced by microRNAs. Nature 455:58-63
    • (2008) Nature , vol.455 , pp. 58-63
    • Selbach, M.1    Schwanhausser, B.2    Thierfelder, N.3
  • 20
    • 33846675660 scopus 로고    scopus 로고
    • Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos
    • DOI 10.1093/nar/gkl1032
    • Yu Z, Jian Z, Shen SH et al (2007) Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos. Nucleic Acids Res 35:152-164 (Pubitemid 46189840)
    • (2007) Nucleic Acids Research , vol.35 , Issue.1 , pp. 152-164
    • Yu, Z.1    Jian, Z.2    Shen, S.-H.3    Purisima, E.4    Wang, E.5
  • 21
    • 0141631876 scopus 로고    scopus 로고
    • A microRNA array reveals extensive regulation of microRNAs during brain development
    • DOI 10.1261/rna.5980303
    • Krichevsky AM, King KS, Donahue CP et al (2003) A microRNA array reveals extensive regulation of microRNAs during brain development. RNA 9:1274-1281 (Pubitemid 37151681)
    • (2003) RNA , vol.9 , Issue.10 , pp. 1274-1281
    • Krichevsky, A.M.1    King, K.S.2    Donahue, C.P.3    Khrapko, K.4    Kosik, K.S.5
  • 22
    • 22244467087 scopus 로고    scopus 로고
    • MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    • DOI 10.1158/0008-5472.CAN-05-0137
    • Chan JA, Krichevsky AM, Kosik KS (2005) MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65:6029-6033 (Pubitemid 40994386)
    • (2005) Cancer Research , vol.65 , Issue.14 , pp. 6029-6033
    • Chan, J.A.1    Krichevsky, A.M.2    Kosik, K.S.3
  • 23
    • 42249090353 scopus 로고    scopus 로고
    • miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism
    • Fujita S, Ito T, Mizutani T et al (2008) miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J Mol Biol 378:492-504
    • (2008) J Mol Biol , vol.378 , pp. 492-504
    • Fujita, S.1    Ito, T.2    Mizutani, T.3
  • 25
    • 38149042783 scopus 로고    scopus 로고
    • Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells
    • Frankel LB, Christoffersen NR, Jacobsen A et al (2008) Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem 283:1026-1033
    • (2008) J Biol Chem , vol.283 , pp. 1026-1033
    • Frankel, L.B.1    Christoffersen, N.R.2    Jacobsen, A.3
  • 26
    • 50249173450 scopus 로고    scopus 로고
    • MiR-21 promotes glioma invasion by targeting MMP regulators
    • Gabriely G, Wurdinger T, Kesari S et al (2008) MiR-21 promotes glioma invasion by targeting MMP regulators. Mol Cell Biol 28:5369-5380
    • (2008) Mol Cell Biol , vol.28 , pp. 5369-5380
    • Gabriely, G.1    Wurdinger, T.2    Kesari, S.3
  • 27
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer
    • DOI 10.1053/j.gastro.2007.05.022, PII S0016508507010025
    • Meng F, Henson R, Wehbe-Janek H et al (2007) MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133:647-658 (Pubitemid 47187346)
    • (2007) Gastroenterology , vol.133 , Issue.2 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 28
    • 40249092910 scopus 로고    scopus 로고
    • MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
    • DOI 10.1038/cr.2008.24, PII CR200824
    • Zhu S, Wu H, Wu F et al (2008) MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res 18:350-359 (Pubitemid 351333899)
    • (2008) Cell Research , vol.18 , Issue.3 , pp. 350-359
    • Zhu, S.1    Wu, H.2    Wu, F.3    Nie, D.4    Sheng, S.5    Mo, Y.-Y.6
  • 29
    • 35148900227 scopus 로고    scopus 로고
    • MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell-delivered S-TRAIL in human gliomas
    • DOI 10.1158/0008-5472.CAN-07-1045
    • Corsten MF, Miranda R, Kasmieh R et al (2007) MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas. Cancer Res 67:8994-9000 (Pubitemid 47535880)
    • (2007) Cancer Research , vol.67 , Issue.19 , pp. 8994-9000
    • Corsten, M.F.1    Miranda, R.2    Kasmieh, R.3    Krichevsky, A.M.4    Weissleder, R.5    Shah, K.6
  • 34
    • 52949127316 scopus 로고    scopus 로고
    • MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
    • Fornari F, Gramantieri L, Ferracin M et al (2008) MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene 27:5651-5661
