Reduced seed region-based off-target activity with lentivirus-mediated RNAi

RNA

Volumn 16, Issue 5, 2010, Pages 879-884

  Klinghoffer, Richard A ^a,b   Magnus, Jill ^a,c   Schelter, Janell ^a   Mehaffey, Michele ^a   Coleman, Casey ^a   Cleary, Michele A ^a,d  

^a ROSETTA INPHARMATICS   (United States)

^b Presage Biosciences   (United States)

^c NuGEN Technologies Inc   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Lentivirus; Off target activity; RNA interference; Seed region; shRNA; siRNA

Indexed keywords

LENTIVIRUS VECTOR; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ARTICLE; DOWN REGULATION; GENE EXPRESSION; GENE SEQUENCE; GENE SILENCING; GENE TARGETING; GENOME; HUMAN; HUMAN CELL; LENTIVIRINAE; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE;

BASE SEQUENCE; GENE SILENCING; GENES, P53; GENETIC VECTORS; HELA CELLS; HUMANS; LENTIVIRUS; MICRORNAS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSDUCTION, GENETIC; TRANSFECTION;

LENTIVIRUS;

EID: 77951194366     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.1977810     Document Type: Article

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