    • (2008) Oncogene , vol.27 , pp. 5651-5661
    • Fornari, F.1    Gramantieri, L.2    Ferracin, M.3
  • 35
    • 34548268220 scopus 로고    scopus 로고
    • Kip1 by miRNA 221/222 in glioblastoma
    • Gillies JK, Lorimer IA (2007) Regulation of p27Kip1 by miRNA 221/222 in glioblastoma. Cell Cycle 6:2005-2009 (Pubitemid 47327888)
    • (2007) Cell Cycle , vol.6 , Issue.16 , pp. 2005-2009
    • Gillies, J.K.1    Lorimer, I.A.J.2
  • 36
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • DOI 10.1038/nature06174, PII NATURE06174
    • Ma L, Teruya-Feldstein J, Weinberg RA (2007) Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449:682-688 (Pubitemid 47552092)
    • (2007) Nature , vol.449 , Issue.7163 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 37
    • 48949116262 scopus 로고    scopus 로고
    • MiR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    • Silber J, Lim DA, Petritsch C et al (2008) miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med 6:14
    • (2008) BMC Med , vol.6 , pp. 14
    • Silber, J.1    Lim, D.A.2    Petritsch, C.3
  • 38
    • 68249139817 scopus 로고    scopus 로고
    • MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC
    • Sasayama T, Nishihara M, Kondoh T et al (2009) MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC. Int J Cancer 125:1407-1413
    • (2009) Int J Cancer , vol.125 , pp. 1407-1413
    • Sasayama, T.1    Nishihara, M.2    Kondoh, T.3
  • 39
    • 76649130555 scopus 로고    scopus 로고
    • Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship
    • Kim H, Huang W, Jiang X et al (2010) Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship. Proc Natl Acad Sci USA 107:2183-2188
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 2183-2188
    • Kim, H.1    Huang, W.2    Jiang, X.3
  • 40
    • 33646444884 scopus 로고    scopus 로고
    • Let-7 microRNA functions as a potential growth suppressor in human colon cancer cells
    • Akao Y, Nakagawa Y, Naoe T (2006) let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. Biol Pharm Bull 29:903-906
    • (2006) Biol Pharm Bull , vol.29 , pp. 903-906
    • Akao, Y.1    Nakagawa, Y.2    Naoe, T.3
  • 44
    • 79952186552 scopus 로고    scopus 로고
    • Let-7 microRNA inhibits the proliferation of human glioblastoma cells
    • doi:10.1007/s11060-010-0286-6
    • Lee ST, Chu K, Oh HJ et al (2010) Let-7 microRNA inhibits the proliferation of human glioblastoma cells. J Neurooncol. doi:10.1007/s11060-010- 0286-6
    • (2010) J Neurooncol
    • Lee, S.T.1    Chu, K.2    Oh, H.J.3
  • 46
    • 42049092138 scopus 로고    scopus 로고
    • Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest
    • Sun F, Fu H, Liu Q et al (2008) Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest. FEBS Lett 582:1564-1568
    • (2008) FEBS Lett , vol.582 , pp. 1564-1568
    • Sun, F.1    Fu, H.2    Liu, Q.3
  • 48
    • 34249812122 scopus 로고    scopus 로고
    • MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
    • DOI 10.1038/sj.onc.1210293, PII 1210293
    • Welch C, Chen Y, Stallings RL (2007) MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene 26:5017-5022 (Pubitemid 47172643)
    • (2007) Oncogene , vol.26 , Issue.34 , pp. 5017-5022
    • Welch, C.1    Chen, Y.2    Stallings, R.L.3
  • 49
    • 77953498262 scopus 로고    scopus 로고
    • MicroRNA-34a is tumor suppressive in brain tumors and glioma stem cells
    • Guessous F, Zhang Y, Kofman A et al (2010) MicroRNA-34a is tumor suppressive in brain tumors and glioma stem cells. Cell Cycle 9:1031-1036
    • (2010) Cell Cycle , vol.9 , pp. 1031-1036
    • Guessous, F.1    Zhang, Y.2    Kofman, A.3
  • 50
    • 70350221952 scopus 로고    scopus 로고
    • MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes
    • Li Y, Guessous F, Zhang Y et al (2009) MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res 69:7569-7576
    • (2009) Cancer Res , vol.69 , pp. 7569-7576
    • Li, Y.1    Guessous, F.2    Zhang, Y.3
  • 51
    • 45549089973 scopus 로고    scopus 로고
    • MicroRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma
    • Kefas B, Godlewski J, Comeau L et al (2008) microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer Res 68:3566-3572
    • (2008) Cancer Res , vol.68 , pp. 3566-3572
    • Kefas, B.1    Godlewski, J.2    Comeau, L.3
  • 52
    • 56449126945 scopus 로고    scopus 로고
    • Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal
    • Godlewski J, Nowicki MO, Bronisz A et al (2008) Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res 68:9125-9130
    • (2008) Cancer Res , vol.68 , pp. 9125-9130
    • Godlewski, J.1    Nowicki, M.O.2    Bronisz, A.3
  • 53
    • 72849108572 scopus 로고    scopus 로고
    • The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors
    • Kefas B, Comeau L, Floyd DH et al (2009) The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. J Neurosci 29:15161-15168
    • (2009) J Neurosci , vol.29 , pp. 15161-15168
    • Kefas, B.1    Comeau, L.2    Floyd, D.H.3
  • 54
    • 77649259296 scopus 로고    scopus 로고
    • MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells
    • Godlewski J, Nowicki MO, Bronisz A et al (2010) MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. Mol Cell 37:620-632
    • (2010) Mol Cell , vol.37 , pp. 620-632
    • Godlewski, J.1    Nowicki, M.O.2    Bronisz, A.3
  • 55
    • 54949103214 scopus 로고    scopus 로고
    • MiR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells
    • Wurdinger T, Tannous BA, Saydam O et al (2008) miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell 14:382-393
    • (2008) Cancer Cell , vol.14 , pp. 382-393
    • Wurdinger, T.1    Tannous, B.A.2    Saydam, O.3
  • 56
    • 67649814967 scopus 로고    scopus 로고
    • Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1
    • Ueda R, Kohanbash G, Sasaki K et al (2009) Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1. Proc Natl Acad Sci USA 106:10746-10751
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 10746-10751
    • Ueda, R.1    Kohanbash, G.2    Sasaki, K.3
  • 57
    • 77955282214 scopus 로고    scopus 로고
    • MiR-195, miR-455-3p and miR-10a(*) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells
    • Ujifuku K, Mitsutake N, Takakura S et al (2010) miR-195, miR-455-3p and miR-10a(*) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells. Cancer Lett 296:241-248
    • (2010) Cancer Lett , vol.296 , pp. 241-248
    • Ujifuku, K.1    Mitsutake, N.2    Takakura, S.3
  • 58
    • 77954655739 scopus 로고    scopus 로고
    • MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients
    • Slaby O, Lakomy R, Fadrus P et al (2010) MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients. Neoplasma 57:264-269
    • (2010) Neoplasma , vol.57 , pp. 264-269
    • Slaby, O.1    Lakomy, R.2    Fadrus, P.3
  • 60
    • 60849128839 scopus 로고    scopus 로고
    • Convection-enhanced delivery of nanocarriers for the treatment of brain tumors
    • Allard E, Passirani C, Benoit JP (2009) Convection-enhanced delivery of nanocarriers for the treatment of brain tumors. Biomaterials 30:2302-2318
    • (2009) Biomaterials , vol.30 , pp. 2302-2318
    • Allard, E.1    Passirani, C.2    Benoit, J.P.3
  • 61
    • 75149112409 scopus 로고    scopus 로고
    • Future of convection-enhanced delivery in the treatment of brain tumors
    • Bidros DS, Liu JK, Vogelbaum MA (2010) Future of convection-enhanced delivery in the treatment of brain tumors. Future Oncol 6:117-125
    • (2010) Future Oncol , vol.6 , pp. 117-125
    • Bidros, D.S.1    Liu, J.K.2    Vogelbaum, M.A.3
  • 62
    • 77951477367 scopus 로고    scopus 로고
    • Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment
    • Liu HL, Hua MY, Chen PY et al (2010) Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment. Radiology 255:415-425
    • (2010) Radiology , vol.255 , pp. 415-425
    • Liu, H.L.1    Hua, M.Y.2    Chen, P.Y.3
  • 63
    • 2942594011 scopus 로고    scopus 로고
    • Modulation of brain tumor capillaries for enhanced drug delivery selectively to brain tumor
    • Black KL, Ningaraj NS (2004) Modulation of brain tumor capillaries for enhanced drug delivery selectively to brain tumor. Cancer Control 11:165-173 (Pubitemid 38758221)
    • (2004) Cancer Control , vol.11 , Issue.3 , pp. 165-173
    • Black, K.L.1    Ningaraj, N.S.2
  • 64
    • 70350228485 scopus 로고    scopus 로고
    • Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer
    • Thomas FC, Taskar K, Rudraraju V et al (2009) Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer. Pharm Res 26:2486-2494
    • (2009) Pharm Res , vol.26 , pp. 2486-2494
    • Thomas, F.C.1    Taskar, K.2    Rudraraju, V.3
  • 65
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • Skog J, Wurdinger T, van Rijn S et al (2008) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10:1470-1476
    • (2008) Nat Cell Biol , vol.10 , pp. 1470-1476
    • Skog, J.1    Wurdinger, T.2    Van Rijn, S.3
  • 66
    • 78149409316 scopus 로고    scopus 로고
    • Export of microRNAs and microRNA-protective protein by mammalian cells
    • doi:10.1093/nar/gkq601
    • Wang K, Zhang S, Weber J et al (2010) Export of microRNAs and microRNA-protective protein by mammalian cells. Nucleic Acids Res. doi:10.1093/nar/gkq601
    • (2010) Nucleic Acids Res
    • Wang, K.1    Zhang, S.2    Weber, J.3
  • 67
    • 77954257796 scopus 로고    scopus 로고
    • Secreted monocytic miR-150 enhances targeted endothelial cell migration
    • Zhang Y, Liu D, Chen X et al (2010) Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell 39:133-144
    • (2010) Mol Cell , vol.39 , pp. 133-144
    • Zhang, Y.1    Liu, D.2    Chen, X.3
  • 68
    • 62749181868 scopus 로고    scopus 로고
    • Transfer of microRNAs by embryonic stem cell microvesicles
    • Yuan A, Farber EL, Rapoport AL et al (2009) Transfer of microRNAs by embryonic stem cell microvesicles. PLoS One 4:e4722
    • (2009) PLoS One , vol.4
    • Yuan, A.1    Farber, E.L.2    Rapoport, A.L.3
  • 69
    • 77951194366 scopus 로고    scopus 로고
    • Reduced seed region-based off-target activity with lentivirus-mediated RNAi
    • Klinghoffer RA, Magnus J, Schelter J et al (2010) Reduced seed region-based off-target activity with lentivirus-mediated RNAi. RNA 16:879-884
    • (2010) RNA , vol.16 , pp. 879-884
    • Klinghoffer, R.A.1    Magnus, J.2    Schelter, J.3
  • 71
    • 33646564701 scopus 로고    scopus 로고
    • Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer
    • Brown BD, Venneri MA, Zingale A et al (2006) Endogenous microRNA regulation suppresses transgene expression in hematopoietic lineages and enables stable gene transfer. Nat Med 12:585-591
    • (2006) Nat Med , vol.12 , pp. 585-591
    • Brown, B.D.1    Venneri, M.A.2    Zingale, A.3
  • 73
    • 48349145992 scopus 로고    scopus 로고
    • A let-7 microRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication
    • Edge RE, Falls TJ, Brown CW et al (2008) A let-7 microRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication. Mol Ther 16:1437-1443
    • (2008) Mol Ther , vol.16 , pp. 1437-1443
    • Edge, R.E.1    Falls, T.J.2    Brown, C.W.3
  • 74
    • 73849105202 scopus 로고    scopus 로고
    • Combinatorial control of suicide gene expression by tissue-specific promoter and microRNA regulation for cancer therapy
    • Wu C, Lin J, Hong M et al (2009) Combinatorial control of suicide gene expression by tissue-specific promoter and microRNA regulation for cancer therapy. Mol Ther 17:2058-2066
    • (2009) Mol Ther , vol.17 , pp. 2058-2066
    • Wu, C.1    Lin, J.2    Hong, M.3
  • 75
    • 55549108699 scopus 로고    scopus 로고
    • Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific microRNA
    • Ylosmaki E, Hakkarainen T, Hemminki A et al (2008) Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific microRNA. J Virol 82:11009-11015
    • (2008) J Virol , vol.82 , pp. 11009-11015
    • Ylosmaki, E.1    Hakkarainen, T.2    Hemminki, A.3


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